The myeloid-lymphoid initiating cell (ML-IC) assay assesses the fate of multipotent human progenitors in vitro

Blood

Volumn 93, Issue 11, 1999, Pages 3750-3756

  Punzel, M ^b   Wissink, S D ^b   Miller, J S ^b   Moore, K A ^b   Lemischka, I R ^b   Verfaillie, C M ^a  

^a Stem Cell Institute   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; FETUS LIVER; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0033153096     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.11.3750.411a37_3750_3756     Document Type: Article

References (45)

1. Hodgson GS, Bradley TR: Properties of hematopoietic stem cells surviving 5-fluorouracil treatment. Nature 281:381, 1979
2. Spangrude GJ, Heimfeld S, Weissman IL: Purification and characterization of mouse hematopoietic stem cells. Science 241:58, 1988
3. Spangrude GJ, Johnson JR: Resting and activated subsets of mouse multipotent hematopoietic stem cells. Proc Natl Acad Sci USA 87:7433, 1990
4. Morrison SJ, Weissman IL: The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1:661, 1994
5. McCune JM, Namikawa R, Kaneshima H, Schultz LD, Lieberman M, Weissman IL: The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function. Science 24: 1632, 1988
6. Fraser CC, Kaneshima H, Hansteen G, Kilpatrick M, Hoffman R, Chen BP: Human allogeneic stem cell maintenance and differentiation in a long-term multilineage SCID-hu graft. Blood 86:1680, 1995
7. Kollmann TR, Kim A, Zhuang X, Hachamovitch M, Goldstein H: Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines. Proc Natl Acad Sci USA 91:8032, 1994
8. Nolta JA, Smogorzewska EM, Kohn DB: Analysis of optimal conditions for retroviral mediated transduction of primitive human hematopoietic cells. Blood 86:101, 1995
9. Nolta JA, Dao MA, Wells S, Smogorzewska EM, Kohn DB: Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice. Proc Natl Acad Sci USA 93:2414, 1996
10. Larochelle A, Vormoor J, Hanenberg H, Wang JC, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick JE: Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy. Nat Med 2:1329, 1996
11. Gan OI, Murdoch B, Larochelle A, Dick JE: Differential maintenance of primitive human SCID-repopulating cells, clonogenic progenitors, and long-term culture-initiating cells after incubation on human bone marrow stromal cells. Blood 90:641, 1997
12. Bhatia M, Wang JCY, Knapp U, Bonnet D, Dick JE: Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci USA 94:5320, 1997
13. Cashman J, Bockhold K, Hogge DE, Eaves AC, Eaves CJ: Sustained proliferation, multi-lineage differentiation and maintenance of primitive human hematopoietic cells in NOD/SCID mice transplanted with human cord blood. Br J Haematol 98:1026, 1997
14. Srour EF, Zanjani ED, Cornetta K, Traycoff CM, Flake AW, Hedrick M, Brandt JE, Leemhuis T, Hoffman R: Persistence of human multilineage, self-renewing lymphohematopoietic stem cells in chimeric sheep. Blood 82:3333, 1993
15. Zanjani ED, Almeida-Porada G, Ascensao JL, MacKintosh FR, Flake AW: Transplantation of hematopoietic stem cells in utero. Stem Cells 15:79, 1997 (suppl 1)
16. Sutherland HJ, Lansdorp PM, Henkelman DH, Eaves AC, Eaves CJ: Functional characterization of individual hematopoietic stem cells cultured at limiting dilution on supportive marrow stroma layers. Proc Natl Acad Sci USA 87:3584, 1990
17. Ploemacher RE, van der Sluijs JP, Voerman JS, Brons NH: An in vitro limiting dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood 74:2755, 1989
18. Breems DA, Blokland EAW, Neben S, Ploemacher RE: Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay. Leukemia 8:1095, 1994
19. Hao QL, Thiemann FT, Petersen D, Smogorzewska EM, Crooks GM: Extended long term culture reveals a highly quiescent and primitive human hematopoietic progenitor population. Blood 88:3306, 1996
20. - cells with both lymphoid and myeloid potential. Blood 91:4145, 1998
21. - progenitors give rise to NK cells, B-lineage cells, dendritic cells and myeloid cells. Blood 93:96, 1999
22. Baum CM, Weissman IL, Tsukamoto AS, Buckle AM, Peault B: Isolation of a candidate human hematopoietic stem cell population. Proc Natl Acad Svi USA 89:2804, 1992
23. Moore KA, Hideo E, Lemischka IR: In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood 89: 4337, 1997
24. Whitlock C, Witte O: Long-term culture of B-lymphocytes and their precursors from murine bone marrow. Proc Natl Acad Sci USA 79:3608, 1982
25. Kierney PC, Dorschkind K: B lymphocyte precursors and myeloid precursors survive in diffusion chamber cultures but B cell differentiation requires close association with stromal cells. Blood 70:1418, 1987
26. Neuberger MS: Antigen receptor signaling gives lymphocytes a long life. Cell 90:971, 1997
27. LeBien TW: B-cell lymphopoiesis in mouse and man. Curr Opin Immunol 10:188, 1998
28. + NK progenitor. Blood 83:2594, 1994
29. Punzel M, Miller JS, Verfaillie CM: The mouse fetal liver cell line, AFT024, supports human myelopoiesis and lymphopoiesis better than primary stroma, but this requires contact with the feeder. Blood 88:2128a, 1996(abstr)
30. Punzel M, Moore KA, Lemischka IR, Verfaillie CM: The type of stromal feeder used in limiting dilution assays influences frequency and maintenance assessment of human long-term culture initiating cells. Leukemia (in press)
31. Miller JS, Oelkers S, Verfaillie CM, McGlave PB: Role of monocytes in the expansion of human activated natural killer cells. Blood 80:2221, 1992
32. Lemieux ME, Eaves CJ: Identification of properties that can distinguish primitive populations of stromal cell-responsive lymphomyeloid cells from cells that are stromal cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients. Blood 88:1639, 1996
33. - hematopoietic stem cells. Blood 83:1515, 1994
34. - bone marrow cells with multilineage potential at the single-cell level: Key role of thrombopoietin. Blood 90:2282, 1997
35. - progenitor cells from human cord blood generate B lymphocytes and granulocytes. Blood 89:3554, 1997
36. - primitive progenitor cells. Blood 88:1619, 1996
37. Verfaillie CM, Miller JS: A novel single cell proliferation assay demonstrates that long-term culture-initiating cell (LTC-IC) maintenance over time results from the extensive proliferation of a small fraction of LTC-IC. Blood 86:2137, 1995
38. Moore KA, Pytowski B, Witte L, Hickling D, Lemischka IR: Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA 94:4011, 1997
39. Smas CM, Sul HS: Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 73:725, 1993
40. Muskavitch M: Delta-notch signaling and drosophila cell fate choice. Dev Biol 166:415, 1994
41. Laborda J, Sausville EA, Hoffman T, Notario V: Dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem 268:3817, 1993
42. Moore KA, Genetti DR, Lemischka IR: Novel molecular mechanisms in the hematopoietic microenvironment. Blood 90:1786a, 1997 (abstr)
43. Moore KA, Lemischka IR: The molecular profile of a stem cell supporting microenvironment. Exp Hematol 25:28a, 1997 (abstr)
44. Verfaillie CM, Catanzarro PM: Direct contact with stroma inhibits proliferation of long-term culture initiating cells. Leukemia 10:498, 1996
45. Hurley RW, McCarthy JB, Verfaillie CM: Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. J Clin Invest 96:5111, 1995