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Volumn 140, Issue 4, 2006, Pages 1157-1168

Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection

Author keywords

caspase 11; cytokines; neurodegeneration; Parkinson; substantia nigra

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 11; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NITRIC OXIDE SYNTHASE INHIBITOR; S METHYLPSEUDOTHIOUREA; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 33745269269     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.02.073     Document Type: Article
Times cited : (48)

References (56)
  • 1
    • 10944234609 scopus 로고    scopus 로고
    • Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice
    • Arai H., Furuya T., Yasuda T., Miura M., Mizuno Y., and Mochizuki H. Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice. J Biol Chem 279 (2004) 51647-51653
    • (2004) J Biol Chem , vol.279 , pp. 51647-51653
    • Arai, H.1    Furuya, T.2    Yasuda, T.3    Miura, M.4    Mizuno, Y.5    Mochizuki, H.6
  • 2
    • 0037330339 scopus 로고    scopus 로고
    • Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration
    • Arimoto T., and Bing G. Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration. Neurobiol Dis 12 (2003) 35-45
    • (2003) Neurobiol Dis , vol.12 , pp. 35-45
    • Arimoto, T.1    Bing, G.2
  • 3
    • 0029983730 scopus 로고    scopus 로고
    • The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
    • Beyaert R., Cuenda A., Vanden Berghe W., Plaisance S., Lee J.C., Haegeman G., Cohen P., and Fiers W. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J 15 (1996) 1914-1923
    • (1996) EMBO J , vol.15 , pp. 1914-1923
    • Beyaert, R.1    Cuenda, A.2    Vanden Berghe, W.3    Plaisance, S.4    Lee, J.C.5    Haegeman, G.6    Cohen, P.7    Fiers, W.8
  • 4
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
    • Bhat N.R., Zhang P., Lee J.C., and Hogan E.L. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18 (1998) 1633-1641
    • (1998) J Neurosci , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 5
    • 0026702955 scopus 로고
    • Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
    • Boje K.M., and Arora P.K. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 587 (1992) 250-256
    • (1992) Brain Res , vol.587 , pp. 250-256
    • Boje, K.M.1    Arora, P.K.2
  • 6
    • 0028364696 scopus 로고
    • Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease
    • Boka G., Anglade P., Wallach D., Javoy-Agid F., Agid Y., and Hirsch E.C. Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease. Neurosci Lett 172 (1994) 151-154
    • (1994) Neurosci Lett , vol.172 , pp. 151-154
    • Boka, G.1    Anglade, P.2    Wallach, D.3    Javoy-Agid, F.4    Agid, Y.5    Hirsch, E.C.6
  • 8
    • 0031881687 scopus 로고    scopus 로고
    • Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system
    • Castaño A., Herrera A.J., Cano J., and Machado A. Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system. J Neurochem 70 (1998) 1584-1592
    • (1998) J Neurochem , vol.70 , pp. 1584-1592
    • Castaño, A.1    Herrera, A.J.2    Cano, J.3    Machado, A.4
  • 9
    • 0036077851 scopus 로고    scopus 로고
    • The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma
    • Castaño A., Herrera A.J., Cano J., and Machado A. The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma. J Neurochem 81 (2002) 150-157
    • (2002) J Neurochem , vol.81 , pp. 150-157
    • Castaño, A.1    Herrera, A.J.2    Cano, J.3    Machado, A.4
  • 10
    • 0026738695 scopus 로고
    • Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
    • Chao C.C., Hu S., Molitor T.W., Shaskan E.G., and Peterson P.K. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149 (1992) 2736-2741
    • (1992) J Immunol , vol.149 , pp. 2736-2741
    • Chao, C.C.1    Hu, S.2    Molitor, T.W.3    Shaskan, E.G.4    Peterson, P.K.5
  • 11
    • 0033020781 scopus 로고    scopus 로고
    • p38 But not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages
