Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis

Biochemical Journal

Volumn 338, Issue 3, 1999, Pages 753-760

  Saint Joanis, Brigitte ^a   Souchon, Hélène ^a   Wilming, Martin ^b   Johnsson, Kai ^b   Alzari, Pedro M ^a   Cole, Stewart T ^a  

^a INSTITUT PASTEUR   (France)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Free radicals; Mycolic acids; Prodrugs

Indexed keywords

CATALASE; FREE RADICAL; HEME; ISONIAZID; LEUCINE; MUTANT PROTEIN; NITROBLUE TETRAZOLIUM; OXIDOREDUCTASE; PEROXIDASE; PROLINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SERINE; THREONINE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DIMERIZATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME STRUCTURE; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DISULFIDES; ENZYME ACTIVATION; HYDROLYSIS; ISONIAZID; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; NITROBLUE TETRAZOLIUM; PEROXIDASES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 0033559410     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3380753     Document Type: Article

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