메뉴 건너뛰기




Volumn 6, Issue 6, 2003, Pages 355-361

Mechanism of action of 2-methoxyestradiol: New developments

Author keywords

2 Methoxyestradiol; Angiogenesis; Anti angiogenesis; Antitumor; HIF 1

Indexed keywords

2 METHOXYESTRADIOL; ANGIOGENESIS INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

EID: 0842269204     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drup.2003.10.001     Document Type: Article
Times cited : (155)

References (40)
  • 2
    • 0037434841 scopus 로고    scopus 로고
    • Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis
    • Basu, A., Haldar, S., 2003. Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. FEBS Lett. 538, 41-47.
    • (2003) FEBS Lett. , vol.538 , pp. 41-47
    • Basu, A.1    Haldar, S.2
  • 3
    • 0038713666 scopus 로고    scopus 로고
    • Resistance to cytotoxic and anti-angiogenic anticancer agents: Similarities and differences
    • Broxterman, H.J., Lankelma, J., Hoekman, K., 2003. Resistance to cytotoxic and anti-angiogenic anticancer agents: similarities and differences. Drug Resist. Updat. 6, 111-127.
    • (2003) Drug Resist. Updat. , vol.6 , pp. 111-127
    • Broxterman, H.J.1    Lankelma, J.2    Hoekman, K.3
  • 4
    • 0034820420 scopus 로고    scopus 로고
    • 2-Methoxy-methylestradiol: A new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics
    • Brueggemeier, R.W., Bhat, A.S., Lovely, C.J., et al., 2001. 2-Methoxy-methylestradiol: a new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics. J. Steroid Biochem. Mol. Biol. 78, 145-156.
    • (2001) J. Steroid Biochem. Mol. Biol. , vol.78 , pp. 145-156
    • Brueggemeier, R.W.1    Bhat, A.S.2    Lovely, C.J.3
  • 5
    • 0037032474 scopus 로고    scopus 로고
    • Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells
    • Bu, S., Blaukat, A., Fu, X., Heldin, N.E., Landstrom, M., 2002. Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. FEBS Lett. 531, 141-151.
    • (2002) FEBS Lett. , vol.531 , pp. 141-151
    • Bu, S.1    Blaukat, A.2    Fu, X.3    Heldin, N.E.4    Landstrom, M.5
  • 6
    • 0037058639 scopus 로고    scopus 로고
    • 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells
    • Carothers, A.M., Hughes, S.A., Ortega, D., Bertagnolli, M.M., 2002. 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells. Cancer Lett. 187, 77-86.
    • (2002) Cancer Lett. , vol.187 , pp. 77-86
    • Carothers, A.M.1    Hughes, S.A.2    Ortega, D.3    Bertagnolli, M.M.4
  • 8
    • 0029008622 scopus 로고
    • Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site
    • Cushman, M., He, H.M., Katzenellenbogen, J.A., Lin, C.M., Hamel, E., 1995. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. J. Med. Chem. 38, 2041-2049.
    • (1995) J. Med. Chem. , vol.38 , pp. 2041-2049
    • Cushman, M.1    He, H.M.2    Katzenellenbogen, J.A.3    Lin, C.M.4    Hamel, E.5
  • 9
    • 0028331925 scopus 로고
    • 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site
    • D'Amato, R.J., Lin, C.M., Flynn, E., Folkman, J., Hamel, E., 1994. 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc. Natl. Acad. Sci. U.S.A. 91, 3964-3968.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 3964-3968
    • D'Amato, R.J.1    Lin, C.M.2    Flynn, E.3    Folkman, J.4    Hamel, E.5
  • 10
    • 0038407728 scopus 로고    scopus 로고
    • Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1
    • Dawling, S., Roodi, N., Parl, F.F., 2003. Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1. Cancer Res. 63, 3127-3132.
    • (2003) Cancer Res. , vol.63 , pp. 3127-3132
    • Dawling, S.1    Roodi, N.2    Parl, F.F.3
  • 11
    • 0038531029 scopus 로고    scopus 로고
    • 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production
    • Djavaheri-Mergny, M., Wietzerbin, J., Besancon, F., 2003. 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production. Oncogene 22, 2558-2567.
    • (2003) Oncogene , vol.22 , pp. 2558-2567
    • Djavaheri-Mergny, M.1    Wietzerbin, J.2    Besancon, F.3
  • 12
    • 0028220858 scopus 로고
    • The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth
    • Fotsis, T., Zhang, Y., Pepper, M.S., Adlercreutz, H., Montesano, R., Nawroth, P.P., Schweigerer, L., 1994. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature 368, 237-239.
    • (1994) Nature , vol.368 , pp. 237-239
    • Fotsis, T.1    Zhang, Y.2    Pepper, M.S.3    Adlercreutz, H.4    Montesano, R.5    Nawroth, P.P.6    Schweigerer, L.7
  • 13
    • 0037302849 scopus 로고    scopus 로고
    • Apoptosis pathways: Turned on their heads?
