메뉴 건너뛰기




Volumn 8, Issue 3, 2006, Pages 415-431

Changes in presenilin 2-binding Wnt proteins, behavior, amyloid-Β 42, γ-secretase activity, and testosterone sensitivity in transgenic mice coexpressing tetracycline-controlled transactivator and human mutant presenilin 2

Author keywords

Alzheimer's disease; GSK; Presenilin 2; Tau; Tetracycline

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; DOXYCYCLINE; GAMMA SECRETASE; PRESENILIN 2; TESTOSTERONE; TRANSACTIVATOR PROTEIN; WNT PROTEIN;

EID: 33745254478     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:8:3:415     Document Type: Article
Times cited : (4)

References (41)
  • 1
    • 0030293676 scopus 로고    scopus 로고
    • Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ-40 ratio in vitro and in vivo
    • Borchelt D. R., Thinakaran G., Eckman C. B., et al. (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ-40 ratio in vitro and in vivo. Neuron 17, 1005-1013.
    • (1996) Neuron , vol.17 , pp. 1005-1013
    • Borchelt, D.R.1    Thinakaran, G.2    Eckman, C.B.3
  • 2
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β protein in both transfected cell and transgenic mice
    • Citron M., Westaway D., Xia W., et al. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β protein in both transfected cell and transgenic mice. Nat. Med. 3, 67-72.
    • (1997) Nat. Med. , vol.3 , pp. 67-72
    • Citron, M.1    Westaway, D.2    Xia, W.3
  • 3
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder E. H., Saunders A. M., Strittmatter W. J., et al. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 828-829.
    • (1993) Science , vol.261 , pp. 828-829
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 4
    • 0032518695 scopus 로고    scopus 로고
    • Signal transduction by Wnt family of ligands
    • Dale T. C. (1998) Signal transduction by Wnt family of ligands. Biochem. J. 15, 209-223.
    • (1998) Biochem. J. , vol.15 , pp. 209-223
    • Dale, T.C.1
  • 5
    • 0037220599 scopus 로고    scopus 로고
    • Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils
    • De Ferrari G. V., Chacon M. A., Barria M. I., et al. (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol. Psychiatry 8, 195-208.
    • (2003) Mol. Psychiatry , vol.8 , pp. 195-208
    • De Ferrari, G.V.1    Chacon, M.A.2    Barria, M.I.3
  • 6
    • 0033535504 scopus 로고    scopus 로고
    • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch interacellular domain
    • De Strooper B., Annaert W., Cupers P., et al. (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch interacellular domain. Nature 398, 518-522.
    • (1999) Nature , vol.398 , pp. 518-522
    • De Strooper, B.1    Annaert, W.2    Cupers, P.3
  • 7
    • 0037383322 scopus 로고    scopus 로고
    • GSK3: Tricks of the trade for a multitasking kinase
    • Doble B. W. and Woodgett J. R. (2003) GSK3: tricks of the trade for a multitasking kinase. J. Cell Sci. 116, 1175-1186.
    • (2003) J. Cell Sci. , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 8
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid β-42(43) in brains of mice expressing mutant presenilin 1
    • Duff K., Eckman C., Zehr C., et al. (1996) Increased amyloid β-42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713.
    • (1996) Nature , vol.383 , pp. 710-713
    • Duff, K.1    Eckman, C.2    Zehr, C.3
  • 9
    • 0025063668 scopus 로고
    • Transgenic mice expressing β-galactosidase in mature neuron under neuron-specific enolase promoter control
    • Forss S., Danielson P. E., Catsicas S., et al. (1990) Transgenic mice expressing β-galactosidase in mature neuron under neuron-specific enolase promoter control. Cell 5, 187-197.
    • (1990) Cell , vol.5 , pp. 187-197
    • Forss, S.1    Danielson, P.E.2    Catsicas, S.3
  • 10
    • 0038385505 scopus 로고    scopus 로고
    • Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: Application for detecting androgens and antiandrogens
    • Hwang D. Y., Cho J. S., Chae K. R., et al. (2003) Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens. Arch. Biochem. Biophys. 415, 137-145.
    • (2003) Arch. Biochem. Biophys. , vol.415 , pp. 137-145
    • Hwang, D.Y.1    Cho, J.S.2    Chae, K.R.3
  • 11
    • 0036275638 scopus 로고    scopus 로고
    • Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease
    • Hwang D. Y., Chae K. R., Kang T. S., et al. (2002) Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease. FASEB J. 16, 805-813.
    • (2002) FASEB J. , vol.16 , pp. 805-813
    • Hwang, D.Y.1    Chae, K.R.2    Kang, T.S.3
  • 12
    • 10744233782 scopus 로고    scopus 로고
    • Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw
