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Volumn 4, Issue 3-4, 2006, Pages 96-108

Physiology of Erectile Function: An Update on Intracellular Molecular Processes{A figure is presented}

Author keywords

Androgens; Erectile dysfunction; Erectile function; NO cGMP signalling; PDE5; Penile smooth muscle tone; RhoA ROK pathway

Indexed keywords

ANDROGEN; CALCIUM; CYCLIC GMP; NEUROTRANSMITTER; NITRIC OXIDE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; RHO KINASE;

EID: 33744776303     PISSN: 18712592     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eeus.2006.03.003     Document Type: Article
Times cited : (15)

References (70)
  • 1
    • 0028837352 scopus 로고
    • Physiology of penile erection
    • Andersson K.E., and Wagner G. Physiology of penile erection. Physiol Rev 75 (1995) 191-236
    • (1995) Physiol Rev , vol.75 , pp. 191-236
    • Andersson, K.E.1    Wagner, G.2
  • 2
    • 0034849563 scopus 로고    scopus 로고
    • Pharmacology of penile erection
    • Andersson K.E. Pharmacology of penile erection. Pharmacol Rev 53 (2001) 417-450
    • (2001) Pharmacol Rev , vol.53 , pp. 417-450
    • Andersson, K.E.1
  • 3
    • 5444234287 scopus 로고    scopus 로고
    • Neural control of erection
    • Giuliano F., and Rampin O. Neural control of erection. Physiol Behav 83 (2004) 189-201
    • (2004) Physiol Behav , vol.83 , pp. 189-201
    • Giuliano, F.1    Rampin, O.2
  • 4
    • 22744447482 scopus 로고    scopus 로고
    • Central control of penile erection: role of the paraventricular nucleus of the hypothalamus
    • Argiolas A., and Melis M.R. Central control of penile erection: role of the paraventricular nucleus of the hypothalamus. Prog Neurobiol 76 (2005) 1-21
    • (2005) Prog Neurobiol , vol.76 , pp. 1-21
    • Argiolas, A.1    Melis, M.R.2
  • 5
    • 4143081589 scopus 로고    scopus 로고
    • Control of penile erection by the melanocortinergic system: experimental evidences and therapeutic perspectives
    • Giuliano F. Control of penile erection by the melanocortinergic system: experimental evidences and therapeutic perspectives. J Androl 25 (2004) 683-691
    • (2004) J Androl , vol.25 , pp. 683-691
    • Giuliano, F.1
  • 6
    • 0024336936 scopus 로고
    • Autonomic innervation of reproductive organs: analysis of the neurons whose axons project in the main penile nerve in the pelvic plexus of the rat
    • Dail W.G., Trujillo D., de la Rosa D., and Walton G. Autonomic innervation of reproductive organs: analysis of the neurons whose axons project in the main penile nerve in the pelvic plexus of the rat. Anat Rec 224 (1989) 94-101
    • (1989) Anat Rec , vol.224 , pp. 94-101
    • Dail, W.G.1    Trujillo, D.2    de la Rosa, D.3    Walton, G.4
  • 8
    • 0033861491 scopus 로고    scopus 로고
    • Erectile dysfunction: from biochemical pharmacology to advances in medical therapy
    • Maggi M., Filippi S., Ledda F., Magini A., and Forti G. Erectile dysfunction: from biochemical pharmacology to advances in medical therapy. Eur J Endocrinol 143 (2000) 143-154
    • (2000) Eur J Endocrinol , vol.143 , pp. 143-154
    • Maggi, M.1    Filippi, S.2    Ledda, F.3    Magini, A.4    Forti, G.5
  • 9
    • 0028988481 scopus 로고
    • A heterogenous population of adrenergic receptors mediates contraction of human corpus cavernosum smooth muscle to norepinephrine
    • Traish A.M., Netsuwan N., Daley J., Padman-Nathan H., Goldstein I., and Saenz de Tejada I. A heterogenous population of adrenergic receptors mediates contraction of human corpus cavernosum smooth muscle to norepinephrine. J Urol 153 (1995) 222-227
    • (1995) J Urol , vol.153 , pp. 222-227