    • Fulda, S., Debatin, K.M., 2003. Apoptosis pathways: turned on their heads? Drug Resist. Updat. 6, 1-3.
    • (2003) Drug Resist. Updat. , vol.6 , pp. 1-3
    • Fulda, S.1    Debatin, K.M.2
  • 14
    • 0013449549 scopus 로고    scopus 로고
    • Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyoestradiol: Therapeutic implications?
    • Ghosh, R., Ott, A.M., Seetharam, D., Slaga, T.J., Kumar, A.P., 2003. Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyoestradiol: therapeutic implications? Melanoma Res. 13, 119-127.
    • (2003) Melanoma Res. , vol.13 , pp. 119-127
    • Ghosh, R.1    Ott, A.M.2    Seetharam, D.3    Slaga, T.J.4    Kumar, A.P.5
  • 15
    • 0345772125 scopus 로고    scopus 로고
    • Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor
    • Golab, J., Nowis, D., Skrzycki, M., et al., 2003. Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. J. Biol. Chem. 278, 407-414.
    • (2003) J. Biol. Chem. , vol.278 , pp. 407-414
    • Golab, J.1    Nowis, D.2    Skrzycki, M.3
  • 16
    • 0033790184 scopus 로고    scopus 로고
    • A super way to kill cancer cells?
    • Halliwell, B., 2000. A super way to kill cancer cells? Nat. Med. 6, 1105-1106.
    • (2000) Nat. Med. , vol.6 , pp. 1105-1106
    • Halliwell, B.1
  • 17
    • 0034699513 scopus 로고    scopus 로고
    • Superoxide dismutase as a target for the selective killing of cancer cells
    • Huang, P., Feng, L., Oldham, E.A., Keating, M.J., Plunkett, W., 2000. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407, 390-395.
    • (2000) Nature , vol.407 , pp. 390-395
    • Huang, P.1    Feng, L.2    Oldham, E.A.3    Keating, M.J.4    Plunkett, W.5
  • 19
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel, R., Folkman, J., 2002. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727-739.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 20
    • 0035736492 scopus 로고    scopus 로고
    • The role of caspase-8 in resistance to cancer chemotherapy
    • Kim, P.K.M., Mahidhara, R., Seol, D.W., 2001. The role of caspase-8 in resistance to cancer chemotherapy. Drug Resist. Updat. 4, 293-296.
    • (2001) Drug Resist. Updat. , vol.4 , pp. 293-296
    • Kim, P.K.M.1    Mahidhara, R.2    Seol, D.W.3
  • 21
    • 0037330674 scopus 로고    scopus 로고
    • 2-Methoxyestradiol interferes with NF kappa B transcriptional activity in primitive neuroectodermal brain tumors: Implications for management
    • Kumar, A.P., Garcia, G.E., Orsborn, J., Levin, V.A., Slaga, T.J., 2003. 2-Methoxyestradiol interferes with NF kappa B transcriptional activity in primitive neuroectodermal brain tumors: implications for management. Carcinogenesis 24, 209-216.
    • (2003) Carcinogenesis , vol.24 , pp. 209-216
    • Kumar, A.P.1    Garcia, G.E.2    Orsborn, J.3    Levin, V.A.4    Slaga, T.J.5
  • 23
    • 0036645421 scopus 로고    scopus 로고
    • 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta
    • LaVallee, T.M., Zhan, X.H., Herbstritt, C.J., Kough, E.C., Green, S.J., Pribluda, V.S., 2002. 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta. Cancer Res. 62, 3691-3697.
    • (2002) Cancer Res. , vol.62 , pp. 3691-3697
    • LaVallee, T.M.1    Zhan, X.H.2    Herbstritt, C.J.3    Kough, E.C.4    Green, S.J.5    Pribluda, V.S.6
  • 24
    • 0037439693 scopus 로고    scopus 로고
    • 2-Methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway
    • LaVallee, T.M., Zhan, X.H., Johnson, M.S., et al., 2003. 2-Methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 63, 468-475.
    • (2003) Cancer Res. , vol.63 , pp. 468-475
    • LaVallee, T.M.1    Zhan, X.H.2    Johnson, M.S.3
  • 26
    • 10744231706 scopus 로고    scopus 로고
    • 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
    • Mabjeesh, N.J., Escuin, D., LaVallee, T.M., et al., 2003. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 3, 363-375.
    • (2003) Cancer Cell , vol.3 , pp. 363-375
    • Mabjeesh, N.J.1    Escuin, D.2    LaVallee, T.M.3
  • 27
    • 0035865363 scopus 로고    scopus 로고
    • Redefining the target: Chemotherapeutics as antiangiogenics
    • Miller, K.D., Sweeney, J., Sledge, Jr., G.W., 2001. Redefining the target: chemotherapeutics as antiangiogenics. J. Clin. Oncol. 19, 1195-1206.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 1195-1206
    • Miller, K.D.1    Sweeney, J.2    Sledge Jr., G.W.3
  • 29
    • 0037071883 scopus 로고    scopus 로고
    • 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells
    • Qanungo, S., Basu, A., Das, M., Haldar, S., 2002. 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells. Oncogene 21, 4149-4157.
