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Volumn 27, Issue 3, 1999, Pages 339-349

EDIT: A new international multicentre programme to develop and evaluate batteries of in vitro tests for acute and chronic systemic toxicity

Author keywords

Acute poisoning; Alternatives; Basal cytotoxicity; Cell morphology; Cell toxicity; Chronic toxicity; Evaluation; Human toxicity; Kinetics; Lethal concentration; Lethal dose; Test development; Toxicity testing; Toxicology

Indexed keywords

CELL RECEPTOR;

EID: 0032978503     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119299902700305     Document Type: Article
Times cited : (38)

References (34)
  • 1
    • 0024955695 scopus 로고
    • MEIC - A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests
    • Bondesson, I., Ekwall, B., Hellberg, S., Romert, L., Stenberg, K. & Walum, E. (1989). MEIC - A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests. Cell Biology and Toxicology 5, 331-347.
    • (1989) Cell Biology and Toxicology , vol.5 , pp. 331-347
    • Bondesson, I.1    Ekwall, B.2    Hellberg, S.3    Romert, L.4    Stenberg, K.5    Walum, E.6
  • 2
    • 0002033758 scopus 로고
    • Cytotoxicity evaluation of the first ten MEIC chemicals: Acute lethal toxicity in man predicted by cytotoxicity in five cellular assays and by oral LD50 tests in rodents
    • Ekwall, B., Bondesson, I., Castell, J.V., Gómez-Lechón, M.J., Hellberg, S., Högberg, J., Jover, R., Ponsoda, X., Romert, L., Stenberg, K. & Walum, E. (1989). Cytotoxicity evaluation of the first ten MEIC chemicals: acute lethal toxicity in man predicted by cytotoxicity in five cellular assays and by oral LD50 tests in rodents. ATLA 17, 83-100.
    • (1989) ATLA , vol.17 , pp. 83-100
    • Ekwall, B.1    Bondesson, I.2    Castell, J.V.3    Gómez-Lechón, M.J.4    Hellberg, S.5    Högberg, J.6    Jover, R.7    Ponsoda, X.8    Romert, L.9    Stenberg, K.10    Walum, E.11
  • 3
    • 20044374739 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part VI. Prediction of human toxicity by rodent LD50 values and results from 61 in vitro tests
    • Ekwall, B. et al. (1998). MEIC evaluation of acute systemic toxicity. Part VI. Prediction of human toxicity by rodent LD50 values and results from 61 in vitro tests. ATLA 26, Suppl. 2, 617-658.
    • (1998) ATLA , vol.26 , Issue.SUPPL. 2 , pp. 617-658
    • Ekwall, B.1
  • 4
    • 0032839104 scopus 로고    scopus 로고
    • Overview of the final MEIC results. II. The in vitro/in vivo evaluation, including a selection of a practical battery of cell tests for prediction of acute lethal blood concentrations in humans
    • in press
    • Ekwall, B. (1999). Overview of the final MEIC results. II. The in vitro/in vivo evaluation, including a selection of a practical battery of cell tests for prediction of acute lethal blood concentrations in humans. Toxicology in Vitro, in press.
    • (1999) Toxicology in Vitro
    • Ekwall, B.1
  • 5
    • 0345158660 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part VIII. Multivariate PLS evaluation, including the selection of a battery of cell line tests with a good prediction of human acute lethal blood concentrations for 50 chemicals
    • in press
    • Ekwall, B., Ekwall, B. & Sjöstrom, M. (1999). MEIC evaluation of acute systemic toxicity. Part VIII. Multivariate PLS evaluation, including the selection of a battery of cell line tests with a good prediction of human acute lethal blood concentrations for 50 chemicals. ATLA, in press.
