Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively

Clinical Immunology

Volumn 98, Issue 1, 2001, Pages 23-30

  Constantinescu, Cris S ^a,b,c   Hilliard, Brendan ^a   Ventura, Elvira ^a   Wysocka, Maria ^d   Showe, Louise ^d   Lavi, Ehud ^a   Fujioka, Toshiki ^a   Scott, Phillip ^e   Trinchieri, Giorgio ^d   Rostami, Abdolmohamad ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d WISTAR INSTITUTE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Experimental autoimmune encephalomyelitis; IL 12; IL 4; Multiple sclerosis; Th1 Th2

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DISEASE PREDISPOSITION; FEMALE; IMMUNITY; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; MOUSE; MOUSE STRAIN; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

EID: 0035177433     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2000.4944     Document Type: Article

References (54)

1. Pathogenesis of neuroimmunologic diseases. Experimental models
2. Experimental autoimmune encephalimyelitis in mice: Genetic control of susceptibility
3. A genetic basis for familial aggregation in MS
4. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
5. Encephalitogenic T cells in the B10.PL model of experimenal allergic encephalomyelitis (EAE) are of Th-1 lymphokine subtype
6. Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell correlates with encephalitogenicity
7. Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: Relative roles of interleukin (IL)-4 and IL-10
8. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination
9. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis
10. Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins
11. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
12. Interleukin-10 prevents experimental allergic encephalomyelitis in rats
13. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
14. Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats
15. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
16. Interleukin-12 and its role in the generation of Th1 cells
17. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system
18. Experimental cutaneous leishmaniasis: Induction and regulation of T cells following infection of mice with Leishmania major
19. Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis
20. Mice with a disrupted IFN-γ gene are susceptible to experimental autoimmune encephalomyelitis (EAE)
21. Tumor necrosis factor and lymphotoxin-α are not required for induction of acute experimental autoimmune encephalomyelitis
22. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
23. Local delivery of IL-4 by retrovirus transduced T lymphocytes ameliorates experimental allergic encephalomyelitis
24. A critical role for IL-4 in regulating disease severity in experimental allergic ericephalomyelitis as demonstrated in IL-4-deficient C57BL/6 and BALB/c mice
25. Acute-relapsing experimental autoimmune encephalomyelitis in IL-4- and alpha-beta T cell deficient C57B1/6 mice
26. Experimental autoimmune encephalomyelitis in IL-4-deficient mice
27. IL-10 is critical in the regulation of autoimmune ericephalomyelitis as demonstrated by studies of IL-10 and IL-4 deficient and transgenic mice
28. Some misconceptions about understanding autoimmunity through experiments with knockouts
29. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice
30. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor
31. Antibodies against IL-12 prevent spontaneous and superantigen-induced relapses of experimental autoimmune encephalomyelitis
32. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species
33. IFN-γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis
34. Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response
35. Production of soluble IL-4 receptors by murine spleen cells is regulated by T cell activation and IL-4
36. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis
37. Experimental autoimmune encephalomyelitis-resistant mice have highly encephalitogenic myelin basic protein (MBP)-specific T cell clones that recognize a MBP peptide with high affinity for MHC class II
38. Experimental autoimmune peripheral neuritis induced in BALB/c mice by myelin basic protein-specific T cell clones
39. Selection for susceptibility to experimental allergic encephalomyelitis also selects for high IFN-γ production
40. Induction of Th 1 and Th2 immunity in neonatal mice
41. Decreased IL-12 production underlies the decreased ability of male lymph node cells to induce experimental autoimmune encephalomyelitis
42. IL-12 unmasks latent autoimmune disease in resistant mice
43. Defective IgE production by SJL/J mice is linked to the absence of CD4+ NK1.1+ T cells that promptly produce interleukin-4
44. IL-12 is required for natural killer cell activation and subsequent T helper I cell development in experimental leishmaniasis
45. Intrinsic defects in macrophage IL-12 production associated with immune dysfunction in the MRL/+ + and New Zealand Black/White F1 lupusprone mice and the Leishmania major-susceptible BALB/c strain
46. Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1 cell development
47. Structure of the mouse IL-12Rβ1 chain and regulation of its expression in BCG/LPS treated mice
48. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
49. A combination of adoptive transfer and antigenic challenge induces consistent experimental autoimmune encephalomyelitis in C57BL/ 6 mice and other reputed resistant strains
50. Physical state of the neuroantigen in adjuvant emulsions determines encephalitogenic status in the BALB/c mouse
51. Microbial products induce autoimmune disease by an IL-12 dependent pathway
52. Up-take of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1a and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation
53. Differentia expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis
54. Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains