메뉴 건너뛰기




Volumn 361, Issue 1467, 2006, Pages 393-401

Finding the molecular basis of complex genetic variation in humans and mice

Author keywords

Association; Complex traits; Genetic mapping; Human genetics; Mouse genetics; Quantitative trait locus

Indexed keywords

GENETIC ANALYSIS; GENETIC VARIATION; MAPPING METHOD; MOLECULAR ANALYSIS; RODENT;

EID: 33646355194     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2005.1798     Document Type: Review
Times cited : (14)

References (66)
  • 1
    • 0242291131 scopus 로고    scopus 로고
    • The nature and identification of quantitative trait loci: A community's view
    • Abiola, O. et al. 2003 The nature and identification of quantitative trait loci: a community's view. Nat. Rev. Genet. 4, 911-916.
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 911-916
    • Abiola, O.1
  • 2
    • 0037015174 scopus 로고    scopus 로고
    • Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL
    • Alemayehu, A., Breen, L., Krenova, D. & Printz, M. P. 2002 Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL. Physiol. Genomics 10, 199-210.
    • (2002) Physiol. Genomics , vol.10 , pp. 199-210
    • Alemayehu, A.1    Breen, L.2    Krenova, D.3    Printz, M.P.4
  • 3
    • 0242329880 scopus 로고    scopus 로고
    • Positional cloning of a novel gene influencing asthma from chromosome 2q14
    • doi:10.1038/ng1256
    • Allen, M. et al. 2003 Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat. Genet. 35, 258-263. (doi:10.1038/ng1256)
    • (2003) Nat. Genet. , vol.35 , pp. 258-263
    • Allen, M.1
  • 4
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • doi:10.1038/79839
    • Altshuler, D. et al. 2000 The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26, 76-80. (doi:10.1038/79839)
    • (2000) Nat. Genet. , vol.26 , pp. 76-80
    • Altshuler, D.1
  • 5
    • 3843052401 scopus 로고    scopus 로고
    • Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains
    • doi:10.1097/01.hjh.0000133720.94075.6f
    • Ariyarajah, A., Palijan, A., Dutil, J., Prithiviraj, K., Deng, Y. & Deng, A. Y. 2004 Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains. J. Hypertens 22, 1495-1502. (doi:10.1097/01.hjh.0000133720.94075.6f)
    • (2004) J. Hypertens , vol.22 , pp. 1495-1502
    • Ariyarajah, A.1    Palijan, A.2    Dutil, J.3    Prithiviraj, K.4    Deng, Y.5    Deng, A.Y.6
  • 6
    • 4444262688 scopus 로고    scopus 로고
    • The knockout mouse project
    • doi:10.1038/ng0904-921
    • Austin, C. P. et al. 2004 The knockout mouse project. Nat. Genet. 36, 921-924. (doi:10.1038/ng0904-921)
    • (2004) Nat. Genet. , vol.36 , pp. 921-924
    • Austin, C.P.1
  • 7
    • 0242360752 scopus 로고    scopus 로고
    • Chromosome substitution strains: Some quantitative considerations for genome scans and fine mapping
    • doi:10.1007/s00335-003-2264-1
    • Belknap, J. K. 2003 Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping. Mamm. Genome 14, 723-732. (doi:10.1007/s00335-003-2264-1)
    • (2003) Mamm. Genome , vol.14 , pp. 723-732
    • Belknap, J.K.1
  • 8
    • 0032947554 scopus 로고    scopus 로고
    • Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice
    • Bihl, F., Brahic, M. & Bureau, J. F. 1999 Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice. Genetics 152, 385-392.
    • (1999) Genetics , vol.152 , pp. 385-392
    • Bihl, F.1    Brahic, M.2    Bureau, J.F.3
  • 9
    • 2342426156 scopus 로고    scopus 로고
    • Nobel lecture. Nature's gift to science
