A quantitative model of cellular senescence influence on cancer and longevity

Toxicology and Industrial Health

Volumn 18, Issue 8, 2002, Pages 365-376

  Pompei, Francesco ^a   Wilson, Richard ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

cancer; dietary restriction; longevity; melatonin; p53; senescence

Indexed keywords

ENVIRONMENTAL CHEMICAL; MELATONIN; PROTEIN P53;

AGING; ANIMAL MODEL; ARTICLE; CANCER; CARCINOGENESIS; CELL COUNT; CONTROLLED STUDY; DIET RESTRICTION; DISEASE ASSOCIATION; DOSE RESPONSE; EXPERIMENTAL MODEL; FEMALE; GENE MUTATION; LIFESPAN; LONGEVITY; MOUSE; NONHUMAN; PREDICTION; QUANTITATIVE ANALYSIS; SENESCENCE;

AGING; ANIMALS; ANTIOXIDANTS; CELL AGING; FEMALE; GENES, P53; LONGEVITY; MELATONIN; MICE; MODELS, STATISTICAL; MUTATION; NEOPLASMS;

ANIMALIA;

EID: 1942502247     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1191/0748233702th164oa     Document Type: Article

References (60)

1. Anisimov, V. N., Zavarzina, N. Y., Zabezhinski, M. A., Popovich, I. G., Zimina, O. A., Shtylick, A. V., Arutjunyan, A. V., Oparina, T. I., Prokopenko, V. M., Mikhalski, A. I. and Yashin, A. I. 2001: Melatonin increases both life span and tumor incidence in female CBA mice. The Journals of Gerontology. Series A. Biological Sciences and Medical Sciences 56, B311-B323.
2. Anisimov, V. N. 2001: Life span extension and cancer risk: myths and reality. Experimental Gerontology 36, 1101-1136.
3. Armitage, P. and Doll, R. 1954: The age distribution of cancer and a multistage theory of carcinogenesis. British Journal of Cancer 8, 1-1.
4. Armstrong, S. M. and Redman, J. R. 1991: Melatonin: a chronobiotic with anti-aging properties? Medical Hypotheses. 34, 300-309.
5. Bargonetti, J. and Manfredi, J. J. 2002: Multiple roles of the tumor suppressor p53. Current Opinion in Oncology 14, 86-91.
6. Beckman, K. B. and Ames, B. N. 1998: The free radical theory of aging matures. Physiological Reviews 78, 547-581.
7. Blagosklonny, M. V. 2002: P53: an ubiquitous target of anticancer drugs. International Journal of Cancer 98, 161-166.
8. Campisi, J., Dimri, G. P., Nehlin, J. O., Testori, A. and Yoshimoto, K. 1996: Coming of age in culture. Experimental Gerontology 31, 7-12.
9. Campisi, J. 1997: The biology of replicative senescence. European Journal of Cancer 33, 703-709.
10. Campisi, J. 2000: Cancer, aging and cellular senescence. In Vivo 14, 183-188.
11. Campisi, J. 2001: From cells to organisms: can we learn about aging from cells in culture? Experimental Gerontology 36, 607-618.
12. Campisi, J., Kim, S. H., Lim, C. S. and Rubio, M. 2001: Cellular senescence, cancer and aging: the telomere connection. Experimental Gerontology 36, 1619-1637.
13. Cristofalo, V. J. and Sharf, B. B. 1973: Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells. Experimental Cell Research 76, 419-427.
14. Cristofalo, V. J., Allen, R. G., Pignolo, R. J., Martin, B. G. and Beck, J. C. 1998: Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. Proceedings of the National Academy of Sciences of the United States of America 95, 10614-10619.
15. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira-Smith, O. et al. 1995: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proceedings of the National Academy of Sciences of the United States of America 92, 9363-9367.
16. Duncan, E. L., Wadhwa, R. and Kaul, S. C. 2000: Senescence and immortalization of human cells. Biogerontology 1, 103-121.
17. Faragher, R. G. 2000: Cell senescence and human aging: where's the link? Biochemical Society Transactions 28, 221-226.
18. Ferbeyre, G. and Lowe, S. W. 2002: The price of tumour suppression? Nature 415, 26-27.
