메뉴 건너뛰기




Volumn 12, Issue 21, 2006, Pages 2645-2660

Antineovascular agents in the treatment of eye diseases

Author keywords

Age related macular degeneration; Angiogenesis; Diabetic retinopathy; Pharmacotherapy; Retina

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACETYLSALICYLIC ACID; ADENOVIRUS VECTOR; ANGIOSTATIN; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPTOPRIL; COMBRETASTATIN; CORTICOSTEROID DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOSTATIN; ENDOTHELIAL CELL GROWTH FACTOR; FUMAGILLOL CHLOROACETYLCARBAMATE; LISINOPRIL; MATRIX METALLOPROTEINASE INHIBITOR; MONOCLONAL ANTIBODY LM 609; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PEGAPTANIB; PIGMENT EPITHELIUM DERIVED FACTOR; PLACEBO; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN KINASE C INHIBITOR; RANIBIZUMAB; RUBOXISTAURIN; SOMATOSTATIN DERIVATIVE; THALIDOMIDE; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VATALANIB;

EID: 33745763138     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161206777698729     Document Type: Review
Times cited : (31)

References (250)
  • 1
    • 0031766152 scopus 로고    scopus 로고
    • Ocular neovascularization: An epidemiologic review
    • Lee P, Wang CC, Adamis AP. Ocular neovascularization: an epidemiologic review. Surv Ophthalmol 1998; 43: 245-69.
    • (1998) Surv Ophthalmol , vol.43 , pp. 245-269
    • Lee, P.1    Wang, C.C.2    Adamis, A.P.3
  • 2
    • 0348048874 scopus 로고    scopus 로고
    • Diabetic retinopathy
    • Frank RN. Diabetic retinopathy. N Engl J Med 2004; 350: 48-58.
    • (2004) N Engl J Med , vol.350 , pp. 48-58
    • Frank, R.N.1
  • 4
    • 0033520648 scopus 로고    scopus 로고
    • The pathogenesis of choroidal neovascularization in patients with age-related macular degeneration
    • Campochiaro PA, Soloway P, Ryan SJ, Miller JW. The pathogenesis of choroidal neovascularization in patients with age-related macular degeneration. Mol Vis 1999; 5: 34.
    • (1999) Mol Vis , vol.5 , pp. 34
    • Campochiaro, P.A.1    Soloway, P.2    Ryan, S.J.3    Miller, J.W.4
  • 5
    • 0038708118 scopus 로고    scopus 로고
    • Age-related macular degeneration: Etiology, pathogenesis, and therapeutic strategies
    • Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 2003; 48: 257-93.
    • (2003) Surv Ophthalmol , vol.48 , pp. 257-293
    • Ambati, J.1    Ambati, B.K.2    Yoo, S.H.3    Ianchulev, S.4    Adamis, A.P.5
  • 7
    • 0035793436 scopus 로고    scopus 로고
    • Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization
    • Gao G, Li Y, Zhang D, Gee S, Crosson C, Ma J. Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization. FEBS Lett 2001; 489: 270-6.
    • (2001) FEBS Lett , vol.489 , pp. 270-276
    • Gao, G.1    Li, Y.2    Zhang, D.3    Gee, S.4    Crosson, C.5    Ma, J.6
  • 8
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid, and other diseases
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid, and other diseases. Nat Med 1995; 1: 27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 9
    • 0036104828 scopus 로고    scopus 로고
    • Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor
    • Volpert OV, Zaichuk T, Zhou W, Reiher F, Ferguson TA, Stuart PM, et al. Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat Med 2002; 8: 349-57.
    • (2002) Nat Med , vol.8 , pp. 349-357
    • Volpert, O.V.1    Zaichuk, T.2    Zhou, W.3    Reiher, F.4    Ferguson, T.A.5    Stuart, P.M.6
  • 10
    • 0036300131 scopus 로고    scopus 로고
    • PEDF: Anti-angiogenic guardian of ocular function
    • Bouck N. PEDF: anti-angiogenic guardian of ocular function. Trends Mol Med 2002; 8: 330-4.
    • (2002) Trends Mol Med , vol.8 , pp. 330-334
    • Bouck, N.1
  • 11
    • 0028815295 scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization
    • Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LE. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization Proc Natl Acad Sci USA 1995; 92: 905-9.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 905-909
    • Pierce, E.A.1    Avery, R.L.2    Foley, E.D.3    Aiello, L.P.4    Smith, L.E.5
  • 12
    • 0032961301 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and its receptor (KDR /flk-1) mRNA in experimental choroidal neovascularization
    • Wada M, Ogata N, Otsuji T, Uyama M. Expression of vascular endothelial growth factor and its receptor (KDR/flk-1) mRNA in experimental choroidal neovascularization. Curr Eye Res 1999; 18: 203-13.
    • (1999) Curr Eye Res , vol.18 , pp. 203-213
    • Wada, M.1    Ogata, N.2    Otsuji, T.3    Uyama, M.4
  • 14
    • 0036129304 scopus 로고    scopus 로고
    • Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
    • Krzystolik MG, Afshari MA, Adamis AP, Gaudreault J, Gragoudas ES, Michaud NA, et al. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol 2002; 120: 338-46.
    • (2002) Arch Ophthalmol , vol.120 , pp. 338-346
    • Krzystolik, M.G.1    Afshari, M.A.2    Adamis, A.P.3    Gaudreault, J.4    Gragoudas, E.S.5    Michaud, N.A.6
  • 15
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/ vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146: 1029-39.
    • (1995) Am J Pathol , vol.146 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3    Dvorak, A.M.4
  • 17
    • 0029074024 scopus 로고
    • Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
    • Stone J, Itin A, Alon T, Pe'er J, Gnessin H, Chan-Ling T, et al. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci 1995; 15: 4738-47.
    • (1995) J Neurosci , vol.15 , pp. 4738-4747
    • Stone, J.1    Itin, A.2    Alon, T.3    Pe'er, J.4    Gnessin, H.5    Chan-Ling, T.6
  • 18
    • 0029171581 scopus 로고
    • Hypoxic induction of endothelial cell growth factors in retinal cells: Identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen
    • Shima DT, Adamis AP, Ferrara N, Yeo KT, Yeo TK, Allende R, et al. Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med 1995; 1: 182-93.
    • (1995) Mol Med , vol.1 , pp. 182-193
    • Shima, D.T.1    Adamis, A.P.2    Ferrara, N.3    Yeo, K.T.4    Yeo, T.K.5    Allende, R.6
  • 20
    • 0000230096 scopus 로고
    • The mode of development of the vascular system of the retina with some observations on its significance for certain retinal diseases
    • Michaelson M. The mode of development of the vascular system of the retina with some observations on its significance for certain retinal diseases. Trans Ophthalmol Soc UK 1948; 68: 137-80.
    • (1948) Trans Ophthalmol Soc UK , vol.68 , pp. 137-180
    • Michaelson, M.1
  • 21
    • 0029018364 scopus 로고
    • Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases
    • Pe'er J, Shweiki D, Itin A, Hemo I, Gnessin H, Keshet E. Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. Lab Invest 1995; 72: 638-45.
    • (1995) Lab Invest , vol.72 , pp. 638-645
    • Pe'er, J.1    Shweiki, D.2    Itin, A.3    Hemo, I.4    Gnessin, H.5    Keshet, E.6
  • 22
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1995; 1: 1024-8.
    • (1995) Nat Med , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Pe'er, J.4    Stone, J.5    Keshet, E.6
  • 23
    • 0003100257 scopus 로고
    • Retinal vascularization in health and disease
    • Ashton, N. Retinal vascularization in health and disease. Am J Ophthalmol 1957; 44: 7-17.
    • (1957) Am J Ophthalmol , vol.44 , pp. 7-17
    • Ashton, N.1
  • 24
    • 0029872517 scopus 로고    scopus 로고
    • Retinal vascular endothelial growth factor (VEGF) mRNA expression is altered in relation to neovascularization in oxygen induced retinopathy
    • Donahue ML, Phelps DL, Watkins RH, LoMonaco MB, Horowitz S. Retinal vascular endothelial growth factor (VEGF) mRNA expression is altered in relation to neovascularization in oxygen induced retinopathy. Curr Eye Res 1996, 15: 175-84.
    • (1996) Curr Eye Res , vol.15 , pp. 175-184
    • Donahue, M.L.1    Phelps, D.L.2    Watkins, R.H.3    LoMonaco, M.B.4    Horowitz, S.5
  • 25
    • 0028145249 scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model
    • Miller JW, Adamis AP, Shima DT, D'Amore PA, Moulton RS, O'Reilly MS, et al. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol 1994; 145: 574-84.
    • (1994) Am J Pathol , vol.145 , pp. 574-584
    • Miller, J.W.1    Adamis, A.P.2    Shima, D.T.3    D'Amore, P.A.4    Moulton, R.S.5    O'Reilly, M.S.6
  • 26
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RP, Arrigg PG, Keyt BA, Jampel HD, Shan ST, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331: 1480-7.
    • (1994) N Engl J Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.P.2    Arrigg, P.G.3    Keyt, B.A.4    Jampel, H.D.5    Shan, S.T.6
  • 27
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • Adamis AP, Miller JW, Bernal MT, D'Amico DJ, Folkman J, Yeo TK, et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy, Am J Ophthalmol 1994; 118: 445-50.
    • (1994) Am J Ophthalmol , vol.118 , pp. 445-450
    • Adamis, A.P.1    Miller, J.W.2    Bernal, M.T.3    D'Amico, D.J.4    Folkman, J.5    Yeo, T.K.6
  • 28
    • 0031006861 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy
    • Miller JW, Adamis A, Aiello LP. Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes Metab Rev 1997; 13: 37-50.
    • (1997) Diabetes Metab Rev , vol.13 , pp. 37-50
    • Miller, J.W.1    Adamis, A.2    Aiello, L.P.3
  • 29
    • 0043125643 scopus 로고    scopus 로고
    • VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization
    • Ishida S, Usui T, Yamashiro Y, Kaji Y, Amano S, Ogura Y, et al. VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med 2003; 198: 483-9.
    • (2003) J Exp Med , vol.198 , pp. 483-489
    • Ishida, S.1    Usui, T.2    Yamashiro, Y.3    Kaji, Y.4    Amano, S.5    Ogura, Y.6
  • 31
    • 0035895711 scopus 로고    scopus 로고
    • Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
    • Zachary I, Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 2001; 49: 568-81.
    • (2001) Cardiovasc Res , vol.49 , pp. 568-581
    • Zachary, I.1    Gliki, G.2
  • 33
    • 0028786651 scopus 로고
    • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, Riddle L, et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA 1995; 92: 10457-61.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10457-10461
    • Aiello, L.P.1    Pierce, E.A.2    Foley, E.D.3    Takagi, H.4    Chen, H.5    Riddle, L.6
  • 34
    • 0030013610 scopus 로고    scopus 로고
    • Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy
    • Robinson GS, Pierce EA, Rook SL, Foley E, Webb R, Smith LE. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci USA 1996; 93: 4851-6.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4851-4856
    • Robinson, G.S.1    Pierce, E.A.2    Rook, S.L.3    Foley, E.4    Webb, R.5    Smith, L.E.6
  • 35
    • 0035407426 scopus 로고    scopus 로고
    • In vivo use of oligonucleotides to inhibit choroidal neovascularisation in the eye
    • Garrett KL, Shen WY, Rakoczy PE. In vivo use of oligonucleotides to inhibit choroidal neovascularisation in the eye. J Gene Med 2001; 3: 373-83.
