Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: Cationic lipid complexes

Journal of Immunology

Volumn 160, Issue 9, 1998, Pages 4580-4586

  Freimark, Bruce D ^a   Blezinger, H Paul ^a   Florack, Valarie J ^a   Nordstrom, Jeffrey L ^a   Long, Scott D ^a   Deshpande, Deepa S ^a   Nochumson, Sam ^a   Petrak, Karel L ^a  

^a GeneMedicine Inc   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CATION; CYTOKINE; LIPID;

AIRWAY PRESSURE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; GENE EXPRESSION; GENE THERAPY; IMMUNE RESPONSE; IMMUNOASSAY; IMMUNOSTIMULATION; LIPID ANALYSIS; MALE; NONHUMAN; PLASMID; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TRANSGENE;

ADMINISTRATION, INHALATION; ANIMALS; CHOLESTEROL; CYTOKINES; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LUNG; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; PLASMIDS; TH1 CELLS; TH2 CELLS;

EID: 0032080647     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Canonico, A. E., J. T. Conary, B. O. Meyrick, and K. L. Brigham. 1994. Aerosol and intravenous transfection of human alpha 1-antitrypsin gene to lungs of rabbits. Am. J. Respir. Cell Mol. Biol. 10:24.
2. Eissa, N. T., C. S. Chu, C. Danel, and R. G. Crystal. 1994. Evaluation of the respiratory epithelium of normals and individuals with cystic fibrosis for the presence of adenovirus E1a sequences relevant to the use of E1a-adenovirus vectors for gene therapy for the respiratory manifestations of cystic fibrosis. Hum. Gene Ther. 5:1105.
3. Welsh, M. J., A. E. Smith, J. Zabner, D. P. Rich, S. M. Graham, R. J. Gregory, B. M. Pratt, and R. A. Moscicki. 1994. Cystic fibrosis gene therapy using an adenovirus vector: in vivo safety and efficacy in nasal epithelium. Hum. Gene Ther. 5:209.
4. Meyer, K. B., M. M. Thompson, M. Y. Levy, L. G. Barron, and F. C. Szoka, Jr. 1995. Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and pharmacokinetics. Gene Ther. 2:450.
5. Stribling, R., E. Brunette, D. Liggitt, K. Gaensler, and R. Debs. 1992. Aerosol gene delivery in vivo. Proc. Natl. Acad. Sci. USA 89:11277.
6. Yoshimura, K., M. A. Rosenfeld, H. Nakamura, E. M. Scherer, A. Pavirani, J. P. Lecocq, and R. G. Crystal. 1992. Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer. Nucleic Acids Res. 20:3233.
7. Scheule, R., J. St. George, R. Bagley, J. Marshall, J. Kaplan, G. Akita, K. Wang, E. Lee, D. Harris, C. Jiang, N. Yew, A. Smith, and S. Cheng. 1997. Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung. Hum. Gene Ther. 8:689.
8. Klinman, D. M., A. K. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. USA 93:2879.
9. Pisetsky, D. S., C. Reich, S. D. Crowley, and M. D. Halpern. 1995. Immunological properties of bacterial DNA. Ann. NY Acad. Sci. 772:152.
10. Raz, E., H. Tighe, Y. Sato, M. Corr, J. A. Dudler, M. Roman, S. L. Swain, H. L. Spiegelberg, and D. A. Carson. 1996. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc. Natl. Acad. Sci. USA 93:5141.
11. Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M. D. Nguyen, G. J. Silverman, M. Lotz, D. A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352.
12. Stacey, K. J., M. J. Sweet, and D. A. Hume. 1996. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:2116.
13. Yamamoto, T., S. Yamamoto, T. Kataoka, and T. Tokunaga. 1994. Lipofection of synthetic oligodeoxyribonucleotide having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity. Microbiol. Immunol. 38:831.
14. Krieg, A. M., A. K. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546.
15. Razin, A., and J. Friedman. 1981. DNA methylation and its possible biological roles. Prog. Nucleic Acids Res. 25:33.
16. Cardon, L. R., C. Burge, D. A. Clayton, and S. Karlin. 1994. Pervasive CpG suppression in animal mitochondrial genomes. Proc. Natl. Acad. Sci. USA 91: 3799.
17. Halpern, M. D., R. J. Kurlander, and D. S. Pisetsky. 1996. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. Cell. Immunol. 167:72.