    • Traish, A.M.1    Netsuwan, N.2    Daley, J.3    Padman-Nathan, H.4    Goldstein, I.5    Saenz de Tejada, I.6
  • 10
    • 0024308753 scopus 로고
    • Noradrenaline release in human corpus cavernosum and its modulation via presynaptic alpha 2-adrenoceptors
    • Molderings G.J., Gothert M., van Ahlen H., and Porst H. Noradrenaline release in human corpus cavernosum and its modulation via presynaptic alpha 2-adrenoceptors. Fundam Clin Pharmacol 3 (1989) 497-504
    • (1989) Fundam Clin Pharmacol , vol.3 , pp. 497-504
    • Molderings, G.J.1    Gothert, M.2    van Ahlen, H.3    Porst, H.4
  • 11
    • 0030965669 scopus 로고    scopus 로고
    • Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries
    • Simonsen U., Prieto D., Hernandez M., Saenz de Tejada I., and Garcia-Sacristan A. Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries. J Urol 157 (1997) 2356-2360
    • (1997) J Urol , vol.157 , pp. 2356-2360
    • Simonsen, U.1    Prieto, D.2    Hernandez, M.3    Saenz de Tejada, I.4    Garcia-Sacristan, A.5
  • 12
    • 0036668551 scopus 로고    scopus 로고
    • Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation
    • Filippi S., Luconi M., Granchi S., Natali A., Tozzi P., Forti G., et al. Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation. Int J Impot Res 14 (2002) 295-307
    • (2002) Int J Impot Res , vol.14 , pp. 295-307
    • Filippi, S.1    Luconi, M.2    Granchi, S.3    Natali, A.4    Tozzi, P.5    Forti, G.6
  • 13
    • 0032744321 scopus 로고    scopus 로고
    • Alpha adrenergic receptors in the penis:identification, characterization and physiological function
    • Traish A.M., Kimm N.N., Goldstein I., and Moreland R.B. Alpha adrenergic receptors in the penis:identification, characterization and physiological function. J Androl 20 (1999) 671-682
    • (1999) J Androl , vol.20 , pp. 671-682
    • Traish, A.M.1    Kimm, N.N.2    Goldstein, I.3    Moreland, R.B.4
  • 14
    • 0035514631 scopus 로고    scopus 로고
    • Systemic and cavernosal plasma levels of endothelin (1-21) during different penile conditions in healthy males and patients with erectile dysfunction
    • Becker A.J., Uckert S., Stief C.G., Truss M.C., Hartmann U., and Jonas U. Systemic and cavernosal plasma levels of endothelin (1-21) during different penile conditions in healthy males and patients with erectile dysfunction. World J Urol 19 (2001) 371-376
    • (2001) World J Urol , vol.19 , pp. 371-376
    • Becker, A.J.1    Uckert, S.2    Stief, C.G.3    Truss, M.C.4    Hartmann, U.5    Jonas, U.6
  • 15
    • 0025990879 scopus 로고
    • Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum
    • Saenz de Tejada I., Carson M.P., de las Morenas A., Goldstein I., and Traish A.M. Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum. Am J Physiol 261 (1991) H1078-H1085
    • (1991) Am J Physiol , vol.261
    • Saenz de Tejada, I.1    Carson, M.P.2    de las Morenas, A.3    Goldstein, I.4    Traish, A.M.5
  • 16
    • 0037810808 scopus 로고    scopus 로고
    • Erectile physiological and pathophysiological pathways involved in erectile dysfunction
    • Andersson K.E. Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol 170 (2003) S6-S14
    • (2003) J Urol , vol.170
    • Andersson, K.E.1
  • 17
    • 0027315831 scopus 로고
    • Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis
    • Burnett A.L., Tillman S.L., Chang T.S., Epstein J.I., Lowenstein C.J., Bredt D.S., et al. Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. J Urol 150 (1993) 73-76
    • (1993) J Urol , vol.150 , pp. 73-76
    • Burnett, A.L.1    Tillman, S.L.2    Chang, T.S.3    Epstein, J.I.4    Lowenstein, C.J.5    Bredt, D.S.6