    • (2001) J Gene Med , vol.3 , pp. 373-383
    • Garrett, K.L.1    Shen, W.Y.2    Rakoczy, P.E.3
  • 36
    • 0034125023 scopus 로고    scopus 로고
    • Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: A role of VEGF and possible treatment for SRN in age-related macular degeneration
    • Honda M, Sakamoto T, Ishibashi T, Inomata H, Ueno H. Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: a role of VEGF and possible treatment for SRN in age-related macular degeneration. Gene Ther 2000; 7: 978-85.
    • (2000) Gene Ther , vol.7 , pp. 978-985
    • Honda, M.1    Sakamoto, T.2    Ishibashi, T.3    Inomata, H.4    Ueno, H.5
  • 37
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997; 57: 4593-9.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6
  • 38
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993; 362: 841-4.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6
  • 39
    • 0030067257 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate
    • Adamis AP, Shima DT, Tolentino MJ, Gragoudas ES, Ferrara N, Folkman J, et al. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol 1996; 114: 66-71.
    • (1996) Arch Ophthalmol , vol.114 , pp. 66-71
    • Adamis, A.P.1    Shima, D.T.2    Tolentino, M.J.3    Gragoudas, E.S.4    Ferrara, N.5    Folkman, J.6
  • 40
    • 33745763669 scopus 로고    scopus 로고
    • Available from Accessed 23 December
    • Available from http://www.macular.org/news/lucentis.html. Accessed 23 December 2005.
    • (2005)
  • 41
    • 0033882794 scopus 로고    scopus 로고
    • Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization
    • Ozaki H, Seo MS, Ozaki K, Yamada H, Yamada E, Okamoto N, et al. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization, Am J Pathol 2000; 156: 697-707.
    • (2000) Am J Pathol , vol.156 , pp. 697-707
    • Ozaki, H.1    Seo, M.S.2    Ozaki, K.3    Yamada, H.4    Yamada, E.5    Okamoto, N.6
  • 42
    • 0036959644 scopus 로고    scopus 로고
    • Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
    • Eyetech Study Group
    • Eyetech Study Group. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 2002; 22: 143-52.
    • (2002) Retina , vol.22 , pp. 143-152
  • 43
    • 0037880734 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: Phase II study results
    • Eyetech Study Group
    • Eyetech Study Group. Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: phase II study results. Ophthalmology 2003; 110: 979-6.
    • (2003) Ophthalmology , vol.110 , pp. 979-986
  • 44
    • 25844513658 scopus 로고    scopus 로고
    • A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    • Macugen Diabetic Retinopathy Study Group
    • Macugen Diabetic Retinopathy Study Group. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology 2005; 112: 1747-57.
    • (2005) Ophthalmology , vol.112 , pp. 1747-1757
  • 45
    • 0037880734 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: Phase II study results
    • Eyetech Study Group
    • Eyetech Study Group. Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: phase II study results. Ophthalmology 2003; 110: 979-86.
    • (2003) Ophthalmology , vol.110 , pp. 979-986
  • 48
    • 0035930456 scopus 로고    scopus 로고
    • Hypoxia: Modulation of endothelial cell proliferation by soluble factors released by retinal cells
    • Eichler W, Yafai Y, Kuhrt H, Hoffmann, S, Wiedemann, P. Reichenbach, A. Hypoxia: modulation of endothelial cell proliferation by soluble factors released by retinal cells. Neuroreport 2001; 12: 4103-8.
    • (2001) Neuroreport , vol.12 , pp. 4103-4108
    • Eichler, W.1    Yafai, Y.2    Kuhrt, H.3    Hoffmann, S.4    Wiedemann, P.5    Reichenbach, A.6
  • 51
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
    • O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997; 88: 277-85.
    • (1997) Cell , vol.88 , pp. 277-285
    • O'Reilly, M.S.1    Boehm, T.2    Shing, Y.3    Fukai, N.4    Vasios, G.5    Lane, W.S.6
  • 53
    • 0034857729 scopus 로고    scopus 로고
    • Suppression of choroidal neovascularization by adeno-associated virus vector expressing angiostatin
    • Lai CC, Wu WC, Chen SL, Xiao X, Tsai TC, Huan SJ, et al. Suppression of choroidal neovascularization by adeno-associated virus vector expressing angiostatin. Invest Ophthalmol Vis Sci 2001; 42: 2401-7.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 2401-2407
    • Lai, C.C.1    Wu, W.C.2    Chen, S.L.3    Xiao, X.4    Tsai, T.C.5    Huan, S.J.6
  • 54
    • 0035404544 scopus 로고    scopus 로고
    • Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin
    • Mori K, Ando A, Gehlbach P, Nesbitt D, Takahashi K, Goldsteen D, et al. Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin. Am J Pathol 2001; 159: 313-20.
    • (2001) Am J Pathol , vol.159 , pp. 313-320
    • Mori, K.1    Ando, A.2    Gehlbach, P.3    Nesbitt, D.4    Takahashi, K.5    Goldsteen, D.6
  • 55
    • 0038603922 scopus 로고    scopus 로고
    • Therapeutic prospects for PEDF: More than a promising angiogenesis inhibitor
    • Tombran-Tink J, Barnstable CJ. Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor. Trends Mol Med 2003; 9: 244-50.
    • (2003) Trends Mol Med , vol.9 , pp. 244-250
    • Tombran-Tink, J.1    Barnstable, C.J.2
  • 56
    • 4043074205 scopus 로고    scopus 로고
    • Neuroprotective and antiangiogenic actions of PEDF in the eye: Molecular targets and therapeutic potential
    • Barnstable CJ, Tombran-Tink J. Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential. Prog Retin Eye Res 2004; 23: 561-77.
    • (2004) Prog Retin Eye Res , vol.23 , pp. 561-577
    • Barnstable, C.J.1    Tombran-Tink, J.2
  • 57
    • 0028803776 scopus 로고
    • Pigment epithelium derived factor behaves like a noninhibitory serpin. Neurotropic activity does not require the serpin reactive loop
    • Becerra SP, Sagasti A, Spinella P, Notario V. Pigment epithelium derived factor behaves like a noninhibitory serpin. Neurotropic activity does not require the serpin reactive loop. J Biol Chem 1995; 270: 24992-9.
    • (1995) J Biol Chem , vol.270 , pp. 24992-24999
    • Becerra, S.P.1    Sagasti, A.2    Spinella, P.3    Notario, V.4
  • 58
    • 11244297196 scopus 로고    scopus 로고
    • Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor
    • Maik-Rachline G, Shaltiel S, Seger R. Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor. Blood 2005; 105: 670-8.
    • (2005) Blood , vol.105 , pp. 670-678
    • Maik-Rachline, G.1    Shaltiel, S.2    Seger, R.3
  • 59
    • 0036184047 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth
    • Duh EJ, Yang HS, Suzuma I, Miyagi M, Youngman E, Mori K, et al. Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Invest Ophthalmol Vis Sci 2002; 43: 821-9.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 821-829
    • Duh, E.J.1    Yang, H.S.2    Suzuma, I.3    Miyagi, M.4    Youngman, E.5    Mori, K.6
  • 60
    • 0035956869 scopus 로고    scopus 로고
    • Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor
    • Stellmach V, Crawford SE, Zhou W, Bouck N. Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc Natl Acad Sci USA 2001; 98: 2593-7.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2593-2597
    • Stellmach, V.1    Crawford, S.E.2    Zhou, W.3    Bouck, N.4
  • 62
    • 2342507629 scopus 로고    scopus 로고
    • Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site
    • Liu H, Ren JG, Cooper WL, Hawkins CE, Cowan MR, Tong PY. Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site. Proc Natl Acad Sci USA 2004; 101: 6605-10.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6605-6610
    • Liu, H.1    Ren, J.G.2    Cooper, W.L.3    Hawkins, C.E.4    Cowan, M.R.5    Tong, P.Y.6
  • 63
    • 0036297886 scopus 로고    scopus 로고
    • Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor
    • Mori K, Gehlbach P, Ando A, McVey D, Wei L, Campochiaro PA. Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 2002; 43: 2428-34.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 2428-2434
    • Mori, K.1    Gehlbach, P.2    Ando, A.3    McVey, D.4    Wei, L.5    Campochiaro, P.A.6
  • 65
    • 0035654217 scopus 로고    scopus 로고
    • Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease
    • Spranger J, Osterhoff M, Reimann M, Mohlig M, Ristow M, Francis MK, et al. Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Diabetes 2001; 50: 2641-5.
    • (2001) Diabetes , vol.50 , pp. 2641-2645
    • Spranger, J.1    Osterhoff, M.2    Reimann, M.3    Mohlig, M.4    Ristow, M.5    Francis, M.K.6
  • 66
    • 0034880565 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment
    • Ogata, N, Tombran-Tink J, Nishikawa M, Nishimura T, Mitsuma Y, Sakamoto T, et al. Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. Am J Ophthalmol 2001; 132: 378-82.
    • (2001) Am J Ophthalmol , vol.132 , pp. 378-382
    • Ogata, N.1    Tombran-Tink, J.2    Nishikawa, M.3    Nishimura, T.4    Mitsuma, Y.5    Sakamoto, T.6
  • 67
    • 0036329579 scopus 로고    scopus 로고
    • Pigment epithelium derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration
    • Holekamp NM, Bouck NP, Volpert OV. Pigment epithelium derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration. Am J Ophthalmol 2002; 134: 220-27.
    • (2002) Am J Ophthalmol , vol.134 , pp. 220-227
    • Holekamp, N.M.1    Bouck, N.P.2    Volpert, O.V.3
  • 68
    • 0036742063 scopus 로고    scopus 로고
    • Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy
    • Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M. Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am J Ophthalmol 2002; 134: 348-53.
    • (2002) Am J Ophthalmol , vol.134 , pp. 348-353
    • Ogata, N.1    Nishikawa, M.2    Nishimura, T.3    Mitsuma, Y.4    Matsumura, M.5
  • 69
    • 11144357806 scopus 로고    scopus 로고
    • Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: Implications for ocular angiogenesis
    • Duh EJ, Yang HS, Haller JA, De Juan E, Humayun MS, Gehlbach P, et al. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis. Am J Ophthalmol 2004; 137: 668-74.
    • (2004) Am J Ophthalmol , vol.137 , pp. 668-674
    • Duh, E.J.1    Yang, H.S.2    Haller, J.A.3    De Juan, E.4    Humayun, M.S.5    Gehlbach, P.6
  • 70
    • 0035514256 scopus 로고    scopus 로고
    • Clinical protocol: An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD)
    • Rasmussen H, Chu KW, Campochiaro P, Gehlbach PL, Haller JA, Handa JT, et al. Clinical protocol: an open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD). Hum Gene Ther 2001; 12: 2029-32.
