Alpha-adrenergic receptors in the penis: Identification, characterization, and physiological function

Journal of Andrology

Volumn 20, Issue 6, 1999, Pages 671-682

  Traish, Abdulmaged M ^a   Kim, Noel N ^a   Goldstein, Irwin ^a   Moreland, Robert B ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 5 METHYLURAPIDIL; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANDROGEN; BRIMONIDINE; CHLOROETHYLCLONIDINE; DELEQUAMINE; DOXAZOSIN; NORADRENALIN; OXYMETAZOLINE; PHENTOLAMINE; PHENYLEPHRINE; POSTSYNAPTIC RECEPTOR; PRAZOSIN; PRESYNAPTIC RECEPTOR; RAUWOLSCINE; RECEPTOR SUBTYPE; TAMSULOSIN; TERAZOSIN; YOHIMBINE;

ADRENERGIC ACTIVITY; CORPUS CAVERNOSUM; HUMAN; MALE; PENIS ERECTION; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SHORT SURVEY; SIGNAL TRANSDUCTION;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; HUMANS; MALE; MODELS, BIOLOGICAL; PENILE ERECTION; PENIS; RECEPTORS, ADRENERGIC, ALPHA;

EID: 0032744321     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (98)

1. Aantaa R, Marjamaki A, Scheinin M. Molecular pharmacology of alpha-2-adrenoceptor subtypes. Ann Med 1995;27:439-449.
2. Abber JC, Lue TF, Luo JA, Juenemann KP, Tanagho EA. Priapism induced by chlorpromazine and trazadone: mechanism of action. J Urol 1987;135:1039-1042.
3. Adaikan PG, Karim SM. Adrenoceptors in the human penis. J Auton Pharmacol 1981;1:199-203.
4. Adams MA, Banting JD, Maurice DH, Morales A, Heaton JPW. Vascular control mechanisms in penile erection: phylogeny and the inevitability of multiple and overlapping systems. Int J Impotence Res 1997;9:69-84.
5. Anderson HK. The innervation of the pelvic and the adjoining viscera. III. The external generative organs. J Physiol 1985;19:85-121.
6. Andersson K-E. Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 1993;45:254-308.
7. Andersson K-E, Holmquist F, Bodker A. Castration enhances NANC-mediated relaxation in rabbit isolated corpus cavernosum. Acta Physiol Scand 1992;146:405-406.
8. Andersson K-E, Wagner G. Physiology of penile erection. Physiol Rev 1995;75:191-236.
9. Azadzoi KM, Payton T, Krane RJ, Goldstein I. Effects of intracavernosal trazodone hydrochloride: animal and human studies. J Urol 1990;144: 1277-1282.
10. Becker AJ, Stief CG, Machtens S, Schultheiss D, Hartmann U, Truss MC, Jonas U. Oral phentolamine as treatment for erectile dysfunction. J Urol 1998;159:1214-1216.
11. Blum MD, Bahnson RR, Porter TN, Carter MF. Effect of local alpha-adrenergic blockade on human penile erection. J Urol 1985;134:479-481.
12. Bradshaw WG, Baum MJ, Awh CC. Attenuation by 5-alpha reductase inhibitor of the activational effect of testosterone propionate on penile erections in castrated male rats. Endocrinology 1981;109:1047-1051.
13. Brindley GS. Cavernosal alpha blockade: a new technique for investigating and treating erectile impotence. Br J Psychiatry 1983;143:332-337.
14. Bruno JF, Whittaker J, Song J, Berelowitz M. Molecular cloning and sequencing of a cDNA encoding a human alpha-1A adrenergic receptor. Biochem Biophys Res Commun 1991;179:1485-1490.
15. Burnett A. Nitric oxide in the penis: physiology and pathology. J Urol 1997;157:320-324.
16. Bylund DB, Regan JW, Faber JE, Hieble JP, Triggle CR, Ruffolo RR Jr. Vascular alpha-adrenoceptors: from gene to human. Can J Physiol Pharmacol 1995;73:553-543.
17. Chamness SL, Ricker DD, Crone JK, Dembeck CL, Maguire MP, Burnett AL, Chang TS. The effects of androgens on nitric oxide synthase in the male reproductive tract of the rat. Fertil Steril 1995;63:1101-1107.