  • 18
    • 0032792815 scopus 로고    scopus 로고
    • Nitric oxide and the cyclic GMP system in the penis
    • Gonzalez-Cadavid N.F., Ignarro L.J., and Rajfer J. Nitric oxide and the cyclic GMP system in the penis. Mol Urol 3 (1999) 51-59
    • (1999) Mol Urol , vol.3 , pp. 51-59
    • Gonzalez-Cadavid, N.F.1    Ignarro, L.J.2    Rajfer, J.3
  • 19
    • 0030611217 scopus 로고    scopus 로고
    • International union of pharmacology nomenclature in nitric oxide research
    • Moncada S., Higgs E.A., and Furchgott R.F. International union of pharmacology nomenclature in nitric oxide research. Pharmacol Rev 49 (1997) 137-142
    • (1997) Pharmacol Rev , vol.49 , pp. 137-142
    • Moncada, S.1    Higgs, E.A.2    Furchgott, R.F.3
  • 20
    • 0033026388 scopus 로고    scopus 로고
    • NO synthase in cholinergic nerves and NO-induced relaxation in the rat isolated corpus cavernosum
    • Hedlund P., Alm P., and Andersson K.E. NO synthase in cholinergic nerves and NO-induced relaxation in the rat isolated corpus cavernosum. Br J Pharmacol Rev 126 (1999) 349-360
    • (1999) Br J Pharmacol Rev , vol.126 , pp. 349-360
    • Hedlund, P.1    Alm, P.2    Andersson, K.E.3
  • 21
    • 0033838307 scopus 로고    scopus 로고
    • Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nerves
    • Gonzalez-Cadavid N.F., Burnett A.L., Magee T.R., Zeller C.B., Vernet D., Smith N., et al. Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nerves. Biol Reprod 63 (2000) 704-714
    • (2000) Biol Reprod , vol.63 , pp. 704-714
    • Gonzalez-Cadavid, N.F.1    Burnett, A.L.2    Magee, T.R.3    Zeller, C.B.4    Vernet, D.5    Smith, N.6
  • 23
    • 0002218885 scopus 로고
    • Modulation of noradrenaline release in human corpus cavernosum by presynaptic prostaglandin receptors
    • Molderings G.J., Gothert M., van Halen H., and Porst H. Modulation of noradrenaline release in human corpus cavernosum by presynaptic prostaglandin receptors. Int J Impot Res 4 (1992) 19-24
    • (1992) Int J Impot Res , vol.4 , pp. 19-24
    • Molderings, G.J.1    Gothert, M.2    van Halen, H.3    Porst, H.4
  • 24
    • 0030071844 scopus 로고    scopus 로고
    • The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience
    • Porst H. The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience. J Urol 155 (1996) 802-815
    • (1996) J Urol , vol.155 , pp. 802-815
    • Porst, H.1
  • 25
    • 0025986754 scopus 로고
    • Intercellular communication through gap junctions: a potential role in pharmacomechanical coupling and syncytial tissue contraction in vascular smooth muscle isolated from the human corpus cavernosum
    • Christ G.J., Moreno A.P., Parker M.E., Gondre C.M., Valcic M., Melman A., et al. Intercellular communication through gap junctions: a potential role in pharmacomechanical coupling and syncytial tissue contraction in vascular smooth muscle isolated from the human corpus cavernosum. Life Sci 49 (1991) PL195-PL200
    • (1991) Life Sci , vol.49
    • Christ, G.J.1    Moreno, A.P.2    Parker, M.E.3    Gondre, C.M.4    Valcic, M.5    Melman, A.6
  • 26
    • 0026289054 scopus 로고
    • The Ayerst Award Lecture 1990. Calcium-dependent mechanisms of regulation of smooth muscle contraction
    • Walsh M.P. The Ayerst Award Lecture 1990. Calcium-dependent mechanisms of regulation of smooth muscle contraction. Biochem Cell Biol 69 (1991) 771-800
    • (1991) Biochem Cell Biol , vol.69 , pp. 771-800
    • Walsh, M.P.1
  • 27
    • 0842281652 scopus 로고    scopus 로고
    • Rho and Rac take center stage
    • Burridge K., and Wennerberg K. Rho and Rac take center stage. Cell 116 (2004) 167-179