    • (2001) Hum Gene Ther , vol.12 , pp. 2029-2032
    • Rasmussen, H.1    Chu, K.W.2    Campochiaro, P.3    Gehlbach, P.L.4    Haller, J.A.5    Handa, J.T.6
  • 71
    • 0035669720 scopus 로고    scopus 로고
    • Protein kinase C and the development of diabetic vascular complications
    • Way KJ, Katai N, King GL. Protein kinase C and the development of diabetic vascular complications. Diabet Med 2001; 18: 945-59.
    • (2001) Diabet Med , vol.18 , pp. 945-959
    • Way, K.J.1    Katai, N.2    King, G.L.3
  • 72
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya, D, King, GL. Protein kinase C activation and the development of diabetic complications. Diabetes 1998; 47: 859-66.
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 73
    • 0033376607 scopus 로고    scopus 로고
    • The role of protein kinase C activation in the pathogenesis of diabetic vascular complications
    • Park JY, Ha SW, King GL. The role of protein kinase C activation in the pathogenesis of diabetic vascular complications. Perit Dial Int 1999; 2: 222-7.
    • (1999) Perit Dial Int , vol.2 , pp. 222-227
    • Park, J.Y.1    Ha, S.W.2    King, G.L.3
  • 74
    • 0346494560 scopus 로고    scopus 로고
    • Protein kinase C inhibition and diabetic retinopathy: A shot in the dark at translational research
    • Donnelly R, Idris I, Forrester JV. Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research. Br J Ophthalmol 2004; 88: 145-51.
    • (2004) Br J Ophthalmol , vol.88 , pp. 145-151
    • Donnelly, R.1    Idris, I.2    Forrester, J.V.3
  • 75
    • 0030863502 scopus 로고    scopus 로고
    • Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro
    • Williams B, Gallacher B, Patel H, Orme C. Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro. Diabetes 1997; 46: 1497-503.
    • (1997) Diabetes , vol.46 , pp. 1497-1503
    • Williams, B.1    Gallacher, B.2    Patel, H.3    Orme, C.4
  • 76
    • 2642709170 scopus 로고    scopus 로고
    • Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
    • Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 1996; 98: 2018-26.
    • (1996) J Clin Invest , vol.98 , pp. 2018-2026
    • Xia, P.1    Aiello, L.P.2    Ishii, H.3    Jiang, Z.Y.4    Park, D.J.5    Robinson, G.S.6
  • 77
    • 0037154156 scopus 로고    scopus 로고
    • Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
    • Suzuma K, Takahara N, Suzuma I, Isshiki K, Ueki K, Leitges M, et al. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci USA 2002; 99: 721-6.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 721-726
    • Suzuma, K.1    Takahara, N.2    Suzuma, I.3    Isshiki, K.4    Ueki, K.5    Leitges, M.6
  • 78
    • 15644366961 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor
    • Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, et al. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 1997; 46: 1473-80.
    • (1997) Diabetes , vol.46 , pp. 1473-1480
    • Aiello, L.P.1    Bursell, S.E.2    Clermont, A.3    Duh, E.4    Ishii, H.5    Takagi, C.6
  • 79
    • 0031126380 scopus 로고    scopus 로고
    • Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates
    • Ozaki H, Hayashi H, Vinores SA, Moromizato Y, Campochiaro PA, Oshima K. Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates. Exp Eye Res 1997; 64: 505-17.
    • (1997) Exp Eye Res , vol.64 , pp. 505-517
    • Ozaki, H.1    Hayashi, H.2    Vinores, S.A.3    Moromizato, Y.4    Campochiaro, P.A.5    Oshima, K.6
  • 80
    • 8944246315 scopus 로고    scopus 로고
    • (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4, 9:16,21-dimetheno-1H,13H-dibenzo [e,k]pyrrolo[3,4-h] [1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase C-β
    • Jirousek MR, Gillig JR, Gonzalez CM, Heath WF, McDonald JH III, Neel DA, et al. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4, 9:16,21-dimetheno-1H,13H-dibenzo [e,k]pyrrolo[3,4-h] [1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C-β. J Med Chem 1996; 39: 2664-71.
    • (1996) J Med Chem , vol.39 , pp. 2664-2671
    • Jirousek, M.R.1    Gillig, J.R.2    Gonzalez, C.M.3    Heath, W.F.4    McDonald III, J.H.5    Neel, D.A.6
  • 81
    • 0031964664 scopus 로고    scopus 로고
    • Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKC beta inhibition with LY333531
    • Danis RP, Bingaman DP, Jirousek M, Yang Y. Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKC beta inhibition with LY333531. Invest Ophthalmol Vis Sci 1998; 39: 171-9.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 171-179
    • Danis, R.P.1    Bingaman, D.P.2    Jirousek, M.3    Yang, Y.4
  • 82
    • 13344293711 scopus 로고    scopus 로고
    • Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor
    • 272
    • Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 1996; 3: 272: 728-31.
    • (1996) Science , vol.3 , pp. 728-731
    • Ishii, H.1    Jirousek, M.R.2    Koya, D.3    Takagi, C.4    Xia, P.5    Clermont, A.6
  • 83
    • 0031459855 scopus 로고    scopus 로고
    • Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats
    • Bursell SE, Takagi C, Clermont AC, Takagi H, Mori F, Ishii H, et al. Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci 1997; 38: 2711-20.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 2711-2720
    • Bursell, S.E.1    Takagi, C.2    Clermont, A.C.3    Takagi, H.4    Mori, F.5    Ishii, H.6
  • 84
    • 0000001975 scopus 로고    scopus 로고
    • Protein kinase C β selective inhibitor LY333531 ameliorates abnormal retinal hemodynamics in patients with diabetes
    • Aiello LP, Bursell S, Devries T, Alatorre C, King GL, Ways K. Protein kinase C β selective inhibitor LY333531 ameliorates abnormal retinal hemodynamics in patients with diabetes. Diabetes 1999, 48: A19.
    • (1999) Diabetes , vol.48
    • Aiello, L.P.1    Bursell, S.2    Devries, T.3    Alatorre, C.4    King, G.L.5    Ways, K.6
  • 85
    • 0036216417 scopus 로고    scopus 로고
    • Is diabetic retinopathy an inflammatory disease?
    • Adamis AP. Is diabetic retinopathy an inflammatory disease? Br J Ophthalmol 2002; 86: 363-5.
    • (2002) Br J Ophthalmol , vol.86 , pp. 363-365
    • Adamis, A.P.1
  • 86
    • 7044228789 scopus 로고    scopus 로고
    • A central role for inflammation in the pathogenesis of diabetic retinopathy
    • Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 2004; 18: 1450-2.
    • (2004) FASEB J , vol.18 , pp. 1450-1452
    • Joussen, A.M.1    Poulaki, V.2    Le, M.L.3    Koizumi, K.4    Esser, C.5    Janicki, H.6
  • 87
    • 0033400348 scopus 로고    scopus 로고
    • Pathogenetic potential of leukocytes in diabetic retinopathy
    • Miyamoto K, Ogura Y. Pathogenetic potential of leukocytes in diabetic retinopathy Semin 1999; 14: 233-9.
    • (1999) Semin , vol.14 , pp. 233-239
    • Miyamoto, K.1    Ogura, Y.2
  • 88
    • 0038321279 scopus 로고    scopus 로고
    • Protein kinase C beta2-dependent phosphorylation of core 2 G1cNAc-T promotes leukocyte-endothelial cell adhesion: A mechanism underlying capillary occlusion in diabetic retinopathy
    • Chibber R, Ben-Mahmud BM, Mann GE, Zhang JJ, Kohner EM. Protein kinase C beta2-dependent phosphorylation of core 2 G1cNAc-T promotes leukocyte-endothelial cell adhesion: a mechanism underlying capillary occlusion in diabetic retinopathy. Diabetes 2003; 52: 1519-27.
    • (2003) Diabetes , vol.52 , pp. 1519-1527
    • Chibber, R.1    Ben-Mahmud, B.M.2    Mann, G.E.3    Zhang, J.J.4    Kohner, E.M.5
  • 89
    • 0033868806 scopus 로고    scopus 로고
    • PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats
    • Nonaka A, Kiryu J, Tsujikawa A, Yamashiro K, Miyamoto K, Nishiwaki H, et al. PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci 2000; 41: 2702-6.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 2702-2706
    • Nonaka, A.1    Kiryu, J.2    Tsujikawa, A.3    Yamashiro, K.4    Miyamoto, K.5    Nishiwaki, H.6
  • 90
    • 0029973474 scopus 로고
    • Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy
    • Mizutani M, Kern TS, Lorenzi M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest 1995; 97: 2883-90.
    • (1995) J Clin Invest , vol.97 , pp. 2883-2890
    • Mizutani, M.1    Kern, T.S.2    Lorenzi, M.3
  • 91
    • 0345346385 scopus 로고    scopus 로고
    • Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo
    • Ceolotto G, Gallo A, Miola M, Sartori M, Trevisan R, Del Prato S, et al. Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo. Diabetes 1999; 48: 1316-22.
    • (1999) Diabetes , vol.48 , pp. 1316-1322
    • Ceolotto, G.1    Gallo, A.2    Miola, M.3    Sartori, M.4    Trevisan, R.5    Del Prato, S.6
  • 92
    • 0346166388 scopus 로고    scopus 로고
    • Design, baseline patient characteristics and high prevalence of clinically significant macular edema (CSME) in patients with moderately severe to very severe nonproliferative diabetic retinopathy (NPDR) in the Protein Kinase C Diabetic Retinopathy Study (PKC-DRS)
    • The PKC Inhibitor Diabetic Retinopathy Study Group
    • Aiello LP, Davis MD, Sheetz MJ. The PKC Inhibitor Diabetic Retinopathy Study Group. Design, baseline patient characteristics and high prevalence of clinically significant macular edema (CSME) in patients with moderately severe to very severe nonproliferative diabetic retinopathy (NPDR) in the Protein Kinase C Diabetic Retinopathy Study (PKC-DRS). Diabetes 2002; 51 (suppl 2): A209.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Aiello, L.P.1    Davis, M.D.2    Sheetz, M.J.3
  • 93
    • 0035217155 scopus 로고    scopus 로고
    • The interaction between the renin-angiotensin system and vascular endothelial growth factor in the pathogenesis of retinal neovascularization in diabetes
    • Wilkinson-Berka JL, Kelly DJ, Gilbert RE. The interaction between the renin-angiotensin system and vascular endothelial growth factor in the pathogenesis of retinal neovascularization in diabetes. J Vase Res 2001; 38: 527-35.
