Neuroprotection by cAMP: Another brick in the wall

Advances in Experimental Medicine and Biology

Volumn 557, Issue , 2005, Pages 164-176

  Silveira, Mariana S ^a   Linden, Rafael ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR STIMULATING AGENT; FORSKOLIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NEUROTROPHIN; PROTEIN BCL 2; UROCORTIN; ZAPRINAST;

APOPTOSIS; CELL DEATH; CHROMATIN; CYTOPLASM; DRUG INHIBITION; HIPPOCAMPUS; HUMAN; MITOCHONDRION; MOLECULAR INTERACTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANIMALS; CELL DEATH; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; NEUROPROTECTIVE AGENTS; SIGNAL TRANSDUCTION;

EID: 33744737215     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (109)

1. Lockshin RA, Zakeri Z. Programmed cell death and apoptosis: origins of the theory. Nat Rev Mol Cell Biol 2001; 2(7):545-550.
2. Uren AG, Vaux DL. Molecular and clinical aspects of apoptosis. Pharmacol Ther 1996; 72(1):37-50.
3. Gibson RM. Does apoptosis have a role in neurodegeneration? Brit Med J 2001; 322(7301):1539-1540.
4. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000; 1(2):120-129.
5. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001; 411(6835):342-348.
6. Aguayo AJ, Clarke DB, Jelsma TN et al. Effects of neurotrophins on the survival and regrowth of injured retinal neurons. Ciba Found Symp 1996; 196:135-144.
7. Bjorklund A. Cell replacement strategies for neurodegenerative disorders. Novartis Found Symp 2000; 231:7-15.
8. Rossi F, Cattaneo E. Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci 2002; 3(5):401-409.
9. Raff, MC. Social controls on cell survival and cell death. Nature 1992; 356(6368):397-400.
10. Robinson GA, Butcher RW, Sutherland EW. Cyclic AMP. Annu Rev Biochem 1968; 37:149-174.
11. McKnight GS. Cyclic AMP second messenger systems. Curr Opin Cell Biol 1991; 3(2):213-217.
12. Selbie LA, Hill SJ. G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends Pharmacol Sci 1998; 19(3):87-93.
13. Hanoune J, Defer N. Regulation and role of adenylyl cyclase isoforms. Annu Rev Pharmacol Toxicol 2001; 41:145-174.
14. Mehats C, Andersen CB, Filopanti M et al. Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling. Trends Endocrinol Metab 2002; 13(1):29-35.
15. Walsh DA, Van Patten SM. Multiple pathway signal transduction by the cAMP-dependent protein kinase. FASEB J 1994; 8(15):1227-136.
16. Clarke PGH. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl) 1990; 181(3):195-213.
17. Dunn WA, Jr. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J Cell Biol 1990; 110: 1923-1933.
18. Dunn WA, Jr. Studies on the mechanisms of autophagy: maturation of the autophagic vacuole. J Cell Biol 1990; 110:1935-1345.
19. Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 2001; 8(6):569-581.
20. Tolkovsky AM, Xue L, Fletcher GC et al. Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease? Biochimie 2002; 84(2-3):233-240.
21. Wyllie AH. Apoptosis: an overview. Br Med Bull 1997; 53(3):451-465.
22. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26:239-257.
23. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407(6805):770-776.
24. Salvesen GS, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell 1997; 91(4):443-446.
25. Wolf BB, Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem 1999; 274(29):20049-20052.
26. Stennicke HR, Ryan CA, Salvesen GS. Reprieval from execution: the molecular basis of caspase inhibition. Trends Biochem Sci 2002; 27(2):94-101.
27. Reed J. Bcl-2 family proteins. Oncogene 1998; 17(25):3225-36.
28. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13(15):1899-9111.
29. Strasser A, O'Connor L, Dixit VM. Apoptosis signaling. Annu Rev Biochem 2000; 69:217-245.
30. Oltvai ZN, Korsmeyer SJ. Checkpoints of dueling dimers foil death wishes. Cell 1994; 79:189-192.
31. Yang E, Zha J, Jockel J et al. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 1995; 80(2):285-291.
32. Datta SR, Dudek H, Tao X et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91(2):231-241.
33. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999; 13(22):2905-2927.