    • (2004) Cell , vol.116 , pp. 167-179
    • Burridge, K.1    Wennerberg, K.2
  • 28
    • 32644449489 scopus 로고    scopus 로고
    • RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeuthic insight
    • Liming J.N., and Burnett A.L. RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeuthic insight. Clin Sci 110 (2006) 153-165
    • (2006) Clin Sci , vol.110 , pp. 153-165
    • Liming, J.N.1    Burnett, A.L.2
  • 31
    • 0031805037 scopus 로고    scopus 로고
    • Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence
    • Moreland R.B. Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res 10 (1998) 113-120
    • (1998) Int J Impot Res , vol.10 , pp. 113-120
    • Moreland, R.B.1
  • 34
    • 0034015869 scopus 로고    scopus 로고
    • Cyclic AMP regulates mRNA expression of alpha-1d and alpha-2a adrenergic receptors in cultured human corpus cavernosum smooth muscle cells
    • Traish A., Kim N.N., Goldstein I., and Moreland R.B. Cyclic AMP regulates mRNA expression of alpha-1d and alpha-2a adrenergic receptors in cultured human corpus cavernosum smooth muscle cells. Int J Impot Res 12 (2000) S41-S47
    • (2000) Int J Impot Res , vol.12
    • Traish, A.1    Kim, N.N.2    Goldstein, I.3    Moreland, R.B.4
  • 35
    • 0032729322 scopus 로고    scopus 로고
    • 1 treatment enhances nitric oxide and erection responses to nerve stimulation in the rat penis by upregulatin constitutive NOS isoforms
    • 1 treatment enhances nitric oxide and erection responses to nerve stimulation in the rat penis by upregulatin constitutive NOS isoforms. J Urol 162 (1999) 2205-2210
    • (1999) J Urol , vol.162 , pp. 2205-2210
    • Escrig, A.1    Marin, R.2    Mas, M.3
  • 36
    • 0033780703 scopus 로고    scopus 로고
    • Rationale for the combination of PGE1 and S-nitroso glutathione to inuce relaxation of human penile smooth muscle
    • Angulo J., Cuevas P., Moncada I., Martin-Morales A., Allona A., Fernandez A., et al. Rationale for the combination of PGE1 and S-nitroso glutathione to inuce relaxation of human penile smooth muscle. J Pharmacol Exp Ther 295 (2000) 586-593
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 586-593
    • Angulo, J.1    Cuevas, P.2    Moncada, I.3    Martin-Morales, A.4    Allona, A.5    Fernandez, A.6
  • 38
    • 0036725094 scopus 로고    scopus 로고
    • K channels as molecular targets for the treatment of erectile dysfunction
    • Christ G.J. K channels as molecular targets for the treatment of erectile dysfunction. J Androl 23 (2002) S10-S19
    • (2002) J Androl , vol.23
    • Christ, G.J.1
  • 39
    • 4744354628 scopus 로고    scopus 로고
    • Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo
    • Christ G.J., Day N., Santizo C., Sato Y., Zhao W., Sclafani T., et al. Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo. Am J Physiol-Hearth 287 (2004) 1544-1553
    • (2004) Am J Physiol-Hearth , vol.287 , pp. 1544-1553
    • Christ, G.J.1    Day, N.2    Santizo, C.3    Sato, Y.4    Zhao, W.5    Sclafani, T.6
  • 40
    • 0035193364 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases: relating structure and function
    • Francis S.H., Turko I.V., and Corbin J.D. Cyclic nucleotide phosphodiesterases: relating structure and function. Prog Nucleic Acid Res Mol Biol 65 (2001) 1-52
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.65 , pp. 1-52
    • Francis, S.H.1    Turko, I.V.2    Corbin, J.D.3
  • 41
    • 20044392483 scopus 로고    scopus 로고
    • Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens
    • Mancina R., Filippi S., Marini M., Morelli A., Vignozzi L., Salonia A., et al. Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens. Mol Hum Reprod 11 (2005) 107-115
