Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway

Journal of Neuroscience

Volumn 17, Issue 1, 1997, Pages 83-90

  Villalba, Martin ^a   Bockaert, Joël ^a   Journot, Laurent ^a,b  

^a CNRS   (France)

^b CCIPE   (France)

Author keywords

apoptosis; cAMP; cerebellum; MAP kinase; PACAP; PD 98059

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIC AMP; DNA FRAGMENT; ENZYME INHIBITOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; POTASSIUM CHLORIDE; RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LOSS; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GRANULE CELL; NEUROTROPISM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0031027331     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-01-00083.1997     Document Type: Article

References (35)

1. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494.
2. Arimura A, Somogyvari-Vigh A, Weill C, Fiore RC, Tatsuno I, Bay V, Brenneman DE (1994) PACAP functions as a neurotrophic factor. Ann NY Acad Sci 739:228-243.
3. Basille M, Gonzalez BJ, Leroux P, Jeandel L, Fournier A, Vaudry H (1993) Localization and characterization of PACAP receptors in the rat cerebellum during development: evidence for a stimulatory effect of PACAP on immature cerebellar granule cells. Neuroscience 57:329-338.
4. Basille M, Gonzalez BJ, Desrues L, Demas M, Fournier A, Vaudry H (1995) Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylyl cyclase and phospholipase C activity in rat cerebellar neuroblasts. J Neurochem 65:1318-1324.
5. Burgering BM, Pronk GJ, van Weeren PC, Chardin P, Bos LJ (1993) cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J 12:4211-4220.
6. Cauvin A, Robberecht P, De Neef P, Gourlet P, Vandermeers A, Vandermeers-Piret M-C, Christophe J (1991) Properties and distribution of receptors for pituitary adenylate cyclase activating peptide (PACAP) in rat brain and spinal cord. Regul Pept 35:161-173.
7. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
8. Cook S, McCormick F (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science 262:1069-1072.
9. Copani A, Bruno VMG, Barresi V, Battaglia G, Condorelli DF, Nicoletti F (1995) Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture. J Neurochem 64:101-108.
10. Cowley S, Paterson H, Kemp P, Marshall CJ (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
11. D'Agata V, Cavallaro S, Stivala F, Travali S, Canonico PL (1996) Tissue-specific and developmental expression of pituitary adenylate cyclaseactivating polypeptide (PACAP) receptors in rat brain. Eur J Neurosci 8:310-318.
12. Deutsch PJ, Sun Y (1992) The 38-amino acid form of pituitary adenylate cyclase-activating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neurite outgrowth. J Biol Chem 267:5108-5113.
13. Deutsch PJ, Schadlow VC, Barzilai N (1993) 38-Amino acid form of pituitary adenylate cyclase activating peptide induces process outgrowth in human neuroblastoma cells. J Neurosci Res 35:312-320.
14. DiCicco-Bloom E, Deutsch PJ (1992) Pituitary adenylate cyclase activating polypeptide (PACAP) potently stimulates mitosis, neuritogenesis, and survival in cultured rat sympathetic neuroblasts. Regul Pept 37:319-325.
15. Didier M, Heaulne M, Soubrié P, Bockaert J, Pin J-P (1990) Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells. J Neurosci Res 27:25-35.
16. D'Mello SR, Galli C, Ciotti T, Calissano P (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci USA 90:10989-10993.
17. Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 92:7686-7689.
18. Earnshaw WC (1995) Nuclear changes in apoptosis. Curr Opin Cell Biol 7:337-343.
19. Edwards SN, Buckmastcr AE, Tolkovsky AM (1991) The death programme in cultured sympathetic neurones can be suppressed at the posttranslational level by nerve growth factor, cyclic AMP, and depolarization. J Neurochem 57:2140-2143.
20. Faure M, Voyno-Yasenetskaya TA, Bourne H (1994) cAMP and βγ subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem 269:7851-7854.
21. Favit A, Scapagnini U, Canonico PL (1995) Pituitary adenylate cyclaseactivating polypeptide activates different signal transducing mechanisms in cultured cerebellar granule cells. Neuroendocrinology 61:377-382.
22. Frödin M, Peraldi P, Van Obberghen E (1994) Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. J Biol Chem 269:6207-6214.
23. Galli C, Meucci O, Scorziello A, Werge TM, Calissano P, Schettini G (1995) Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J Neurosci 15:1172-1179.
24. Gallo V, Giovanini C, Levi G (1990) Modulation of non-N-methyl-D-aspartate receptors in cultured cerebellar granule cells. J Neurochem 54:1619-1625.
25. Graves LM, Bornfeldt KE, Raines EW, Potts BC, McDonald SG, Ross R, Krebs EG (1993) Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc Natl Acad Sci USA 90:10300-10304.
26. Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S (1993) Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase activating polypeptide. Neuron 11:333-342.
27. Hernandez A, Kimball B, Romanchuk G, Mulholland MW (1995) Pituitary adenylate cyclase-activating peptide stimulates neurite growth in PC12 cells. Peptides 16:927-932.
28. Hockenberry D, Nuñez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336.
29. Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S (1992) Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron 8:811-819.
30. 2+-dependent stimulatory effect of pituitary adenylate cyclase-activating polypeptide on catecholamine secretion from cultured porcine adrenal medullary chromaffin cells. Endocrinology 132:1757-1765.
31. Wyllie AH (1980) Glucocorticoid-induced thymocytes apoptosis is associated with endogenous endonuclease activation. Nature 284:555-556.
32. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331.
33. Yan G-M, Ni B, Weller M, Wood KA, Paul SM (1994) Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res 656:43-51.
34. Yan G-M, Lin S-Z, Irwin RP, Paul SM (1995a) Activation of G proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons. J Neurochem 65:2425-2431.
35. Yan G-M, Lin S-Z, Irwin RP, Paul SM (1995b) Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol Pharmacol 47:248-257.