Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent β barrel protein

Journal of Biological Chemistry

Volumn 281, Issue 18, 2006, Pages 12959-12967

  Ignatova, Zoya ^a,b   Gierasch, Lila M ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; AMINES; BIOCHEMISTRY; DISEASE CONTROL; MOLECULAR BIOLOGY; NEUROLOGY; NUCLEATION; PATHOLOGY; PERTURBATION TECHNIQUES; POLYMERIZATION; POLYPEPTIDES; TOXICITY;

BARREL PROTEINS; INTERMOLECULAR ASSOCIATIONS; POLYGLUTAMINE SEGMENTS; POLYGLUTAMINE TRACTS;

PROTEINS;

CELLULAR RETINOIC ACID BINDING PROTEIN 1; GENE PRODUCT; GLOBULAR PROTEIN; HUNTINGTIN; POLYGLUTAMINE; POLYPEPTIDE; REPETITIVE DNA; RETINOIC ACID BINDING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL FRACTIONATION; CHIMERA; CIRCULAR DICHROISM; CONTROLLED STUDY; DEGENERATIVE DISEASE; ELECTRON MICROSCOPY; ESCHERICHIA COLI; EXON; FLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MODEL; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; TOXICITY;

ESCHERICHIA COLI; GLUTAMINE; HUMANS; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PEPTIDES; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, RETINOIC ACID; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

EID: 33744952750     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511523200     Document Type: Article

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