Protein tyrosine kinase inhibitors suppress the production of nitric oxide in mixed glia, microglia-enriched or astrocyte-enriched cultures

Brain Research

Volumn 729, Issue 1, 1996, Pages 102-109

  Kong, Ling Yuan ^a   McMillian, Michael K ^a   Maronpot, Robert ^a   Hong, Jau Shyong ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Astrocyte; Inducible nitric oxide synthase; Lipopolysaccharide; Microglia; Nitric oxide; Protein tyrosine kinase inhibitor

Indexed keywords

GAMMA INTERFERON; GENISTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE INHIBITOR; TYRPHOSTIN A25; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CONTROLLED STUDY; GLIA CELL; IMMUNOCYTOCHEMISTRY; MALE; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

EID: 0030570790     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00417-9     Document Type: Article

References (35)

1. [1] Adams, O.D. and Hamilton, T.A., The cell biology of macrophage activation, Annu. Rev. Immunol., 2 (1984) 283-318.
2. [2] Akiyama, T., Ishida, J., Nakagawa, S., Ogaware, H., Watanabe, S., Itoh, N., Shibuy, M. and Fukami, Y., Genistein, a specific inhibitor of tyrosine-specific protein kinases, J. Biol. Chem., 262 (1987) 5592-5595.
3. [3] Chao, C.C., Hu, S., Molitor, T.W., Shaskan, E.G. and Peterson, P.K., Activated microglia mediate neuronal cell injury via a nitric oxide mechanism, J. Immunol., 149 (1992) 2736-2741.
4. [4] Corbett, J.A., Hwang, P.M., Glatt, C.E., Lowenstein, C., Reed, R.R. and Snyder, S.H., A 1-hour pulse with IL-1β induces formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans; evidence for a tyrosine kinase signaling mechanism, FASEB J., 7 (1993) 369-374.
5. [5] Cohen, G.B., Ren, R. and Baltimore, D., Modular binding domains in signal transduction proteins, Cell, 80 (1995) 237-248.
6. [6] Dawson, V.L., Dawson, T.M., London, E.D., Bredt, D.S. and Snyder, S.H., Nitric oxide mediates glutamate neurotoxicity in primary cultures, Proc. Natl. Acad. Sci. USA, 88 (1991) 6368-6371.
7. [7] Dickson, D.M., Lee, S.C., Liu, W. and Brosnan, C.F., Microglia involvement in the aquired immunodeficiency syndrome (AIDS), Neuropathol. Appl. Neurobiol., 20 (1994) 211-213.
8. [8] Dong, Z., Qi, X., Xie, K. and Fidler, I.J., Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages, J. Immunol., 151 (1993) 2717-2724.
9. [9] Feinstein, D.L., Galea, E., Cermak, J., Chugh, P., Lyandvert, L. and Reis, D.J., Nitric oxide synthase expression in glial cells: suppression by tyrosine kinase inhibitors, J. Neurochem., 62 (1994) 811-814.
10. [10] Fuortes, M., Jin, W.W. and Nathan, C., Beta 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor, Cell Biol., 127 (1995) 1477-1483.
11. [11] Galea, E., Feinstein, D.L. and Reis, D.L., Induction of calcium-independent nitric oxide synthase activity in primary cultures of rat astrocytes, Proc. Natl. Acad. Sci. USA, 89 (1992) 10945-10949.
12. [12] Giulian D., Li, J., Li, X., George, J. and Rutecki, P.A., The impact of microglia-derived cytokines upon gliosis in the CNS, Dev. Neurosci, 16 (1994) 128-136.
13. [13] Hancock, M.B., Visualization of peptide-immunoreactive processes on serotonin-immunoreactive cells using two-color immunoperoxidase staining, J. Histochem. Cytochem., 32 (1984) 311-314.
14. [14] Hattori, S., Hattori, Y., Banba, N., Kasai, K. and Shimoda, S., Pentamethyl-hydroxychromane, vitamin E derivative, inhibits induction of nitric oxide synthase by bacterial lipopolysaccharide, Biochem. Mol. Biol. Int., 35 (1995) 177-183.