    • (1999) ATLA
    • Ekwall, B.1    Ekwall, B.2    Sjöstrom, M.3
  • 6
    • 0001044613 scopus 로고    scopus 로고
    • Dynamic qualities of validation and the evolution of new in vitro toxicological tests
    • Walum, E., Forsby, A., Clemedson, C. & Ekwall, B. (1996). Dynamic qualities of validation and the evolution of new in vitro toxicological tests. ATLA 24, 333-338.
    • (1996) ATLA , vol.24 , pp. 333-338
    • Walum, E.1    Forsby, A.2    Clemedson, C.3    Ekwall, B.4
  • 7
    • 0028125252 scopus 로고
    • Principles for the validation of in vitro toxicology test methods
    • Walum, E., Clemedson, C. & Ekwall, B. (1994). Principles for the validation of in vitro toxicology test methods. Toxicology in Vitro 8, 807-812.
    • (1994) Toxicology in Vitro , vol.8 , pp. 807-812
    • Walum, E.1    Clemedson, C.2    Ekwall, B.3
  • 9
    • 0000497866 scopus 로고
    • Can the in vivo maximum tolerated dose be predicted using in vitro techniques? A working hypothesis
    • Shrivastava, R., John, G., Rispat, G., Chevalier, A. & Massingham, R. (1991). Can the in vivo maximum tolerated dose be predicted using in vitro techniques? A working hypothesis. ATLA 19, 393-402.
    • (1991) ATLA , vol.19 , pp. 393-402
    • Shrivastava, R.1    John, G.2    Rispat, G.3    Chevalier, A.4    Massingham, R.5
  • 10
    • 0003139527 scopus 로고
    • Long-term cytotoxicity testing of the first twenty MEIC chemicals by the determination of the protein content in human embryonic lung cells
    • Dierickx, P. & Ekwall, B. (1992). Long-term cytotoxicity testing of the first twenty MEIC chemicals by the determination of the protein content in human embryonic lung cells. ATLA 20, 285-289.
    • (1992) ATLA , vol.20 , pp. 285-289
    • Dierickx, P.1    Ekwall, B.2
  • 11
    • 0001951416 scopus 로고
    • Long-term cytotoxicity testing of the MEIC chemicals 21-50 by the determination of the protein content in human embryonic lung cells
    • Dierickx, P.J. & Ekwall, B. (1993). Long-term cytotoxicity testing of the MEIC chemicals 21-50 by the determination of the protein content in human embryonic lung cells. AATEX 2, 33-36.
    • (1993) AATEX , vol.2 , pp. 33-36
    • Dierickx, P.J.1    Ekwall, B.2
  • 12
    • 0019225293 scopus 로고
    • Toxicity to HeLa cells of 205 drugs as determined by the metabolic inhibition test supplemented by microscopy
    • Ekwall, B. (1980). Toxicity to HeLa cells of 205 drugs as determined by the metabolic inhibition test supplemented by microscopy. Toxicology 17, 273-295
    • (1980) Toxicology , vol.17 , pp. 273-295
    • Ekwall, B.1
  • 13
    • 0018892845 scopus 로고
    • Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells. II. Drug toxicity in the MIT-24 system compared with mouse and human lethal dosage of 52 drugs
    • Ekwall, B. (1980). Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells. II. Drug toxicity in the MIT-24 system compared with mouse and human lethal dosage of 52 drugs. Toxicology Letters 5, 309-317.
    • (1980) Toxicology Letters , vol.5 , pp. 309-317
    • Ekwall, B.1
  • 14
    • 2542546742 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis
    • Clemedson, C. et al. (1998). MEIC evaluation of acute systemic toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis. ATLA 26, Suppl. 1, 131-183.
    • (1998) ATLA , vol.26 , Issue.SUPPL. 1 , pp. 131-183
    • Clemedson, C.1
  • 15
    • 0020644295 scopus 로고
    • Screening of toxic compounds in mammalian cell cultures