19. Fernandes, G., Yunis, E. J. and Good, R. A. 1976: Influence of diet on survival of mice. Proceedings of the National Academy of Sciences of the United States of America 73, 1279-1283.
20. Greenberg, J. A. 1999: Organ metabolic rates and aging: two hypotheses. Medical Hypotheses 52, 15-22.
21. Hansen, B. C., Bodkin, N. L. and Ortmeyer, H. K. 1999: Calorie restriction in nonhuman primates: mechanisms of reduced morbidity and mortality. Toxicological Sciences 52, 56-60.
22. Hart, R. W. and Setlow, R. B. 1976: DNA repair in late-passage human cells. Mechanisms of Ageing and Development 5, 67-77.
23. Hart, R. W., Dixit, R., Seng, J., Turturro, A., Leakey, J. E., Feuers, R., Duffy, P., Buffington, C., Cowan, G., Lewis, S., Pipkin, J. and Li, S. Y. 1999: Adaptive role of caloric intake on the degenerative disease processes. Toxicological Sciences 52, 3-12.
24. Haseman, J. K. 1991: Value of historical controls in the interpretation of rodent tumor data. Drug Information Journal 26, 199-200.
25. Hass, B. S., Hart, R. W., Gaylor, D. W., Poirier, L. A. and Lyn-Cook, B. D. 1992: An in vitro pancreas acinar cell model for testing the modulating effects of caloric restriction and ageing on cellular proliferation and transformation. Carcinogenesis 13, 2419-2425.
26. Hayflick, L., 1965: The limited in vitro lifetime of human diploid cell strains. Experimental Cell Research 37, 614-636.
27. Hayflick, L., Moorhead, P. S., 1961: The serial cultivation of human diploid cell strains. Experimental Cell Research 25, 585-621.
28. Jennings, B. J., Ozanne, S. E. and Hales, C. N. 2000: Nutrition, oxidative damage, telomere shortening, and cellular senescence: individual or connected agents of aging? Molecular Genetics and Metabolism 71, 32-42.
29. Kodell, R. L., Farmer, J. H., Littlefield, N. A. and Frith, C. H. 1980: Analysis of life-shortening effects in female BALB/C mice fed 2-acetylaminofluorene. Journal of Environmental Pathology and Toxicology 3, 69-87.
30. Leung, J. K. and Pereira-Smith, O. M. 2001: Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing. Novartis Foundation Symposium 235, 105-110; discussion 110-5; 146-9.
31. Liao, K. H., Gustafson, D. L., Fox, M. H., Chubb, L. S., Reardon, K. F. and Yang, R. S. 2001: A biologically based model of growth and senescence of Syrian hamster embryo (SHE) cells after exposure to arsenic. Environ-ironmental Health Perspectives 109, 1207-1213.
32. Masoro, E. J., Yu, B. P. and Bertrand, H. A. 1982: Action of food restriction in delaying the aging process. Proceedings of the National Academy of Sciences of the United States of America 79, 4239-4241.
33. Moolgavkar, S., Krewski, D. and Schwartz, M. 1999: Mechanisms of carcinogenesis and biologically based models for estimation and prediction of risk. IARC Scientific Publications No. 131, Lyon, France: International Agency for Research on Cancer.
34. Moolgavkar, S. H. and Knudsen, A. G. 1981: Mutation and cancer: a model for human carcinogenesis. Journal of the National Cancer Institute 66-66.
35. Moolgavkar, S. H. 1978: The multistage theory of carcinogenesis and the age distribution of cancer in man. Journal of the National Cancer Institute 61, 49-52.
36. Paradis, V., Youssef, N., Dargere, D., Ba, N., Bonvoust, F., Deschatrette, J. and Bedossa, P. 2001: Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Human Pathology 32, 327-332.
37. Pierpaoli, W. and Regelson, W. 1994: Pineal control of aging: effect of melatonin and pineal grafting on aging mice. Proceedings of the National Academy of Sciences of the United States of America 91, 787-791.
38. Pompei, F. and Wilson, R. 2001a: Age distribution of cancer: the incidence turnover at old age. Human and Ecological Risk Assessment 7, 1619-1650.
