Ocular aspirin distribution: A comparison of intravenous, topical, and coulomb-controlled iontophoresis administration

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 10, 2002, Pages 3299-3306

  Voigt, Monika ^a   Kralinger, Martina ^a   Kieselbach, Gerhard ^a   Chapon, Pascal ^a   Anagnoste, Scott ^a   Hayden, Brandy ^a   Parel, Jean Marie ^a  

^a Ophthalmic Biophysics Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; SALICYLIC ACID DERIVATIVE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG SAFETY; DRUG TISSUE LEVEL; EYE; EYE INJURY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; IONTOPHORESIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; EYE; INJECTIONS, INTRAVENOUS; IONTOPHORESIS; RABBITS; SAFETY; TISSUE DISTRIBUTION;

EID: 0036786633     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Vane JR, Botting RM. Mechanism of action of nonsteroidal anti-inflammatory drugs. Am J Med. 1998;104:S2-S8.
2. Higgs GA, Salmon JA, Henderson B, Vane JR. Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Proc Natl Acad Sci USA. 1987;84:1417-1420.
3. Bazan HE, Birkle DL, Beuerman R, Bazan NG. Cryogenic lesion alters the metabolism of arachidonic acid in rabbit cornea layers. Invest Ophthalmol Vis Sci. 1985;26:474-480.
4. Bazan HE, Birkle DL, Beuerman R, Bazan NG. Inflammation-induced stimulation of the synthesis of prostaglandins and lipoxygenase-reaction products in rabbit cornea. Curr Eye Res. 1985;4:175-179.
5. Preud'homme Y, Demolle D, Boeynaems JM. Metabolism of arachidonic acid in rabbit iris and retina. Invest Ophthalmol Vis Sci. 1985;26:1336-1342.
6. Birkle DL, Bazan NG. Lipoxygenase- and cyclooxygenase-reaction products and incorporation into glycerolipids or radiolabeled arachidonic acid in the bovine retina. Prostaglandins. 1984;27:203-216.
7. Birkle DL, Bazan NG. Light exposure stimulates arachidonic acid metabolism in intact rat retina and isolated rod outer segments. Neurochem Res. 1989;14:185-190.
8. Bar-Ilan A, Naveh N, Weissman C, Belkin M, Schwartz M. Prostaglandin E2 changes in the retina and optic nerve of an eye with injured optic nerve. Neuroscience. 1991;45:221-225.
9. Naveh N, Belkin M, Ben-Chaim O, Weissman C, Treister G. Prostanoids in the vitreous of diabetic and nondiabetic human eyes with retinal detachment. Ophthalmic Res. 1990;22:3-11.
10. Stjernschantz J. Autocoids and peptides in pharmacology of the eye. In: Sears ML, ed. Handbook of Experimental Pharmacology. Vol. 69. Berlin: Springer-Verlag; 1984.
11. Flower RW, Blake DA. Retrolental fibroplasia: evidence for a role of the prostaglandin cascade in the pathogenesis of oxygen-induced retinopathy in the newborn beagle. Pediatr Res. 1981;15: 1293-1302.
12. Form DM, Auerbach R. PGE2 and angiogenesis. Proc Soc Exp Biol Med. 1983;172:214-218.
13. BenEzra D. Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants. Am J Ophthalmol. 1978;86: 455-461.
14. BenEzra D. Neovasculogenesis. Triggering factors and possible mechanisms. Surv Ophthalmol. 1978;24:167-176.
15. Cheng T, Cao W, Wen R, Steinberg RH, LaVail MM. Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells. Invest Ophthalmol Vis Sci. 1998;39:581-591.
16. Miyake K, Shirasawa E, Hikita M. Hypotheses on the role of prostaglandins in the pathogenesis of epinephrine maculopathy and aphakic cystoid macular edema. Prog Clin Biol Res. 1989;312: 265-276.
17. Miyake K. Prostaglandins as a causative factor of the cystoid macular edema after the lens extraction. Nippon Ganka Gakkaiz Asshi. 1977;81:1449-1464.