    • ed. G.M. Williams, V.C. Dunkel & V.A. Ray, New York, USA: The New York Academy of Sciences
    • Ekwall, B. (1983) Screening of toxic compounds in mammalian cell cultures. In Annals of the New York Academy of Sciences, Vol. 407, Cellular Systems for Toxicity Testing (ed. G.M. Williams, V.C. Dunkel & V.A. Ray), pp. 64-77. New York, USA: The New York Academy of Sciences.
    • (1983) Annals of the New York Academy of Sciences, Vol. 407, Cellular Systems for Toxicity Testing , vol.407 , pp. 64-77
    • Ekwall, B.1
  • 16
    • 0343676224 scopus 로고    scopus 로고
    • Closing the gap between cell death and in vitro toxicity testing
    • ed. L.F.M. van Zutphen & M. Balls, Amsterdam, The Netherlands: Elsevier
    • Zucco, F. (1997). Closing the gap between cell death and in vitro toxicity testing. In Animal Alternatives, Welfare and Ethics (ed. L.F.M. van Zutphen & M. Balls), pp. 541-548. Amsterdam, The Netherlands: Elsevier.
    • (1997) Animal Alternatives, Welfare and Ethics , pp. 541-548
    • Zucco, F.1
  • 17
    • 2842588325 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis
    • Clemedson, C. et al. (1996). MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA 24, Suppl. 1, 273-311.
    • (1996) ATLA , vol.24 , Issue.SUPPL. 1 , pp. 273-311
    • Clemedson, C.1
  • 18
    • 2542620018 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis
    • Clemedson, C. et al. (1998). MEIC evaluation of acute systemic toxicity. Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA 26, Suppl. 1, 93-129.
    • (1998) ATLA , vol.26 , Issue.SUPPL. 1 , pp. 93-129
    • Clemedson, C.1
  • 19
    • 0002232109 scopus 로고    scopus 로고
    • Microtitration fluorometric assays on living cells: New tools for screening in cell pharmacotoxicology
    • ed. L.F.M. van Zutphen & M. Balls, Amsterdam, The Netherlands: Elsevier
    • Rat, P., Osseni, R., Christen, M.O., Thevenin, M., Warnet, J-M. & Adolphe, M. (1997). Microtitration fluorometric assays on living cells: new tools for screening in cell pharmacotoxicology. In Animal Alternatives, Welfare and Ethics (ed. L.F.M. van Zutphen & M. Balls), pp. 813-823. Amsterdam, The Netherlands: Elsevier.
    • (1997) Animal Alternatives, Welfare and Ethics , pp. 813-823
    • Rat, P.1    Osseni, R.2    Christen, M.O.3    Thevenin, M.4    Warnet, J.-M.5    Adolphe, M.6
  • 21
    • 20944432074 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals
    • Ekwall, B., Clemedson, C., Crafoord, B., Ekwall, B., Hallander, S., Walum, E. & Bondesson, I. (1998). MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals. ATLA 26, Suppl. 2, 571-616.
    • (1998) ATLA , vol.26 , Issue.SUPPL. 2 , pp. 571-616
    • Ekwall, B.1    Clemedson, C.2    Crafoord, B.3    Ekwall, B.4    Hallander, S.5    Walum, E.6    Bondesson, I.7
  • 22
    • 0020393568 scopus 로고
    • In vitro comparative toxicity of selected drugs and chemicals in HeLa cells, chang liver cells, and rat hepatocytes
    • Ekwall, B. & Acosta, D. (1982). In vitro comparative toxicity of selected drugs and chemicals in HeLa cells, Chang liver cells, and rat hepatocytes. Drug and Chemical Toxicology 5, 219-231.
    • (1982) Drug and Chemical Toxicology , vol.5 , pp. 219-231
    • Ekwall, B.1    Acosta, D.2
  • 23
    • 0023910751 scopus 로고
    • Comments on the use of diverse cell systems in toxicity testing
    • Ekwall, B. & Ekwall, K. (1988). Comments on the use of diverse cell systems in toxicity testing. ATLA 15, 193-200.
