-
1
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ-40 ratio in vitro and in vivo
-
Borchelt D. R., Thinakaran G., Eckman C. B., et al. (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ-40 ratio in vitro and in vivo. Neuron 17, 1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
-
2
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β protein in both transfected cell and transgenic mice
-
Citron M., Westaway D., Xia W., et al. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β protein in both transfected cell and transgenic mice. Nat. Med. 3, 67-72.
-
(1997)
Nat. Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
-
3
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder E. H., Saunders A. M., Strittmatter W. J., et al. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 828-829.
-
(1993)
Science
, vol.261
, pp. 828-829
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
-
4
-
-
0032518695
-
Signal transduction by Wnt family of ligands
-
Dale T. C. (1998) Signal transduction by Wnt family of ligands. Biochem. J. 15, 209-223.
-
(1998)
Biochem. J.
, vol.15
, pp. 209-223
-
-
Dale, T.C.1
-
5
-
-
0037220599
-
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils
-
De Ferrari G. V., Chacon M. A., Barria M. I., et al. (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol. Psychiatry 8, 195-208.
-
(2003)
Mol. Psychiatry
, vol.8
, pp. 195-208
-
-
De Ferrari, G.V.1
Chacon, M.A.2
Barria, M.I.3
-
6
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch interacellular domain
-
De Strooper B., Annaert W., Cupers P., et al. (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch interacellular domain. Nature 398, 518-522.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
-
7
-
-
0037383322
-
GSK3: Tricks of the trade for a multitasking kinase
-
Doble B. W. and Woodgett J. R. (2003) GSK3: tricks of the trade for a multitasking kinase. J. Cell Sci. 116, 1175-1186.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 1175-1186
-
-
Doble, B.W.1
Woodgett, J.R.2
-
8
-
-
16044366039
-
Increased amyloid β-42(43) in brains of mice expressing mutant presenilin 1
-
Duff K., Eckman C., Zehr C., et al. (1996) Increased amyloid β-42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
-
9
-
-
0025063668
-
Transgenic mice expressing β-galactosidase in mature neuron under neuron-specific enolase promoter control
-
Forss S., Danielson P. E., Catsicas S., et al. (1990) Transgenic mice expressing β-galactosidase in mature neuron under neuron-specific enolase promoter control. Cell 5, 187-197.
-
(1990)
Cell
, vol.5
, pp. 187-197
-
-
Forss, S.1
Danielson, P.E.2
Catsicas, S.3
-
10
-
-
0038385505
-
Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: Application for detecting androgens and antiandrogens
-
Hwang D. Y., Cho J. S., Chae K. R., et al. (2003) Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens. Arch. Biochem. Biophys. 415, 137-145.
-
(2003)
Arch. Biochem. Biophys.
, vol.415
, pp. 137-145
-
-
Hwang, D.Y.1
Cho, J.S.2
Chae, K.R.3
-
11
-
-
0036275638
-
Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease
-
Hwang D. Y., Chae K. R., Kang T. S., et al. (2002) Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease. FASEB J. 16, 805-813.
-
(2002)
FASEB J.
, vol.16
, pp. 805-813
-
-
Hwang, D.Y.1
Chae, K.R.2
Kang, T.S.3
-
12
-
-
10744233782
-
Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw
-
Hwang D. Y., Cho J. S., Lee S. H., et al. (2004) Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw. Exp. Neurol. 186, 20-32.
-
(2004)
Exp. Neurol.
, vol.186
, pp. 20-32
-
-
Hwang, D.Y.1
Cho, J.S.2
Lee, S.H.3
-
13
-
-
0030771534
-
Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I)
-
Janicki S. and Monteiro M. J. (1997) Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I). J. Cell Biol. 139, 485-495.
-
(1997)
J. Cell Biol.
, vol.139
, pp. 485-495
-
-
Janicki, S.1
Monteiro, M.J.2
-
14
-
-
0019742305
-
Sexual dimorphism of SDS-peptide patterns from submaxillary gland of mice
-
Kim Y. K. and Ogita Z. (1981) Sexual dimorphism of SDS-peptide patterns from submaxillary gland of mice. J. Exp. Zool. 218, 447-453.