    • (2001) J Vase Res , vol.38 , pp. 527-535
    • Wilkinson-Berka, J.L.1    Kelly, D.J.2    Gilbert, R.E.3
  • 94
    • 1542544705 scopus 로고    scopus 로고
    • Pathogenesis of diabetic retinopathy and the renin-angiotensin system
    • Funatsu H, Yamashita H. Pathogenesis of diabetic retinopathy and the renin-angiotensin system. Ophthalmic Physiol Opt 2003; 23: 495-501.
    • (2003) Ophthalmic Physiol Opt , vol.23 , pp. 495-501
    • Funatsu, H.1    Yamashita, H.2
  • 95
    • 0032477583 scopus 로고    scopus 로고
    • Effect of Lisinopril on progression of retinopathy in normotensive people with type I diabetes
    • The EUCLID Study Group. EURODIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes Mellitus
    • Chaturvedi N, Sjolie AK, Stephenson JM, Abrahamian H, Keipes M, Castellarin A, et al. Effect of Lisinopril on progression of retinopathy in normotensive people with type I diabetes. The EUCLID Study Group. EURODIAB Controlled Trial of Lisinopril in Insulin-Dependent Diabetes Mellitus. Lancet 1998; 351: 28-31.
    • (1998) Lancet , vol.351 , pp. 28-31
    • Chaturvedi, N.1    Sjolie, A.K.2    Stephenson, J.M.3    Abrahamian, H.4    Keipes, M.5    Castellarin, A.6
  • 96
    • 0030908772 scopus 로고    scopus 로고
    • Randmised placebo-controlled trial of lisinopril in normotensive patients with insulin-dependent diabetes and normoalbuminuria or microalbuminuria
    • The EUCLID Study Group
    • The EUCLID Study Group. Randmised placebo-controlled trial of lisinopril in normotensive patients with insulin-dependent diabetes and normoalbuminuria or microalbuminuria. Lancet 1997; 349: 1787-92.
    • (1997) Lancet , vol.349 , pp. 1787-1792
  • 97
    • 0041358796 scopus 로고    scopus 로고
    • Diabetic retinopathy and diabetic macular edema. Pathophysiology, screening, and novel therapies
    • Ciulla TA, Amador AG, Zinman B. Diabetic retinopathy and diabetic macular edema. Pathophysiology, screening, and novel therapies. Diabetes Care 2003; 26: 2653-64
    • (2003) Diabetes Care , vol.26 , pp. 2653-2664
    • Ciulla, T.A.1    Amador, A.G.2    Zinman, B.3
  • 98
    • 20144389813 scopus 로고    scopus 로고
    • Selective suppression of pathologic, but not physiologic, retinal neovascularization by blocking the angiotensin II type 1 receptor
    • Nagai N, Noda K, Urano T, Kubota Y, Shinoda H, Koto T, et al. Selective suppression of pathologic, but not physiologic, retinal neovascularization by blocking the angiotensin II type 1 receptor. Invest Ophthalmol Via Sci 2005; 46: 1078-84.
    • (2005) Invest Ophthalmol Via Sci , vol.46 , pp. 1078-1084
    • Nagai, N.1    Noda, K.2    Urano, T.3    Kubota, Y.4    Shinoda, H.5    Koto, T.6
  • 99
    • 0032481348 scopus 로고    scopus 로고
    • Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells
    • Chua CC, Hamdy RC, Chua BH. Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells. Biochim Biophys Acta 1998; 1401: 187-94.
    • (1998) Biochim Biophys Acta , vol.1401 , pp. 187-194
    • Chua, C.C.1    Hamdy, R.C.2    Chua, B.H.3
  • 100
    • 0032559771 scopus 로고    scopus 로고
    • Angiotensin II potentiates vascular endothelial growth factor-induced angiogenic activity in retinal microcapillary endothelial cells
    • Otani A, Takagi H, Suzuma K, Honda Y. Angiotensin II potentiates vascular endothelial growth factor-induced angiogenic activity in retinal microcapillary endothelial cells. Circ Res 1998; 82: 619-28.
    • (1998) Circ Res , vol.82 , pp. 619-628
    • Otani, A.1    Takagi, H.2    Suzuma, K.3    Honda, Y.4
  • 101
    • 0042880651 scopus 로고    scopus 로고
    • Captopril and vascular endothelial growth factor in a mouse model of retinopathy
    • Higgins RD, Yan Y, Geng Y, Sharma J, Barr SM. Captopril and vascular endothelial growth factor in a mouse model of retinopathy. Curr Eye Res 2003; 27: 123-9.
    • (2003) Curr Eye Res , vol.27 , pp. 123-129
    • Higgins, R.D.1    Yan, Y.2    Geng, Y.3    Sharma, J.4    Barr, S.M.5
  • 105
    • 0035140915 scopus 로고    scopus 로고
    • Hyperoxia/normoxia-driven retinal angiogenesis in mice: A role for angiotensin II
    • Lonchampt M, Pennel L, Duhault J. Hyperoxia/normoxia-driven retinal angiogenesis in mice: a role for angiotensin II. Invest Ophthalmol Vis Sci 2001; 42: 429-32.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 429-432
    • Lonchampt, M.1    Pennel, L.2    Duhault, J.3
  • 106
    • 0034939090 scopus 로고    scopus 로고
    • The angiotensin II receptor antagonist candesartan cilexetil (TCV-116) ameliorates retinal disorders in rats
    • Nagisa Y, Shintani A, Nakagawa S. The angiotensin II receptor antagonist candesartan cilexetil (TCV-116) ameliorates retinal disorders in rats. Diabetologia 2001; 44: 883-8.
    • (2001) Diabetologia , vol.44 , pp. 883-888
    • Nagisa, Y.1    Shintani, A.2    Nakagawa, S.3
  • 108
    • 0032511601 scopus 로고    scopus 로고
    • Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39
    • UK Prospective Diabetes Study Group
    • UK Prospective Diabetes Study Group: Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. Brit Med J 1998; 317: 713-72.
    • (1998) Brit Med J , vol.317 , pp. 713-772
  • 109
    • 4444275738 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas
    • Ayalasomayajula SP, Amrite AC, Kompella UB. Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas. Eur J Pharmacol 2004; 498: 275-8.
    • (2004) Eur J Pharmacol , vol.498 , pp. 275-278
    • Ayalasomayajula, S.P.1    Amrite, A.C.2    Kompella, U.B.3
  • 110
    • 0032719928 scopus 로고    scopus 로고
    • The effect of selective cyclooxygenase-2 inhibitor on corneal angiogenesis in the rat
    • Yamada M, Kawai M, Kawai Y, Mashima Y. The effect of selective cyclooxygenase-2 inhibitor on corneal angiogenesis in the rat. Curr Eye Res 1999; 19: 300-4.
    • (1999) Curr Eye Res , vol.19 , pp. 300-304
    • Yamada, M.1    Kawai, M.2    Kawai, Y.3    Mashima, Y.4
  • 112
    • 0036468287 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo
    • Leahy KM, Ornberg RL, Wang Y, Zweifel BS, Koki AT, Masferrer JL. Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Res 2002; 62: 625-31.
    • (2002) Cancer Res , vol.62 , pp. 625-631
    • Leahy, K.M.1    Ornberg, R.L.2    Wang, Y.3    Zweifel, B.S.4    Koki, A.T.5    Masferrer, J.L.6
  • 113
    • 0028143547 scopus 로고
    • Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P
    • Ziche M, Morbidelli L, Masini E, Amerini S, Granger HJ, Maggi CA, et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 1994; 94:2036-44.
    • (1994) J Clin Invest , vol.94 , pp. 2036-2044
    • Ziche, M.1    Morbidelli, L.2    Masini, E.3    Amerini, S.4    Granger, H.J.5    Maggi, C.A.6
  • 114
    • 0020000982 scopus 로고
    • Role of prostaglandin E1 and copper in angiogenesis
    • Ziche M, Jones J, Gullino PM. Role of prostaglandin E1 and copper in angiogenesis. J Natl Cancer Inst 1982; 69: 475-82.
    • (1982) J Natl Cancer Inst , vol.69 , pp. 475-482
    • Ziche, M.1    Jones, J.2    Gullino, P.M.3
  • 116
    • 0033567459 scopus 로고    scopus 로고
    • Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis
    • Daniel TO, Liu H, Morrow JD, Crews BC, Marnett LJ. Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis. Cancer Res 1999; 59: 4574-7.
    • (1999) Cancer Res , vol.59 , pp. 4574-4577
    • Daniel, T.O.1    Liu, H.2    Morrow, J.D.3    Crews, B.C.4    Marnett, L.J.5
  • 117
    • 4644243612 scopus 로고    scopus 로고
    • Vasoactive factors and diabetic retinopathy: Vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide
    • Wilkinson-Berka JL. Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide. Curr Pharm Des 2004; 10: 3331-48.
    • (2004) Curr Pharm Des , vol.10 , pp. 3331-3348
    • Wilkinson-Berka, J.L.1
  • 118
    • 4644243657 scopus 로고    scopus 로고
    • Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats
    • Du Y, Sarthy VP, Kern TS. Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats. Am J Physiol Regul Integr Comp Physiol 2004; 287: 735-41.
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287 , pp. 735-741
    • Du, Y.1    Sarthy, V.P.2    Kern, T.S.3
  • 119
    • 0036517850 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression
    • Joussen AM, Poulaki V, Mitsiades N, Kirchhof B, Koizumi K, Dohmen S, et al. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J 2002; 16: 438-40.
    • (2002) FASEB J , vol.16 , pp. 438-440
    • Joussen, A.M.1    Poulaki, V.2    Mitsiades, N.3    Kirchhof, B.4    Koizumi, K.5    Dohmen, S.6
  • 120
    • 0031594643 scopus 로고    scopus 로고
    • Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Müller cells
    • Cheng T, Cao W, Wen R, Steinberg RH, LaVail MM. Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Müller cells. Invest Ophthalmol Via Sci 1998; 39: 581-91.
    • (1998) Invest Ophthalmol Via Sci , vol.39 , pp. 581-591
    • Cheng, T.1    Cao, W.2    Wen, R.3    Steinberg, R.H.4    LaVail, M.M.5
  • 121
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998; 93: 705-16.
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3    Sawaoka, H.4    Hori, M.5    DuBois, R.N.6
  • 122
    • 0037394105 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-1 and -2 modulates angiogenic responses to engagement of alphav beta3
    • Murphy JF, Steele C, Belton O, Fitzgerald DJ. Induction of cyclooxygenase-1 and -2 modulates angiogenic responses to engagement of alphav beta3. Br J Haematol 2003; 121: 157-64.
    • (2003) Br J Haematol , vol.121 , pp. 157-164
    • Murphy, J.F.1    Steele, C.2    Belton, O.3    Fitzgerald, D.J.4
  • 123
    • 0037374468 scopus 로고    scopus 로고
    • Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer
    • Gupta RA, Tejada LV, Tong BJ, Das SK, Morrow JD, Dey SK, et al. Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. Cancer Res 2003; 63: 906-11.
    • (2003) Cancer Res , vol.63 , pp. 906-911
    • Gupta, R.A.1    Tejada, L.V.2    Tong, B.J.3    Das, S.K.4    Morrow, J.D.5    Dey, S.K.6
  • 124
    • 0034282465 scopus 로고    scopus 로고
    • Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice
    • Chulada PC, Thompson MB, Mahler JF, Doyle CM, Gaul BW, Lee C, et al. Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res 2000, 60: 4705-8.