    • (1988) ATLA , vol.15 , pp. 193-200
    • Ekwall, B.1    Ekwall, K.2
  • 24
    • 0342853868 scopus 로고
    • Cytotoxicity of metal ions from the viewpoint of cell recovery
    • Imai, K., Nakamura, F., Takoka, Y. & Nakamura, M. (1988). Cytotoxicity of metal ions from the viewpoint of cell recovery. Journal of Dental Technology 16, 980-983.
    • (1988) Journal of Dental Technology , vol.16 , pp. 980-983
    • Imai, K.1    Takoka, F.2    Nakamura, M.3
  • 26
    • 0032865119 scopus 로고    scopus 로고
    • Overview of the final MEIC results. I. The in vitro/in vitro evaluation
    • in press
    • Clemedson, C. & Ekwall, B. (1999). Overview of the final MEIC results. I. The in vitro/in vitro evaluation. Toxicology in Vitro, in press.
    • (1999) Toxicology in Vitro
    • Clemedson, C.1    Ekwall, B.2
  • 27
    • 0345158657 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part VII. Prediction of human toxicity by results from testing of the first 30 reference chemicals with 27 further in vitro assays
    • in press
    • Clemedson et al. (1999). MEIC evaluation of acute systemic toxicity. Part VII. Prediction of human toxicity by results from testing of the first 30 reference chemicals with 27 further in vitro assays. ATLA, in press.
    • (1999) ATLA
    • Clemedson1
  • 28
    • 0028964164 scopus 로고
    • The blood - Brain barrier: In vitro methods and toxicological applications
    • Walker, I. & Coleman, M. (1995). The blood - brain barrier: in vitro methods and toxicological applications. Toxicology in Vitro 9, 191-204.
    • (1995) Toxicology in Vitro , vol.9 , pp. 191-204
    • Walker, I.1    Coleman, M.2
  • 29
    • 0001450573 scopus 로고    scopus 로고
    • In vitro models of the blood - brain barrier
    • Garberg, P. (1998). In vitro models of the blood - brain barrier. ATLA 26, 821-847.
    • (1998) ATLA , vol.26 , pp. 821-847
    • Garberg, P.1
  • 30
    • 0031024172 scopus 로고    scopus 로고
    • Discrimination between drug candidates using models for evaluation of intestinal absorption
    • Stewart, B.H., Chan, O.H., Jezyk, N. & Fleisher, D. (1997). Discrimination between drug candidates using models for evaluation of intestinal absorption. Advanced Drug Delivery Reviews 23, 27-45.
    • (1997) Advanced Drug Delivery Reviews , vol.23 , pp. 27-45
    • Stewart, B.H.1    Chan, O.H.2    Jezyk, N.3    Fleisher, D.4
  • 31
    • 0031013760 scopus 로고    scopus 로고
    • Selection of development candidates based on in vitro permeability measurements
    • Lee, C-P., de Vrueh, R.L.A. & Smith, P.L. (1997). Selection of development candidates based on in vitro permeability measurements. Advanced Drug Delivery Reviews 23, 47-62.
    • (1997) Advanced Drug Delivery Reviews , vol.23 , pp. 47-62
    • Lee, C.-P.1    De Vrueh, R.L.A.2    Smith, P.L.3
  • 32
    • 2542573862 scopus 로고    scopus 로고
    • När, Sweden: CTLU
    • Ekwall, B. (1997). The EDIT programme. Web site http://www.ctlu.se. När, Sweden: CTLU.
    • (1997) The EDIT Programme
    • Ekwall, B.1
  • 34
    • 0344728387 scopus 로고
    • Cytoplasmic blebbing of HeLa cells in response to toxic concentrations of drugs and chemicals
    • Abstract 63
    • Ekwall, B. (1982). Cytoplasmic blebbing of HeLa cells in response to toxic concentrations of drugs and chemicals. In Vitro 18, 3, Part II, Abstract 63.
    • (1982) In Vitro , vol.18 , Issue.PART II , pp. 3
    • Ekwall, B.1


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