    • (2005) Mol Hum Reprod , vol.11 , pp. 107-115
    • Mancina, R.1    Filippi, S.2    Marini, M.3    Morelli, A.4    Vignozzi, L.5    Salonia, A.6
  • 42
    • 0032541484 scopus 로고    scopus 로고
    • Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase
    • Loughney K., Hill T.R., Florio V.A., Uher L., Rosman G.J., Wolda S.L., et al. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase. Gene 216 (1998) 139-147
    • (1998) Gene , vol.216 , pp. 139-147
    • Loughney, K.1    Hill, T.R.2    Florio, V.A.3    Uher, L.4    Rosman, G.J.5    Wolda, S.L.6
  • 43
    • 0032543366 scopus 로고    scopus 로고
    • Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5)
    • Stacey P., Rulten S., Dapling A., and Phillips S.C. Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5). Biochem Biophys Res Commun 247 (1998) 249-254
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 249-254
    • Stacey, P.1    Rulten, S.2    Dapling, A.3    Phillips, S.C.4
  • 44
    • 7344243173 scopus 로고    scopus 로고
    • Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene
    • Yanaka N., Kotera J., Ohtsuka A., Akatsuka H., Imai Y., Michibata H., et al. Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene. Eur J Biochem 255 (1998) 391-399
    • (1998) Eur J Biochem , vol.255 , pp. 391-399
    • Yanaka, N.1    Kotera, J.2    Ohtsuka, A.3    Akatsuka, H.4    Imai, Y.5    Michibata, H.6
  • 45
    • 0036189959 scopus 로고    scopus 로고
    • Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters
    • Lin C.S., Chow S., Lau A., Tu R., and Lue T.F. Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters. Int J Impot Res 14 (2002) 15-24
    • (2002) Int J Impot Res , vol.14 , pp. 15-24
    • Lin, C.S.1    Chow, S.2    Lau, A.3    Tu, R.4    Lue, T.F.5
  • 46
    • 11144355591 scopus 로고    scopus 로고
    • Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa
    • Morelli A., Filippi S., Mancina R., Luconi M., Vignozzi L., Marini M., et al. Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa. Endocrinology 145 (2004) 2253-2263
    • (2004) Endocrinology , vol.145 , pp. 2253-2263
    • Morelli, A.1    Filippi, S.2    Mancina, R.3    Luconi, M.4    Vignozzi, L.5    Marini, M.6
  • 47
    • 13844271285 scopus 로고    scopus 로고
    • Testosterone regulates PDE5 expression and in vivo responsiveness to tadalafil in rat corpus cavernosum
    • Zhang X.-H., Morelli A., Luconi M., Vignozzi L., Filippi S., Marini M., et al. Testosterone regulates PDE5 expression and in vivo responsiveness to tadalafil in rat corpus cavernosum. Eur Urol 47 (2005) 409-416
    • (2005) Eur Urol , vol.47 , pp. 409-416
    • Zhang, X.-H.1    Morelli, A.2    Luconi, M.3    Vignozzi, L.4    Filippi, S.5    Marini, M.6
  • 48
    • 13444302224 scopus 로고    scopus 로고
    • Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism
    • Champion H.C., Bivalacqua T.J., Takimoto E., Kaas D.A., and Burnett A.L. Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism. Proc Natl Acad Sci 102 (2005) 1661-1666
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 1661-1666
    • Champion, H.C.1    Bivalacqua, T.J.2    Takimoto, E.3    Kaas, D.A.4    Burnett, A.L.5
  • 49
    • 0038148533 scopus 로고    scopus 로고
    • Up and down-regulation of phosphodiesterase-5 as related to tachiphylaxis and priapism
    • Lin G., Xin Z.C., Lue T.F., and Lin C.S. Up and down-regulation of phosphodiesterase-5 as related to tachiphylaxis and priapism. J Urol 170 (2003) S15-S19
    • (2003) J Urol , vol.170
    • Lin, G.1    Xin, Z.C.2    Lue, T.F.3    Lin, C.S.4
  • 52
    • 0018475367 scopus 로고