34. Harada H, Becknell B, Wilm M et al. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell 1999; 3(4):413-422.
35. Bonni A, Brunet A, West AE et al. Cell survival promotrd by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999; 286:1358-1362.
36. Bertolotto C, Maulon L, Filippa N et al. Protein kinase C q and e promote T-cell survival by a Rsk-dependent phosphorylation and inactivation of BAD. J Biol Chem 2000; 275:37246-37250.
37. Harada H, Andersen JS, Mann M et al. P70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Nat Acad Sci USA 2001; 98:9666-9670.
38. Tan Y, Demeter MR, Ruan H et al. BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival. J Biol Chem 2000; 275:25865-25869.
39. Zhou X, Liu Y, Payne G et al. Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155. J Biol Chem 2000; 275:25046-25051.
40. Datta SR, Katsov A, Hu L et al. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 2000; 6:41-51.
41. Dramsi S, Scheid MP, Maiti A et al. Identification of a novel phosphorylation site, Ser170, as a regulator of BAD pro-apoptotic activity. J Biol Chem 2002; 277:6399-6405.
42. Lanotte M, Riviere JB, Hermouet S et al. Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. J Cell Physiol 1991; 146(1):73-80.
43. Duprez E, Gjertsen BT, Bernard O et al. Antiapoptotic effect of heterozygously expressed mutant RI (Ala336→Asp) subunit of cAMP kinase I in a rat leukemia cell line. J Biol Chem 1993; 268(11):8332-8340.
44. Lomo J, Blomhoff HK, Beiske K et al. TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes. J Immunol 1995; 154(4):1634-1643.
45. Mentz F, Merle-Beral H, Ouaaz F et al. Theophylline, a new inducer of apoptosis in B-CLL: role of cyclic nucleotides. Br J Haematol 1995; 90(4):957-959.
46. Selander KS, Harkonen PL, Valve E et al. Calcitonin promotes osteoclast survival in vitro. Mol Cell Endocrinol 1996; 122(2):119-129.
47. von Knethen A, Brune B. Attenuation of macrophage apoptosis by the cAMP-signaling system. Mol Cell Biochem 2000; 212(1-2):35-43.
48. Boucher MJ, Duchesne C, Laine J et al. cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition. Biochem Biophys Res Commun 2001; 285(2):207-216.
49. Takano M, Arai T, Mokuno Y et al. Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-alpha-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression. Cell Stress Chaperones 1998; 3(2):109-117.
50. Tanaka J, Koshimura K, Murakami Y et al. Neuronal protection from apoptosis by pituitary adenylate cyclase-activating polypeptide. Regul Pept 1997; 72(1):1-8.
51. Barbacid M. Neurotrophic factors and their receptors. Curr Opin Cell Biol 1995; 7(2):148-155.
52. Heerssen HM, Segal RA. Location, location, location: a spatial view of neurotrophin signal transduction. Trends Neurosci 2002; 25(3):160-165.
53. Cardona-Gomez GP, Mendez P, DonCarlos LL et al. Interactions of estrogens and insulin-like growth factor-I in the brain: implications for neuroprotection. Brain Res Brain Res Rev 2001; 37(1-3):320-334.
54. Gozes I, Brenneman DE. A new concept in the pharmacology of neuroprotection. J Mol Neurosci 2000; 14(1-2):61-68.
55. Airaksinen MS, Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 2002; 3(5):383-394.
56. Linden R. The anti-death league: Associative control of apoptosis in developing retinal tissue. Brain Res Brain Res Rev 2000; 32(1):146-158.
57. Rodbell M. The complex regulation of receptor-coupled G-proteins. Adv Enzyme Regul 1997; 37:427-435.
58. Brenneman DE, Fitzgerald S, Litzinger MJ. Neuronal survival during electrical blockade is increased by 8-bromo cyclic adenosine 3′,5′ monophosphate. J Pharm Exp Ther 1985; 233:402-408.
59. Rydel RE, Greene IA. cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor. Proc Natl Acad Sci USA 1988; 85:1257-1261.