18. Chang DJ, Chang TK, Yamanishi SS, Salazar FH, Kosaka AH, Khare R, Bhakta S, Jasper JR, Shieh IS, Lesnick JD, Ford AP, Daniels DV, Eglen RM, Clarke DE, Bach C, Chan HW. Molecular cloning, genomic characterization, and experssion of novel human alpha-1a-adrenoceptor isoforms. FEBS Lett 1998;422:279-283.
19. Christ GJ, Maayani S, Valcic M, Melman A. Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. Br J Pharmacol 1990;101:375-381.
20. Christ GJ, Stone B, Melman A. Age-dependent alterations in the efficacy of phenylephrine-induced contractions in vascular smooth muscle isolated from the corpus cavernosum of impotent men. Can J Physiol Pharmacol 1991;69:909-913.
21. Chuang AT, Steers WD. Neurophysiology of penile erection. In: Carson CC, Kirby RS, Goldstein I, eds. Textbook of Erectile Dysfunction. Oxford: Isis Medical Media Ltd; 1999:59-72.
22. Chuang AT, Strauss JD, Murphy RA, Steers WD. Sildenafil, a type-5 cGMP phosphodiesterase inhibitor, specifically amplifies endogenous cGMP-dependent relaxation in rabbit corpus cavernosum smooth muscle in vitro. J Urol 1998;160:257-261.
23. Costa PM, Soulie-Vassal L, Sarrazin B, Rebillard X, Navratil H, Bali JP. Adrenergic receptors on smooth muscle cells isolated from human penile corpus cavernosum. J Urol 1993;150:859-863.
24. Dausse JP, Leriche A, Yablonsky F. Patterns of messenger RNA expression for alpha-1-adrenoceptor subtypes in human corpus cavernosum. J Urol 1998;160:597-600.
25. Dhabuwala CB, Ramakrishna CV, Anderson GF. Beta-adrenergic receptors in human cavernous tissue. J Urol 1985;133:721-723.
26. Diederichs W, Stief CG, Lue TF, Tanagho EA. Norepinephrine involvement in penile detumescence. J Urol 1990;143:1264-1266.
27. Dinsmore WW, Alderdice DK. Vasoactive intestinal polypeptide and phentolamine mesylate administered by autoinjector in the treatment of patients with erectile dysfunction resistant to other intracavernosal agents. Br J Urol 1998;81:437-440.
28. Ellis WJ, Grayhack JT. Sexual function in aging males after orchiectomy and estrogen therapy. J Urol 1963;89:895-898.
29. Ford A, Williams TJ, Blue DR, Clarke DE. α1-adrenoceptor classification: sharpening Occam's razor. Trends Pharmacol Sci 1994;15:167-170.
30. Furukawa K, Chess-Williams R, Uchiyama T. Alpha-1B-adrenoreceptor subtype mediating the phenylephrine-induced contractile response in rabbit corpus cavernosum, Jpn J Pharmacol 1996;71:325-331.
31. Giuliano FA, Rampin O, Benoit G, Jardin A. Neural control of penile erection. Urol Clin N Am 1995;22:747-766.
32. Grimm RH, Grandits GA, Prineas RJ, McDonald RH, Lewis CE, Flack JM, Yunis C, Svendsen K, Liebson PR, Elmer PJ, Stammler J. Long-term effects on sexual function of five anti-hypertensive drugs and nutrional hygienic treatmentin hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS). Hypertension 1997;29: 8-14.
33. Gupta S, Moreland RB, Daley JT, Yang S, Goldstein I, Traish AM. Corpus cavernosum smooth muscle expresses functional postsynaptic alpha-2-adrenergic receptors. Br J Pharmacol 1998;123:1237-1245.
34. Gwinup G. Oral phentolamine in nonspecific erectile insufficiency. Ann Int Med 1988;109:162-163.
35. Hedlund H, Andersson K-E. Comparison of the responses to drugs acting on adrenoceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery. J Auton Pharmacol 1985;5:81-88.
36. Hedlund H, Andersson K-E, Mattiasson A. Pre- and postjunctional adreno- and muscarinic-receptor function in the isolated corpus spongiosum urethrae. J Auton Phamacol 1984;4:241-246.
37. Hieble JP, Bondinell WE, Ruffolo RR Jr. α and β-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem 1995a;38:3415-3444.
