Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions

Biochemistry

Volumn 45, Issue 27, 2006, Pages 8427-8443

  McLean, Kirsty J ^a   Warman, Ashley J ^b   Seward, Harriet E ^b   Marshall, Ker R ^b   Girvan, Hazel M ^a   Cheesman, Myles R ^c   Waterman, Michael R ^d   Munro, Andrew W ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BACTERIA; BIOCHEMISTRY; COORDINATION REACTIONS; NITROGEN COMPOUNDS; SPECTROSCOPIC ANALYSIS;

ELECTRON TRANSFER COMPLEX; MYCOBACTERIUM TUBERCULOSIS; STEROL DEMETHYLASE P450;

ENZYMES;

1 PHENYLIMIDAZOLE; 2 PHENYLIMIDAZOLE; 4 PHENYLIMIDAZOLE; BACTERIAL ENZYME; CARBON MONOXIDE; ESTRIOL; FERREDOXIN; FLAVOPROTEIN REDUCTASE; HEME; IMIDAZOLE DERIVATIVE; IRON; IRON SULFUR PROTEIN; OXIDOREDUCTASE; STEROL 14ALPHA DEMETHYLASE; STEROL DEMETHYLASE P450; UNCLASSIFIED DRUG;

ARTICLE; BIOPHYSICS; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME PURIFICATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATION REDUCTION REACTION; POTENTIOMETRY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTON TRANSPORT; SPECTROSCOPY; THERMODYNAMICS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CARBON MONOXIDE; CYTOCHROME P-450 ENZYME SYSTEM; FERREDOXINS; HEME; HYDROGEN-ION CONCENTRATION; IRON; KINETICS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; OXIDOREDUCTASES; POTENTIOMETRY; SPECTRUM ANALYSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 33745832316     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0601609     Document Type: Article

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