    • (2000) Cancer Res , vol.60 , pp. 4705-4708
    • Chulada, P.C.1    Thompson, M.B.2    Mahler, J.F.3    Doyle, C.M.4    Gaul, B.W.5    Lee, C.6
  • 126
    • 0035136729 scopus 로고    scopus 로고
    • Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease
    • Yu DY, Cringle SJ. Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog Retin Eye Res 2001; 20: 175-208.
    • (2001) Prog Retin Eye Res , vol.20 , pp. 175-208
    • Yu, D.Y.1    Cringle, S.J.2
  • 128
    • 0242456167 scopus 로고    scopus 로고
    • Ocular neovascularization: A valuable model system
    • Campochiaro PA, Hackett SF. Ocular neovascularization: a valuable model system. Oncogene 2003; 22: 6537-48.
    • (2003) Oncogene , vol.22 , pp. 6537-6548
    • Campochiaro, P.A.1    Hackett, S.F.2
  • 129
    • 13744256029 scopus 로고    scopus 로고
    • Chemoprevention of colorectal cancer: Ready for routine use?
    • Arber N, Levin B. Chemoprevention of colorectal cancer: ready for routine use? Recent Results Cancer Res 2005; 166: 213-30.
    • (2005) Recent Results Cancer Res , vol.166 , pp. 213-230
    • Arber, N.1    Levin, B.2
  • 130
    • 0036085164 scopus 로고    scopus 로고
    • Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks
    • Moran EM. Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks. J Environ Pathol Toxicol Oncol 2002; 21: 193-201.
    • (2002) J Environ Pathol Toxicol Oncol , vol.21 , pp. 193-201
    • Moran, E.M.1
  • 131
    • 0025853982 scopus 로고
    • Effects of aspirin treatment on diabetic retinopathy. ETDRS report number 8
    • Early Treatment Diabetic Retinopathy Study Research Group
    • Early Treatment Diabetic Retinopathy Study Research Group. Effects of aspirin treatment on diabetic retinopathy. ETDRS report number 8. Ophthalmology 1991; 98 (suppl): 757-65.
    • (1991) Ophthalmology , vol.98 , Issue.SUPPL. , pp. 757-765
  • 133
    • 1242314857 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in colorectal cancer
    • Sinicrope FA, Gill S. Role of cyclooxygenase-2 in colorectal cancer. Cancer Metastasis Rev 2004; 23: 63-75.
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 63-75
    • Sinicrope, F.A.1    Gill, S.2
  • 134
    • 3042788940 scopus 로고    scopus 로고
    • COX-2 inhibition and colorectal cancer
    • Koehne CH, Dubois RN. COX-2 inhibition and colorectal cancer. Semin Oncol 2004; 31: 12-21.
    • (2004) Semin Oncol , vol.31 , pp. 12-21
    • Koehne, C.H.1    Dubois, R.N.2
  • 135
    • 0141765733 scopus 로고    scopus 로고
    • Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia
    • Lukiw WJ, Ottlecz A, Lambrou G, Grueninger M, Finley J, Thompson HW, et al. Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Invest Ophthalmol Vis Sci 2003; 44: 4163-70.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 4163-4170
    • Lukiw, W.J.1    Ottlecz, A.2    Lambrou, G.3    Grueninger, M.4    Finley, J.5    Thompson, H.W.6
  • 136
    • 0037166355 scopus 로고    scopus 로고
    • Eicosanoid regulation of vascular endothelial growth factor expression and angiogenesis in microvessel endothelial cells
    • Mezentsev A, Sets F, Dunn MW, Ono N, Falck JR, Laniado-Schwartzman M. Eicosanoid regulation of vascular endothelial growth factor expression and angiogenesis in microvessel endothelial cells. J Biol Chem 2002; 277: 18670-6.
    • (2002) J Biol Chem , vol.277 , pp. 18670-18676
    • Mezentsev, A.1    Sets, F.2    Dunn, M.W.3    Ono, N.4    Falck, J.R.5    Laniado-Schwartzman, M.6
  • 137
    • 4344663889 scopus 로고    scopus 로고
    • Effect of COX inhibitors on VEGF-induced retinal vascular leakage and experimental corneal and choroidal neovascularization
    • Castro MR, Lutz D, Edelman JL. Effect of COX inhibitors on VEGF-induced retinal vascular leakage and experimental corneal and choroidal neovascularization. Exp Eye Res 2004, 79: 275-85.
    • (2004) Exp Eye Res , vol.79 , pp. 275-285
    • Castro, M.R.1    Lutz, D.2    Edelman, J.L.3
  • 139
    • 0035409354 scopus 로고    scopus 로고
    • Pharmacological inhibition of diabetic retinopathy: Aminoguanidine and aspirin
    • Kern TS, Engerman RL. Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin. Diabetes 2001; 50: 1636-42.
    • (2001) Diabetes , vol.50 , pp. 1636-1642
    • Kern, T.S.1    Engerman, R.L.2
  • 140
    • 0032805459 scopus 로고    scopus 로고
    • Indomethacin improves oxygen-induced retinopathy in the mouse
    • Nandgaonkar BN, Rotschild T, Yu K, Higgins RD. Indomethacin improves oxygen-induced retinopathy in the mouse. Pediatr Res 1999; 46:184-8.
    • (1999) Pediatr Res , vol.46 , pp. 184-188
    • Nandgaonkar, B.N.1    Rotschild, T.2    Yu, K.3    Higgins, R.D.4
  • 141
    • 0344155296 scopus 로고    scopus 로고
    • Ibuprofen improves oxygen-induced retinopathy in a mouse model
    • Sharma J, Barr SM, Geng Y, Yon Y, Higgins RD. Ibuprofen improves oxygen-induced retinopathy in a mouse model. Curr Eye Res 2003; 27: 309-14.
    • (2003) Curr Eye Res , vol.27 , pp. 309-314
    • Sharma, J.1    Barr, S.M.2    Geng, Y.3    Yon, Y.4    Higgins, R.D.5
  • 145
    • 0034041303 scopus 로고    scopus 로고
    • Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers
    • Ke TL, Graff G, Spellman JM, Yanni JM. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation 2000; 24: 371-84.
    • (2000) Inflammation , vol.24 , pp. 371-384
    • Ke, T.L.1    Graff, G.2    Spellman, J.M.3    Yanni, J.M.4
  • 146
    • 0034045508 scopus 로고    scopus 로고
    • Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy
    • Gamache DA, Graff G, Brady MT, Spellman JM, Yanni JM. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation 2000; 24: 357-70.
    • (2000) Inflammation , vol.24 , pp. 357-370
    • Gamache, D.A.1    Graff, G.2    Brady, M.T.3    Spellman, J.M.4    Yanni, J.M.5
  • 147
    • 0036786633 scopus 로고    scopus 로고
    • Ocular aspirin distribution: A comparison of intravenous, topical, and coulomb-controlled iontophoresis administration
    • Voigt M, Kralinger M, Kieselbach G, Chapon P, Anagnoste S, Hayden B, et al. Ocular aspirin distribution: a comparison of intravenous, topical, and coulomb-controlled iontophoresis administration. Invest Ophthalmol Vis Sci 2002; 43: 3299-306.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 3299-3306
    • Voigt, M.1    Kralinger, M.2    Kieselbach, G.3    Chapon, P.4    Anagnoste, S.5    Hayden, B.6
  • 148
    • 0030279709 scopus 로고    scopus 로고
    • Improved ocular bioavailability of indomethacin by novel ocular drug carriers
    • Calvo P, Alonso MJ, Vila-Jato JL, Robinson JR. Improved ocular bioavailability of indomethacin by novel ocular drug carriers. J Pharm Pharmacol 1996; 48: 1147-52.
    • (1996) J Pharm Pharmacol , vol.48 , pp. 1147-1152
    • Calvo, P.1    Alonso, M.J.2    Vila-Jato, J.L.3    Robinson, J.R.4
  • 149
    • 0345827826 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for in-domethacin
    • Balasubramaniam J, Kant S, Pandit JK. In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for in-domethacin. Acta Pharm 2003; 53: 251-61.
    • (2003) Acta Pharm , vol.53 , pp. 251-261
    • Balasubramaniam, J.1    Kant, S.2    Pandit, J.K.3
  • 150
    • 0033845493 scopus 로고    scopus 로고
    • Pharmacokinetics and anti-inflammatory activity in rabbits of a novel indomethacin ophthalmic solution
    • Chetoni P, Panichi L, Burgalassi S, Benelli U, Saettone MF. Pharmacokinetics and anti-inflammatory activity in rabbits of a novel indomethacin ophthalmic solution. J Ocul Pharmacol Ther 2000; 16: 363-72.
    • (2000) J Ocul Pharmacol Ther , vol.16 , pp. 363-372
    • Chetoni, P.1    Panichi, L.2    Burgalassi, S.3    Benelli, U.4    Saettone, M.F.5
  • 151
    • 0023626528 scopus 로고
    • Angiostatic steroids
    • Folkman J, Ingber D. Angiostatic steroids. Am Surg 1987; 206: 374-83.
    • (1987) Am Surg , vol.206 , pp. 374-383
    • Folkman, J.1    Ingber, D.2
  • 152
    • 0029620301 scopus 로고
    • Exudative macular degeneration and intravitreal triamcinolone: A pilot study
    • Penfold PL, Gyory JF, Hunyor AB, Billson FA. Exudative macular degeneration and intravitreal triamcinolone: a pilot study. Aust NZ J Ophthalmol 1995; 23: 293-8.
    • (1995) Aust NZ J Ophthalmol , vol.23 , pp. 293-298
    • Penfold, P.L.1    Gyory, J.F.2    Hunyor, A.B.3    Billson, F.A.4
  • 154
    • 0030472037 scopus 로고    scopus 로고
    • Inhibition of preretinal and optic nerve head neovascularization in pigs by intravitreal triamcinolone acetonide
    • Danis RP, Bingaman DP, Yang Y, Ladd B. Inhibition of preretinal and optic nerve head neovascularization in pigs by intravitreal triamcinolone acetonide. Ophthalmology 1996; 103: 2099-104.
    • (1996) Ophthalmology , vol.103 , pp. 2099-2104
    • Danis, R.P.1    Bingaman, D.P.2    Yang, Y.3    Ladd, B.4
  • 155
    • 0021874413 scopus 로고
    • Effects of intravitreal administration of steroids on experimental subretinal neovascularization in the subhuman primate
    • Ishibashi T, Miki K, Sorgente N, Patterson R, Ryan SJ. Effects of intravitreal administration of steroids on experimental subretinal neovascularization in the subhuman primate. Arch Ophthalmol 1985, 103: 708-11.
