Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: A model for misfolding in polyglutamine disease

Journal of Molecular Biology

Volumn 335, Issue 1, 2004, Pages 333-341

  Chow, Michelle K M ^a   Paulson, Henry L ^b   Bottomley, Stephen P ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Ataxin 3; Conformational disease; Fibrillogenesis; Polyglutamine repeat; Protein misfolding

Indexed keywords

ATAXIN 3; POLYGLUTAMINE; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; DEGENERATIVE DISEASE; DENATURATION; FIBRILLOGENESIS; NERVE CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN VARIANT;

EID: 0345118103     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2003.08.064     Document Type: Article

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