Molecular insights into the mechanisms of HIV-1 reverse transcriptase resistance to nucleoside analogs

Mini-Reviews in Medicinal Chemistry

Volumn 6, Issue 5, 2006, Pages 549-555

  Carvalho, Alexandra P ^a   Fernandes, Pedro A ^a   Ramos, Maria J ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

HIV 1; NRTIs; Resistance mutations; Reverse transcriptase

Indexed keywords

ABACAVIR; ADENINE; ADENOSINE DIPHOSPHATE; DIDANOSINE; DIOXOLANE GUANOSINE; DOUBLE STRANDED DNA; ISOLEUCINE; LAMIVUDINE; METHIONINE; NUCLEOTIDE DERIVATIVE; PHOSPHATE; PURINE; RIBOSE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SINGLE STRANDED RNA; STAVUDINE; TENOFOVIR; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; ENZYME SUBSTRATE; GENOME; HOST CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOLECULAR MECHANICS; PATHOGENESIS; POINT MUTATION; POLYMERIZATION; REVERSE TRANSCRIPTION; REVIEW; VIRUS MUTATION;

DRUG RESISTANCE, VIRAL; HIV-1 REVERSE TRANSCRIPTASE; MODELS, MOLECULAR; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 33646590228     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955706776876276     Document Type: Review

References (66)