    • (1985) Arch Ophthalmol , vol.103 , pp. 708-711
    • Ishibashi, T.1    Miki, K.2    Sorgente, N.3    Patterson, R.4    Ryan, S.J.5
  • 157
    • 0842267262 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide for diabetic diffuse macular edema. Preliminary results of a prospective controlled trial
    • Massin P, Audren F, Haouchine B, Erginay A, Bergmann JF, Benosman R, et al. Intravitreal triamcinolone acetonide for diabetic diffuse macular edema. Preliminary results of a prospective controlled trial. Ophthalmology 2004; 111: 218-25.
    • (2004) Ophthalmology , vol.111 , pp. 218-225
    • Massin, P.1    Audren, F.2    Haouchine, B.3    Erginay, A.4    Bergmann, J.F.5    Benosman, R.6
  • 158
    • 0036727854 scopus 로고    scopus 로고
    • Modulation of permeability and adhesion molecule expression by human choroidal endothelial cells
    • Penfold PL, Wen L, Madigan MC, King NJ, Provis JM. Modulation of permeability and adhesion molecule expression by human choroidal endothelial cells. Invest Ophthalmol Vis Sci 2002; 43: 3125-30.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 3125-3130
    • Penfold, P.L.1    Wen, L.2    Madigan, M.C.3    King, N.J.4    Provis, J.M.5
  • 159
    • 0026655453 scopus 로고
    • Treatment with intravitreous steroid reduces blood-retinal barrier breakdown due to retinal photocoagulation
    • Wilson CA, Berkowitz BA, Sato Y, Ando N, Handa JT, de Juan E Jr. Treatment with intravitreous steroid reduces blood-retinal barrier breakdown due to retinal photocoagulation. Arch Ophthalmol 1992; 110: 1155-9.
    • (1992) Arch Ophthalmol , vol.110 , pp. 1155-1159
    • Wilson, C.A.1    Berkowitz, B.A.2    Sato, Y.3    Ando, N.4    Handa, J.T.5    de Juan Jr., E.6
  • 160
    • 11144314751 scopus 로고    scopus 로고
    • Repeated intravitreal injection of triamcinolone acetonide for diffuse diabetic macular oedema
    • Jonas JB, Kreissig I, Degenring RF, Kamppeter BA. Repeated intravitreal injection of triamcinolone acetonide for diffuse diabetic macular oedema. Br J Ophthalmol 2005; 89: 122.
    • (2005) Br J Ophthalmol , vol.89 , pp. 122
    • Jonas, J.B.1    Kreissig, I.2    Degenring, R.F.3    Kamppeter, B.A.4
  • 161
    • 0033944912 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide in exudative age-related macular degeneration
    • Danis RP, Ciulla TA, Pratt LM, Anliker W. Intravitreal triamcinolone acetonide in exudative age-related macular degeneration. Retina 2000; 20: 244-250.
    • (2000) Retina , vol.20 , pp. 244-250
    • Danis, R.P.1    Ciulla, T.A.2    Pratt, L.M.3    Anliker, W.4
  • 163
    • 9644254053 scopus 로고    scopus 로고
    • Factors influencing visual acuity after intravitreal triamcinolone acetonide as treatment of exudative age related macular degeneration
    • Jonas JB, Kreissig I, Degenring RF. Factors influencing visual acuity after intravitreal triamcinolone acetonide as treatment of exudative age related macular degeneration. Br J Ophthalmol 2004; 86: 1557-62.
    • (2004) Br J Ophthalmol , vol.86 , pp. 1557-1562
    • Jonas, J.B.1    Kreissig, I.2    Degenring, R.F.3
  • 164
    • 0037653669 scopus 로고    scopus 로고
    • Randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration: One-year results
    • Gillies MC, Simpson JM, Luo W, Penfold P, Hunyor AB, Chua W, et al. Randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration: one-year results. Arch Ophthalmol 2003; 121: 667-73.
    • (2003) Arch Ophthalmol , vol.121 , pp. 667-673
    • Gillies, M.C.1    Simpson, J.M.2    Luo, W.3    Penfold, P.4    Hunyor, A.B.5    Chua, W.6
  • 165
    • 0035161760 scopus 로고    scopus 로고
    • The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity
    • Penn JS, Rajaratnam VS, Collier RJ, Clark AF. The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci 2001; 42: 283-90.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 283-290
    • Penn, J.S.1    Rajaratnam, V.S.2    Collier, R.J.3    Clark, A.F.4
  • 166
    • 9644252831 scopus 로고    scopus 로고
    • Anecortave acetate: Author reply
    • Miller JW, Lane AM. Anecortave acetate: Author reply. Ophthalmology 2004; 111: 2316-7.
    • (2004) Ophthalmology , vol.111 , pp. 2316-2317
    • Miller, J.W.1    Lane, A.M.2
  • 167
    • 0344442766 scopus 로고    scopus 로고
    • Anecortave acetate as monotherapy for treatment of subfoveal neovascularization in age-related macular degeneration: Twelve-month clinical outcomes
    • Anecortave Acetate Clinical Study Group
    • D'Amico DJ, Goldberg MF, Hudson H, Jerdan JA, Krueger DS, Luna SP, et al. Anecortave Acetate Clinical Study Group. Anecortave acetate as monotherapy for treatment of subfoveal neovascularization in age-related macular degeneration: twelve-month clinical outcomes. Ophthalmology 2003; 110: 2372-83.
    • (2003) Ophthalmology , vol.110 , pp. 2372-2383
    • D'Amico, D.J.1    Goldberg, M.F.2    Hudson, H.3    Jerdan, J.A.4    Krueger, D.S.5    Luna, S.P.6
  • 168
    • 5344258973 scopus 로고    scopus 로고
    • Adverse effects of thalidomide administration in patients with neoplastic diseases
    • Dimopoulos MA, Eleutherakis-Papaiakovou V. Adverse effects of thalidomide administration in patients with neoplastic diseases. Am J Med 2004; 117: 508-15.
    • (2004) Am J Med , vol.117 , pp. 508-515
    • Dimopoulos, M.A.1    Eleutherakis-Papaiakovou, V.2
  • 170
    • 4043113512 scopus 로고    scopus 로고
    • Anti-angiogenic effects of thalidomide: Expression of apoptosis-inducible active-caspase-3 in a three-dimensional collagen gel culture of aorta
    • Fujita Y, Asami Y, Tanaka Y, Akita M, Merker HJ. Anti-angiogenic effects of thalidomide: expression of apoptosis-inducible active-caspase-3 in a three-dimensional collagen gel culture of aorta. Histochem Cell Biol 2004, 122: 27-33.
    • (2004) Histochem Cell Biol , vol.122 , pp. 27-33
    • Fujita, Y.1    Asami, Y.2    Tanaka, Y.3    Akita, M.4    Merker, H.J.5
  • 171
    • 0035186865 scopus 로고    scopus 로고
    • Thalidomide and its analogues inhibit lipopolysaccharide-mediated induction of cyclooxygenase-2
    • Fujita J, Mestre JR, Zeldis JB, Subbaramaiah K, Dannenberg AJ. Thalidomide and its analogues inhibit lipopolysaccharide-mediated induction of cyclooxygenase-2. Clin Cancer Res 2001; 7: 3349-55.
    • (2001) Clin Cancer Res , vol.7 , pp. 3349-3355
    • Fujita, J.1    Mestre, J.R.2    Zeldis, J.B.3    Subbaramaiah, K.4    Dannenberg, A.J.5
  • 172
    • 7044230866 scopus 로고    scopus 로고
    • Thalidomide in solid tumours: The resurrection of an old drug
    • Sleijfer S, Kruit WH, Stoter G. Thalidomide in solid tumours: the resurrection of an old drug. Eur J Cancer 2004; 40: 2377-82.
    • (2004) Eur J Cancer , vol.40 , pp. 2377-2382
    • Sleijfer, S.1    Kruit, W.H.2    Stoter, G.3
  • 173
    • 0027230553 scopus 로고
    • Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation
    • Moreira AL, Sampaio EP, Zmuidzinas A, Frindt P, Smith KA, Kaplan G. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med 1993; 177: 1675-80.
    • (1993) J Exp Med , vol.177 , pp. 1675-1680
    • Moreira, A.L.1    Sampaio, E.P.2    Zmuidzinas, A.3    Frindt, P.4    Smith, K.A.5    Kaplan, G.6
  • 175
    • 0032865755 scopus 로고    scopus 로고
    • Tbalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro
    • Moreira AL, Friedlander DR, Shif B, Kaplan G, Zagzag D. Tbalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro. J Neurooncol 1999; 43: 109-14.
    • (1999) J Neurooncol , vol.43 , pp. 109-114
    • Moreira, A.L.1    Friedlander, D.R.2    Shif, B.3    Kaplan, G.4    Zagzag, D.5
  • 177
    • 0031171663 scopus 로고    scopus 로고
    • Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization
    • Kenyon BM, Browne F, D'Amato RJ. Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res 1997; 64: 971-8.
    • (1997) Exp Eye Res , vol.64 , pp. 971-978
    • Kenyon, B.M.1    Browne, F.2    D'Amato, R.J.3
  • 179
    • 0033390282 scopus 로고    scopus 로고
    • Effect of thalidomide and structurally related compounds on corneal angiogenesis is comparable to their teratological potency
    • Joussen AM, Germann T, Kirchhof B. Effect of thalidomide and structurally related compounds on corneal angiogenesis is comparable to their teratological potency. Graefe's Arch Clin Exp Ophthalmol 1999; 237: 952-61.
    • (1999) Graefe's Arch Clin Exp Ophthalmol , vol.237 , pp. 952-961
    • Joussen, A.M.1    Germann, T.2    Kirchhof, B.3
  • 181
    • 0036823323 scopus 로고    scopus 로고
    • Thalidomide prevents donor corneal graft neovascularization in an alkali burn model of corneal angiogenesis
    • Abbas A, Khan B, Feroze AH, Hyman GF. Thalidomide prevents donor corneal graft neovascularization in an alkali burn model of corneal angiogenesis. J Pak Med Assoc 2002; 52: 476-82.
    • (2002) J Pak Med Assoc , vol.52 , pp. 476-482
    • Abbas, A.1    Khan, B.2    Feroze, A.H.3    Hyman, G.F.4
  • 182
    • 0346846764 scopus 로고    scopus 로고
    • Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats
    • Bosco AA, Lerario AC, Santos RF, Wajchenberg BL. Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats. Diabetologia 2003; 46: 1669-75.
    • (2003) Diabetologia , vol.46 , pp. 1669-1675
    • Bosco, A.A.1    Lerario, A.C.2    Santos, R.F.3    Wajchenberg, B.L.4
  • 184
    • 33745758816 scopus 로고    scopus 로고
    • Available from Accessed 23 December
    • Available from http://drgeene.mediwire.com/main/ Default.aspx?P=Content&ArticleID=3208. Accessed 23 December 2005.
    • (2005)
  • 185
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signalling in cell adhesion
    • Hynes RO. Integrins: versatility, modulation, and signalling in cell adhesion. Cell 1992; 69: 11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 191
    • 0032829104 scopus 로고    scopus 로고
    • Tumor angiogenesis-new drugs on the block
    • Brower V. Tumor angiogenesis-new drugs on the block. Nat Biotechnol 1999; 17: 963-8.