    • Brenner, S. 2003 Nobel lecture. Nature's gift to science. Biosci. Rep. 23, 225-237.
    • (2003) Biosci. Rep. , vol.23 , pp. 225-237
    • Brenner, S.1
  • 10
    • 0016689766 scopus 로고
    • Genotype-environment interaction. III. Interactions in Drosophila melanogaster
    • Caligari, P. D. & Mather, K. 1975 Genotype-environment interaction. III. Interactions in Drosophila melanogaster. Proc. R. Soc. B 191, 387-411.
    • (1975) Proc. R. Soc. B , vol.191 , pp. 387-411
    • Caligari, P.D.1    Mather, K.2
  • 11
    • 3442894519 scopus 로고    scopus 로고
    • Epistasis: Too often neglected in complex trait studies?
    • doi:10.1038/nrg1407
    • Carlborg, O. & Haley, C. S. 2004 Epistasis: too often neglected in complex trait studies? Nat. Rev. Genet. 5, 618-625. (doi:10.1038/nrg1407)
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 618-625
    • Carlborg, O.1    Haley, C.S.2
  • 12
    • 23244441610 scopus 로고    scopus 로고
    • Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels
    • Cervino, A. C. et al. 2005 Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics 86, 505-5017.
    • (2005) Genomics , vol.86 , pp. 505-5017
    • Cervino, A.C.1
  • 13
    • 0032568517 scopus 로고    scopus 로고
    • Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene
    • doi:10.1073/pnas.95.11. 6480
    • Cha, J. H., Kosinski, C. M., Kerner, J. A., Alsdorf, S. A., Mangiarini, L., Davies, S. W., Penney, J. B., Bates, G. P. & Young, A. B. 1998 Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene. Proc. Natl Acad. Sci. USA 95, 6480-6485. (doi:10.1073/pnas.95.11. 6480)
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 6480-6485
    • Cha, J.H.1    Kosinski, C.M.2    Kerner, J.A.3    Alsdorf, S.A.4    Mangiarini, L.5    Davies, S.W.6    Penney, J.B.7    Bates, G.P.8    Young, A.B.9
  • 14
    • 20144386111 scopus 로고    scopus 로고
    • Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    • doi:10.1038/ng1518
    • Chesler, E. J. et al. 2005 Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat. Genet. 37, 233-242. (doi:10.1038/ng1518)
    • (2005) Nat. Genet. , vol.37 , pp. 233-242
    • Chesler, E.J.1
  • 15
    • 2542417881 scopus 로고    scopus 로고
    • Fine mapping of a murine growth locus to a 1.4-cM region and resolution of linked QTL
    • doi:10.1007/s00335-004-3046-0
    • Christians, J. K. & Keightley, P. D. 2004 Fine mapping of a murine growth locus to a 1.4-cM region and resolution of linked QTL. Mamm. Genome 15, 482-491. (doi:10.1007/s00335-004-3046-0)
    • (2004) Mamm. Genome , vol.15 , pp. 482-491
    • Christians, J.K.1    Keightley, P.D.2
  • 16
    • 14644441018 scopus 로고    scopus 로고
    • The Collaborative Cross, a community resource for the genetic analysis of complex traits
    • doi:10.1038/ng1104-1133
    • Churchill, G. A. et al. 2004 The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat. Genet. 36, 1133-1137. (doi:10.1038/ng1104-1133)
    • (2004) Nat. Genet. , vol.36 , pp. 1133-1137
    • Churchill, G.A.1
  • 18
    • 0037426052 scopus 로고    scopus 로고
    • Problems of reporting genetic associations with complex outcomes
    • doi:10.1016/S0140-6736(03)12715-8
    • Colhoun, H. M., McKeigue, P. M. & Davey Smith, G. 2003 Problems of reporting genetic associations with complex outcomes. Lancet 361, 865-872. (doi:10.1016/S0140-6736(03)12715-8)
    • (2003) Lancet , vol.361 , pp. 865-872
    • Colhoun, H.M.1    McKeigue, P.M.2    Davey Smith, G.3
  • 19
    • 10244250341 scopus 로고    scopus 로고
