Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1738, Issue 1-3, 2005, Pages 121-132

  Yeh, Hui Chun ^a   Hsu, Pei Yung ^a   Wang, Jinn Shyan ^a,b   Tsai, Ah Lim ^a   Wang, Lee Ho ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Active site; Cytochrome P450; Heterologous expression; Homolysis of peroxide bond; Prostanoid

Indexed keywords

CLOTRIMAZOLE; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 2C5; DITHIONITE; HEME; IMIDAZOLE; IMIDAZOLE DERIVATIVE; NICKEL; PEROXIDE; PROSTACYCLIN; PROSTACYCLIN SYNTHASE; PROSTAGLANDIN SYNTHASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL ANALYSIS; CIRCULAR DICHROISM; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ELECTROPHORESIS; ENZYME PURIFICATION; GENE EXPRESSION SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECTROSCOPY; STEADY STATE; ULTRAVIOLET SPECTROSCOPY;

AMINO ACID SEQUENCE; BINDING SITES; CIRCULAR DICHROISM; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; HEME; HISTIDINE; HUMANS; HYDROPHOBICITY; INTRAMOLECULAR OXIDOREDUCTASES; KINETICS; LIGANDS; LINOLEIC ACIDS; MOLECULAR SEQUENCE DATA; PEROXIDES; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET;

PROKARYOTA;

EID: 31044436812     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2005.11.007     Document Type: Article

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