38. Hieble JP, Bylund DB, Clarke DE, Eikenburg DC, Langer SZ, Lefkowitz RJ, Minneman KP, Ruffolo RR Jr. International Union of Pharmacology. X. Recommendation for nomenclature of alpha-1-adrenoceptors: consensus update. Pharmacol Rev 1995b;47:267-270.
39. Hieble JP, Ruffolo RR Jr. Subclassification and nomenclature of alpha-1-and alpha-2-adrenoceptors. Prog Drug Res 1996;47:81-130.
40. Hirasawa A, Horie K, Tanaka T, Takagaki K, Murai M, Yano J, Tsujimoto O. Cloning, functional expression, and tissue distribution of human cDNA for the alpha-1C-adrenergic receptor. Biochem Biophys Res Commun 1993;195:902-909.
41. Hirasawa A, Shibata K, Horie K, Takei Y, Obika K, Tanaka T, Muramoto N, Takagaki K, Yano J, Tsujimoto G. Cloning, functional expression, and tissue distribution of human alpha-1c-adrenoceptor splice variants. FEBS Lett 1995;363:256-260.
42. Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM. Rajfer J. Nitric oxide and cyclic GMP formation upon electrical stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1990;170:843-850.
43. Jünemann K-P, Alken P. Pharmacotherapy of erectile dysfunction: a review. Int J Impotence Res 1989;1:71-93.
44. Kaplan SA, Reis RB, Kohn IJ, Shabsigh R, Te AE. Combination therapy using oral alpha blockers and intracavernosal injection in men with erectile dysfunction. Urology 1998;52:739-743.
45. Kim N, Azadzoi KM, Goldstein I, Saenz de Tejada I. A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J Clin Investig 1991; 88:112-118.
46. Kim NN, Kim JJ, Hypolite J, Garcia-Diaz JF, Broderick GA, Tomheim K, Daley JT, Levin R, and Saenz de Tejada I. Altered contractility of rabbit corpus cavernosum smooth muscle by hypoxia. J Urol 1996; 155:772-778.
47. Kirkeby HJ, Forman A, Sorensen S, Andersson K-E. Alpha-adrenoceptor function in isolated penile circumflex veins from potent and impotent men. J Urol 1989;142:1369-1371.
48. Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ, Regan JW. Cloning, sequencing, and expression of the gene coding for the human platelet alpha-2-adrenergic receptor. Science 1987;238:650-656.
49. Levin RM, Wein AJ. Adrenergic alpha receptors outnumber beta receptors in human penile corpus cavernosum. Investig Urol 1980;18:225-226.
50. Lomasney JW, Lorenz W, Allen LF, King K, Regan JW, Yang-Feng TL, Caron MG, Lefkowitz RJ. Expansion of the alpha-2-adrenergic receptor family: cloning and characterization of a human alpha-2-adrenergic receptor subtype, the gene for which is located on chromosome 2. Proc Natl Acad Sci USA 1990;87:5094-5098.
51. Lue TF, Dahiya R. Molecular biology of erectile function and dysfunction. Mol Urol 1997;1:55-64.
52. Lugg J, Ng C, Rajfer J, Gonzalez-Cadavid N. Cavernosal nerve stimulation in the rat reverses castration-induced decrease in penile NOS activity. Am J Physiol 1996;271:E354-E361.
53. MacKinnon AC, Speding M, Brown CM. α-2-adrenoceptors: more subtypes but fewer functional differences. Trends Pharmacol Sci 1994; 15:119-123.
54. Marson L. Central nervous system control. In: Carson CC, Kirby RS, Goldstein I, eds. Textbook of Erectile Dysfunction. Oxford: Isis Medical Media Ltd; 1999:73-88.
55. McKenna KE. Central control of penile erection. Int J Impotence Res (Suppl 1) 1998;10:S25-S34.
56. McMahon CG. A pilot study of the role of intracavernous injection of vasoactive intestinal peptide (VIP) and phentolamine mesylate in the treatment of erectile dysfunction. Int J Impotence Res 1996;8:233-236.
57. Miller RC, Mony MC, Shini V, Schoffter P, Stocelet JC. Endothelial mediated inhibition of contraction and increases in cGMP levels evoked by alpha-adrenoceptor agonist BHT 920 in rat isolated aorta. Br J Pharmacol 1984;83:903-908.