    • (2002) Oncogene , vol.21 , pp. 4149-4157
    • Qanungo, S.1    Basu, A.2    Das, M.3    Haldar, S.4
  • 30
    • 0037374464 scopus 로고    scopus 로고
    • Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma
    • Ryschich, E., Werner, J., Gebhard, M.M., Klar, E., Schmidt, J., 2003. Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma. Pancreas 26, 166-172.
    • (2003) Pancreas , vol.26 , pp. 166-172
    • Ryschich, E.1    Werner, J.2    Gebhard, M.M.3    Klar, E.4    Schmidt, J.5
  • 31
    • 0037902947 scopus 로고    scopus 로고
    • 2-Methoxyestradiol alters cell motility, migration, and adhesion
    • Sattler, M., Quinnan, L.R., Pride, Y.B., et al., 2003. 2-Methoxyestradiol alters cell motility, migration, and adhesion. Blood 102, 289-296.
    • (2003) Blood , vol.102 , pp. 289-296
    • Sattler, M.1    Quinnan, L.R.2    Pride, Y.B.3
  • 32
    • 0024373582 scopus 로고
    • The cytotoxic effects of estradiol-17 beta, catecholestradiols and methoxyestradiols on dividing MCF-7 and HeLa cells
    • Seegers, J.C., Aveling, M.L., Van Aswegen, C.H., Cross, M., Koch, F., Joubert, W.S., 1989. The cytotoxic effects of estradiol-17 beta, catecholestradiols and methoxyestradiols on dividing MCF-7 and HeLa cells. J. Steroid Biochem. 32, 797-809.
    • (1989) J. Steroid Biochem. , vol.32 , pp. 797-809
    • Seegers, J.C.1    Aveling, M.L.2    Van Aswegen, C.H.3    Cross, M.4    Koch, F.5    Joubert, W.S.6
  • 33
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G.L., 2003. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721-732.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 34
    • 0038011249 scopus 로고    scopus 로고
    • Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis
    • Shimada, K., Nakamura, M., Ishida, E., Kishi, M., Konishi, N., 2003. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24, 1067-1075.
    • (2003) Carcinogenesis , vol.24 , pp. 1067-1075
    • Shimada, K.1    Nakamura, M.2    Ishida, E.3    Kishi, M.4    Konishi, N.5
  • 35
    • 0037370558 scopus 로고    scopus 로고
    • Dose-response effects of 2-methoxyestradiol on estrogen target tissues in the ovariectomized rat
    • Sibonga, J.D., Lotinun, S., Evans, G.L., Pribluda, V.S., Green, S.J., Turner, R.T., 2003. Dose-response effects of 2-methoxyestradiol on estrogen target tissues in the ovariectomized rat. Endocrinology 144, 785-792.
    • (2003) Endocrinology , vol.144 , pp. 785-792
    • Sibonga, J.D.1    Lotinun, S.2    Evans, G.L.3    Pribluda, V.S.4    Green, S.J.5    Turner, R.T.6
  • 36
    • 0036379215 scopus 로고    scopus 로고
    • Evidence that 2-methoxyestradiol suppresses proliferation and accelerates apoptosis in normal rat growth plate chondrocytes
    • Sibonga, J.D., Sommer, U., Turner, R.T., 2002. Evidence that 2-methoxyestradiol suppresses proliferation and accelerates apoptosis in normal rat growth plate chondrocytes. J. Cancer Res. Clin. Oncol. 128, 477-483.
    • (2002) J. Cancer Res. Clin. Oncol. , vol.128 , pp. 477-483
    • Sibonga, J.D.1    Sommer, U.2    Turner, R.T.3
  • 38
    • 0038037108 scopus 로고    scopus 로고
    • Role of Jun and Jun kinase in resistance of cancer cells to therapy
    • Vasilevskaya, I., O'Dwyer, P.J., 2003. Role of Jun and Jun kinase in resistance of cancer cells to therapy. Drug Resist. Updat. 6, 147-156.
    • (2003) Drug Resist. Updat. , vol.6 , pp. 147-156
    • Vasilevskaya, I.1    O'Dwyer, P.J.2
  • 39
    • 0030949341 scopus 로고    scopus 로고
    • 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: Possible role for stress-activated protein kinase signaling pathway and Fas expression
    • Yue, T.L., Wang, X., Louden, C.S., Gupta, S., Pillarisetti, K., Gu, J.L., Hart, T.K., Lysko, P.G., Feuerstein, G.Z., 1997. 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. Mol. Pharmacol. 51, 951-962.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 951-962
    • Yue, T.L.1    Wang, X.2    Louden, C.S.3    Gupta, S.4    Pillarisetti, K.5    Gu, J.L.6    Hart, T.K.7    Lysko, P.G.8    Feuerstein, G.Z.9
  • 40
    • 0037926836 scopus 로고    scopus 로고
    • Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents
    • Zhou, Y., Hileman, E.O., Plunkett, W., Keating, M.J., Huang, P., 2003. Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. Blood 101, 4098-4104.
    • (2003) Blood , vol.101 , pp. 4098-4104
    • Zhou, Y.1    Hileman, E.O.2    Plunkett, W.3    Keating, M.J.4    Huang, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.