18. Thomas MA, O'Grady GE, Swartz SL. Prostaglandin levels in human vitreous. Br J Ophthalmol. 1985;69:275-279.
19. Rabiah PK, Fiscella RG, Tessler HH. Intraocular penetration of periocular ketorolac and efficacy in experimental uveitis. Invest Ophthalmol Vis Sci. 1996;37:613-618.
20. Valeri P, Romanelli L, De Paolis L, Martinelli B. Ocular distribution of aspirin and salicylate following systematic administration of aspirin to rabbits. J Pharm Pharmacol. 1988;40:823-824.
21. Valeri P, Romanelli L, Martinelli B, Guglielmotti A, Catanese B. Time-course of aspirin and salicylate in ocular tissues of rabbits. Lens Eye Toxic Res. 1989;6:465-475.
22. Rossetti L, Chaudhuri J, Dickersin K. Medical prophylaxis and treatment of cystoid macular edema after cataract surgery: the results of a meta-analysis. Ophthalmology. 1998;105:397-405.
23. Nichols J, Snyder RW. Topical nonsteroidal anti-inflammatory agents in ophthalmology. Curr Opin Ophthalmol. 1998;9:40-44.
24. Koay P. The emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology. Br J Ophthalmol. 1996;80:480-485.
25. Calvo P, Alonso MJ, Vila-Jato JL, Robinson JR. Improved ocular bioavailability of indomethacin by novel ocular drug carriers. J Pharm Pharmacol. 1996;48:1147-1152.
26. Kralinger M, Hamasaki D, Kieselbach G, Voigt M, Parel JM. Intravitreal acetylsalicylic acid in silicone oil: pharmacokinetics and evaluation of its safety by ERG and histology. Graefes Arch Clin Exp Ophthalmol. 2001;239:208-216.
27. Nose I, Parel J-M, Lee W, et al. Ocular coulomb controlled iontophoresis (OCCI) [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1996;37(3):S41. Abstract nr 185.
28. Sarraf D, Lee DA. The role of iontophoresis in ocular drug delivery. J Ocul Pharmacol. 1994;10:69-81.
29. Kahler C, Kieselbach G, Reinisch N, et al. Fibroblast growth-promoting activity in proliferative vitreoretinopathy: antagonism by acetylsalicylic acid. Eur J Pharmacol. 1994;262:261-269.
30. Fogel J, Epstein P, Chen P. Simultaneous high-performance liquid chromatography assay of acetylsalicylic acid and salicylic acid in film-coated aspirin tablets. J Chromatogr. 1984;317:507-511.
31. Brandon RA, Eadie MJ, Smith MT. A sensitive liquid chromatographic assay for plasma aspirin and salicylate concentrations after low doses of aspirin. Ther Drug Monit. 1985;7:216-221.
32. Marangos MN, Onyeji CO, Nicolau DP, Nightingale CH. Disposition kinetics of aspirin in female New Zealand white rabbits. Lab Anim Sci. 1995;45:67-69.
33. Hughes L, Maurice DM. A fresh look at iontophoresis. Arch Ophthalmol. 1984;102:1825-1829.
34. Singh P, Maibach HI. Iontophoresis in drug delivery: basic principles and applications. Crit Rev Ther Drug Carrier Syst. 1994;11: 161-213.
35. Gangarosa LP Sr, Ozawa A, Ohkido M, Shimomura Y, Hill J. Iontophoresis for enhancing penetration of dermatologic and antiviral drugs. J Dermatol. 1995;22:865-875.
36. Callegan MC, O'Callaghan RJ, Hill JM. Pharmacokinetic considerations in the treatment of bacterial keratitis. Clin Pharmacokinet. 1994;27:129-124.
37. Burstein NL, Leopold LH, Bemacchi DB. Trans-scleral iontophoresis of gentamicin. J Ocul Pharmacol. 1985;1:363-368.
38. Hill JM, Kwon BS, Burch KD, et al. Acyclovir and vidarabine monophosphate: comparison of iontophoretic and intravenous administration for the treatment of HSV-1 stromal keratitis. Am J Med. 1982;73:300-304.