    • Hwang D. Y., Cho J. S., Lee S. H., et al. (2004) Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw. Exp. Neurol. 186, 20-32.
    • (2004) Exp. Neurol. , vol.186 , pp. 20-32
    • Hwang, D.Y.1    Cho, J.S.2    Lee, S.H.3
  • 13
    • 0030771534 scopus 로고    scopus 로고
    • Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I)
    • Janicki S. and Monteiro M. J. (1997) Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I). J. Cell Biol. 139, 485-495.
    • (1997) J. Cell Biol. , vol.139 , pp. 485-495
    • Janicki, S.1    Monteiro, M.J.2
  • 14
    • 0019742305 scopus 로고
    • Sexual dimorphism of SDS-peptide patterns from submaxillary gland of mice
    • Kim Y. K. and Ogita Z. (1981) Sexual dimorphism of SDS-peptide patterns from submaxillary gland of mice. J. Exp. Zool. 218, 447-453.
    • (1981) J. Exp. Zool. , vol.218 , pp. 447-453
    • Kim, Y.K.1    Ogita, Z.2
  • 15
    • 0030890399 scopus 로고    scopus 로고
    • Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells
    • Kim T. W., Pettingell W. H., Hallmark O. G., et al. (1997a) Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J. Biol. Chem. 272, 11,006-11,010.
    • (1997) J. Biol. Chem. , vol.272
    • Kim, T.W.1    Pettingell, W.H.2    Hallmark, O.G.3
  • 16
    • 0030868903 scopus 로고    scopus 로고
    • Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
    • Kim T. W., Pettingell W. H., Jung Y. K., et al. (1997b) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376.
    • (1997) Science , vol.277 , pp. 373-376
    • Kim, T.W.1    Pettingell, W.H.2    Jung, Y.K.3
  • 17
    • 0029671451 scopus 로고    scopus 로고
    • Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains
    • Kuo Y. M., Emmerling M. R., Vigo-Pelfrey C., et al. (1996) Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. J. Biol. Chem. 271, 4077-4081.
    • (1996) J. Biol. Chem. , vol.271 , pp. 4077-4081
    • Kuo, Y.M.1    Emmerling, M.R.2    Vigo-Pelfrey, C.3
  • 18
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E., Wasco W., Poorkaj P., et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 19
    • 23844435090 scopus 로고    scopus 로고
    • NSE-controlled carboxyl-terminus of APP gene overexpressing in transgenic mice induces altered expression in behavior, Aβ-42, and GSK3β binding proteins
    • Lim H. J., Cho J. S., Oh J. H., et al. (2005) NSE-controlled carboxyl-terminus of APP gene overexpressing in transgenic mice induces altered expression in behavior, Aβ-42, and GSK3β binding proteins. Cell Mol. Neurobiol. 25, 833-850.
    • (2005) Cell Mol. Neurobiol. , vol.25 , pp. 833-850
    • Lim, H.J.1    Cho, J.S.2    Oh, J.H.3
  • 20
    • 0030873546 scopus 로고    scopus 로고
    • Presenilins are processed by caspase-type proteases
    • Loetscher H., Deuschle U., Brockhaus M., et al. (1997) Presenilins are processed by caspase-type proteases. J. Biol. Chem. 272, 20,655-20,659.
    • (1997) J. Biol. Chem. , vol.272
    • Loetscher, H.1    Deuschle, U.2    Brockhaus, M.3
  • 21
    • 0032888131 scopus 로고    scopus 로고
    • Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
    • Lue L. F., Kuo Y. M., Roher A. E., et al. (1999) Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155, 853-862.
    • (1999) Am. J. Pathol. , vol.155 , pp. 853-862
    • Lue, L.F.1    Kuo, Y.M.2    Roher, A.E.3
  • 22
    • 0030298416 scopus 로고    scopus 로고
    • The vagaries of variegating transgenes
    • Martin D. I. and Whitelaw E. (1996) The vagaries of variegating transgenes. Bioassay 18, 919-923.
    • (1996) Bioassay , vol.18 , pp. 919-923
    • Martin, D.I.1    Whitelaw, E.2
  • 23
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • McLean C. A., Cherny R. A., Fraser F. W., et al. (1999) Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann. Neurol. 46, 860-866.
    • (1999) Ann. Neurol. , vol.46 , pp. 860-866
    • McLean, C.A.1    Cherny, R.A.2    Fraser, F.W.3
  • 24
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris R. G. M., Garrud P., Rawlins J. N. P., et al. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683.
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.M.1    Garrud, P.2    Rawlins, J.N.P.3
  • 25
    • 0031866596 scopus 로고    scopus 로고
    • Direct association of presenilin-1 with beta-catenin
    • Murayama M., Tanake S., Palacino J., et al. (1998) Direct association of presenilin-1 with beta-catenin. FEBS Lett. 433, 73-77.
    • (1998) FEBS Lett. , vol.433 , pp. 73-77
    • Murayama, M.1    Tanake, S.2    Palacino, J.3
  • 26
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Naslund J., Haroutunian V., Moshs R., et al. (2000) Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. J. Am. Med. Assoc. 283, 1571-1577.
