Serum albumin binding at cytotoxic concentrations of chemicals as determined with a cell proliferation assay

Toxicology Letters

Volumn 137, Issue 3, 2003, Pages 159-168

  Gülden, Michael ^a   Mörchel, Sabine ^a   Seibert, Hasso ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Balb c 3T3 cells; Bioavailability; Cytotoxic potency; MEIC; Protein binding

Indexed keywords

ACETYLSALICYLIC ACID; BOVINE SERUM ALBUMIN; ETHYLENE GLYCOL; HEXACHLOROPHENE; MERCURIC CHLORIDE; MERCURY; PARAQUAT; PENTACHLOROPHENOL; PROTEIN; SERUM ALBUMIN; THIORIDAZINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCULATION; CELL ASSAY; CELL CULTURE; CELL LINE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

3T3 CELLS; ALGORITHMS; ANIMALS; CELL DIVISION; CELL SURVIVAL; CULTURE MEDIA; EXTRACELLULAR SPACE; FIBROBLASTS; MICE; MICE, INBRED BALB C; PROTEIN BINDING; SERUM ALBUMIN, BOVINE;

BOVINAE;

EID: 0037415394     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00399-5     Document Type: Article

References (25)

1. Baselt R.C., Cravey R.H. Disposition of Toxic Drugs and Chemicals in Man. Third Ed. 1990;Year Book Medical Publishers, Chicago.
2. Blaauboer B.J. Toxicodynamic modelling and the interpretation of in vitro toxicity data. Toxicol. Lett. 120:2001;111-123.
3. Bondesson I., Ekwall B., Hellberg S., Romert L., Stenberg K., Walum E. MEIC - a new international multicenter project to evaluate the relevance to human toxicty of in vitro cytotoxicity tests. Cell Biol. Toxicol. 5:1989;331-347.
4. Ekwall B., Clemedson C., Crafoord B., Ekwall B., Hallander S., Walum E., Bondesson I. MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals. ATLA. 26:(Suppl. 2):1998;571-616.
5. 50 values and results from 61 in vitro methods. ATLA. 26:(Suppl. 2):1998;617-658.
6. Fang S.C., Fallin E. The binding of various mercurial compounds to serum proteins. Bull. Environ. Contam. Toxicol. 19:1976;110-117.
7. Finlay G.J., Baguley B.C. Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs. Cancer Chemother. Pharmacol. 45:2000;417-422.
8. Frazier J.M., Tyson C.A., McCarthy C., McCormick J.J., Meyer D., Powis G., Ducat L. Potential use of human tissues for toxicity research and testing. Toxicol. Appl. Pharmacol. 97:1989;387-397.
9. Garle M.J., Fentem J.H., Fry J.R. In vitro cytotoxicity tests for the prediction of acute toxicity in vivo. Toxicol. In Vitro. 8:1994;1303-1312.
10. Gülden M., Seibert H. Cytotoxic and non-cytotoxic effects of MEIC reference chemicals on spontaneously contracting primary cultured rat skeletal muscle cells. Toxicol. In Vitro. 10:1996;395-406.
11. Gülden M., Seibert H., Voss J.-U. Inclusion of physicochemical data in quantitative comparisons of in vitro and in vivo toxic potencies. ATLA. 22:1994;185-192.
12. Gülden M., Seibert H., Voss J.-U. In vitro toxicity screening using cultured rat skeletal muscle cells. II. Agents affecting excitable membranes. Toxicol. In Vitro. 8:1994;197-206.
13. Gülden M., Mörchel S., Seibert H. Factors influencing nominal effective concentrations of chemical compounds in vitro: cell concentration. Toxicol. In Vitro. 15:2001;233-243.
14. Gülden M., Mörchel S., Tahan S., Seibert H. Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. Toxicology. 175:2002;201-213.
15. Hoben H.J., Ching S.A., Young R.A., Casarett L.J. A study of the inhalation of pentachlorophenol by rats. Part V. A protein binding study of pentachlorophenol. Bull. Environ. Contam. Toxicol. 16:1976;225-232.
16. ICCVAM, 2001. Report of the international workshop on in vitro methods for assessing acute systemic toxicity. Report of an international workshop organised by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). NIH Publication No.01-4499.
17. Ichinose R., Kurihara N. Uptake of dieldrin, lindane, and DDT by isolated rat hepatocytes. Pestic. Biochem. Physiol. 23:1985;116-122.
18. Jusko W.J., Gretch M. Plasma and tissue binding of drugs in pharmacokinetics. Drug Metab. Rev. 5:1976;43-140.
19. Lindup W.E. Plasma protein binding of drugs - some basic and clinical aspects. Bridges J.W., Chasseaud L.F., Gibson G.G. Progress in Drug Metabolism. 10:1987;141-185 Taylor & Francis, London.
20. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
21. Seibert H., Balls M., Fentem J.H., Bianchi V., Clothier H., Dierickx P.J., Ekwall B., Garle M.J., Gomez-Lechon M.J., Gülden M., Liebsch M., Rasmussen E., Roguet R., Shrivastava R., Walum E. Acute toxicity testing in vitro and the classification and labeling of chemicals. The report and recommendations of ECVAM workshop 16. ATLA. 24:1996;499-510.
22. Seibert H., Mörchel S., Gülden M. Factors influencing nominal effective concentrations of chemical compounds in vitro: serum albumin concentration. Toxicol. In Vitro. 16:2002;289-297.
23. Uhl S., Schmid P., Schlatter C. Pharmacokinetics of pentachlorophenol in man. Arch. Toxicol. 58:1986;182-186.
24. Van den Berg K.J. Interaction of chlorinated phenols with thyroxine binding sites of human transthyretin, albumin and thyroid binding globulin. Chem. Biol. Interact. 76:1990;63-75.
25. Weinbach E.C., Garbus J. Restoration by albumin of oxidative phosphorylation and related reactions. J. Biol. Chem. 241:1966;169-175.