58. Miller RC, Schini V, Schoeffter P. Modulation by the endothelium of agonist-induced contractions of vascular smooth muscle. In: Vanhoutte PM, ed. Relaxing and Contracting Factors. Clifton: The Humana Press Inc; 1988:241-267.
59. Mills TM, Reilly CM, Lewis BW. Androgens and penile erection: a review. J Andrology 1996;17:633-638.
60. Mills TM, Wiedmeier VT, Stopper VS. Androgen maintenance of erectile function in the rat penis. Biol Reprod 1992;46:342-348.
61. Molderings GJ, Gothert M, Van Ahlen H, Porst H. Noradrenaline release in human corpus cavernosum and its modulation via presynaptic alpha-2-adrenoreceptors. Fundam Clinic Pharmacol 1989;3:497-504.
62. Morales A, Condra M. Owen JA, Surridge DH, Fenemore J, Harris C. Is yohimbine effective in the treatment of organic impotence? Results of a controlled trial. J Urol 1987;137:1169-1172.
63. Morales A, Heaton JPW, Johnston B, Adams MA. Oral and topical treatment of erectile dysfunction: present and future. Urol Clin N Am 1995;22:879-886.
64. Muller SC, Hsieh JT, Lue TF, Tanagho EA. Castration and erection: an animal study. Eur Urol 1988;15:118-124.
65. Munoz M, Bancroft J, Turner M. Evaluating the effects of an alpha-2-adrenoceptor antagonist on erectile function in the male. 1. The erectile response to erotic stimuli in volunteers. Pyschopharmacology 1994a;115:463-470.
66. Munoz M, Bancroft J, Turner M. Evaluating the effects of an alpha-2 adrenoceptor antagonist on erectile function in the male. 2. The erectile response to erotic stimuli in men with erectile dysfunction, in relation to age and in comparison with normal volunteers. Pyschopharmacology 1994b;115:471-477.
67. Nitahara KS, Lue TF. Microscopic anatomy of the penis. In: Carson CC, Kirby RS, Goldstein I, eds. Textbook of Erectile Dysfunction. Oxford: Isis Medical Media Ltd; 1999:31-42.
68. Peterson CA, Bennett AH, Hellstrom WJ, Kaiser FE, Morley JE, Nemo KJ, Padma-Nathan H, Place VA, Prendergast J, Tamn PY, Tangaho EA, Todd LK, Varady JC, Gesundheit N. Erectile response to transurethral alprostadil, prazosin, and alprostadil-prazosin combinations. J Urol 1998;159:1523-1527.
69. Price DT, Chari RS, Berkowitz DE, Meyers WC, Schwinn DA. Expression of alpha-1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha-1-adrenergic receptor subtype classification. Mol Pharmacol 1994a;46:221-226.
70. Price DT, Lefkowitz RJ, Caron MG, Berkowitz D, Schwinn DA. Localization of mRNA for the three distinct 1-adrenergic receptor subtypes in human tissues: implications for human 1-adrenergic physiology. Mol Pharmacol 1994b;45:171-175.
71. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro L. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992; 326:90-94.
72. Ramarao CS, Kincade-Denker JM, Perez DM, Gaivin RJ, Riek RP, Graham RM. Genomic organization and expression of the human alpha-1B-adrenergic receptor. J Biol Chem 1992;267:21936-21945.
73. Regan JW, Kobilka TS, Yang-Feng TL, Caron MG, Lefkowitz RJ, Kobilka BK. Cloning and expression of a human kidney cDNA for an alpha-2-adrenergic receptor subtype. Proc Natl Acad Sci USA 1988; 85:6301-6305.
74. Reid K, Morales A, Harris C, Surridge DHC, Condra M, Owen J, Fenemore J. Double-blind trial of yohimbine in treatment of psychogenic impotence. Lancet 1987;2:421-423.
75. Reilly CM, Zamorano P, Stopper VS, Mills TM. Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum. J Andrology 1997a;18:26-31.
76. Reilly CM, Zamorano P, Stopper VS, Mills TM. Androgenic regulation of NO availability in rat penile erection. J Andrology 1997b;18:110-115.
77. Riley AJ, Goodman RE, Kellet JM, Orr R. Double-blind trial of yohimbine hydrochloride in the treatment of erectile inadequacy. Sex Marital Ther 1989;4:17-28.
78. Ruffolo RR Jr, Bondinell WE, Hieble JP. Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure activity relationships and therapeutic applications. J Med Chem 1995;38:3681-3716.