39. Pompei, F. and Wilson, R. 2001b: Response to outliving the risk for cancer: novel hypothesis or wishful thinking? Human and Ecological Risk Assessment 7, 1659-1662.
40. Pompei, F., Polkanov, M. and Wilson, R. 2001: Age distribution of cancer in mice: the incidence turnover at old age. Toxicology and Industrial Health 17, 7-16.
41. Potter, J. D. 1997: beta-Carotene and the role of intervention studies. Cancer Letters 114, 329-331.
42. Ran, Q. and Pereira-Smith, O. M. 2000: Genetic approaches to the study of replicative senescence. Experimental Gerontology 35, 7-13.
43. Reddel, R. R. 1998: A reassessment of the telomere hypothesis of senescence. Bioessays 20, 977-984.
44. Reiter, R. J. 1999: Oxidative damage to nuclear DNA: amelioration by melatonin. NEL Review. Neuroendocrinology Letters 20, 145-150.
45. Roth, G. S., Ingram, D. K. and Lane, M. A. 2001: Caloric restriction in primates and relevance to humans. Annals of the New York Academy of Sciences 928, 305-315.
46. Rubelj, I. and Vondracek, Z. 1999: Stochastic mechanism of cellular aging-abrupt telomere shortening as a model for stochastic nature of cellular aging. Journal of Theoretical Biology 197, 425-438.
47. Rubelj, I., Huzak, M. and Brdar, B. 2000: Sudden senescence syndrome plays a major role in cell culture proliferation. Mechanisms of Ageing and Development 112, 233-241.
48. Ruiz-Torres, A., Gimeno, A., Melon, J., Mendez, L., Munoz, F. J. and Macia, M. 1999: Age-related loss of proliferative activity of human vascular smooth muscle cells in culture. Mechanisms of Ageing and Development 110, 49-55.
49. Sager, R. 1991: Senescence as a mode of tumor suppression. Environmental Health Perspectives 93, 59-62.
50. Seilkop, S. K. 1995: The effect of body weight on tumor incidence and carcinogenicity testing in B6C3F1 mice and F344 rats. Fundamental and Applied Toxicology 24, 247-259.
51. Sheldon, W. G., Bucci, T. J., Hart, R. W. and Turturro, A. 1995: Age-related neoplasia in a lifetime study of ad libitum-fed and food-restricted B6C3F1 mice. Toxicologic Pathology 23, 458-476.
52. Suzuki, K., Mori, I., Nakayama, Y., Miyakoda, M., Kodama, S. and Watanabe, M. 2001: Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening. Radiation Research 155, 248-253.
53. Thomas, E., al-Baker, E., Dropcova, S., Denyer, S., Ostad, N., Lloyd, A., Kill, I. R. and Faragher, R. G. 1997: Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells. Experimental Cell Research 236, 355-358.
54. Toussaint, O., Medrano, E. E. and von Zglinicki, T. 2000: Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Experimental Gerontology 35, 927-945.
55. Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., Hee Park, S., Thompson, T., Karsenty, G., Bradley, A. and Donehower, L. A. 2002: p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53.
56. Venkatachalam, S., Shi, Y. P., Jones, S. N., Vogel, H., Bradley, A., Pinkel, D. and Donehower, L. A. 1998: Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. The EMBO Journal 17, 4657-4667.
57. Weindruch, R. and Walford, R. L. 1982: Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 215, 1415-1418.
58. Weindruch, R., Walford, R. L., Fligiel, S. and Guthrie, D. 1986: The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. The Journal of Nutrition 116, 641-654.
59. Wynford-Thomas, D. 1999: Cellular senescence and cancer. The Journal of Pathology 187, 100-111.
60. Yang, L., Suwa, T., Wright, W. E., Shay, J. W. and Hornsby, P. J. 2001: Telomere shortening and decline in replicative potential as a function of donor age in human adreno-cortical cells. Mechanisms of Ageing and Development 122, 1685-1694.