1. Telesnitsky, A.; Goff, S.P. in Retroviruses: Coffin, J.M.; Hughes S.H.; Varmus, H.E., Ed., Cold Spring Harbor Laboratory Press: New York, 1997; pp. 121-160.
2. Mizrahi V.; Lazarus G.M.; Miles L.M.; Meyers C.A.; Debouck C. Arch. Biochem. Biophys., 1989, 273, 347.
3. Kohlstaedt L.A.; Wang J.; Friedman J.M.; Rice P.A.; Steitz T.A., Science, 1992, 256, 1783.
4. Le Grice S.F.; Naas T.; Wohlgensinger B.; Schatz O. EMBO J., 1991, 10, 3905.
5. Majumdar, C.; Abbotts, J.; Broder, S.; Wilson, S. J. Biol. Chem., 1988, 263, 5657.
6. Kati, W.M.; Johnson, K.A.; Jerva, L.F.; Anderson, K.S. J. Biol. Chem., 1992, 267, 25988.
7. Reardon, J.E. J. Biol. Chem., 1993, 268, 8743.
8. Hsieh, J-C, Zinnen, S., Modrich, P. J. Biol. Chem., 1993, 268, 24607.
9. Thrail, S.; Krebs, R.; Wöhrl, B.: Cellai, L.; Goody, R.; Restle, T. Biochemistry, 1998, 37, 13349.
10. Vaccaro, J.; Singh, H., Anderson, K. Biochemistry, 1999, 38, 15978.
11. Wöhrl, B.M.; Krebs, R.; Goody, R.S.; Restle, T. J. Mol. Biol., 1999, 292, 333.
12. Huang, H.; Chopra, R.; Verdine, G.L.; Harrison, S.C. Science, 1998, 282, 1669.
13. Battula, N.; Loeb, L. J. Biol. Chem., 1976, 251, 982.
14. Roberts, J.D.; Bebenek, K.; Kunkel, T.A. Science, 1988, 242, 1171.
15. Balzarini. J. Biochem. Pharm., 1999, 58, 1.
16. Selmi B.; Boretto J.; Navarro J.M.; Sire J.; Longhi S.; Guerreiro C.; Mulard L.; Sarfati S.; Canard B. J. Mol. Biol., 2001, 276, 13965.
17. Selmi, B.; Boretto, J.; Sarfati, S.R.; Guerreiro, C.; Canard B. J. Biol. Chem., 2001, 276, 48466.
18. Sluis-Cremer, N.; Arion, D.; Parniak, M.A.; Cell Mol. Life Sci., 2000, 57, 1408.
19. Unge, T.; Knight, S.; Bhikhabhai, R.; Lovgren, S.; Dauter, Z.; Wilson, K.; Strandberg, B. Structure, 1994, 2, 953.
20. Rodgers, D.W.; Gamblin, S.J.; Harris, B.A.; Ray, S.; Culp, J.S.; Hellmig, B.; Woolf, D.J.; Debouck, C.; Harrison, S.C. Proc. Natl. Acad. Sci. USA, 1995, 2, 1222.
21. Esnouf, R.; Ren, J.; Ross, C.; Jones, Y.; Stammers, D.; Stuart, D. Nat. Struct. Biol., 1995, 2, 303.
22. Hsiou, Y.; Ding, J.; Das, K.; Clark Jr. A.D.; Hughes, S.H.; Arnold, E. Structure., 1996, 4, 853.
23. Hsiou, Y.; Ding, J.; Das, K.; Clark Jr. A.D.; Boyer, P.L.; Lewi, P.; Janssen, P.A.; Kleim, J.P.; Rosner, M.; Hughes, S.H.; Arnold, E. J. Mol. Biol., 2001, 309, 437.
24. Sarafianos, S.G.; Das, K.; Clark Jr. A.D.; Ding, J.; Boyer, P.L.; Hughes, S.H.; Arnold, E. Proc. Natl. Acad. Sci. USA, 1999, 96, 10027.
25. Ren, J; Nichols, C.; Bird, L.; Chamberlain, P.; Weaver, K.; Short, S.; Shiart, D.I.; Stammers, D.K. J. Mol. Biol., 2001, 312, 795.
26. Ding, J.; Das, K.; Hsiou, Y.; Sarafianos, S.G.; Clark Jr. A.D.; Jacobo-Molina, A.; Tantillo, C.; Hughes, S.H.; Arnold, E. J. Mol. Biol., 1998, 284, 1095.
27. Sarafianos, S.G.; Das, K.; Tantillo, C.; Clark Jr. A.D.; Ding, J.; Whitcomb, J.M.; Boyer, P.L.; Hughes, S.H.; Arnold, E. EMBO J., 2001, 20, 1449.
28. Peletskaya, E.N.; Kogon, A.A.; Tuske, S.; Arnold, E.; Hughes, S.H. J. Virol., 2004, 78, 3387.
29. Sarafianos, S.G.; Clark, A.D. Jr.; Das, K.; Tuske, S.; Birktoft, J.J.; Ilankumaran, P.; Ramesha, A.R.; Sayer, J.M.; Jerina, D.M.; Boyer, P.L.; Hughes, S.H.; Arnold, E. EMBO J., 2002, 21, 6614.
30. Tuske S.; Sarafianos S.G.; Clark A.D. Jr.; Ding J.; Naeger L.K.; White K.L.; Miller M.D.; Gibbs C.S.; Boyer P.L.; Clark P.; Wang G.; Gaffney B.L.; Jones R.A.; Jerina D.M.; Hughes S.H.; Arnold E. Nat. Struct. Mol. Biol., 2004, 11, 469.
31. Boucher, C.A.; Cammack, N.; Schipper, P., Schuurman, R., Rouse, P., Wainberg, M.A., Cameron, J.M. Antimicrob. Agents Chemother., 1993, 37, 2231.