18. MacGregor, G. R., and C. T. Caskey. 1989. Construction of plasmids that express E. coli beta-galactosidase in mammalian cells. Nucleic Acids Res. 17:2365.
19. Mishell, B. B., and S. M. Shiigi. 1980. Selected Methods in Cellular Immunology. W. H. Freeman and Company, New York.
20. Hansbrough, J. R., S. M. Fine, and J. I. Gordon. 1993. A transgenic mouse model for studying the lineage relationships and differentiation program of type II pneumocytes at various stages of lung development. J. Biol. Chem. 268:9762.
21. Heinzel, F. P., R. M. Rerko, P. Ling, J. Hakimi, and D. S. Schoenhaut. 1994. Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect. Immun. 62:4244.
22. Jansen, P. M., T. C. van der Pouw Kraan, I. W. de Jong, G. van Mierlo, J. Wijdenes, A. A. Chang, L. A. Aarden, F. B. Taylor, Jr., and C. E. Hack. 1996. Release of interleukin-12 in experimental Escherichia coli septic shock in baboons: relation to plasma levels of interleukin-10 and interferon-gamma. Blood 87:5144.
23. Klinman, D., G. Yamshchikov, and Y. Ishigatsubo. 1997. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J. Immunol. 158:3635.
24. Tsan, M., N. J. Tacy, B. A. Lindau-Shepard, and J. E. White. 1997. Protection of rats against oxygen toxicity by tracheal administration of plasmid DNA: role of endogenous tumor necrosis factor. Proc. Assoc. Am. Physicians 109:409.
25. Schwartz, D. A., T. J. Quinn, P. S. Thorne, S. Sayeed, A. Yi, and A. M. Krieg. 1997. CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract. J. Clin. Invest. 100:68.
26. Cassatella, M. A., L. Meda, S. Gasperini, A. D'Andrea, X. Ma, and G. Trinchieri. 1995. Interleukin-12 production by human polymorphonuclear leukocytes. Eur. J. Immunol. 25:1.
27. Romani, L., A. Menacacci, E. Cenci, R. Spaccapelo, G. Del Sero, I. Nicoletti, G. Trincheri, F. Bistoni, and P. Puccetti. 1997. Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice. J. Immunol. 158:5349.
28. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
29. Fulton, S. A., J. M. Johnsen, S. F. Wolf, D. S. Sieburth, and W. H. Boom. 1996. Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis. Infect. Immun. 64:2523.
30. Hayes, M. P., J. Wang, and M. A. Norcross. 1995. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood 86:646.
31. Hahon, N., and V. Castranova. 1997. Interferon production in rat type II pneumocytes and alveolar macrophages. Exp. Lung Res. 15:429.
32. McKnight, A. J., G. J. Zimmer, I. Fogelman, S. F. Wolf, and A. K. Abbas. 1994. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152:2172.
33. + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
34. Neuzil, K. M., Y. W. Tang, and B. S. Graham. 1996. Protective role of TNF-alpha in respiratory syncytial virus infection in vitro and in vivo. Am. J. Med. Sci. 311:201.
35. Ramarathinam, L., D. W. Niesel, and G. R. Klimpel. 1993. Salmonella typhimurium induces IFN-γ production in murine splenocytes: role of natural killer cells and macrophages. J. Immunol. 150:3973.
36. Giese, N. A., R. T. Gazzinelli, J. K. Actor, R. A. Morawetz, M. Sarzotti, and H. Morse. 1996. Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS. Immunology 87:467.
37. Nestel, F. P., K. S. Price, T. A. Seemayer, and W. S. Lapp. 1992. Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease. J. Exp. Med. 175:405.
38. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
39. Flesch, I. E., J. H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S. H. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha. J. Exp. Med. 181:1615.
40. + T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α. J. Immunol. 157:798.
41. Gazzinelli, R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533.
42. Hunter, C. A., T. Slifer, and F. Araujo. 1996. Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon. Infect. Immun. 64:2381.
43. Hunter, C. A., C. S. Subauste, V. H. Van Cleave, and J. S. Remington. 1994. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect. Immun. 62:2818.