    • Chen C.C., and Wang J.K. p38 But not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol Pharmacol 55 (1999) 481-488
    • (1999) Mol Pharmacol , vol.55 , pp. 481-488
    • Chen, C.C.1    Wang, J.K.2
  • 12
    • 0028089896 scopus 로고
    • Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures
    • Dawson V.L., Brahmbhatt H.P., Mong J.A., and Dawson T.M. Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology 33 (1994) 1425-1430
    • (1994) Neuropharmacology , vol.33 , pp. 1425-1430
    • Dawson, V.L.1    Brahmbhatt, H.P.2    Mong, J.A.3    Dawson, T.M.4
  • 13
    • 0032431135 scopus 로고    scopus 로고
    • The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF-alpha
    • de Bock F., Derijard B., Dornand J., Bockaert J., and Rondouin G. The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF-alpha. Eur J Neurosci 10 (1998) 3107-3114
    • (1998) Eur J Neurosci , vol.10 , pp. 3107-3114
    • de Bock, F.1    Derijard, B.2    Dornand, J.3    Bockaert, J.4    Rondouin, G.5
  • 14
    • 0034796306 scopus 로고    scopus 로고
    • Prevalence between different alpha subunits performing the benzodiazepine binding sites in native heterologous GABA(A) receptors containing the alpha2 subunit
    • del Río J.C., Araujo F., Ramos B., Ruano D., and Vitorica J. Prevalence between different alpha subunits performing the benzodiazepine binding sites in native heterologous GABA(A) receptors containing the alpha2 subunit. J Neurochem 79 (2001) 183-191
    • (2001) J Neurochem , vol.79 , pp. 183-191
    • del Río, J.C.1    Araujo, F.2    Ramos, B.3    Ruano, D.4    Vitorica, J.5
  • 15
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with reference to AIDS and Alzheimer's disease
    • Dickson D.W., Lee S.C., Mattiace L.A., Yen S.H., and Brosnan C. Microglia and cytokines in neurological disease, with reference to AIDS and Alzheimer's disease. Glia 7 (1993) 75-83
    • (1993) Glia , vol.7 , pp. 75-83
    • Dickson, D.W.1    Lee, S.C.2    Mattiace, L.A.3    Yen, S.H.4    Brosnan, C.5
  • 17
    • 1442275733 scopus 로고    scopus 로고
    • Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • Furuya T., Hayakawa H., Yamada M., Yoshimi K., Hisahara S., Miura M., Mizuno Y., and Mochizuki H. Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci 24 (2004) 1865-1872
    • (2004) J Neurosci , vol.24 , pp. 1865-1872
    • Furuya, T.1    Hayakawa, H.2    Yamada, M.3    Yoshimi, K.4    Hisahara, S.5    Miura, M.6    Mizuno, Y.7    Mochizuki, H.8
  • 18
    • 0036316772 scopus 로고    scopus 로고
    • Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons. relevance to Parkinson's disease
    • Gao H.M., Jiang J., Wilson B., Zhang W., Hong J.S., and Liu B. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons. relevance to Parkinson's disease. J Neurochem 81 (2002) 1285-1297
    • (2002) J Neurochem , vol.81 , pp. 1285-1297
    • Gao, H.M.1    Jiang, J.2    Wilson, B.3    Zhang, W.4    Hong, J.S.5    Liu, B.6
  • 19
    • 0037203948 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS)-induced dopamine cell loss in culture. roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide
    • Gayle D.A., Ling Z., Tong C., Landers T., Lipton J.W., and Carvey P.M. Lipopolysaccharide (LPS)-induced dopamine cell loss in culture. roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Brain Res Dev Brain Res 133 (2002) 27-35
    • (2002) Brain Res Dev Brain Res , vol.133 , pp. 27-35
    • Gayle, D.A.1    Ling, Z.2    Tong, C.3    Landers, T.4    Lipton, J.W.5    Carvey, P.M.6
  • 20
    • 0037204864 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells
    • Han I.O., Kim K.W., Ryu J.H., and Kim W.K. p38 Mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells. Neurosci Lett 325 (2002) 9-12
    • (2002) Neurosci Lett , vol.325 , pp. 9-12
    • Han, I.O.1    Kim, K.W.2    Ryu, J.H.3    Kim, W.K.4
  • 21
    • 0842277733 scopus 로고    scopus 로고
    • Inflammation and dopaminergic neuronal loss in Parkinson's disease. a complex matter
