메뉴 건너뛰기




Volumn 14, Issue 1, 2002, Pages 15-24

Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters

Author keywords

Alternative first exon; Isoform; PDE5A promoter; Penis; Smooth muscle; Transcription factor

Indexed keywords

CYCLIC AMP; CYCLIC GMP; MESSENGER RNA; PHOSPHODIESTERASE; PHOSPHODIESTERASE V; SILDENAFIL; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

EID: 0036189959     PISSN: 09559930     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijir.3900802     Document Type: Article
Times cited : (90)

References (30)
  • 2
    • 0032698819 scopus 로고    scopus 로고
    • Beta-adrenergic receptor agonists and cyclic nucleotide phosphodiesterase inhibitors: Shifting the focus from inotropy to cyclic adenosine monophosphate
    • (1999) J Am Coll Cardiol , vol.34 , pp. 318-324
    • Movsesian, M.A.1
  • 3
    • 0032445219 scopus 로고    scopus 로고
    • Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
    • (1998) J Urol , vol.159 , pp. 2164-2171
    • Ballard, S.A.1
  • 5
    • 0030154874 scopus 로고    scopus 로고
    • Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
    • (1996) Int J Impot Res , vol.8 , pp. 47-52
    • Boolell, M.1
  • 8
    • 0027486271 scopus 로고
    • The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone
    • (1993) J Biol Chem , vol.268 , pp. 22863-22873
    • McAllister-Lucas, L.M.1
  • 9
    • 0030725663 scopus 로고    scopus 로고
    • Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development
    • (1997) Eur J Biochem , vol.249 , pp. 434-442
    • Kotera, J.1
  • 11
    • 0032541484 scopus 로고    scopus 로고
    • Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase
    • (1998) Gene , vol.216 , pp. 139-147
    • Loughney, K.1
  • 12
    • 7344243173 scopus 로고    scopus 로고
    • Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene
    • (1998) Eur J Biochem , vol.255 , pp. 391-399
    • Yanaka, N.1
  • 16
    • 0025212744 scopus 로고
    • Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: Identification of a potential calcium-binding domain
    • (1990) Mol Cell Biol , vol.10 , pp. 1818-1821
    • Lin, C.-S.1    Aebersold, R.H.2    Leavitt, J.3
  • 17
  • 20
    • 0024546509 scopus 로고
    • The scanning model for translation: An update
    • (1989) J Cell Biol , vol.108 , pp. 229-241
    • Kozak, M.1
  • 22
    • 18344409972 scopus 로고    scopus 로고
    • Significance of the CAG repeat polymorphism of the androgen receptor gene in prostate cancer progression
    • (2000) J Urol , vol.164 , pp. 567-572
    • Nam, R.K.1
  • 23
    • 0034015831 scopus 로고    scopus 로고
    • The expansion of the CAG repeat in exon 1 of the human androgen receptor gene is associated with uterine endometrial carcinoma
    • (2000) Mol Carcinog , vol.27 , pp. 237-244
    • Sasaki, M.1
  • 24
    • 0034104253 scopus 로고    scopus 로고
    • Shorter CAG repeat length in the androgen receptor gene is associated with more aggressive forms of breast cancer
    • (2000) Breast Cancer Res Treat , vol.59 , pp. 153-161
    • Yu, H.1
  • 25
    • 0032795038 scopus 로고    scopus 로고
    • Polymorphic CAG repeats of the androgen receptor gene and rheumatoid arthritis
    • (1999) Ann Rheum Dis , vol.58 , pp. 500-502
    • Kawasaki, T.1
  • 26
    • 0035140015 scopus 로고    scopus 로고
    • Trinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: Molecular markers of risk for male infertility
    • (2001) Fertil Steril , vol.75 , pp. 275-281
    • Mifsud, A.1
  • 27
    • 0030614286 scopus 로고    scopus 로고
    • Etiology of (CAG)n triplet repeat neurodegenerative diseases such as Huntington’s disease is connected to stimulation of glutamate receptors
    • (1997) Med Hypotheses , vol.48 , pp. 393-398
    • Fischer, K.M.1
  • 28
    • 0030665303 scopus 로고    scopus 로고
    • Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene
    • (1997) Biochem J , vol.328 , pp. 539-548
    • Bolger, G.B.1
  • 30
    • 0031006428 scopus 로고    scopus 로고
    • Characterization of an intronic promoter of a cyclic adenosine 3′, 5′-monophosphate (cAMP)-specific phosphodiesterase gene that confers hormone and cAMP inducibility
    • (1997) Mol Endocrinol , vol.11 , pp. 839-850
    • Vicini, E.1    Conti, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.