    • (1999) Nat Biotechnol , vol.17 , pp. 963-968
    • Brower, V.1
  • 192
    • 0029925079 scopus 로고    scopus 로고
    • Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization
    • Hammes HP, Brownlee M, Jonczyk A, Sutter A, Preissner KT. Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization. Nat Med 1996; 2: 529-33.
    • (1996) Nat Med , vol.2 , pp. 529-533
    • Hammes, H.P.1    Brownlee, M.2    Jonczyk, A.3    Sutter, A.4    Preissner, K.T.5
  • 193
    • 2442598322 scopus 로고    scopus 로고
    • Inhibition of experimental choroidal neovascularization in rats by an alpha(v)-integrin antagonist
    • Yasukawa T, Hoffmann S, Eichler W, Friedrichs, U, Wang YS, Wiedemann P. Inhibition of experimental choroidal neovascularization in rats by an alpha(v)-integrin antagonist. Curr Eye Res 2004; 28: 359-66.
    • (2004) Curr Eye Res , vol.28 , pp. 359-366
    • Yasukawa, T.1    Hoffmann, S.2    Eichler, W.3    Friedrichs, U.4    Wang, Y.S.5    Wiedemann, P.6
  • 195
    • 0028670833 scopus 로고
    • Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, et al. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994; 79:1157-64.
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1    Montgomery, A.M.2    Rosenfeld, M.3    Reisfeld, R.A.4    Hu, T.5    Klier, G.6
  • 196
    • 0033134622 scopus 로고    scopus 로고
    • MMP in angiogenesis: A moving target for therapeutic intervention
    • Stetler-Stevenson WG. MMP in angiogenesis: a moving target for therapeutic intervention. J Clin Invest 1999; 103: 1237-41.
    • (1999) J Clin Invest , vol.103 , pp. 1237-1241
    • Stetler-Stevenson, W.G.1
  • 197
    • 0034176764 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Multi-functional contributors to tumor progression
    • McCawley LJ, Matrisian LM. Matrix metalloproteinases: multi-functional contributors to tumor progression. Mol Med Today 2000; 6: 149-56.
    • (2000) Mol Med Today , vol.6 , pp. 149-156
    • McCawley, L.J.1    Matrisian, L.M.2
  • 198
    • 0033618337 scopus 로고    scopus 로고
    • Matrix metalloproteinases
    • Nagase H, Woessner JF. Matrix metalloproteinases. J Biol Chem 1999; 274: 21491-4.
    • (1999) J Biol Chem , vol.274 , pp. 21491-21494
    • Nagase, H.1    Woessner, J.F.2
  • 199
    • 0027383944 scopus 로고
    • Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation
    • Murphy AN, Unsworth EJ, Stetler-Stevenson WG. Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. J Cell Physiol 1993; 157: 351-8.
    • (1993) J Cell Physiol , vol.157 , pp. 351-358
    • Murphy, A.N.1    Unsworth, E.J.2    Stetler-Stevenson, W.G.3
  • 201
    • 0028000141 scopus 로고
    • Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: Implications for an anti-angiogenic therapy
    • Benelli R, Adatia R, Ensoli B, Stetler-Stevenson WG, Santi L, Albini A. Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy. Oncol Res 1994; 6: 251-7.
    • (1994) Oncol Res , vol.6 , pp. 251-257
    • Benelli, R.1    Adatia, R.2    Ensoli, B.3    Stetler-Stevenson, W.G.4    Santi, L.5    Albini, A.6
  • 202
    • 0032582686 scopus 로고    scopus 로고
    • Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
    • Hiraoka N, Allen E, Appel IJ, Gyetko MR, Weiss SJ. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell 1998; 95:365-77.
    • (1998) Cell , vol.95 , pp. 365-377
    • Hiraoka, N.1    Allen, E.2    Appel, I.J.3    Gyetko, M.R.4    Weiss, S.J.5
  • 203
    • 0346963598 scopus 로고    scopus 로고
    • MMP-9/gelatinase B is a key regulator of growth plate angio-genesis and apoptosis of hypertrophic chondrocytes
    • Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, et al. MMP-9/gelatinase B is a key regulator of growth plate angio-genesis and apoptosis of hypertrophic chondrocytes. Cell 1998; 93: 411-22.
    • (1998) Cell , vol.93 , pp. 411-422
    • Vu, T.H.1    Shipley, J.M.2    Bergers, G.3    Berger, J.E.4    Helms, J.A.5    Hanahan, D.6
  • 205
    • 0034645060 scopus 로고    scopus 로고
    • Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones
    • Engsig MT, Chen QJ, Vu TH, Pedersen AC, Therkidsen B, Lund LR, et al. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol 2000; 151: 879-89.
    • (2000) J Cell Biol , vol.151 , pp. 879-889
    • Engsig, M.T.1    Chen, Q.J.2    Vu, T.H.3    Pedersen, A.C.4    Therkidsen, B.5    Lund, L.R.6
  • 206
    • 0642364446 scopus 로고    scopus 로고
    • MMP-2 and MMP9 synergize in promoting choroidal neovascularization
    • Lambert V, Wielockx B, Munaut C, Galopin C, Jost M, Itoh T, et al. MMP-2 and MMP9 synergize in promoting choroidal neovascularization. FASEB J 2003; 17: 2290-2.
    • (2003) FASEB J , vol.17 , pp. 2290-2292
    • Lambert, V.1    Wielockx, B.2    Munaut, C.3    Galopin, C.4    Jost, M.5    Itoh, T.6
  • 207
    • 0031719049 scopus 로고    scopus 로고
    • Matrix metalloprotemases and metalloprotemase inhibitors in choroidal neovascular membranes
    • Steen B, Sejersen S, Berglin L, Seregard S, Kvanta A. Matrix metalloprotemases and metalloprotemase inhibitors in choroidal neovascular membranes. Invest Ophthalmol Vis Sci 1998; 39: 2194-200.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 2194-2200
    • Steen, B.1    Sejersen, S.2    Berglin, L.3    Seregard, S.4    Kvanta, A.5
  • 208
  • 209
    • 0028598887 scopus 로고
    • Protease inhibitors: Role and potential therapeutic use in human cancer
    • DeClerck YA, Imren S. Protease inhibitors: role and potential therapeutic use in human cancer. Eur J Cancer 1994; 30: 2170-80.
    • (1994) Eur J Cancer , vol.30 , pp. 2170-2180
    • DeClerck, Y.A.1    Imren, S.2
  • 210
    • 0028104790 scopus 로고
    • Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line
    • Montgomery AM, Mueller BM, Reisfeld RA, Taylor SM, De-Clerck YA. Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line. Cancer Res 1994; 54: 5467-73
    • (1994) Cancer Res , vol.54 , pp. 5467-5473
    • Montgomery, A.M.1    Mueller, B.M.2    Reisfeld, R.A.3    Taylor, S.M.4    De-Clerck, Y.A.5
  • 211
    • 0028140295 scopus 로고
    • Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1
    • Khokha R. Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1. J Natl Cancer Inst 1994; 86: 299-304.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 299-304
    • Khokha, R.1
  • 212
    • 0028129494 scopus 로고
    • Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth
    • Koop S, Khokha R, Schmidt EE, MacDonald IC, Morris VL, Chambers AF, et al. Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth. Cancer Res 1994; 54: 4791-7.
    • (1994) Cancer Res , vol.54 , pp. 4791-4797
    • Koop, S.1    Khokha, R.2    Schmidt, E.E.3    MacDonald, I.C.4    Morris, V.L.5    Chambers, A.F.6
  • 213
    • 0023696675 scopus 로고
    • Inhibition by human recombinant tissue inhibitor of metallo proteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells
    • Schultz RM, Silberman S, Persky B, Bajkowski AS, Carmichael DF. Inhibition by human recombinant tissue inhibitor of metallo proteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells. Cancer Res 1988; 48: 5539-45.
    • (1988) Cancer Res , vol.48 , pp. 5539-5545
    • Schultz, R.M.1    Silberman, S.2    Persky, B.3    Bajkowski, A.S.4    Carmichael, D.F.5
  • 214
    • 0025238632 scopus 로고
    • Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases
    • Alvarez OA, Carmichael DF, DeClerck YA. Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases. J Natl Cancer Inst 1990; 82: 589-95.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 589-595
    • Alvarez, O.A.1    Carmichael, D.F.2    DeClerck, Y.A.3
  • 215
    • 0024593647 scopus 로고
    • Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells
    • Khokha R. Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells. Science 1989; 243: 947-50.
    • (1989) Science , vol.243 , pp. 947-950
    • Khokha, R.1
  • 216
    • 0024201509 scopus 로고
    • Inhibitors of collagenase IV and cell adhesion reduce the invasive activity of malignant tumour cells
    • Reich R, Stratford B, Klein K, Martin GR, Mueller RA, Fuller GC. Inhibitors of collagenase IV and cell adhesion reduce the invasive activity of malignant tumour cells. Ciba Found Symp 1988; 141: 193-210.
    • (1988) Ciba Found Symp , vol.141 , pp. 193-210
    • Reich, R.1    Stratford, B.2    Klein, K.3    Martin, G.R.4    Mueller, R.A.5    Fuller, G.C.6
  • 217
    • 0035188727 scopus 로고    scopus 로고
    • How matrix metalloproteinases regulate cell behavior
    • Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001; 17: 463-516.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 463-516
    • Sternlicht, M.D.1    Werb, Z.2
  • 218
    • 0033863530 scopus 로고    scopus 로고
    • Ongoing trials with matrix metalloproteinase inhibitors
    • Brown PD. Ongoing trials with matrix metalloproteinase inhibitors. Expert Opin Investig Drugs 2000; 9: 2167-77.
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2167-2177
    • Brown, P.D.1
  • 219
    • 0032791421 scopus 로고    scopus 로고
    • Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: Single agent and combination chemotherapy studies
    • Shalinsky DR, Brekken J, Zou H, Bloom LA, McDermott CD, Zook S, et al. Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies. Clin Cancer Res 1999; 5: 1905-17.
    • (1999) Clin Cancer Res , vol.5 , pp. 1905-1917
    • Shalinsky, D.R.1    Brekken, J.2    Zou, H.3    Bloom, L.A.4    McDermott, C.D.5    Zook, S.6
  • 220
    • 0032837028 scopus 로고    scopus 로고
    • Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials
    • Shalinsky DR, Brekken J, Zou H, McDermott CD, Forsyth P, Edwards D, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sci 1999; 878: 236-70.
    • (1999) Ann N Y Acad Sci , vol.878 , pp. 236-270
    • Shalinsky, D.R.1    Brekken, J.2    Zou, H.3    McDermott, C.D.4    Forsyth, P.5    Edwards, D.6
  • 221
    • 0035986464 scopus 로고    scopus 로고
    • The effect of prinomastat (AG2240), a synthetic inhibitor of matrix metalloproteinases, on uveal melanoma rabbit model
    • Ozerdem U, Mach-Hofacre B, Varki N, Folberg R, Mueller AJ, Ochabski R, et al. The effect of prinomastat (AG2240), a synthetic inhibitor of matrix metalloproteinases, on uveal melanoma rabbit model. Curr Eye Res 2002; 24: 86-91.