    • Hartmann A., Hunot S., and Hirsch E.C. Inflammation and dopaminergic neuronal loss in Parkinson's disease. a complex matter. Exp Neurol 184 (2003) 561-564
    • (2003) Exp Neurol , vol.184 , pp. 561-564
    • Hartmann, A.1    Hunot, S.2    Hirsch, E.C.3
  • 22
    • 0033835748 scopus 로고    scopus 로고
    • The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system
    • Herrera A.J., Castaño A., Venero J.L., Cano J., and Machado A. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. Neurobiol Dis 7 (2000) 429-447
    • (2000) Neurobiol Dis , vol.7 , pp. 429-447
    • Herrera, A.J.1    Castaño, A.2    Venero, J.L.3    Cano, J.4    Machado, A.5
  • 24
    • 0035176139 scopus 로고    scopus 로고
    • Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination
    • Hisahara S., Yuan J., Momio T., Okano H., and Miura M. Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination. J Exp Med 193 (2001) 111-122
    • (2001) J Exp Med , vol.193 , pp. 111-122
    • Hisahara, S.1    Yuan, J.2    Momio, T.3    Okano, H.4    Miura, M.5
  • 25
    • 0033121299 scopus 로고    scopus 로고
    • FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells
    • Hunot S., Dugas N., Faucheux B., Hartmann A., Tardieu M., Debre P., Agid Y., Dugas B., and Hirsch E.C. FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells. J Neurosci 19 (1999) 3440-3447
    • (1999) J Neurosci , vol.19 , pp. 3440-3447
    • Hunot, S.1    Dugas, N.2    Faucheux, B.3    Hartmann, A.4    Tardieu, M.5    Debre, P.6    Agid, Y.7    Dugas, B.8    Hirsch, E.C.9
  • 26
    • 0035955438 scopus 로고    scopus 로고
    • Induction of caspase-11 by inflammatory stimuli in rat astrocytes. lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway
    • Hur J., Kim S.Y., Kim H., Cha S., Lee M.S., and Suk K. Induction of caspase-11 by inflammatory stimuli in rat astrocytes. lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway. FEBS Lett 26 (2001) 157-162
    • (2001) FEBS Lett , vol.26 , pp. 157-162
    • Hur, J.1    Kim, S.Y.2    Kim, H.3    Cha, S.4    Lee, M.S.5    Suk, K.6
  • 27
    • 0036499736 scopus 로고    scopus 로고
    • Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration
    • Iravani M.M., Kashefi K., Mander P., Rose S., and Jenner P. Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration. Neuroscience 110 (2002) 49-58
    • (2002) Neuroscience , vol.110 , pp. 49-58
    • Iravani, M.M.1    Kashefi, K.2    Mander, P.3    Rose, S.4    Jenner, P.5
  • 28
    • 23244449641 scopus 로고    scopus 로고
    • The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
    • Iravani M.M., Leung C.C., Sadeghian M., Haddon C.O., Rose S., and Jenner P. The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation. Eur J Neurosci 22 2 (2005) 317-330
    • (2005) Eur J Neurosci , vol.22 , Issue.2 , pp. 317-330
    • Iravani, M.M.1    Leung, C.C.2    Sadeghian, M.3    Haddon, C.O.4    Rose, S.5    Jenner, P.6
  • 29
    • 0036275058 scopus 로고    scopus 로고
    • p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures
    • Jeohn G.H., Cooper C.L., Wilson B., Chang R.C., Jang K.J., Kim H.C., Liu B., and Hong J.S. p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures. Ann N Y Acad Sci 62 (2002) 332-346
    • (2002) Ann N Y Acad Sci , vol.62 , pp. 332-346
    • Jeohn, G.H.1    Cooper, C.L.2    Wilson, B.3    Chang, R.C.4    Jang, K.J.5    Kim, H.C.6    Liu, B.7    Hong, J.S.8
  • 31
    • 0036792478 scopus 로고    scopus 로고
    • Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response
    • Kang S.J., Wang S., Kuida K., and Yuan J. Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death Differ 9 (2002) 1115-1125
    • (2002) Cell Death Differ , vol.9 , pp. 1115-1125
    • Kang, S.J.1    Wang, S.2    Kuida, K.3    Yuan, J.4
  • 32
    • 0034663061 scopus 로고    scopus 로고
    • Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain. role of microglia
    • Kim W.G., Mohney R.P., Wilson B., Jeohn G.H., Liu B., and Hong J.S. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain. role of microglia. J Neurosci 20 (2000) 6309-6316