39. Behar-Cohen FF, Savoldelli M, Parel JM, et al. Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis. Invest Ophthalmol Vis Sci. 1998;39:897-904.
40. Behar-Cohen FF, Parel JM, Pouliquen Y, et al. Iontophoresis of dexamethasone in the treatment of endotoxin-induced-uveitis in rats. Exp Eye Res. 1997;65:533-545.
41. Lam TT, Fu J, Chu R, Stojack K, Siew E, Tso MO. Intravitreal delivery of ganciclovir in rabbits by transscleral iontophoresis. J Ocul Pharmacol. 1994;10:571-575.
42. Brand RM, Wahl A, Iversen PL. Effects of size and sequence on the iontophoretic delivery of oligonucleotides. J Pharm Sci. 1998;87: 49-52.
43. van der Geest R, Hueber F, Szoka FC Jr, Guy RH. Iontophoresis of bases, nucleosides, and nucleotides. Pharm Res. 1996;13:553- 558.
44. Asahara T, Shinomiya K, Naito T, Shiota H. Induction of genes into the rabbit eye by iontophoresis. Nippon Ganka Gakkaiz Asshi. 1999;103:178-185.
45. Lee RD, White HS, Scott ER. Visualization of iontophoretic transport paths in cultured and animal skin models. J Pharm Sci. 1996;85:1186-1190.
46. Yoshizumi MO, Dessouki A, Lee DA, Lee G. Determination of ocular toxicity in multiple applications of foscamet iontophoresis. J Ocul Pharmacol Ther. 1997;13:529-536.
47. Lam TT, Fu J, Tso MO. A histopathologic study of retinal lesions inflicted by transscleral iontophoresis [published correction appears in Graefes Arch Clin Exp Ophthalmol. 1992;230:1991. Graefes Arch Clin Exp Ophthalmol. 1991;229:389-94.
48. Savoldelli M, Parel J-M, D'Hermie F, et al. An histologic and ultrastructural study of the rat and the rabbit eye after iontophoresis [ARVO Abstract]. Invest Ophthalmol Vis Sci. 1998;39(4):S927. Abstract nr 4267.
49. Kralinger MT, Voigt M, Kieselbach G, Hamasaki D, Parel JM. In vivo safety of repetitive coulomb controlled iontophoresis administered acetylsalicylic acid [ARVO Abstract]. Invest Ophthalmol Vis Sci. 2001;42(4):S172. Abstract nr 918.
50. Chauveaud D, Behar-Cohen FF, Parel JM, Renard G. Transscleral iontophoresis of corticosteroids: phase II clinical trial [ARVO Abstract]. Invest Ophthalmol Vis Sci. 2000;41(4):S79. Abstract nr 414.
51. Miyake K, Shirasawa E, Hikita M. Active transport system of prostaglandins: clinical implications and considerations. J Cataract Refract Surg. 1992;18:100-105.
52. Antoszyk AN, Gottlieb JL, Casey RC, Hatchell DL, Machemer R. An experimental model of preretinal neovascularization in the rabbit. Invest Ophthalmol Vis Sci 1991;32:46-52.
53. Rotschild T, Nandgaonkar BN, Yu K, Higgins RD. Dexamethasone reduces oxygen induced retinopathy in a mouse model. Pediatr Res. 1999;46:94-100.
54. Chandler DB, Quansah FA, Hida T, Machemer R. A refined experimental model for proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol. 1986;224:86-91.
55. Rubsamen PE, Cousins SW. Therapeutic effect of periocular corticosteroids in experimental proliferative vitreoretinopathy. Retina. 1997;17:44-50.
56. Gerli R, Gresele P, Bistoni O, et al. Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism. J Immunol. 2001;166:832-840.
57. Gerli R, Paolucci C, Gresele P, et al. Salicylates inhibit adhesion and transmigration of T lymphocytes by preventing integrin activation induced by contact with endothelial cells. Blood. 1998;92:2389-2398.