Repeated PGE1 treatment enhances nitric oxide and erection responses to nerve stimulation in the rat penis by upregulating constitutive NOS isoforms

Journal of Urology

Volumn 162, Issue 6, 1999, Pages 2205-2210

  Escrig, Ana ^a   Marin, Raquel ^a   Mas, Manuel ^a,b  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Nitric oxide; Nitric oxide synthase; Penile erection; Prostaglandin E1

Indexed keywords

ISOENZYME; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DOSE RESPONSE; ELECTROSTIMULATION; ENZYME INDUCTION; INTRACAVERNOUS DRUG ADMINISTRATION; MALE; NERVE CELL STIMULATION; NONHUMAN; PENIS ERECTION; PRESSURE; PRIORITY JOURNAL; RAT; TISSUE LEVEL;

EID: 0032729322     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)68160-8     Document Type: Article

References (27)

1. Porst, H.: The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience. J. Urol., 155: 802, 1996.
2. Linet, O. I. and Ogrin, F. G.: Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. New England J. Med., 334: 873, 1996.
3. Willke, R. J., Glick, H. A., McCarron, T. J., Erder, M. H., Althop, S. E. and Linet, O. I.: Quality of life effects of alprostadil therapy for erectile dysfunction. J. Urol., 157: 2124, 1997.
4. Kim, N., Azadozoi, K. M., Goldstein, I. and Saenz de Tejada, I.: A nitric oxide-like factor mediates nonadrenergic noncholinergic neurogenic relaxation of penile smooth muscle. J. Clin. Invest., 88: 112, 1991.
5. Burnett, A. L.: Nitric oxide in the penis: physiology and pathology. J. Urol., 157: 320, 1997.
6. Andersson, K-E. and Wagner, G.: Physiology of penile erection. Physiol. Rev., 75: 191, 1995.
7. Hung, A., Vernet, D., Rajavashisth, T., Rodriguez, J. A., Rajfer, J. and González-Cadavid, N. F.: Expression of inducible nitric oxide synthase in smooth muscle cells from rat penile corpora cavernosa. J. Androl., 16: 469, 1995.
8. Schörr, K.: Erectile dysfunction-Vasomotor actions of PGE1, its metabolites and other prostaglandins. In: Advances in Prostaglandin, Thromboxane and Leukotriene Research, Vol 23, Samuelsson et al (eds). New York: Raven Press, pp. 533-538, 1995.
9. Molderings, G. J., van Ahlen, H. and Göthert, M.: Modulation of noradrenaline release in human corpus cavernosum by presynaptic prostaglandin receptors. Int. J. Impotence Res., 4:19, 1992.
10. Escrig A., Gonzalez-Mora, J. L. and Mas, M.: Nitric oxide release in penile corpora cavernosa in a rat model of erection J. Physiol. (London), 516: 261, 1999.
11. Thomas, J. O. and Kornberg, R. D.: An octamer of histones in chromatin and free in solution. Proc. Natl. Acad. Sci. USA, 72: 2626, 1975.
12. Johnson, D. A., Gautsch, J. W., Sportsman, J. R. and Elder, J. H.: Improved technique utilizing nonfat dry milk for analysis of proteins and nucleic acids transferred to nitrocellulose. Gene Anal. Technol., 1: 3, 1984.
13. Marin, R., Escrig, A., Abreu, P. and Mas, M.: Androgen-dependent nitric oxide release in rat penis correlates with levels of constitutive nitric oxide synthase isoenzymes. Biol. Reprod., 1999 (in press).
14. Chen, K. K., Chan, J. Y. H., Chang, L. S., Chen, M-T. and Chan, S. H. H.: Intracavernous presssure as an experimental index in a rat model for the evaluation of penile erection. J. Urol., 147: 1124, 1992.
15. Zhao, W., Rehman, J., Melman, A. and Christ, G. J.: Functional evidence for the presence of a physiologically relevant cyclic AMP pathway in the apparent absence of an EP receptor subtype in rat corpus cavernosum in vivo. J. Urol. (Suppl.), 159: 101, abstract 387, 1998.
16. Miller, M. A. W., Morgan, R. J., Thompson, C. S., Mikhailidis, D. P. and Jeremy, J. Y.: Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: an in vitro study. Brit. J. Urol., 74: 106, 1994.
17. Koller, A., Sun, D., Messina, E. J. and Kaley, G.: L-Arginine analogues blunt prostaglandin-related dilation of arterioles. Am. J. Physiol., 264: H1194, 1993.
18. Kimura, T., Yoshida, Y. and Toda, N.: Mechanisms of relaxation induced by prostaglandins in isolates canine uterine arteries. Am. J. Obstet. Gynecol., 167: 1409, 1992.
19. Dail, W. G., Barba, V., Leyba, L and Galindo, R.: Neural and endothelial nitric oxide synthase activity in rat penile erectile tissue. Cell Tissue Res., 282: 109, 1995.
20. Bloch, W., Klotz, T., Sedlaczec, P., Zumbé, J., Engelmann, U. and Addicks, K.: Evidence for the involvement of endothelial nitric oxide synthase from smooth muscle cells in the erectile function of the human corpus cavernosum. Urol. Res., 26: 129, 1998.
21. Garbán, H., Marquez, D., Magee, T., Moody, J., Rajavashisth, T., Rodriguez, J. A., Hung, A., Vernet, D., Rajfer, J. and González-Cadavid, N. F.: Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction. Biol. Reprod., 56: 954, 1997.
22. Nathan, C. and Xie, Q.: Regulation of biosynthesis of nitric oxide. J. Biol. Chem., 269: 13725, 1994.
23. Reilly, C. M., Zamorano, P., Stopper, V. S. and Mills, T. M.: Androgenic regulation of NO availability in rat penile erection. J. Androl., 18: 110, 1997.
24. Chamness, S. L., Ricker, D. D., Crone, J. K., Dembeck, C. L., Maguire, M. P., Burnett, A. L. and Chang, T. S.: The effect of androgen on NOS in the male reproductive tract of the rat. Fertil. Steril., 63: 1101, 1995.
25. Nishida, K., Harrison, D. G., Navas, J. P., Fisher, A., Dockery, S. P., Uematsu, M., Neren, R. M., Alexander, R. W. and Murphy, T. J.: Molecular cloning and characterization of constitutive bovine aortic endothelial cell nitric oxide synthase. J. Clin. Invest., 90: 2092, 1992.
26. Trigo-Rocha, F., Donatucci, C. F., Hsu, G. L., Nunes, L., Lue, T. F. and Tanagho, E. A.: The effect of intracavernous injection of potassium channel openers in monkeys and dogs. Int. J. Impot. Res., 7: 41, 1995.
27. Sharlip, I. D.: Does natural erectile function improve following intracavernous injections of vasoactive drugs? Int. J. Impotence Res., 9: 193, 1997.