15. [15] Hunter, T., Signal transduction: cytokine connections, Nature, 366 (1993) 114-116.
16. [16] Koprowski, H., Zheng, Y.M., Heber-Katz, E., Fraser, N., Rorke, L., Fu, Z.F., Hanlon, C. and Dietzschold, B., In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases, Proc. Natl. Acad. Sci. USA, 90 (1993) 3024-3027.
17. [17] Lee, S.C., Dickson, D.W., Liu, W. and Brosnan, C.F., Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma, J. Neuroimmunol., 46 (1993) 19-24.
18. [18] Levitzki, A. and Gilon, C., Tyrphostins as molecular tools and potential antiproliferative drugs, Trends Pharmacol., 12 (1991) 171-173.
19. [19] Levitzki, A., Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction, FASEB J., 6 (1992) 3275-3282.
20. [20] Lorsbach, R.B. and Russell, S.W., A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages. Infect. Immun., 60 (1992) 2133-2135.
21. [21] Lowenstein, C.J., Alley, E.W., Raval, P., Snowman, A.M., Snyder, S.H., Russell, S.W. and Murphy, W.J., Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide, Proc. Natl. Acad. Sci. USA, 90 (1993) 9730-9734.
22. [22] Marczin, N., Parapetropoulos, A. and Catravas, J.D., Tyrosine kinase inhibitors suppress endotoxin- and IL-1β-induced NO synthesis in aortic smooth muscle cells, Am. J. Physiol., 265 (1993) 1014-1018.
23. 3H]phorbol-12, 13-dibutyrate binding by AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) in neonatal striatal cell cultures, Brain Res., 593 (1992) 307-310.
24. [24] Moncada, S., Palmer, R.M.J. and Higgs, E.A., Nitric oxide: physiology, pathology, and pharmacology, Pharmacol. Rev., 43 (1991) 109-142.
25. [25] Murphy, S., Simmons, M.L., Agullo, L., Garcia, A., Feinstein, D.L., Galea, E. and Reis, D.J., Synthesis of nitric oxide in CNS glial cells, Trends Neurosci., 16 (1993) 323-328.
26. [26] O'Dell, T.J., Kandell, E.R. and Grant, G.V., Long term potentiation in the hipocampus is blocked by tyrosine kinase inhibitors, Nature, 353 (1991) 558-560.
27. [27] Peterson, P.K., Hu, S., Anderson, W.R. and Chao, C.C., Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain, J. Infect. Dis., 170 (1994) 457-460.
28. [28] Sherman, M.P., Griscavage, J.M. and Ignarro, L.J., Nitric oxidemediate neuronal injury in multiple sclerosis, Med. Hypotheses, 39 (1992) 143-146.
29. [29] Simmons, M.L. and Murphy, S., Induction of nitric oxide synthase in glial cells. J. Neurochem., 59 (1992) 897-905.
30. [30] Stuehr, D.J. and Nathan, C.F., Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells, J. Exp. Med., 169 (1989) 1543-1555.
31. [31] Suzumura, A., Mezitis, S.G.E., Gonatas, N.K. and Silberberg, D.H., MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by γ-interferon, J. Neuroimmunol., 15 (1987) 263-278.
32. [32] Velazquez, L., Fellous, M., Stark, G.R. and Pellegrini, S., A protein tyrosine kinase in the interferon alpha/beta signaling pathway, Cell, 70 (1992) 313-322.
33. [33] Weinstein, S.L., Sanghera, J.S., Lemke, K., DeFranco, A.L. and Pelech, S.L., Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages, J. Biol. Chem., 267 (1992) 14955-14962.
34. [34] Xie, Q.W., Kashiwabara, Y. and Nathan, C., Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase, J. Biol. Chem., 269 (1994) 4705-4708.
35. [35] Youdim, M.B., Lavie, L. and Riederer, P., Oxygen free radicals and neurodegeneration in Parkinson's disease: a role for nitric oxide, Ann. NY Acad. Sci., 738 (1994) 64-68.