    • (2000) J Neurosci , vol.20 , pp. 6309-6316
    • Kim, W.G.1    Mohney, R.P.2    Wilson, B.3    Jeohn, G.H.4    Liu, B.5    Hong, J.S.6
  • 33
    • 0036785216 scopus 로고    scopus 로고
    • Neuroprotective effects of prostaglandin E2 or cAMP against microglial and neuronal free radical mediated toxicity associated with inflammation
    • Kim E.J., Kwon K.J., Park J.Y., Lee S.H., Moon C.H., and Baik E.J. Neuroprotective effects of prostaglandin E2 or cAMP against microglial and neuronal free radical mediated toxicity associated with inflammation. J Neurosci Res 70 (2002) 97-107
    • (2002) J Neurosci Res , vol.70 , pp. 97-107
    • Kim, E.J.1    Kwon, K.J.2    Park, J.Y.3    Lee, S.H.4    Moon, C.H.5    Baik, E.J.6
  • 34
    • 0030570790 scopus 로고    scopus 로고
    • Protein tyrosine kinase inhibitors suppress the production of nitric oxide in mixed glia, microglia-enriched or astrocyte-enriched cultures
    • Kong L.Y., McMillian M.K., Maronpot R., and Hong J.S. Protein tyrosine kinase inhibitors suppress the production of nitric oxide in mixed glia, microglia-enriched or astrocyte-enriched cultures. Brain Res 729 (1996) 102-109
    • (1996) Brain Res , vol.729 , pp. 102-109
    • Kong, L.Y.1    McMillian, M.K.2    Maronpot, R.3    Hong, J.S.4
  • 35
    • 0027298505 scopus 로고
    • Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta
    • Lee S.C., Liu W., Dickson D.W., Brosnan C.F., and Berman J.W. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J Immunol 150 7 (1993) 2659-2667
    • (1993) J Immunol , vol.150 , Issue.7 , pp. 2659-2667
    • Lee, S.C.1    Liu, W.2    Dickson, D.W.3    Brosnan, C.F.4    Berman, J.W.5
  • 36
    • 0034015558 scopus 로고    scopus 로고
    • Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
    • Liu B., Du L., and Hong J.S. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. J Pharmacol Exp Ther 293 (2000) 607-617
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 607-617
    • Liu, B.1    Du, L.2    Hong, J.S.3
  • 37
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases. mechanisms and strategies for therapeutic intervention
    • Liu B., and Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases. mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304 (2003) 1-7
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 39
    • 0029003760 scopus 로고
    • Eicosanoids are produced by microglia, not by astrocytes, in rat glial cell cultures
    • Matsuo M., Hamasaki Y., Fujiyama F., and Miyazaki S. Eicosanoids are produced by microglia, not by astrocytes, in rat glial cell cultures. Brain Res 685 (1995) 201-204
    • (1995) Brain Res , vol.685 , pp. 201-204
    • Matsuo, M.1    Hamasaki, Y.2    Fujiyama, F.3    Miyazaki, S.4
  • 41
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer P.L., Itagaki S., Boyes B.E., and McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38 (1988) 1285-1291
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 42
    • 0031985513 scopus 로고    scopus 로고
    • Microglia as effector cells in brain damage and repair. focus on prostanoids and nitric oxide
    • Minghetti L., and Levi G. Microglia as effector cells in brain damage and repair. focus on prostanoids and nitric oxide. Prog Neurobiol 54 (1998) 99-125
    • (1998) Prog Neurobiol , vol.54 , pp. 99-125
    • Minghetti, L.1    Levi, G.2
  • 43
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease
    • Mogi M., Harada M., Narabayashi H., Inagaki H., Minami M., and Nagatsu T. Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neurosci Lett 211 (1996) 13-16
    • (1996) Neurosci Lett , vol.211 , pp. 13-16
    • Mogi, M.1    Harada, M.2    Narabayashi, H.3    Inagaki, H.4    Minami, M.5    Nagatsu, T.6
  • 44
    • 1642634614 scopus 로고    scopus 로고
    • Nitric oxide. a potential inducer of adhesion-related apoptosis-anoikis
    • Monteiro H.P., Silva E.F., and Stern A. Nitric oxide. a potential inducer of adhesion-related apoptosis-anoikis. Nitric Oxide 10 1 (2004) 1-10
    • (2004) Nitric Oxide , vol.10 , Issue.1 , pp. 1-10