    • Castration for sex offenders: treatment or punishment? A review and critique of recent European literature
    • Heim N., and Hursch C.J. Castration for sex offenders: treatment or punishment? A review and critique of recent European literature. Archiv Sex Behav 8 (1979) 281-304
    • (1979) Archiv Sex Behav , vol.8 , pp. 281-304
    • Heim, N.1    Hursch, C.J.2
  • 53
    • 0000535172 scopus 로고
    • Sexual function in aging males after orchidectomy and estrogen therapy
    • Ellis W.J., and Grayhack J.T. Sexual function in aging males after orchidectomy and estrogen therapy. J Urol 89 (1963) 895-899
    • (1963) J Urol , vol.89 , pp. 895-899
    • Ellis, W.J.1    Grayhack, J.T.2
  • 54
    • 0023868487 scopus 로고
    • Sexuality changes in prostate cancer patients receiving antihormonal therapy combining the antiandrogen flutamide with medical (LHRH agonist) or surgical castration
    • Rousseau L., Dupont A., Labrie F., and Couture M. Sexuality changes in prostate cancer patients receiving antihormonal therapy combining the antiandrogen flutamide with medical (LHRH agonist) or surgical castration. Archiv Sex Behav 17 (1988) 87-98
    • (1988) Archiv Sex Behav , vol.17 , pp. 87-98
    • Rousseau, L.1    Dupont, A.2    Labrie, F.3    Couture, M.4
  • 55
    • 28444486296 scopus 로고    scopus 로고
    • The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function
    • Traish A.M., and Kim N.N. The physiological role of androgens in penile erection: regulation of corpus cavernosum structure and function. J Sex Med 2 (2005) 759-770
    • (2005) J Sex Med , vol.2 , pp. 759-770
    • Traish, A.M.1    Kim, N.N.2
  • 56
    • 0032981996 scopus 로고    scopus 로고
    • Effects of castration and androgen replacement on erectile function in a rabbit model
    • Traish A.M., Park K., Dhir V., Kim N.N., Moreland R.B., and Goldstein I. Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology 140 (1999) 1861-1868
    • (1999) Endocrinology , vol.140 , pp. 1861-1868
    • Traish, A.M.1    Park, K.2    Dhir, V.3    Kim, N.N.4    Moreland, R.B.5    Goldstein, I.6
  • 57
    • 0347908983 scopus 로고    scopus 로고
    • Effects of medical or surgical castration on erectile function in an animal model
    • Traish A.M., Munarriz R., O'Connell L., Choi S., Kim S.W., Kim N.N., et al. Effects of medical or surgical castration on erectile function in an animal model. J Androl 24 (2003) 381-387
    • (2003) J Androl , vol.24 , pp. 381-387
    • Traish, A.M.1    Munarriz, R.2    O'Connell, L.3    Choi, S.4    Kim, S.W.5    Kim, N.N.6
  • 58
    • 0037359386 scopus 로고    scopus 로고
    • Effect of androgen deprivation on penile ultrastructure
    • Shen Z.J., Zhou X.L., Lu Y.L., and Chen Z.D. Effect of androgen deprivation on penile ultrastructure. Asian J Androl 5 (2003) 33-36
    • (2003) Asian J Androl , vol.5 , pp. 33-36
    • Shen, Z.J.1    Zhou, X.L.2    Lu, Y.L.3    Chen, Z.D.4
  • 59
    • 0346027209 scopus 로고    scopus 로고
    • The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action
    • Bhasin S., Taylor W.E., Singh R., Artaza J., Sinha-Hikim I., Jasuja R., et al. The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol 58 (2003) M1103-M1110
    • (2003) J Gerontol , vol.58
    • Bhasin, S.1    Taylor, W.E.2    Singh, R.3    Artaza, J.4    Sinha-Hikim, I.5    Jasuja, R.6
  • 60
    • 0242468434 scopus 로고    scopus 로고
    • Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    • Singh R., Artaza J.N., Taylor W.E., Gonzalez-Cadavid N.F., and Bhasin S. Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology 144 (2003) 5081-5088
    • (2003) Endocrinology , vol.144 , pp. 5081-5088