79. Saenz de Tejada I, Kim N, Lagan I, Krane RJ, Goldstein I. Regulation of adrenergic activity in penile corpus cavernosum. J Urol 1989;142: 1117-1121.
80. Saenz de Tejada I, Ware JC, Blanco R, Pittard JT, Nadig PW, Azadzoi KM, Krane RJ, Goldstein I. Pathophysiology of prolonged penile erection associated with trazodone use. J Urol 1991;145:60-64.
81. Schwinn DA, Johnston GI, Page SO, Mosely MJ, Wilson KH, Worman NR Campbell S, Fidock MD, Furness LM, Parry-Smith DJ, Peter B, Bailey DS. Cloning and pharmacological characterization of human alpha-1-adrenergic receptors: sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther 1995; 272:134-142.
82. Shabsigh R. The effects of testosterone on the cavernous tissue and erectile function. World J Urol 1997;15:21-26.
83. Shelly SD, Farah RN. Anatomy of erectile function. In: Carson CC, Kirby RS, Goldstein I, eds. Textbook of Erectile Dysfunction. Oxford: Isis Medical Media Ltd; 1999:25-30.
84. Simonsen U, Prielo D, Hernandez M, Saenz de Tejada I, Garcia-Sacristan A. Adrenoceptor-mediated regulation of the contractility in horse penile resistance arteries. J Vasc Res 1997a;34:90-102.
85. Simonsen U, Prieto D, Hernandez M, Saenz de Tejada I, Garcia-Sacristan A. Prejunctional alpha-2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries. J Urol 1997b;157:2356-2360.
86. Steers WD. Neural control of penile erection. Sem Urol 1990;8:66-79.
87. Stief CG, Noack T, Andersson K-E. Signal transduction in cavernous smooth muscle. World J Urol 1997;15:27-31.
88. Tong YC, Cheng JT. Subtyping of alpha-1-adrenoceplors responsible for the contractile response in the rat corpus cavernosum. Neurosci Lett 1997;228:159-162.
89. Traish A, Gupta S, Gallant C, Huang Y-H, Goldstein I. Phentolamine mesylate relaxes penile corpus cavernosum tissue by adrenergic and nonadrenergic mechanisms. Int J Impotence Res 1998;10:215-223.
90. Traish AM, Moreland RB, Huang Y-H, Goldstein I. Expression of functional alpha-2-adrenergic receptor subtypes in human corpus cavernosum and in human corpus cavernosum smooth muscle cells. Recept Signal Transduct 1997;7:55-67.
91. Traish AM, Netsuwan N, Daley J, Padman-Nathan P Goldstein I, Saenz de Tejada I. A heterogenous population of alpha-1-adrenergic receptors mediates contraction of human corpus cavernosum smooth muscle to norepinephrine. J Urol 1994;153:222-227.
92. Traish AM, Park K, Dhir V, Kim NN, Moreland RB, Goldstein I. Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology 1999;140:1861-1868.
93. Traish AM, Toselli P, Gupta S, Saenz de Tejada I, Goidstein I, Moreland RB. Identification of α-1-adrenergic receptor subtypes in human corpus cavernosum tissue and in cultured trabecular smooth muscle cells. Receptors 1995;5:145-157.
94. Vaidyanathan S, Soni BM, Singh G, Sett R, Krishnan KR. Prolonged penile erection association with terazosin in a cervical spinal cord injury patient. Spinal Cord 1998;36:805.
95. Veronneau-Longueville F, Rampin O, Jardin A, Benoit G, Giuliano F. Expression of α-1-adrenoceptor subtypes in the rat corpus cavernosum. Int J Impotence Res 1998;10:187-194.
96. Wiley MG, Andersson K-E. Orally active agents: the potential of alpha-adrenoceptor antagonists. In: Carson CC, Kirby RS, Goldstein I, eds. Textbook of Erectile Dysfunction. Oxford: Isis Medical Media Ltd; 1999:317-322.
97. Yildirim MK, Yildirim S, Utkan T, Sarioglu Y, Yalman Y. Effects of castration on adrenergic and nonadrenergic, noncholinergic responses of isolated corpus cavernosum from rabbit. Br J Urol 1997;79:964-970.
98. Zorgniotti AW. Experience with buccal phentolamine mesylate for impotence. Int J Impotence Res 1994;6:37-41.