The Valine-to-Threonine 75 Substitution in Human Immunodeficiency Virus Type I Reverse Transcriptase and Its Relation with Stavudine Resistance

Journal of Biological Chemistry

Volumn 276, Issue 17, 2001, Pages 13965-13974

  Selmi, Boulbaba ^a   Boretto, Joëlle ^a   Navarro, Jean Marc ^b   Sire, Josephine ^b   Longhi, Sonia ^a   Guerreiro, Catherine ^c   Mulard, Laurence ^b   Sarfati, Simon ^c   Canard, Bruno ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSERM   (France)

^c INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; DNA; VIRUSES;

NUCLEOTIDE-BINDING POCKET;

ENZYMES;

2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDINE 5' MONOPHOSPHATE; 2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDINE 5' TRIPHOSPHATE; 3' AZIDO 3' DEOXYTHHYMIDINE 5' MONOPHOSPHATE; AMINO ACID; ANTIRETROVIRUS AGENT; DNA; FOSCARNET; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; THREONINE; UNCLASSIFIED DRUG; VALINE; ZIDOVUDINE; ADENOSINE TRIPHOSPHATE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIVIRUS AGENT; RECOMBINANT PROTEIN; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVE SITE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; VIROGENESIS; VIRUS INFECTION; VIRUS MUTATION; VIRUS RESISTANCE; BINDING SITE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DNA REPAIR; DRUG EFFECT; DRUG RESISTANCE; GENETIC TRANSFECTION; HELA CELL; IC 50; KINETICS; METABOLISM; TIME;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

ADENOSINE TRIPHOSPHATE; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; BINDING SITES; CELL LINE; DNA; DNA REPAIR; DRUG RESISTANCE; HELA CELLS; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; PLASMIDS; RECOMBINANT PROTEINS; STAVUDINE; THREONINE; TIME FACTORS; TRANSFECTION; TYROSINE; VALINE; ZIDOVUDINE;

EID: 0035957999     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009837200     Document Type: Article

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