    • Monteiro, H.P.1    Silva, E.F.2    Stern, A.3
  • 45
    • 0026629902 scopus 로고
    • Nitric oxide as a secretory product of mammalian cells
    • Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 6 12 (1992) 3051-3064
    • (1992) FASEB J , vol.6 , Issue.12 , pp. 3051-3064
    • Nathan, C.1
  • 48
    • 0033771987 scopus 로고    scopus 로고
    • Selective up-regulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia. in vitro and in vivo studies
    • Possel H., Noack H., Putzke J., Wolf G., and Sies H. Selective up-regulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia. in vitro and in vivo studies. Glia 32 (2000) 51-59
    • (2000) Glia , vol.32 , pp. 51-59
    • Possel, H.1    Noack, H.2    Putzke, J.3    Wolf, G.4    Sies, H.5
  • 49
    • 0034733040 scopus 로고    scopus 로고
    • GABA(A) and alpha-amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus
    • Ruano D., Araujo F., Revilla E., Vela J., Bergis O., and Vitorica J. GABA(A) and alpha-amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus. J Biol Chem 275 (2000) 19585-19593
    • (2000) J Biol Chem , vol.275 , pp. 19585-19593
    • Ruano, D.1    Araujo, F.2    Revilla, E.3    Vela, J.4    Bergis, O.5    Vitorica, J.6
  • 50
    • 0028848015 scopus 로고
    • Isothioureas. potent inhibitors of nitric oxide synthases with variable isoform selectivity
    • Southan G.J., Szabo C., and Thiemermann C. Isothioureas. potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 114 (1995) 510-516
    • (1995) Br J Pharmacol , vol.114 , pp. 510-516
    • Southan, G.J.1    Szabo, C.2    Thiemermann, C.3
  • 51
    • 0028990125 scopus 로고
    • Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
    • Tewari M., Quan L.T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D.R., Poirier G.G., Salvesen G.S., and Dixit V.M. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81 (1995) 801-809
    • (1995) Cell , vol.81 , pp. 801-809
    • Tewari, M.1    Quan, L.T.2    O'Rourke, K.3    Desnoyers, S.4    Zeng, Z.5    Beidler, D.R.6    Poirier, G.G.7    Salvesen, G.S.8    Dixit, V.M.9
  • 52
    • 0035216995 scopus 로고    scopus 로고
    • Rapid PCR-mediated synthesis of competitor molecules for accurate quantification of beta2 GABA(A) receptor subunit mRNA
    • Vela J., Vitorica J., and Ruano D. Rapid PCR-mediated synthesis of competitor molecules for accurate quantification of beta2 GABA(A) receptor subunit mRNA. Brain Res Protoc 8 (2001) 184-190
    • (2001) Brain Res Protoc , vol.8 , pp. 184-190
    • Vela, J.1    Vitorica, J.2    Ruano, D.3
  • 53
    • 0345269186 scopus 로고    scopus 로고
    • Rat hippocampal GABAergic molecular markers are differentially affected by ageing
    • Vela J., Gutierrez A., Vitorica J., and Ruano D. Rat hippocampal GABAergic molecular markers are differentially affected by ageing. J Neurochem 85 (2003) 368-377
    • (2003) J Neurochem , vol.85 , pp. 368-377
    • Vela, J.1    Gutierrez, A.2    Vitorica, J.3    Ruano, D.4
  • 54
    • 0242516020 scopus 로고    scopus 로고
    • Oxidative neurotoxicity in rat cerebral cortex neurons. synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3
    • Wang J.Y., Shum A.Y., Ho Y.J., and Wang J.Y. Oxidative neurotoxicity in rat cerebral cortex neurons. synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3. J Neurosci Res 72 (2003) 508-519
    • (2003) J Neurosci Res , vol.72 , pp. 508-519
    • Wang, J.Y.1    Shum, A.Y.2    Ho, Y.J.3    Wang, J.Y.4
  • 55
    • 14744283139 scopus 로고    scopus 로고
    • Differential effects of oligomeric and fibrillar amyloid-β1-42 on astrocyte-mediated inflammation
    • White J.A., Manelli A.M., Holmberg K.H., Van Eldik L.J., and LaDu M.J. Differential effects of oligomeric and fibrillar amyloid-β1-42 on astrocyte-mediated inflammation. Neurobiol Dis 18 (2005) 459-465
    • (2005) Neurobiol Dis , vol.18 , pp. 459-465
    • White, J.A.1    Manelli, A.M.2    Holmberg, K.H.3    Van Eldik, L.J.4    LaDu, M.J.5


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