    • (2002) Curr Eye Res , vol.24 , pp. 86-91
    • Ozerdem, U.1    Mach-Hofacre, B.2    Varki, N.3    Folberg, R.4    Mueller, A.J.5    Ochabski, R.6
  • 223
    • 0035996280 scopus 로고    scopus 로고
    • Efficacy of prinomastat (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization
    • Garcia C, Bartsch DU, Rivero ME, Hagedorn M, McDermott CD, Bergeron-Lynn G, et al. Efficacy of prinomastat (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization. Curr Eye Res 2002; 24: 33-8.
    • (2002) Curr Eye Res , vol.24 , pp. 33-38
    • Garcia, C.1    Bartsch, D.U.2    Rivero, M.E.3    Hagedorn, M.4    McDermott, C.D.5    Bergeron-Lynn, G.6
  • 224
    • 0032955659 scopus 로고    scopus 로고
    • Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor
    • Das A, McLamore A, Song W, McGuire PG. Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor. Arch Ophthalmol 1999; 117: 498-503.
    • (1999) Arch Ophthalmol , vol.117 , pp. 498-503
    • Das, A.1    McLamore, A.2    Song, W.3    McGuire, P.G.4
  • 225
    • 0000532327 scopus 로고    scopus 로고
    • Effects of Prinomastat (AG3340), an angiogenesis in-hibitor, in patients with subfoveal choroidal neovascularization associated with age-related macular degeneration
    • Blodi BA. Effects of Prinomastat (AG3340), an angiogenesis in-hibitor, in patients with subfoveal choroidal neovascularization associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 2001; 42: S311.
    • (2001) Invest Ophthalmol Vis Sci , vol.42
    • Blodi, B.A.1
  • 226
    • 0030863133 scopus 로고    scopus 로고
    • Essential role of growth hormone in ischemia-induced retinal neovascularization
    • Smith LE, Kopchick JJ, Chen W, Knapp J, Kinose F, Daley D, et al. Essential role of growth hormone in ischemia-induced retinal neovascularization. Science 1997; 276: 1706-9.
    • (1997) Science , vol.276 , pp. 1706-1709
    • Smith, L.E.1    Kopchick, J.J.2    Chen, W.3    Knapp, J.4    Kinose, F.5    Daley, D.6
  • 227
    • 0027394750 scopus 로고
    • Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: Comparative studies with basic fibroblast growth factor
    • Grant MB, Mames RN, Fitzgerald C, Ellis EA, Aboufriekha M, Guy J. Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor. Diabetologia 1993; 36: 282-91.
    • (1993) Diabetologia , vol.36 , pp. 282-291
    • Grant, M.B.1    Mames, R.N.2    Fitzgerald, C.3    Ellis, E.A.4    Aboufriekha, M.5    Guy, J.6
  • 229
    • 0031019186 scopus 로고    scopus 로고
    • Inhibition of experimental angiogenesis by the Somatostatin analogue octreotide acetate (SMS 201-995)
    • Danesi R, Agen C, Benelli U, Paolo AD, Nardini D, Bocci G, et al. Inhibition of experimental angiogenesis by the Somatostatin analogue octreotide acetate (SMS 201-995). Clin Cancer Res 1997; 3: 265-72.
    • (1997) Clin Cancer Res , vol.3 , pp. 265-272
    • Danesi, R.1    Agen, C.2    Benelli, U.3    Paolo, A.D.4    Nardini, D.5    Bocci, G.6
  • 231
    • 0027453942 scopus 로고
    • Inhibition of IGF-I and bFGF stimulated growth of human retinal endothelial cells by the somatostatin analogue, octreotide: A potential treatment for ocular neovascularization
    • Grant MB, Caballero S, Millard WJ. Inhibition of IGF-I and bFGF stimulated growth of human retinal endothelial cells by the somatostatin analogue, octreotide: a potential treatment for ocular neovascularization. Regul Pept 1993; 48: 267-78.
    • (1993) Regul Pept , vol.48 , pp. 267-278
    • Grant, M.B.1    Caballero, S.2    Millard, W.J.3
  • 232
    • 0041836171 scopus 로고    scopus 로고
    • Development of targeted somatostatin-based antiangiogenic therapy: A review and future perspectives
    • Woltering EA. Development of targeted somatostatin-based antiangiogenic therapy: a review and future perspectives. Cancer Biother Radiopharm 2003; 18: 601-9.
    • (2003) Cancer Biother Radiopharm , vol.18 , pp. 601-609
    • Woltering, E.A.1
  • 234
    • 0027008734 scopus 로고
    • Stabilization of severe proliferative diabetic retinopathy by long-term treatment with SMS 201-995
    • Mallet B, Vialettes B, Haroche S, Escoffier P, Gastaut P, Taubert JP, et al. Stabilization of severe proliferative diabetic retinopathy by long-term treatment with SMS 201-995. Diabete Metab 1992; 18: 438-44.
    • (1992) Diabete Metab , vol.18 , pp. 438-444
    • Mallet, B.1    Vialettes, B.2    Haroche, S.3    Escoffier, P.4    Gastaut, P.5    Taubert, J.P.6
  • 235
    • 0034082810 scopus 로고    scopus 로고
    • The efficacy of octreotide in the therapy of severe nonproliferative and early proliferative diabetic retinopathy
    • Grant MB, Mames RN, Fitzgerald C, Hazariwala KM, Cooper-DeHoff R, Caballero S, et al. The efficacy of octreotide in the therapy of severe nonproliferative and early proliferative diabetic retinopathy. Diabetes Care 2000; 23: 504-9.
    • (2000) Diabetes Care , vol.23 , pp. 504-509
    • Grant, M.B.1    Mames, R.N.2    Fitzgerald, C.3    Hazariwala, K.M.4    Cooper-DeHoff, R.5    Caballero, S.6
  • 236
    • 0026406121 scopus 로고
    • Effect of a long-acting somatostatin analogue (BIM23014) on proliferative diabetic retinopathy: A pilot study
    • McCombe M, Lightman S, Eckland DJ, Hamilton AM, Lightman SL. Effect of a long-acting somatostatin analogue (BIM23014) on proliferative diabetic retinopathy: a pilot study. Eye 1991; 5: 569-75.
    • (1991) Eye , vol.5 , pp. 569-575
    • McCombe, M.1    Lightman, S.2    Eckland, D.J.3    Hamilton, A.M.4    Lightman, S.L.5
  • 237
    • 0035191536 scopus 로고    scopus 로고
    • The effect of a growth hormone receptor antagonist drug on proliferative diabetic retinopathy
    • Growth Hormone Antagonist for Proliferative Diabetic Retinopathy Study Group
    • Growth Hormone Antagonist for Proliferative Diabetic Retinopathy Study Group. The effect of a growth hormone receptor antagonist drug on proliferative diabetic retinopathy. Ophthalmology 2001; 108: 2266-72.
    • (2001) Ophthalmology , vol.108 , pp. 2266-2272
  • 238
    • 0346433524 scopus 로고    scopus 로고
    • Combretastatins: From natural products to drug discovery
    • Cirla A, Mann J. Combretastatins: from natural products to drug discovery. Nat Prod Rep 2003; 20: 558-64.
    • (2003) Nat Prod Rep , vol.20 , pp. 558-564
    • Cirla, A.1    Mann, J.2
  • 239
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 2004; 10: 415-27.
    • (2004) Clin Cancer Res , vol.10 , pp. 415-427
    • Thorpe, P.E.1
  • 241
    • 27644466314 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling
    • Vincent L, Kermani P, Young LM, Cheng J, Zhang F, Shido K, et al. Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling. J Clin Invest 2005; 115: 2992-3006.
    • (2005) J Clin Invest , vol.115 , pp. 2992-3006
    • Vincent, L.1    Kermani, P.2    Young, L.M.3    Cheng, J.4    Zhang, F.5    Shido, K.6
  • 242
    • 0035417875 scopus 로고    scopus 로고
    • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability
    • Tozer GM, Prise VE, Wilson J, Cemazar M, Shan S, Dewhirst MW, et al. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Res 2001; 61: 6413-22.
    • (2001) Cancer Res , vol.61 , pp. 6413-6422
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3    Cemazar, M.4    Shan, S.5    Dewhirst, M.W.6
  • 243
    • 0042343848 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization
    • Nambu H, Nambu R, Melia M, Campochiaro PA. Combretastatin A-4 phosphate suppresses development and induces regression of choroidal neovascularization. Invest Ophthalmol Vis Sci 2003; 44: 3650-5.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3650-3655
    • Nambu, H.1    Nambu, R.2    Melia, M.3    Campochiaro, P.A.4
  • 244
    • 13444267332 scopus 로고    scopus 로고
    • Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines
    • Simoni D, Grisolia G, Giannini G, Roberti M, Rondanin R, Piccagli L, et al. Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines. J Med Chem 2005; 48: 723-36.
    • (2005) J Med Chem , vol.48 , pp. 723-736
    • Simoni, D.1    Grisolia, G.2    Giannini, G.3    Roberti, M.4    Rondanin, R.5    Piccagli, L.6
  • 246
    • 33745742121 scopus 로고    scopus 로고
    • Available from Accessed 23 December
    • Available from http://www.biotechnologyhealthcare.com/Daily/ DailyDetail.cfm?chosen=436. Accessed 23 December 2005.
    • (2005)
  • 247
    • 33745758312 scopus 로고    scopus 로고
    • Available from Accessed 23 December
    • Available from http://www.mdsupport.org/library/anti-angio.html. Accessed 23 December 2005.
    • (2005)
  • 248
    • 0346025502 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Current & future directions
    • Mousa SA, Mousa AS. Angiogenesis inhibitors: current & future directions. Curr Pharm Des 2004; 10(1): 1-9.
    • (2004) Curr Pharm Des , vol.10 , Issue.1 , pp. 1-9
    • Mousa, S.A.1    Mousa, A.S.2
  • 249
    • 21044440895 scopus 로고    scopus 로고
    • Novel approaches in the treatment of angiogenic eye disease
    • Wegewitz U, Gohring I, Spranger J. Novel approaches in the treatment of angiogenic eye disease. Curr Pharm Des 2005; 11(18): 2311-30.
    • (2005) Curr Pharm Des , vol.11 , Issue.18 , pp. 2311-2330
    • Wegewitz, U.1    Gohring, I.2    Spranger, J.3
  • 250
    • 4644243612 scopus 로고    scopus 로고
    • Vasoactive factors and diabetic retinopathy: Vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide
    • Wilkinson-Berka JL. Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide. Curr Pharm Des 2004; 10(27): 3331-48.
    • (2004) Curr Pharm Des , vol.10 , Issue.27 , pp. 3331-3348
    • Wilkinson-Berka, J.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.