Vasoconstriction, RhoA/Rho-kinase and the erectile response

International Journal of Impotence Research

Volumn 15, Issue , 2003, Pages S20-S24

  Mills, T M ^a   Lewis, R W ^a   Wingard, C J ^a   Linder, A E ^a   Jin, L ^a   Webb, R C ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Nitric oxide; Penile erection; Rho kinase

Indexed keywords

NITRIC OXIDE; RHO KINASE;

ARTERIOLE; BLOOD FLOW; CONFERENCE PAPER; CORPUS CAVERNOSUM; HUMAN; MALE; PENIS ERECTION; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; VASOCONSTRICTION; VASODILATATION;

HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MUSCLE, SMOOTH; PENILE ERECTION; PENIS; PROTEIN-SERINE-THREONINE KINASES; RHOA GTP-BINDING PROTEIN; VASOCONSTRICTION;

EID: 0142153250     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901068     Document Type: Article

References (30)

1. Mills TM et al. Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation. J Appl Physiol 2001; 91: 1269-1273.
2. Mills TM, Chitaley K, Lewis R. Vasoconstrictors in erectile physiology. Int J Impot Res 2001; 13: S29-S34.
3. Rees RW et al. Human and rabbit cavernosal smooth muscle cells express Rho-kinase. Int J Impot Res 2002; 14: 1-7.
4. Rees RW et al. Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum. Rr JPharmacol 2001; 133: 455-458.
5. Chitaley K, Webb RC, Mills TM. RhoA/Rho-kinase: a novel player in the regulation of penile erection. Int J Impot Res 2001; 13: 67-72.
6. Andersson KE. Pharmacology of erectile function and dysfunction. Urol Clin NA 2001; 28: 233-247.
7. Andersson KE. Pharmacology of penile erection. Pharmacol Rev 2001; 53: 417-450.
8. Andersson KE. Neurophysiology/pharmacology of erection. Int J Impot Res 2001; 13: S8-S17.
9. Naylor AM. Endogenous neurotransmitters mediating penile erection. Br J Urol 1998; 81: 424-431.
10. Redmond EM et al. Regulation of endothelin receptors by nitric oxide in cultured rat vascular smooth muscle cells. J Cell Physiol 1996; 166: 469-479.
11. Traish A, Kim NN, Moreland RB, Goldstein I. Role of alpha adrenergic receptors in erectile function. Int J Impot Res 2000; 12: S48-S63.
12. Dai Y et al. Receptor-specific influence of endothelin-1 in the erectile response of the rat. Am J Physiol 2000; 279: R25-R30.
13. Pollock DM, Tasker AS. In: Pollock DM, Highsmith RF (eds). Endothelin Receptors and Receptor Antagonists, Endothelin Receptors and Signaling Mechanisms. Springer: Berlin, Heidelberg, New York, 1998, pp 3-15
14. Somlyo AP, Wu X, Walker LA, Somlyo AV. Pharmacomecha-nical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Riochem Pharmacol 1999; 134: 201-234.
15. DeFeo T, Morgan K. Calcium-force relationships as detected with Aequorin in two different vascular smooth muscles of the ferret. J Physiol 1985; 369: 269-292.
16. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000; 522 (Part 2): 177-185.
17. Stief CG, Noack T, Andersson KE. Signal transduction in cavernous smooth muscle. World J Urol 1997; 15: 27-31.
18. Burnett AL. The role of nitric oxide in the physiology of erection (A Minireview). Riol Reprod 1995; 52: 485-489.
19. Sauzeau V et al. Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2 + sensitization of contraction in vascular smooth muscle. J Riol Chem 2000; 275: 21722-21729.
20. de Tejada IS. Molecular mechanisms for the regulation of penile smooth muscle. Int J Impot Res 2002; 14: S6-S10.
21. 2+ sensitization in erectile function. J Riol Chem 2003; 277: 30614-30621.
22. Chitaley K et al Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med 2001; 7: 119-122.
23. Mills T et al. Endothelin-1 induced vasoconstriction is inhibited during erection in rats. Am J Physiol 2001; 281: R476-R483.
24. Wingard C, Lewis RW, Mills TM. Erection and NO override the vasoconstrictor effect of alpha adrenergic stimulation in the rat penile vasculature. Int J Impot Res 2001; 13: 212-220.
25. Chang S et al. Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta. Int J Impot Res 2003; 15: 53-62.
26. Park JK et al. Role of Rho-kinase activity in angiotensin II-mediated contraction of rabbit clitoral cavernosum smooth muscle. Int J Impot Res 2003; 14: 472-477.
27. Chitaley K et al. Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats. Riochem Riophys Res Comm 2002; 298: 427-432.
28. Reilly CM, Stopper VS, Mills TM. Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum. J Androl 1997; 18: 26-31.
29. Chitaley K, Weber D, Webb RC. RhoA/Rho-kinase, vascular changes, and hypertension. Curr Hyperten Rep 2001; 3: 139-144.
30. Mills TM, Chitaley K, Lewis RW, Webb RC. Nitric oxide inhibits RhoA/Rho-kinase signaling to cause erection. Eur J Pharmacol 2002; 439: 173-174.