60. Edwards SN, Buckmaster AE, Tolkovsky AM. The death programme in cultured sympathetic neurones can be supressed at the posttranslational level by nerve growth factor, cyclic AMP, and depolarization. J Neurochem 1991; 57:2140-2143.
61. Kew JNC, Smith DW, Sofroniew MV. Nerve growth factor withdrawal induces the apoptotic death of developing septal cholinergic neurons in vitro: protection by cyclic AMP analogues and high potassium. Neuroscience 1996; 70:329-339.
62. Hartikka J, Staufenbiel M, Lübbert H. Cyclic AMP, but not basic FGF, increases the in vitro survival of mesencephalic dopaminergic neurons and protects them from MPP+-induced degeneration. J. Neurosci Res 1992; 32:190-201.
63. Kaiser PK, Lipton SA. VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro. Neuron 1990; 5:373-381.
64. Brenneman DE, Neale EA, Foster GA et al. Nonneuronal Cells Mediate Neurotrophic Action of Vasoactive Intestinal Peptide. J Cell Biology 1987; 104:1603-1610.
65. Chang JY, Korolev VV, Wang JZ. Cyclic AMP and pituitary adenylate cyclase-activating polypeptide (PACAP) prevent programmed cell death of cultured rat cerebellar granule cells. Neurosci Lett 1996; 206(2-3):181-184.
66. Villalba M, Biackaert J, Journot L. Pituitary adenylate cyclase-activating polypeptide (PACAP38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP Kinase) pathway. J Neurosci 1997; 17(1):83-90.
67. Chang JY, Korolev VV. Cyclic AMP and sympathetic neuronal programmed cell death. Neurochem Int 1997; 31(2):161-167.
68. Varella MH, Correa DF, Campos CBL et al. Protein kinases selectively modulate apoptosis in the developing retina in vitro. Neurochem Int 1997; 31:217-227.
69. Morio H, Tatsuno I, Hirai A et al. Pituitary adenylate cyclase-activating polypeptide protects rat-cultured cortical neurons from glutamate-induced cytotoxicity. Brain Res 1996; 741(1-2):82-88.
70. Shoge KS, Mishima HK, Saitoh T et al. Protective effects of vasoactive intestinal peptide against delayed glutamate neurotoxicity in cultured retina. Brain Res 1998; 809:127-136.
71. Ferreira JM, Paes-de-Carvalho R. Long-term activation of adenosine A(2a) receptors blocks glutamate excitotoxicity in cultures of avian retinal neurons. Brain Res 2001; 900(2):169-176.
72. Pedersen WA, McCullers D, Culmsee C et al. Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease. Neurobiol Dis 2001; 8(3):492-503.
73. Pedersen WA, Wan R, Zhang P et al. Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. J Neurosci 2002; 22(2):404-412.
74. Meyer-Franke A, Kaplan MR, Pfrieger FW et al. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron 1995; 15(4):805-19.
75. Meyer-Franke A, Wilkinson GA, Kruttgen A et al. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 1998; 21(4):681-693.
76. Hanson MG Jr, Shen S, Wiemelt AP et al. Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. J Neurosci 1998; 18(18):7361-7371.
77. Linden R, Rehen SK, Chiarini LB. Apoptosis in developing retinal tissue. Progr Retinal Eye Res 1999; 18:133-165.
78. Rehen SK, Varella MH, Freitas FG et al. Contrasting effects of protein synthesis and of cyclic AMP on apoptosis in the developing retina. Development 1996; 122:1439-1448.
79. Rehen SK, Neves DDC, Fragel-Madeira L et al. Selective sensitivity of early post-mitotic retinal cells to apoptosis induced by inhibition of protein synthesis. Eur J Neurosci 1999; 11:349-356.
80. Chiarini LB, Leal-Ferreira ML, de Freitas FG et al. Changing sensitivity to cell death during development of retinal photoreceptors. J Neurosci Res 2003; 74(6):875-83.
81. Young SH, Poo MM. Spontaneous release of transmitter from growth cones of embryonic neurones. Nature 1983; 305(5935):634-637.
82. Fernandes AJ, Martinez AMB, Linden R. Estruturas juncionais precoces na camada plexiforme interna da retina do rato em desenvolvimento. Res XII Col Soc Bras Micr Eletr 1988; 225-226.
