Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 13, 1997, Pages 2711-2720

  Bursell, Sven Erik ^a,b   Takagi, Chikako ^a   Clermont, Allen C ^a   Takagi, Hitoshi ^a   Mori, Fumihiko ^a   Ishii, Hidehiro ^a   King, George L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

Diabetes; Diacylglycerol; Diacylglycerol kinase; Protein kinase C; Retinal hemodynamics

Indexed keywords

3 [2 [4 (4,4' DIFLUOROBENZHYDRYLIDENE)PIPERIDINO]ETHYL] 2,3 DIHYDRO 2 THIOXO 4(1H) QUINAZOLINONE; DIACYLGLYCEROL; DIACYLGLYCEROL DERIVATIVE; DIACYLGLYCEROL KINASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; RUBOXISTAURIN; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; ENZYME ANALYSIS; HEMODYNAMIC MONITORING; HYPERGLYCEMIA; KIDNEY BLOOD FLOW; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA BLOOD FLOW; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD FLOW VELOCITY; DIABETES MELLITUS, EXPERIMENTAL; DIACYLGLYCEROL KINASE; DIGLYCERIDES; ENZYME INHIBITORS; FLUORESCEIN ANGIOGRAPHY; HYPERGLYCEMIA; INDOLES; ISOENZYMES; MALE; MALEIMIDES; PIPERIDINES; PROTEIN KINASE C; QUINAZOLINES; QUINAZOLINONES; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL VESSELS;

EID: 0031459855     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Pirart J. Diabetes mellitus and its degenerative complications: A prospective study of 4,400 patients observed between 1947 and 1973. Diabetic Care. 1978;1:168-188.
2. Krolewski AS, Warram JH, Rand LI, Kahn CR. Epidemiologic approach to the etiology of type 1 diabetes mellitus and its complications. N Engl J Med. 1987; 317:1390-1398.
3. The Diabetic Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.
4. King GL, Shiba T, Oliver J, Inoguchi T, Bursell S-E. Cellular and molecular abnormalities in the vascular endothelium of Diabetes Mellitus. Annu Rev Med. 1994;45:179-188.
5. Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL. Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 1992;89:11059-11063.
6. Shiba T, Inoguchi T, Sportsman R, Heath WF, Bursell S, King GL. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol. 1993;265:E783-E793.
7. Craven PA, Derubertis FR. Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. J Clin Invest. 1989;83:1667-1675.
8. Craven PA, Davidson CM, DeRubertis FR. Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes. 1990;39:667-674.
9. Clermont AC, Takagi C, Jirousek M, Bursell SE, King GL. A PKCβ isoform selective antagonist normalized retinal blood flow in STZ diabetic rats: First report of an oral agent selective for the PKCβII isoenzyme. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995; 36:S173.
10. Ishii H, Jirousek MR, Koya D, et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC-β inhibitor. Science. 1996;272:728-731.
11. de Chaffoy de Courcelles D, Roevens P, Van Belle H, Kennis L, Somers Y, De Clerck F. The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. J Biol Chem. 1989; 264:3274-3285.
12. Takagi C, King GL, Clermont AC, Cummins DR, Takagi H, Bursell SE. Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an α-glucosidase inhibitor. Curr Eye Res. 1995;14:741-749.
13. Clermont AC, Brittis MB, Shiba T, McGovern T, King GL, Bursell SE. Normalization of retinal blood flow in diabetic rats with primary intervention using insulin pumps. Invest Ophthalmol Vis Sci. 1994;35:981-990.
14. Takagi C, King GL, Takagi H, Lin Y-W, Clermont AC, Bursell S-E. Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia. Invest Ophthalmol Vis Sci. 1996;37:2099-2109.
15. Takagi C, Bursell S-E, Lin Y-W, et al. Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1. Invest Ophthalmol Vis Sci. 1996;37:2504-2518.
16. Hughes A. A schematic eye for rat. Vision Res. 1979;5:406-412.
17. Williams B, Schrier RW. Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells. Diabetes. 1992;41:1464-1472.
18. Pu X, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL. Characterization of the mechanism for the chronic activation of Diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 1994;43:1122-1129.
19. Koyama T, Matsuo N, Shimizu K, et al. Retinal circulation times in quantitative fluorescein angiography. Graefes Arch Clin Exp Ophthalmol. 1990;228:442-446.
20. Riva CE, Feke GT, Ben-Sira I. Fluorescein dye-dilution technique and retinal circulation. Am J Physiol. 1978;234:H315-H321.
21. Bulpitt CJ, Dollery CT. Estimation of retinal blood flow by measurement of mean circulation time. Cardiovasc Res. 1971;5:406-412.
22. Kohner EM, Hamilton AM, Saunders SJ, Sutcliffe BA, Bulpitt CJ. The retinal blood flow in diabetes. Diabetologia. 1975;11:27-33.
23. Bursell S-E, Clermont AC, Kinsley BT, Simonson DC, Wolpert HA. Retinal blood flow changes in patients with insulin-dependent diabetes mellitus (IDDM) and no diabetic retinopathy: A video fluorescein angiographic study. Invest Ophthalmol Vis Sci. 1996;37:886-897.
24. Feke G, Buzney SM, Ogasawara N, et al. Retinal circulatory abnormalities in type I diabetes. Invest Ophthalmol Vis Sci. 1994;35:2968-2975.
25. Zatz R, Brenner B. Pathogenesis of diabetic microangiopathy: The hemodynamic review. Am J Med. 1986;80:443-453.
26. Grunwald JE, Bursell S-E. Hemodynamic changes as early markers in diabetic retinopathy. Curr Opin Endocrinol Diabetes. 1996;3:298-306.
27. Kunisaki M, Bursell SE, Clermont AC, Umeda F, Nawata H, King GL. Vitamin E treatment prevents diabetes-induced abnormality in retinal blood flow possibly through the diacylglycerol-protein kinase C pathway. Am J Physiol. 1995;269:E239-E246.
28. Kanoh H, Yamada K, Sakane F. Diacylglycerol kinase: A key modulator of signal transduction? Trends Biochem Sci. 1990;15:47-50.
29. Rasmussen H, Forder J, Kojima I, Scriabine A. TPA-induced contraction of isolated rabbit vascular smooth muscle. Biochem Biophys Res Commun. 1984;122:776-784.
30. De la Rubia G, Oliver FJ, Inoguchi T, King GL. Induction of resistance to endothelin-1's biochemical actions by elevated glucose levels in retinal pericytes. Diabetes. 1992;41:1533-1539.
31. Takahashi K, Brooks RA, Kanse SM, Ghatei MA, Kohner EM, Bloom SR. Production of endothelin-1 by cultured bovine retinal endothelial cells and presence of endothelin receptors on associated pericytes. Diabetes. 1989;38:1200-1202.
32. Bohlen HG, Lash JM. Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles. Am J Physiol. 1993;265:H219-225.
33. Langenstroer P, Pieper GM. Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals. Am J Physiol. 1992;265:H257-H265.
34. Inoguchi T, Xia P, Kunisaki M, Higashi S, Feener EP, King GL. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol. 1994;267:E369-E379.
35. Engerman RL, Kern TS. Progression of incipient diabetic retinopathy during good glycemic control. Diabetes. 1987;36:808-812.
36. Kern TS, Engerman RL. Kidney morphology in experimental hyperglycemia. Diabetes. 1987;36:244-249.