-
(1981)
J. Exp. Zool.
, vol.218
, pp. 447-453
-
-
Kim, Y.K.1
Ogita, Z.2
-
15
-
-
0030890399
-
Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells
-
Kim T. W., Pettingell W. H., Hallmark O. G., et al. (1997a) Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J. Biol. Chem. 272, 11,006-11,010.
-
(1997)
J. Biol. Chem.
, vol.272
-
-
Kim, T.W.1
Pettingell, W.H.2
Hallmark, O.G.3
-
16
-
-
0030868903
-
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
-
Kim T. W., Pettingell W. H., Jung Y. K., et al. (1997b) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376.
-
(1997)
Science
, vol.277
, pp. 373-376
-
-
Kim, T.W.1
Pettingell, W.H.2
Jung, Y.K.3
-
17
-
-
0029671451
-
Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains
-
Kuo Y. M., Emmerling M. R., Vigo-Pelfrey C., et al. (1996) Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J. Biol. Chem. 271, 4077-4081.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4077-4081
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Vigo-Pelfrey, C.3
-
18
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E., Wasco W., Poorkaj P., et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
-
19
-
-
23844435090
-
NSE-controlled carboxyl-terminus of APP gene overexpressing in transgenic mice induces altered expression in behavior, Aβ-42, and GSK3β binding proteins
-
Lim H. J., Cho J. S., Oh J. H., et al. (2005) NSE-controlled carboxyl-terminus of APP gene overexpressing in transgenic mice induces altered expression in behavior, Aβ-42, and GSK3β binding proteins. Cell Mol. Neurobiol. 25, 833-850.
-
(2005)
Cell Mol. Neurobiol.
, vol.25
, pp. 833-850
-
-
Lim, H.J.1
Cho, J.S.2
Oh, J.H.3
-
20
-
-
0030873546
-
Presenilins are processed by caspase-type proteases
-
Loetscher H., Deuschle U., Brockhaus M., et al. (1997) Presenilins are processed by caspase-type proteases. J. Biol. Chem. 272, 20,655-20,659.
-
(1997)
J. Biol. Chem.
, vol.272
-
-
Loetscher, H.1
Deuschle, U.2
Brockhaus, M.3
-
21
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue L. F., Kuo Y. M., Roher A. E., et al. (1999) Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155, 853-862.
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
-
22
-
-
0030298416
-
The vagaries of variegating transgenes
-
Martin D. I. and Whitelaw E. (1996) The vagaries of variegating transgenes. Bioassay 18, 919-923.
-
(1996)
Bioassay
, vol.18
, pp. 919-923
-
-
Martin, D.I.1
Whitelaw, E.2
-
23
-
-
0032590054
-
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
McLean C. A., Cherny R. A., Fraser F. W., et al. (1999) Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann. Neurol. 46, 860-866.
-
(1999)
Ann. Neurol.
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
-
24
-
-
0019957779
-
Place navigation impaired in rats with hippocampal lesions
-
Morris R. G. M., Garrud P., Rawlins J. N. P., et al. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683.
-
(1982)
Nature
, vol.297
, pp. 681-683
-
-
Morris, R.G.M.1
Garrud, P.2
Rawlins, J.N.P.3
-
25
-
-
0031866596
-
Direct association of presenilin-1 with beta-catenin
-
Murayama M., Tanake S., Palacino J., et al. (1998) Direct association of presenilin-1 with beta-catenin. FEBS Lett. 433, 73-77.
-
(1998)
FEBS Lett.
, vol.433
, pp. 73-77
-
-
Murayama, M.1
Tanake, S.2
Palacino, J.3
-
26
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Naslund J., Haroutunian V., Moshs R., et al. (2000) Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. J. Am. Med. Assoc. 283, 1571-1577.