83. Shearman LP, Zeitzer J, Weaver DR. Widespread expression of functional D1-dopamine receptors in fetal rat brain. Brain Res Dev Brain Res 1997; 102(1):105-115.
84. Wu DK, Cepko CL. Development of dopaminergic neurons is insensitive to optic nerve section in the neonatal rat retina. Brain Res Dev Brain Res 1993; 20;74(2):253-260.
85. Schambra UB, Duncan GE, Breese GR et al. Ontogeny of D1A and D2 dopamine receptor sub-types in rat brain using in situ hybridization and receptor binding. Neuroscience 1994; 62(1):65-85.
86. Shelke RR, Lakshmana MK, Ramamohan Y et al. Levels of dopamine and noradrenaline in the developing of retina-Effect of light deprivation. Int J Dev Neurosci 1997; 15(1):139-143.
87. Witkovsky P, Schutte M. The organization of dopaminergic neurons in vertebrate retinas. Vis Neurosci 1991; 7(1-2):113-124.
88. Varella MH, Mello FG, Linden R. Evidence for an antiapoptotic role of dopamine in developing retinal tissue. J Neurochem 1999; 73:485-492.
89. Silveira MS, Costa MR, Bozza M et al. Pituitary Adenylyl Cyclase-Activating Polypeptide Prevents Induced Cell Death In Retinal Tissue Through Activation Of Cyclic AMP-Dependent Protein Kinase. J Biol. Chem 2002; 27(18):16075-16080.
90. Chiarini LB, Freitas ARO, Martins VM et al. Cellular prion protein transduces neuroprotective signals. EMBO J 2002; 21:3317-3326.
91. Zanata SM, Lopes MH, Mercadante AF et al. The stress- inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. EMBO J 2002; 21:3307-3316.
92. Taylor SS. cAMP-dependent protein kinase. Model for an enzyme family. J Biol Chem 1989; 264(15):8443-8446.
93. Riccio A, Ahn S, Davenport CM et al. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 1999; 286(5448):2358-2361.
94. Frodin M, Gammeltoft S. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol 1999; 151(1-2):65-77.
95. Lonze BE, Riccio A, Cohen S et al. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 2002; 34(3):371-385.
96. Stork PJ, Schmitt JM. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 2002; 12(6):258-266.
97. Dugan LL, Kim JS, Zhang Y et al. Differential effects of cAMP in neurons and astrocytes. Role of B-raf. J Biol Chem 1999; 274(36):25842-25848.
98. Nakamura T, Gold GH. A cyclic nucleotide-gated condutance in olfactory cilia. Nature 1987; 325:342-344.
99. Dhallan RS, Yau K, Scrader K et al. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature 1990; 347:184-187.
100. Goulding EH, Ngai J, Kramer RH et al. Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory. Neuron 1992; 8(1):45-58.
101. McConkey DJ, Orrenius S. The role of calcium in the regulation of apoptosis. Biochem Biophys Res Commun. 1997; 239(2):357-366.
102. Xiao AY, Wei L, Xia S et al. Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons. J Neurosci 2002; 22(4):1350-1362.
103. Gallo V, Kingsbury A, Balazs R et al. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci 1987; 7(7):2203-2213.
104. Rooji J, Zwartkruis FJT, Verheijen MHG et al. Epac is a Rap1 guanine nucleotide-exchange factor directly activated by cyclic AMP. Nature 1998; 396:474-477.
105. Kawasaki H, Springett GM, Mochizuki N et al. A family of cAMP-binding proteins that directly activate Rap1. Science 1998; 282:2275-2279.
106. Pham N, Cheglakov I, Koch CA et al. The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP. Curr Biol 2000; 10:555-558.
107. Mei FC, Qiao J, Tsygankova OM et al. Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem 2002; 277(13):11497-11504.
108. Clarke G, Collins RA, Leavitt BR et al. A one-hit model of cell death in inherited neuronal degenerations. Nature 2000; 406(6792):195-199.
109. Richards JS. New signaling pathways for hormones and cyclic adenosine 3′,5′-monophosphate action in endocrine cells. Mol Endocrinol 2001; 15(2):209-218.