32. Gao, Q.; Go, Z.; Parniak, M.A.; Cameron, J.; Cammack, N.; Boucher, C.; Wainberg, M.A. Antimicrob. Agents Chemother., 1993, 37, 1390.
33. Keulen, W.; Back N.K.; van Wijk, A.; Boucher, C.A.; Berkhout, B. J. Virol., 1997, 71, 3346.
34. Feng, J.Y.; Anderson, K.S. Biochem., 1999, 38, 9440.
35. Guex, N. and Peitsch, M.C. Electrophoresis, 1997, 18, 2714.
36. Shirasaka, T.; Klavlick M.F.; Ueno et al. Proc. Natl. Acad. Sci. USA, 1995, 92, 2398.
37. Iversen, A.K.; Shafer, R.W.; Werly, K.; Winters, M.A.; Mullins, J.L.; Chesebro, B.; Merigan, T.C. J. Virol., 1996, 70, 1086.
38. Kavlick, M.F.; Wyvill, K.; Yarchoan, R.; Mitsuya, H. J. Inf. Dis., 1998, 177, 1506.
39. Ueno, T.; Shirasaka, T.; Mitsuya, H. J. Biol. Chem., 1995, 270, 23605.
40. Garcia Lerma, J.; Schinazi, R.F.; Juodawlkis, A.S.; Soriano, V.; Lin, Y.; Tatti, K.; Rimland, D.; Folks, T.M.; Heneine, W. Antimicrob. Agents Chemother., 1999, 43, 264.
41. Lacely, S.F. & Larder B.A. Antimicrob. Agents Chemother., 1994, 38, 1428.
42. Lin, P.F.; Gonzalez, C.J.; Griffith, B.; Friedland, G.; Calvez, V.; Ferchal, F.; Schinazi, R.F.; Shepp, D.H.; Ashraf, A.B.; Wainberg, M.A.; Soriano, V.; Mellors, J.W.; Colonno, R.J. Antivir. Ther., 1999, 4, 21.
43. Roge, B.T.; Katezenstein, T.L.; Obel, N.; Nielsen, H.; Kirk, O.; Pedersen, C.; Mathiesen, L.; Lundgren, J.; Gerstoft, J. Antivir. Ther., 2003, 8, 173.
44. Schinazi R.F.; Larder, B.A.; Mellors, J.W. Int. Antivir. News, 2000, 8, 65.
45. Kozal, M.J.; Kroodsma, K.; Winters, A.M.; Shafer, R.W.; Efron, B.; Katzenstein, D.; Merigan, T.C. Ann. Int. Med., 1994, 121, 263.
46. Tisdale M.; Alnadaf, T.; Cousens, D. Antimicrob. Agents Chemother., 1997, 41, 1094.
47. Bazmi, H.Z.; Hammond, J.L.; Cavalcanti, S.C.; Chu, C.K.; Schinazi, R.F.; Mellors, J.W. Antimicrob. Agents Chemother., 2000, 44, 1783.
48. Soriano, V.; de Mendoza, C. HIV Clin. Trials. 2002, 3, 237.
49. Loveday C. J. Acquir. Immune Defic. Syndr. 2001, 26, 1.
50. Lange J. Antivir. Ther., 2001, 6, 45.
51. Gotte, M.; Wainberg, M.A. Drug Resist Updat., 2000, 3, 30.
52. De Mendoza, C.; Gallego, O.; Soriano, V. AIDS Rev., 2002, 4, 64.
53. Lacely, S.F.; Reardon, J.E.; Furfine, E.S.; Kunkel, T.A.; Bebenek, K.; Eckert, K.A.; Kemp, S.D.; Larder, B.A. J. Biol. Chem., 1992, 267, 15789.
54. Arion, D.; Kaushik, N.; McCormick, S.; Borkow, G.; Parniak, M.A. Biochemistry, 1998, 37, 15908.
55. Meyer, P.R.; Matsura, S.E.; Mian, A.M.; So, A.G; Scott, W.A. Molecular Cell, 1999, 4, 35.
56. Naeger, L.; Margot, N.; Miller, M. Antimicrob. Agents Chemoter., 2002, 46, 2179.
57. Boyer, P.L.; Sarafianos, S.G.; Arnold, E.; Hughes, S.H. J. Virol., 2001, 75, 4832.
58. Boyer, P.L.; Sarafianos, S.G.; Arnold, E.; Hughes, S.H. J. Virol., 2002, 76, 9143.
59. Boyer, P.L.; Sarafianos, S.G.; Arnold, E.; Hughes, S.H. J. Virol., 2002, 76, 3248.
60. Mas, A.; Parera, M.; Briones, C.; Soriano, V.; Martinez, M.A.; Domingo, E.; Menedez-Arias, L. EMBO J., 2000, 19, 5752.
61. Meyer, P.R; Matsuura, S.E.; So, A.G.; Scott, W.A. Proc. Natl. Acad. Sci. USA, 1998, 95, 13471.
62. Meyer P.R.; Matsuura S.E.; Tolun A.A.; Pfeifer I.; So A.G.; Mellors J.W.; Scott W.A. Antimicrob. Agents Chemother., 2000, 46, 1540.
63. Meyer, P.R.; Lennestrand, J.; Matsuura, S.E.; Larder, B.A.; Scott, W.A. J. Virol., 2003, 77, 3871.
64. Sarafianos, S.G.; Hughes, S.H.; Arnold, E. Int. J. Biochem. Cell Biol., 2004, 36, 1706.
65. Boyer, P.L.; Imamichi, T.; Sarafianos, S.G.; Arnold, E.; Hughes, S.H. J. Virol., 2004, 78, 9987.
66. Meyer, P.R.; Smith, A.J.; Matsuura, S.E.; Scott, W.A. J. Biol. Chem., 2004, 279, 45389.