Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs

International Journal of Biochemistry and Cell Biology

Volumn 36, Issue 9, 2004, Pages 1706-1715

  Sarafianos, Stefan G ^a   Hughes, Stephen H ^b   Arnold, Eddy ^a  

^a RUTGERS UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AZIDO 2',3' DIDEOXYTHYMIDINE 5' TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTICOAGULANT AGENT; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DIADENOSINE TETRAPHOSPHATE; DINUCLEOSIDE TETRAPHOSPHATE; DNA; DNA POLYMERASE; LAMIVUDINE; NUCLEOSIDE ANALOG; NUCLEOTIDE DERIVATIVE; PYROPHOSPHATE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ZIDOVUDINE 5' MONOPHOSPHATE; ZIDOVUDINE DERIVATIVE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG TARGETING; EXCISION REPAIR; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MULTIDRUG RESISTANCE; REVIEW; TREATMENT OUTCOME; VIRUS LOAD; VIRUS MUTATION; VIRUS REPLICATION; VIRUS STRAIN;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, VIRAL; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 2942564337     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2004.02.027     Document Type: Review

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