Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells

Cancer

Volumn 89, Issue 7, 2000, Pages 1440-1447

  Schnelldorfer, Thomas ^a   Gansauge, Susanne ^a   Gansauge, Frank ^a   Schlosser, Sophia ^a   Beger, Hans G ^a   Nussler, Andreas K ^a,b  

^a UNIVERSITY OF ULM   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

5 FU; AsPC 1; BSO; Cell growth; Chemotherapy; Glutathione; Melphalan; Pancreatic carcinoma

Indexed keywords

BUTHIONINE SULFOXIMINE; FLUOROURACIL; GLUTATHIONE PEROXIDASE; MELPHALAN; TRANSFORMING GROWTH FACTOR ALPHA;

APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CYTOSTASIS; DNA REPAIR; ENZYME INHIBITION; ENZYME SUBSTRATE; FLOW CYTOMETRY; GENE DELETION; GROWTH INHIBITION; HUMAN; HUMAN TISSUE; NUCLEOTIDE METABOLISM; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR RESISTANCE;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; CELL DIVISION; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; GLUTATHIONE; HUMAN; MALE; MELPHALAN; MIDDLE AGE; PANCREATIC NEOPLASMS;

EID: 0034306869     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20001001)89:7<1440::AID-CNCR5>3.0.CO;2-0     Document Type: Article

References (45)

1. Glutathione, ascorbate, and cellular protection
2. Glutathione: An overview of biosynthesis and modulation
3. Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy
4. The ATM gene and protein: Possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress
5. Mammalian G1 and G2 phase checkppints
6. Oxidants and antioxidants in proliferative senescence
7. Nitric oxide-induced apoptosis in human pancreatic carcinoma cell lines is associated with a G1-arrest and an increase of the cyclin-dependent kinase inhibitor p21
8. Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis
9. Clinical studies of reversal of drug resistance based on glutathione
10. Clinical trials of agents that reverse multidrug resistance: A literature review
11. Glutathione levels and variability in breast tumors and normal tissue
12. Sensitive enzymatic cycling assay for glutathione: Measurements of glutathione content and its modulation by buthionine sulfoximine in vivo and in vitro in human colon cancer
13. Assessment of P-glycoprotein, glutathione-based detoxifying enzymes and O6-alkylguanine-DNA alkyltransferase as potential indicators of constitutive drug resistance in human colorectal tumors
14. Parallel assessment of glutathione-based detoxifying enzymes, O6-alkylguanine-DNA alkyltransferase and P-glycoprotein as indicators of drug resistance in tumor and normal lung of patients with lung cancer
15. Cellular glutathione and thiol measurements from surgically resected human lung tumor and normal lung tissue
16. Patterns of drug resistance parameters in adult leukemia
17. Glutathione-S-transferases and glutathione in human head and neck cancer
18. Glutathione and drug resistance
19. Coordinate changes in expression of protective genes in drug-resistant cells
20. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2
21. Evidence for altered regulation of γ-glutamylcysteine synthetase gene expression among cisplatin-sensitive and -resistant human ovarian cancer cell lines
22. Expression of glutathione S-transferases in normal and malignant pancreas: An immunohistochemical study
23. Multidrug resistance proteins and other drug transport-related resistance to natural product agents
24. Recent trends in glutathione biochemistry- glutathione-protein interactions: A molecular link between oxidative stress and cell proliferation
25. Glutathione content and growth in A549 human lung carcinoma cells
26. Modulation of glutathione level during butyrate-induced differentiation in human colon derived HT-29 cells
27. Buthionine sulfoximine-induced cytostasis does not correlate with glutathione depletion
28. Elevation of intracellular glutathione content associated with mitogenic stimulation of quiescent fibroblasts
29. Potential for selective modulation of glutathione in cancer chemotherapy
30. Kinetic analysis of the reaction of melphalan with water, phosphate, and glutathione
31. Role of glutathione in cellular resistance to alkylating agents
32. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione
33. Measurement of protein using bicinchoninic acid
34. Effects of hepatocellular mitogens on cytokine induced nitric oxide synthesis and nitric oxide induced apoptosis in human hepatocytes
35. Methods utilized in the study of apoptosis
36. Pancreatic carcinoma
37. Pathology of cancer of the pancreas
38. Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer
39. Production of transforming growth factor alpha in human pancreatic cancer cells: Evidence for a superagonist autocrine cycle
40. An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines
41. Deoxyribonucleoside triphosphate pools and growth of glutathione-depleted 3T6 mouse fibroblasts
42. The induction of apoptosis in proliferating human fibroblasts by oxygen radicals is associated with a p53- and p21(WAF1CIP1) induction
43. Control of cell proliferation by reactive oxygen species
44. Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan
45. Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer