Flavonoids of Honey and Propolis: Characterization and Effects on Hepatic Drug-Metabolizing Enzymes and Benzo[a]pyrene-DNA Binding in Rats

Journal of Agricultural and Food Chemistry

Volumn 44, Issue 8, 1996, Pages 2297-2301

  Siess, Marie Hélène ^a   Le Bon, Anne Marie ^a   Canivenc Lavier, Marie Chantal ^a   Amiot, Marie Josèphe ^a   Sabatier, Sylvie ^a   Aubert, Serge Y ^a   Suschetet, Marc ^a  

^a CEMAGREF   (France)

Author keywords

Benzo a pyrene DNA binding; Drug metabolizing enzymes; Flavonoids; Propolis; Sunflower honey

Indexed keywords

HELIANTHUS; PROPOLIS;

EID: 0001129498     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf9504733     Document Type: Article

References (24)

1. Berahia, T.; Cerrati, C.; Sabatier, S; Amiot, M. J. Gas chromatography-mass spectrometry analysis of flavonoids in honey. Sci. Aliment, 1993, 13, 15-24.
2. Chadha, A.; Madyastha, K. M. Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes. Xenobiotica 1984, 14, 365-374.
3. Deschner, E. E.; Ruperto, J.; Wong, G.; Newmark, H. L. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 1991, 7, 1193-1196.
4. Greenaway, W.; Scaysbrook, T.; Whatley, F. R. The composition and plant origins of propolis: a report of work at Oxford. Bee World 1990, 71, 107-118.
5. Griffiths L. A. Mammalian metabolism of flavonoids. In The flavonoids: Advances in research; Harborne, J. B.; Mabry, T. J., Eds.; Chapman and Hall: London, New York, 1982; pp 681-718.
6. Habig, W. H.; Pabst, M. J.; Jakoby, W. B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249, 7130-7139.
7. Hertog, M. G. L.; Hollman, P. C. H.; Katan, B. B.; Kromhout, D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr. Cancer 1993, 20, 21-29.
8. Le Bon, A.-M.; Siess, M.-H.; Suschetet, M. Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. Chem. Biol. Interact. 1992a, 83, 65-71.
9. Le Bon, A. M.; Ziegler, L.; Amiot, M. J.; Suschetet, M. Inhibition in vitro de la liaison du benzopyrène à l'ADN en présence de flavonoïdes du miel et de la propolis. Bull. Liaison Groupe Polyphénols 1992b, 16, 279-283.
10. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193, 265-275.
11. Marcucci, M. C. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie 1995, 26, 83-99.
12. McLean, A. E. M.; Driver, H. E. Combined effects of low doses of DDT and phenobarbital on cytochrome P450 and amidopyrine demethylation. Biochem. Pharmacol. 1977, 26, 1299-1302.
13. Mulder, G. J.; Van Doom, A. B. D. A rapid NAD+-linked assay for microsomal uridine diphosphate glucuronyltransferase of rat liver and some observations on substrate specificity of the enzyme. Biochem. J. 1975, 151, 131-140.
14. Sabatier, S.; Amiot, M. J.; Tacchini, M.; Aubert, S. Identification of flavonoids in sunflower honey. J. Food Sci. 1992, 57, 773-777.
15. Salaün, J. P.; Benveniste, I.; Reichhart, D.; Durst, F. A microsomal (cytochrome P-450 (-linked lauric-acid-monooxygenase from aged Jerusalem-artichoke-tuber tissues. Eur. J. Biochem. 1978, 90, 155-159.
16. Siess, M. H.; Guillermic, M.; Le Bon, A. M.; Suschetet, M. Induction of monooxygenase and transferase activities in rat by dietary administration of flavonoids. Xenobiotica 1989, 19, 1379-1386.
17. Siess, M. H.; Le Bon, A. M.; Suschetet, M. Dietary modification of drug-metabolizing enzyme activities: Dose-response effect of flavonoids. J. Toxicol. Environ. Health 1992, 35, 141-152.
18. Smith, T. J.; Yang, C. S. Effects of food phytochemicals on xenobiotic metabolim and tumorigenesis. In Food Phytochemicals for Cancer Prevention I; Huang, M.-T., Osawa, T., Ho, C-T., Rosen, R. T., Eds.; ACS Symposium Series 547; American Chemical Society: Washington, DC, 1994; pp 17-48.
19. Suschetet, M.; Frayssinet, C.; Le Bon, A. M.; Siess M. H. Inhibition de la toxicité du benzo(a)pyrène par des flavonoïdes. Bull. Liaison Groupe Polyphenols 1990, 15, 149-152.
20. Verma, A. K.; Johnson, J. A.; Gould, M. N.; Tanner M. A. Inhibition of 7,12-dimethylbenz(a)anthracene- and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Res. 1988, 48, 5754-5758.
21. Vernet, A.; Siess, M. H. Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes. Food Chem. Toxicol. 1986, 24, 857-861.
22. Watkins, P. B.; Wrighton, S. A.; Maurel, P.; Schuetz, E. G.; Mendez-Picon, G.; Parker, G. A; Guzelian, P. S. Identification of an inducible form of cytochrome P-450 in human liver. Proc. Natl. Acad. Sci. U.S.A. 1985, 82, 6310-6314.
23. Wattenberg, L. W.; Leong, J. L. Inhibition of the carcinogenic action of benzo[a]pyrene by flavones. Cancer Res. 1970, 30, 1922-1925.
24. Zheng, G-q.; Kenney, P. M; Lam, L. K. T. Potential anticarcinogenic natural products isolated from lemongrass oil and galanga root oil. J. Agric. Food Chem. 1993, 41, 153-156.