    • (2000) J. Am. Med. Assoc. , vol.283 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Moshs, R.3
  • 27
    • 0032916351 scopus 로고    scopus 로고
    • WNT targets. Repression and activation
    • Nusse R. (1999) WNT targets. Repression and activation. Trends Genet. 15, 1-3.
    • (1999) Trends Genet. , vol.15 , pp. 1-3
    • Nusse, R.1
  • 28
    • 18544411933 scopus 로고    scopus 로고
    • Mutant presenilin 2 transgenic mouse: Effect on an age-dependent increase of amyloid beta-protein 42 in the brain
    • Oyama F., Sawamura N., Kobayashi K., et al. (1998) Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. J. Neurochem. 71, 313-322.
    • (1998) J. Neurochem. , vol.71 , pp. 313-322
    • Oyama, F.1    Sawamura, N.2    Kobayashi, K.3
  • 29
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev E. I., Sherrington R., Rogaeva E. A., et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3
  • 30
    • 0034623284 scopus 로고    scopus 로고
    • Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin
    • Sawamura N., Morishima-Kawashima M., Waki H., et al. (2000) Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J. Biol. Chem. 275, 27,901-27,908.
    • (2000) J. Biol. Chem. , vol.275
    • Sawamura, N.1    Morishima-Kawashima, M.2    Waki, H.3
  • 31
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D., Eckman C., Jensen M., et al. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2, 864-870.
    • (1996) Nat. Med. , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3
  • 32
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R., Rogaev E., Liang Y., et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.2    Liang, Y.3
  • 33
    • 0034705204 scopus 로고    scopus 로고
    • In search of gamma-secretase: Presenilin at the cutting edge
    • Selkoe D. J. and Wolfe M. S. (2000) In search of gamma-secretase: presenilin at the cutting edge. Proc. Natl. Acad. Sci. USA 97, 5690-5692.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5690-5692
    • Selkoe, D.J.1    Wolfe, M.S.2
  • 35
    • 0031695652 scopus 로고    scopus 로고
    • Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons
    • Takashima A., Honda T., Yasutake K., et al. (1998a) Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neurosci. Res. 31, 317-323.
    • (1998) Neurosci. Res. , vol.31 , pp. 317-323
    • Takashima, A.1    Honda, T.2    Yasutake, K.3
  • 36
    • 13144265717 scopus 로고    scopus 로고
    • Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
    • Takashima A., Murayama M., Murayama O., et al. (1998b) Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc. Natl. Acad. Sci. USA 95, 9637-9641.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9637-9641
    • Takashima, A.1    Murayama, M.2    Murayama, O.3
  • 37
    • 0030446363 scopus 로고    scopus 로고
    • The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    • Tsien J. Z., Huerta P. T., and Tonegawa S. (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87, 1327-1338.
    • (1996) Cell , vol.87 , pp. 1327-1338
    • Tsien, J.Z.1    Huerta, P.T.2    Tonegawa, S.3
  • 38
    • 13244299288 scopus 로고    scopus 로고
    • Presenilin 2 familial Alzheimer's disease mutation in partial loss of function and dramatic changes in Abeta 42/40 ratios
    • Walker E. S., Martinez M., Brunkan A. L., et al. (2005) Presenilin 2 familial Alzheimer's disease mutation in partial loss of function and dramatic changes in Abeta 42/40 ratios. J. Neurochem. 92, 294-301.
    • (2005) J. Neurochem. , vol.92 , pp. 294-301
    • Walker, E.S.1    Martinez, M.2    Brunkan, A.L.3
  • 39
    • 0034523058 scopus 로고    scopus 로고
    • FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: Evidence for direct involvement of PS1 in the gamma-secretase cleavage complex
    • Xia W., Ostaszewski B. L., Kimberly W. T., et al. (2000) FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiol. Dis. 7, 673-681.
    • (2000) Neurobiol. Dis. , vol.7 , pp. 673-681
    • Xia, W.1    Ostaszewski, B.L.2    Kimberly, W.T.3
  • 40
    • 0032568821 scopus 로고    scopus 로고
    • The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
    • Yu G., Chen F., Levesque G., et al. (1998) The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J. Biol. Chem. 273, 16,470-16,475.
    • (1998) J. Biol. Chem. , vol.273
    • Yu, G.1    Chen, F.2    Levesque, G.3
  • 41
    • 0032531793 scopus 로고    scopus 로고
    • Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
    • Zhang Z., Hartmann H., Do V. M., et al. (1998) Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698-702.
    • (1998) Nature , vol.395 , pp. 698-702
    • Zhang, Z.1    Hartmann, H.2    Do, V.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.