Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7

Journal of Biological Chemistry

Volumn 280, Issue 35, 2005, Pages 30949-30955

  Wang, Huanchen ^a   Liu, Yudong ^a   Chen, Yuxiang ^a,c   Robinson, Howard ^b   Ke, Hengming ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CONFORMATIONS; CRYSTAL STRUCTURE; DISEASES;

CYCLIC NUCLEOTIDE; INHIBITOR SELECTIVITY;

ENZYMES;

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 4; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 7; ETAZOLATE; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE 4D2; PHOSPHODIESTERASE 7A1; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHODIESTERASE VII INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG; ZARDAVERINE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ENGINEERING; ENZYME INHIBITION; INHIBITION KINETICS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS; WILD TYPE;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

EID: 24744456706     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504398200     Document Type: Article

References (40)

1. Antoni, F. (2000) Front. Neuroendocrinol. 21, 103-132
2. Carvajal, J. A., Germain, A. M., Huidobro-Toro, J. P., and Weiner, C. P. (2000) J. Cell. Physiol. 184, 409-420
3. Torphy, T. J. (1998) Am. J. Respir. Crit. Care Med. 157, 351-370
4. Soderling, S. H., and Beavo, J. A. (2000) Curr. Opin. Cell Biol. 12, 174-179
5. Mehats, C., Andersen, C. B., Filopanti, M., Jin, S. L., and Conti, M. (2002) Trends Endocrinol. Metab. 13, 29-35
6. Trass, M. C., Stief, C. G., Uckert, S., Becker, A. J., Wafer, J., Schultheiss, D., and Jonas, U. (2001) World J. Urol. 19, 344-350
7. Liu, Y., Shakur, Y., Yoshitake, M., and Kambayashi, J. J. (2001) Cardiovas. Drug Rev. 19, 369-386
8. Huang, Z., Ducharme, Y., MacDonald, D., and Robinchaud, A. (2001) Curr. Opin. Chem. Biol. 5, 432-438
9. Corbin, J. D., and Francis, S. H. (2002) Int. J. Clin. Pract. 56, 453-459
10. Rotella, D. P. (2002) Nature Rev. Drug Discovery 1, 674-682
11. Castro, A., Jerez, M. J., Gil, C., and Martinez, A. (2005) Med. Res. Rev. 25, 229-244
12. Lipworth, B. J. (2005) Lancet 365, 167-175
13. Giembycz, M. A. (2002) Monaldi Arch. Chest Dis. 57, 48-64
14. Bloom, T. J., and Beavo, J. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14188-14192
15. Giembycz, M. A., Corrigan, C. J., Seybold, J., Newton, R., and Barnes, P. J. (1996) Br. J. Pharmacol. 118, 1945-1958
16. Li, L., Yee, C., and Beavo, J. A. (1999) Science 283, 848-851
17. Miro, X., Perez-Torres, S., Palacios, J. M., Puigdomenech, P., and Mengod, G. (2001) Synapse 40, 201-214
18. Lee, R., Wolda, S., Moon, E., Esselstyn, J., Hertel, C., and Lerner, A. (2002) Cell Signal. 14, 277-284
19. Yang, G., McIntyre, K. W., Townsend, R. M., Shen, H. H., Pitts, W. J., Dodd, J. H., Nadler, S. G., McKinnon, M., and Watson, A. J. (2003) J. Immunol. 171, 6414-6420
20. Michaeli, T., Bloom, T. J., Martins, T., Loughney, K., Ferguson, K., Riggs, M., Rodgers, L., Beavo, J. A., and Wigler, M. (1993) J. Biol. Chem. 268, 12925-12932
21. Hau, P., Zhu, X., and Michaeli, T. (1997) J. Biol. Chem. 272, 16152-16157
22. Gardner, C., Robas, N., Cawkill, D., and Fidock, M. (2000) Biochem. Biophys. Res. Commun. 272, 186-192
23. Hetman, J. M., Soderling, S. H., Glavas, N. A., and Beavo, J. A. (2000) Proc. Natl. Acad. Sci., U. S. A. 97, 472-476
24. Richter, W., Hermsdorf, T., Kronbach, T., and Dettmer, D. (2002) Protein Expression Purif. 25, 138-148
25. Huai, Q., Wang, H., Sun, Y., Kim, H. Y., Liu, Y., and Ke, H. (2003) Structure 11, 865-873
26. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
27. Navaza, J., and Saludjian, P. (1997) Methods Enzymol. 276, 581-594
28. Collaborative Computational Project, Number 4 (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
29. Jones, T. A., Zou, J-Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
30. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Cryst. Sect. D Biol. Crystallogr. 54, 905-921
31. Xu, R. X., Hassell, A. M., Vanderwall, D., Lambert, M. H., Holmes, W. D., Luther, M. A., Rocque, W. J., Milburn, M. V., Zhao, Y., Ke, H., and Nolte, R. T (2000) Science 288, 1822-1825
32. Xu, R. X., Rocque, W. J., Lambert, M. H., Vanderwall, D. E., Luther, M. A., and Nolte, R. T. (2004) J. Mol. Biol. 337, 355-365
33. Lee, M. E., Markowitz, J., Lee, J. O., and Lee, H. (2002) FEBS Lett., 530, 53-58
34. Sung, B. J., Hwang, K. Y., Jeon Y. H., Lee, J. I., Heo, Y. S., Kim, J. H., Moon, J., Yoon, J. M., Hyun, Y. L., Kim, E., Eum, S. J., Park, S., Lee, J. O., Lee, T. G., Ro, S., and Cho, J. M. (2003) Nature 425, 98-102
35. Huai, Q., Colicelli, J., and Ke, H. (2003) Biochemistry 42, 13220-13226
36. Huai, Q., Liu, Y., Francis, S. H., Corbin, J. D., and Ke, H. (2004) J. Biol. Chem. 279, 13095-13101
37. Huai, Q., Wang, H., Zhang, W., Colman, R. W., Robinson, H., and Ke, H. (2004) Proc. Natl. Acad. Sci., U. S. A., 101, 9624-9629
38. Zhang, K. Y., Card, G. L., Suzuki, Y., Artis, D. R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B. L., Zhang, C., Milburn, M. V., Kim, S. H., Schlessinger, J., and Bollag, G. (2004) Mol. Cell. 15, 279-286
39. Card, G. L., England, B. P., Suzuki, Y., Fong, D., Powell, B., Lee, B., Luu, C., Tabrizizad, M., Gillette, S., Ibrahim, P. N., Artis, D. R., Bollag, G., Milburn, M. V., Kim, S. H., Schlessinger, J., and Zhang, K. Y. (2004) Structure 12, 2233-2247
40. Scapin, G., Patel, S. B., Chung, C., Varnerin, J. P., Edmondson, S. D., Mastracchio, A., Parmee, E. R., Singh, S. B., Becker, J. W., Van der Ploeg, L. H., and Tota, M. R. (2004) Biochemistry 43, 6091-6100