    • The immunogenetics of asthma and eczema: A new focus on the epithelium
    • doi:10.1038/nri1500
    • Cookson, W. 2004 The immunogenetics of asthma and eczema: a new focus on the epithelium. Nat. Rev. Immunol. 4, 978-988. (doi:10.1038/nri1500)
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 978-988
    • Cookson, W.1
  • 20
    • 4043089215 scopus 로고    scopus 로고
    • Consomic rat model systems for physiological genomics
    • doi:10.1111/j.1365-201X.2004.01334.x
    • Cowley Jr, A. W., Liang, M., Roman, R. J., Greene, A. S. & Jacob, H. J. 2004 Consomic rat model systems for physiological genomics. Acta Physiol. Scand. 181, 585-592. (doi:10.1111/j.1365-201X.2004.01334.x)
    • (2004) Acta Physiol. Scand. , vol.181 , pp. 585-592
    • Cowley Jr., A.W.1    Liang, M.2    Roman, R.J.3    Greene, A.S.4    Jacob, H.J.5
  • 21
    • 0031975307 scopus 로고    scopus 로고
    • Experimental strategies for the genetic dissection of complex traits in animal models
    • doi:10.1038/ng0198-19
    • Darvasi, A. 1998 Experimental strategies for the genetic dissection of complex traits in animal models. Nat. Genet. 18, 19-24. (doi:10.1038/ng0198-19)
    • (1998) Nat. Genet. , vol.18 , pp. 19-24
    • Darvasi, A.1
  • 22
    • 0035930563 scopus 로고    scopus 로고
    • In silico mapping of mouse quantitative trait loci
    • doi:10.1126/science.294.5551.2423a
    • Darvasi, A. 2001 In silico mapping of mouse quantitative trait loci. Science 294, 2423. (doi:10.1126/science.294.5551.2423a)
    • (2001) Science , vol.294 , pp. 2423
    • Darvasi, A.1
  • 23
    • 0028803358 scopus 로고
    • Advanced intercross lines, an experimental population for fine genetic mapping
    • Darvasi, A. & Soller, M. 1995 Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 141, 1199-1207.
    • (1995) Genetics , vol.141 , pp. 1199-1207
    • Darvasi, A.1    Soller, M.2
  • 24
    • 19844366096 scopus 로고    scopus 로고
    • Cisacting expression quantitative trait loci in mice
    • doi:10.1101/gr.3216905
    • Doss, S., Schadt, E. E., Drake, T. A. & Lusis, A. J. 2005 Cisacting expression quantitative trait loci in mice. Genome Res. 15, 681-691. (doi:10.1101/gr.3216905)
    • (2005) Genome Res. , vol.15 , pp. 681-691
    • Doss, S.1    Schadt, E.E.2    Drake, T.A.3    Lusis, A.J.4
  • 25
    • 11144357228 scopus 로고    scopus 로고
    • Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: Nomination of Kcnj10 as a causative gene
    • doi:10.1007/s00335-003-2270-3
    • Ferraro, T. N. et al. 2004 Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene. Mamm. Genome 15, 239-251. (doi:10.1007/s00335-003-2270-3)
    • (2004) Mamm. Genome , vol.15 , pp. 239-251
    • Ferraro, T.N.1
  • 26
    • 0742324932 scopus 로고    scopus 로고
    • Little epistasis for anxiety-related measures in the DeFries strains of laboratory mice
    • doi:10.1007/s00335-003-3033-x
    • Flint, J., De Fries, J. C. & Henderson, N. D. 2004 Little epistasis for anxiety-related measures in the DeFries strains of laboratory mice. Mamm. Genome 15, 77-82. (doi:10.1007/s00335-003-3033-x)
    • (2004) Mamm. Genome , vol.15 , pp. 77-82
    • Flint, J.1    De Fries, J.C.2    Henderson, N.D.3
  • 27
    • 15944376562 scopus 로고    scopus 로고
    • Strategies for mapping and cloning quantitative trait genes in rodents
    • doi:10.1038/nrg1576
    • Flint, J., Valdar, W., Shifman, S. & Mott, R. 2005 Strategies for mapping and cloning quantitative trait genes in rodents. Nat. Rev. Genet. 6, 271-286. (doi:10.1038/nrg1576)
