Molecular mechanism of cGMP-mediated smooth muscle relaxation

Journal of Cellular Physiology

Volumn 184, Issue 3, 2000, Pages 409-420

  Carvajal, Jorge A ^a,b,c   Germain, Alfredo M ^b   Huidobro Toro, Juan Pablo ^b   Weiner, Carl P ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; ION CHANNEL; POTASSIUM; PROTEIN KINASE C;

ARTICLE; CELL MEMBRANE; ENZYME ACTIVITY; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SECOND MESSENGER; SMOOTH MUSCLE;

EID: 0033898257     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K     Document Type: Article

References (150)

1. Hemeoxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy
2. Atrial natriuretic factor receptors and signal transduction mechanisms
3. Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase. Involvement of a pertussis toxin-sensitive G protein
4. Effects of cGMP on calcium handling in ATP-stimulated rat resistance arteries
5. Angiotensin II-stimulated phospholipase C responses of two vascular smooth muscle-derived cell lines. Role of cyclic GMP
6. Effects of inhibitors of cGMP-dependent protein kinase in atrial heart and aortic smooth muscle from rats
7. Cyclic nucleotide-dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related protein
8. The small heat shock-related protein, HSP20, is phosphorylated on serine 16 during cyclic nucleotide-dependent relaxation
9. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
10. Comparative effects of exogenous nitrovasodilators on cGMP levels in different canine blood vessels
11. Pulmonary soluble guanylate cyclase, a nitric oxide receptor, is increased during the perinatal period
12. Diverse biological actions of atrial natriuretic peptide
13. Small heat shock proteins and vasospasm in human umbilical artery smooth muscle
14. The small heat shock-related protein-20 is an actin-associated protein
15. Regional expression of natriuretic peptide receptors during the formation of arterial neointima in the rabbit
16. Involvement of a nitric oxide-cyclic guanosine monophosphate pathway in control of human uterine contractility during pregnancy
17. Atrial natriuretic peptide suppresses the transcription of its guanylyl cyclase-linked receptor
18. Modulation of calcium movements by nitroprusside in isolated vascular smooth muscle cells
19. Corticotropin-releasing hormone-induced vasodilatation in the human fetal-placental circulation: Involvement of the nitric oxide-cyclic guanosine 3',5'-monophosphate-mediated pathway
20. The molecular biology of cyclic nucleotide phosphodiesterases
21. Regulation of sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in vascular smooth muscle cells
22. Characterization of a novel potent and specific inhibitor of type V phosphodiesterase
23. 2+](i), and arterial smooth muscle relaxation
24. Vascular smooth muscle cell heme oxygenases generate guanylyl cyclasestimulatory carbon monoxide
25. Activation by autophosphorylation or cGMP binding produces a similar apparent conformational change in cGMP-dependent protein kinase
26. Localization of atrial natriuretic factor receptors in the mesenteric arterial bed. Comparison with angiotensin II and endothelin receptors
27. Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma?
28. Characterization and distribution of natriuretic peptide receptors in the rat uterus
29. Expression of cGMP-dependent protein kinase I and phosphorylation of its substrate, vasodilator-stimulated phosphoprotein, in human endothelial cells of different origin
30. Neuromodulatory effects of atrial natriuretic factor are independent of guanylate cyclase in adrenergic neuronal pheochromocytoma cells
31. Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase
32. Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea
33. - transport by heat-stable enterotoxin: Activation of cAMP-dependent protein kinase by cGMP
34. Mechanisms of regulation and functions of guanylyl cyclases
35. Structure and function of cyclic nucleotide-dependent protein kinases
36. Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase
37. 2+ pump by cyclic nucleotides in cultured vascular smooth muscle cells
38. BNP: Pathophysiological and potential therapeutic roles in acute congestive heart failure
39. Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic-3',5'-guanosine monophosphate-stimulated phosphodiesterase to reverse hypoxic pulmonary vasoconstriction in the perfused rat lung
40. Evidence that spontaneous contractile activity in the rat myometrium is not inhibited by NO-mediated increases in tissue levels of cyclic GMP
41. Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells
42. Mechanisms of smooth muscle contraction
43. HSP27 in signal transduction and association with contractile proteins in smooth muscle cells
44. C-type natriuretic peptide in chronic renal failure and its action in humans
45. A beta-adrenoceptor agonist evokes a nitric oxide-cGMP relaxation mechanism modulated by adenylyl cyclase in rat aorta
46. Endothelial-dependent vasodilation is associated with increases in the phosphorylation of a small heat shock protein (HSP20)