    • Singh, R.1    Artaza, J.N.2    Taylor, W.E.3    Gonzalez-Cadavid, N.F.4    Bhasin, S.5
  • 61
    • 29344440814 scopus 로고    scopus 로고
    • Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
    • Singh R., Artaza J.N., Taylor W.E., Braga M., Yuan X., Gonzalez-Cadavid N.F., et al. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 147 (2006) 141-154
    • (2006) Endocrinology , vol.147 , pp. 141-154
    • Singh, R.1    Artaza, J.N.2    Taylor, W.E.3    Braga, M.4    Yuan, X.5    Gonzalez-Cadavid, N.F.6
  • 62
    • 14344264330 scopus 로고    scopus 로고
    • Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: a potential mechanism for veno-occlusive dysfunction in androgen deficiency
    • Traish A.M., Toselli P., Jeong S.J., and Kim N.N. Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: a potential mechanism for veno-occlusive dysfunction in androgen deficiency. J Androl 26 (2005) 242-248
    • (2005) J Androl , vol.26 , pp. 242-248
    • Traish, A.M.1    Toselli, P.2    Jeong, S.J.3    Kim, N.N.4
  • 64
    • 3142613193 scopus 로고    scopus 로고
    • Organic, relational and psychological factors in erectile dysfunction in men with diabetes mellitus
    • Corona G., Mannucci E., Mansani R., Petrone L., Bartolini M., Giommi R., et al. Organic, relational and psychological factors in erectile dysfunction in men with diabetes mellitus. Eur Urol 46 (2004) 222-228
    • (2004) Eur Urol , vol.46 , pp. 222-228
    • Corona, G.1    Mannucci, E.2    Mansani, R.3    Petrone, L.4    Bartolini, M.5    Giommi, R.6
  • 65
    • 0042836843 scopus 로고    scopus 로고
    • Hypogonadism and erectile dysfunction: the role for testosterone therapy
    • Shabsigh R. Hypogonadism and erectile dysfunction: the role for testosterone therapy. Int J Impot Res 4 (2003) S9-S13
    • (2003) Int J Impot Res , vol.4
    • Shabsigh, R.1
  • 66
    • 0038670738 scopus 로고    scopus 로고
    • Androgens improve cavernous vasodilation and response to sildenafil in patients with erectile dysfunction
    • Aversa A., Isidori A.M., Spera G., Lenzi A., and Fabbri A. Androgens improve cavernous vasodilation and response to sildenafil in patients with erectile dysfunction. Clin Endocrinol 58 (2003) 632-638
    • (2003) Clin Endocrinol , vol.58 , pp. 632-638
    • Aversa, A.1    Isidori, A.M.2    Spera, G.3    Lenzi, A.4    Fabbri, A.5
  • 67
    • 3142546340 scopus 로고    scopus 로고
    • Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone
    • Shabsigh R., Kaufman J.M., Steidle C., and Padma-Nathan H. Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. J Urol 172 (2004) 658-663
    • (2004) J Urol , vol.172 , pp. 658-663
    • Shabsigh, R.1    Kaufman, J.M.2    Steidle, C.3    Padma-Nathan, H.4
  • 69
    • 0036934069 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus
    • Vickers M.A., and Satyanarayana R. Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus. Int J Impot Res 14 (2002) 466-471
    • (2002) Int J Impot Res , vol.14 , pp. 466-471
    • Vickers, M.A.1    Satyanarayana, R.2
  • 70
    • 33645996073 scopus 로고    scopus 로고
    • Testosterone Restores Diabetes-Induced Erectile Dysfunction and Sildenafil Responsiveness in Two Distinct Animal Models of Chemical Diabetes
    • Zhang X.H., Filippi S., Morelli A., Vignozzi L., Luconi M., Donati S., et al. Testosterone Restores Diabetes-Induced Erectile Dysfunction and Sildenafil Responsiveness in Two Distinct Animal Models of Chemical Diabetes. J Sex Med 3 (2006) 253-266
    • (2006) J Sex Med , vol.3 , pp. 253-266
    • Zhang, X.H.1    Filippi, S.2    Morelli, A.3    Vignozzi, L.4    Luconi, M.5    Donati, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.