-
(2000)
J. Am. Med. Assoc.
, vol.283
, pp. 1571-1577
-
-
Naslund, J.1
Haroutunian, V.2
Moshs, R.3
-
27
-
-
0032916351
-
WNT targets. Repression and activation
-
Nusse R. (1999) WNT targets. Repression and activation. Trends Genet. 15, 1-3.
-
(1999)
Trends Genet.
, vol.15
, pp. 1-3
-
-
Nusse, R.1
-
28
-
-
18544411933
-
Mutant presenilin 2 transgenic mouse: Effect on an age-dependent increase of amyloid beta-protein 42 in the brain
-
Oyama F., Sawamura N., Kobayashi K., et al. (1998) Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. J. Neurochem. 71, 313-322.
-
(1998)
J. Neurochem.
, vol.71
, pp. 313-322
-
-
Oyama, F.1
Sawamura, N.2
Kobayashi, K.3
-
29
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev E. I., Sherrington R., Rogaeva E. A., et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
-
30
-
-
0034623284
-
Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin
-
Sawamura N., Morishima-Kawashima M., Waki H., et al. (2000) Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J. Biol. Chem. 275, 27,901-27,908.
-
(2000)
J. Biol. Chem.
, vol.275
-
-
Sawamura, N.1
Morishima-Kawashima, M.2
Waki, H.3
-
31
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D., Eckman C., Jensen M., et al. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864-870.
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
32
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R., Rogaev E., Liang Y., et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.2
Liang, Y.3
-
33
-
-
0034705204
-
In search of gamma-secretase: Presenilin at the cutting edge
-
Selkoe D. J. and Wolfe M. S. (2000) In search of gamma-secretase: presenilin at the cutting edge. Proc. Natl. Acad. Sci. USA 97, 5690-5692.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5690-5692
-
-
Selkoe, D.J.1
Wolfe, M.S.2
-
35
-
-
0031695652
-
Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons
-
Takashima A., Honda T., Yasutake K., et al. (1998a) Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neurosci. Res. 31, 317-323.
-
(1998)
Neurosci. Res.
, vol.31
, pp. 317-323
-
-
Takashima, A.1
Honda, T.2
Yasutake, K.3
-
36
-
-
13144265717
-
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
-
Takashima A., Murayama M., Murayama O., et al. (1998b) Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc. Natl. Acad. Sci. USA 95, 9637-9641.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9637-9641
-
-
Takashima, A.1
Murayama, M.2
Murayama, O.3
-
37
-
-
0030446363
-
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
-
Tsien J. Z., Huerta P. T., and Tonegawa S. (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87, 1327-1338.
-
(1996)
Cell
, vol.87
, pp. 1327-1338
-
-
Tsien, J.Z.1
Huerta, P.T.2
Tonegawa, S.3
-
38
-
-
13244299288
-
Presenilin 2 familial Alzheimer's disease mutation in partial loss of function and dramatic changes in Abeta 42/40 ratios
-
Walker E. S., Martinez M., Brunkan A. L., et al. (2005) Presenilin 2 familial Alzheimer's disease mutation in partial loss of function and dramatic changes in Abeta 42/40 ratios. J. Neurochem. 92, 294-301.
-
(2005)
J. Neurochem.
, vol.92
, pp. 294-301
-
-
Walker, E.S.1
Martinez, M.2
Brunkan, A.L.3
-
39
-
-
0034523058
-
FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: Evidence for direct involvement of PS1 in the gamma-secretase cleavage complex
-
Xia W., Ostaszewski B. L., Kimberly W. T., et al. (2000) FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiol. Dis. 7, 673-681.
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 673-681
-
-
Xia, W.1
Ostaszewski, B.L.2
Kimberly, W.T.3
-
40
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
Yu G., Chen F., Levesque G., et al. (1998) The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J. Biol. Chem. 273, 16,470-16,475.
-
(1998)
J. Biol. Chem.
, vol.273
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
-
41
-
-
0032531793
-
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
-
Zhang Z., Hartmann H., Do V. M., et al. (1998) Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698-702.
-
(1998)
Nature
, vol.395
, pp. 698-702
-
-
Zhang, Z.1
Hartmann, H.2
Do, V.M.3
|