47. Airways of a hyperresponsive rat strain show decreased relaxant responses to sodium nitroprusside
48. Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries
49. Neuromodulatory effect of the atrial natrinretic factor clearance receptor binding peptide, cANF(4-23)-NH2 in rabbit isolated vasa deferentia
50. Decreased sensitivity to vasoconstrictors in aortic rings after acute exposure to nitric oxide
51. Modulation of nitric oxide-dependent relaxation of pig tracheal smooth muscle by inhibitors of guanylyl cyclase and calcium activated potassium channels
52. Phosphorylation of phospholamban correlates with relaxation of coronary artery induced by nitric oxide, adenosine, and prostacyclin in the pig
53. Nitric oxide and nitrovasodilators: Similarities, differences, and interactions
54. 2+ sensitization in triton X-100-demembranated rabbit arterial smooth muscle
55. Changes in cyclic adenosine monophosphate-phosphodiesterase activity in nonpregnant and pregnant human myometrium
56. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)
57. Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase
58. Phosphorylation of the inositol 1,4,5-trisphosphate receptor. Cyclic GMP-dependent protein kinase mediates cAMP and cGMP dependent phosphorylation in the intact rat aorta
59. Regulation of secretion and clearance of C-type natriuretic peptide in the interaction of vascular endothelial cells and smooth muscle cells
60. Regulation of endothelial production of C-type natriuretic peptide in coculture with vascular smooth muscle cells. Role of the vascular natriuretic peptide system in vascular growth inhibition
61. Cyclic GMP-independent effects of nitric oxide on guinea-pig uterine contractility
62. Expression of guanylyl cyclase-A/atrial natriuretic peptide receptor blocks the activation of protein kinase C in vascular smooth muscle cells. Role of cGMP and cGMP-dependent protein kinase
63. Phosphorylation of cGMP-dependent protein kinase increases the affinity for cyclic AMP
64. 2+ desensitization in vascular smooth muscle by activating the myosin light chain phosphatase
65. Cyclic 3':5'-nucleotide phosphodiesterase in human myometrium at the end of pregnancy: Partial purification and characterization of the different soluble isoenzymes
66. Effect of pregnancy on PDE4 cAMP-specific phosphodiesterase messenger ribonucleic acid expression in human myometrium
67. Intracellular cyclic GMP receptor proteins
68. 2+ by cAMP in vascular smooth muscle cells
69. Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase
70. Receptors of atrial natriuretic factor
71. Role of atrial natriuretic factor in volume control
72. The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
73. Effects of atrial natriuretic peptide and 8-brom cyclic guanosine monophosphate on human tracheal smooth muscle
74. Isoenzymes of cyclic nucleotide phosphodiesterase in the human aorta: Characterization and the effects of E4021
75. Nitric oxide: Physiology, pathophysiology, and pharmacology
76. Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide
77. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP
78. Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells
79. cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase
80. Activation of protein kinase C is required for oxytocin-induced contractility in human pregnant myometrium
81. What are the molecular mechanisms for the antiproliferative effects of nitric oxide and cGMP in vascular smooth muscle?
82. Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassembly
83. Identification of the G protein-activating domain of the natriuretic peptide clearance receptor (NPR-C)
84. Excitatory response of rabbit myometrium to nitric oxide in vitro
85. Effects of cGMP and the nitric oxide donors glyceryl trinitrate and sodium nitroprusside on contractions in vitro of isolated myometrial tissue from pregnant women
86. Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation
87. The effect of 1H-[1,2,4]oxadiazolo[4,3-alquinoxalin-1-one (ODQ) and charybdotoxin (CTX) on relaxations of isolated cerebral arteries to nitric oxide
88. Regulation of vascular smooth muscle soluble guanylate cyclase activity, mRNA, and protein levels by cAMP-elevating agents
89. cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue
90. Regulation of Ca(2+)-activated K+ channels in pulmonary vascular smooth muscle cells: Role of nitric oxide
91. Cyclic GMP-dependent protein kinase blocks pertussis toxin-sensitive hormone receptor signaling pathways in Chinese hamster ovary cells
92. Defective smooth muscle regulation in cGMP kinase I-deficient mice
93. Evidence that potassium channels make a major contribution to SIN-1-evoked relaxation of rat isolated mesenteric artery
94. Endothelin-1 modulates cyclic GMP production and relaxation in human pulmonary vessels
95. Voltage-gated calcium channel currents in human coronary myocytes. Regulation by cyclic GMP and nitric oxide
96. Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle
97. Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta
98. 2+-ATPase by cGMP-dependent protein kinase
99. Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases
100. Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation
101. Atrial natriuretic factor and related peptide hormones
102. 2+ sensitisation by myosin phosphatase inhibition
103. 2+ channels by cyclic nucleotide cross activation of opposing protein kinases in rabbit portal vein
104. Induction of guinea pig airway hyperresponsiveness by inactivation of guanylate cyclase
105. A selective type V phosphodiesterase inhibitor, E4021, dilates porcine large coronary artery
106. Atrial natriuretic peptide and hemodynamic changes during normal human pregnancy
107. Potentiating effect of nicorandil, an antianginal agent, on relaxation induced by isoproterenol in isolated rat aorta: Involvement of cyclic GMP-inhibitable cyclic AMP phosphodiesterase
108. Paracrine function of endothelium-derived nitric oxide
109. C-type natriuretic peptide and brain natriuretic peptide inhibit adenylyl cyclase activity: Interaction with ANF-R2/ANP-C receptors
110. Cardiovascular activity of WIN 65579, a novel inhibitor of cyclic GMP phosphodiesterase 5
111. The role of cGMP in the relaxation to nitric oxide donors in airway smooth muscle
112. C-type natriuretic peptide (CNP): A new member of natriuretic peptide family identified in porcine brain
113. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide
114. Both soluble guanylate cyclase and particulate guanylate cyclase regulate myometrial contractility
115. cDNA cloning and gene expression of human type I alpha cGMP-dependent protein kinase
116. Involvement of maxi-K(Ca) channel activation in atrial natriuretic peptide-induced vasorelaxation
117. C-natriuretic peptide but not atrial natriuretic peptide increases cyclic GMP in cerebral arterial smooth muscle cells
118. 2+ channel availability in basilar artery smooth muscle cells
119. The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide
120. Enhancement of smooth muscle contraction with protein phosphatase inhibitor 1: Activation of inhibitor 1 by cGMP-dependent protein kinase
121. Beta-adrenoceptors, cAMP and airway smooth muscle relaxation: Challenges to the dogma
122. Cyclic nucleotide-dependent protein kinases in airway smooth muscle
123. Atrial natriuretic factor alters neurotransmission independently of guanylate cyclase-coupled receptors in the rabbit vas deferens
124. C-type natriuretic peptide neuromodulates via 'clearance' receptors
125. Effects of chronic oral administration of levcromakalim on in vitro contractile responses of arterial smooth muscle
126. Insulin increases cyclic nucleotide content in human vascular smooth muscle cells: A mechanism potentially involved in insulin-induced modulation of vascular tone
127. Studies on the influence of insulin on cyclic adenosine monophosphate in human vascular smooth muscle cells: Dependence on cyclic guanosine monophosphate and modulation of catecholamine effects
128. Porcine detrusor cyclic nucleotide phosphodiesterase isoenzymes: Characterization and functional effects of various phosphodiesterase inhibitors in vitro
129. Signalling by cGMP-dependent protein kinases
130. Myosin light chain kinase phosphorylation in nitrovasodilator induced swine carotid artery relaxation
131. Phosphorylation of aorta caldesmon by endogenous proteolytic fragments of protein kinase C
132. 2+ pump of smooth muscle via phosphorylation of phosphatidylinositol
133. Smooth muscle protein kinase C
134. Carbon monoxide-induced vasorelaxation and the underlying mechanisms
135. The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells
136. Evidence for the involvement of cGMP in neural bronchodilator responses in humal trachea
137. Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism
138. Differential relaxant responses of guinea-pig lung strips and bronchial rings to sodium nitroprusside: A mechanism independent of cGMP formation
139. Phosphorylation events associated with cyclic nucleotide-dependent inhibition of smooth muscle contraction
140. Regulation of cGMP-induced relaxation and cGMP-dependent protein kinase in rat myometrium during pregnancy
141. Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphate
142. ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells
143. + channels in porcine tracheal smooth muscle cells
144. 2+ pump AT-Pase of vascular smooth muscle via phosphorylation of a 240-kDa protein
145. Vascular action of circulating and local natriuretic peptide systems is potentiated in obese/hyperglycemic and hypertensive rats
146. Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor
147. cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway
148. + currents by cGMP-dependent protein kinase in tracheal smooth muscle and Chinese hamster ovary cells
149. Regulation of stably expressed and native BK channels from human myometrium by cGMP- and cAMP-dependent protein kinase
150. Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus