Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): Modeling and dynamics studies

Nucleic Acids Research

Volumn 34, Issue 11, 2006, Pages 3326-3337

  Zhang, Ling ^a   Rechkoblit, Olga ^b   Wang, Lihua ^a   Patel, Dinshaw J ^b   Shapiro, Robert ^a   Broyde, Suse ^a  

^a NEW YORK UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2'-DEOXYADENOSINE TRIPHOSPHATE; 2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE; CARCINOGEN; DEOXYADENOSINE PHOSPHATE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE PHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE; DEOXYGUANOSINE PHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DEOXYRIBONUCLEOTIDE; DNA; DNA DIRECTED DNA POLYMERASE BETA; DRUG DERIVATIVE; IMIDAZOLE DERIVATIVE; N (DEOXYGUANOSIN 8 YL) 2 AMINO 1 METHYL 6 PHENYLIMIDAZO(4,5 B)PYRIDINE; N-(DEOXYGUANOSIN-8-YL)-2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-B)PYRIDINE; PYRIMIDINE NUCLEOTIDE; THYMIDINE 5'-TRIPHOSPHATE; THYMIDINE TRIPHOSPHATE;

ARTICLE; BINDING SITE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; DNA ADDUCT; ENZYMOLOGY; METABOLISM; MOTION; MUTAGENESIS; SULFOLOBUS SOLFATARICUS;

BINDING SITES; CARCINOGENS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DEOXYADENINE NUCLEOTIDES; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DEOXYGUANOSINE; DEOXYRIBONUCLEOTIDES; DNA; DNA ADDUCTS; DNA POLYMERASE BETA; IMIDAZOLES; MODELS, MOLECULAR; MOTION; MUTAGENESIS; NUCLEIC ACID CONFORMATION; SULFOLOBUS SOLFATARICUS; THYMINE NUCLEOTIDES;

EID: 33746269679     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl425     Document Type: Article

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