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 271-286
    • Flint, J.1    Valdar, W.2    Shifman, S.3    Mott, R.4
  • 28
    • 13844264131 scopus 로고    scopus 로고
    • Accuracy of haplotype reconstruction from haplotype-tagging single-nucleotide polymorphisms
    • doi:10.1086/428439
    • Forton, J., Kwiatkowski, D., Rockett, K., Luoni, G., Kimber, M. & Hull, J. 2005 Accuracy of haplotype reconstruction from haplotype-tagging single-nucleotide polymorphisms. Am. J. Hum. Genet. 76, 438-448. (doi:10.1086/428439)
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 438-448
    • Forton, J.1    Kwiatkowski, D.2    Rockett, K.3    Luoni, G.4    Kimber, M.5    Hull, J.6
  • 29
    • 0035570186 scopus 로고    scopus 로고
    • Genetic dissection of region around the Sa gene on rat chromosome 1: Evidence for multiple loci affecting blood pressure
    • Frantz, S., Clemitson, J. R., Bihoreau, M. T., Gauguier, D. & Samani, N. J. 2001 Genetic dissection of region around the Sa gene on rat chromosome 1: evidence for multiple loci affecting blood pressure. Hypertension 38, 216-221.
    • (2001) Hypertension , vol.38 , pp. 216-221
    • Frantz, S.1    Clemitson, J.R.2    Bihoreau, M.T.3    Gauguier, D.4    Samani, N.J.5
  • 30
    • 4444329913 scopus 로고    scopus 로고
    • Segmental phylogenetic relationships of inbred mouse strains revealed by fine-scale analysis of sequence variation across 4.6 mb of mouse genome
    • doi:10. 1101/gr.2627804
    • Frazer, K. A., Wade, C. M., Hinds, D. A., Patil, N., Cox, D. R. & Daly, M. J. 2004 Segmental phylogenetic relationships of inbred mouse strains revealed by fine-scale analysis of sequence variation across 4.6 mb of mouse genome. Genome Res. 14, 1493-1500. (doi:10. 1101/gr.2627804)
    • (2004) Genome Res. , vol.14 , pp. 1493-1500
    • Frazer, K.A.1    Wade, C.M.2    Hinds, D.A.3    Patil, N.4    Cox, D.R.5    Daly, M.J.6
  • 31
    • 0036134391 scopus 로고    scopus 로고
    • Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats
    • doi:10.1007/s00335-001-2114-y
    • Garrett, M. R. & Rapp, J. P. 2002a Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats. Mamm. Genome 13, 41-44. (doi:10.1007/s00335-001-2114-y)
    • (2002) Mamm. Genome , vol.13 , pp. 41-44
    • Garrett, M.R.1    Rapp, J.P.2
  • 32
    • 0346929380 scopus 로고    scopus 로고
    • Two closely linked interactive blood pressure QTL on rat Chromosome 5 defined using congenic Dahl rats
    • Garrett, M. R. & Rapp, J. P. 2002b Two closely linked interactive blood pressure QTL on rat Chromosome 5 defined using congenic Dahl rats. Physiol. Genomics 8, 81-86.
    • (2002) Physiol. Genomics , vol.8 , pp. 81-86
    • Garrett, M.R.1    Rapp, J.P.2
  • 35
    • 3543046736 scopus 로고    scopus 로고
    • A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
    • doi:10.1038/ng1391
    • Guo, D. et al. 2004 A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat. Genet. 36, 837-841. (doi:10.1038/ng1391)
    • (2004) Nat. Genet. , vol.36 , pp. 837-841
    • Guo, D.1
  • 36
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • doi:10.1038/nrg1521
    • Hirschhorn, J. N. & Daly, M. J. 2005 Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6, 95-108. (doi:10.1038/nrg1521)
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 38
    • 11144357144 scopus 로고    scopus 로고
    • Characterization of a common susceptibility locus for asthma-related traits
    • doi:10.1126/science.1090010
    • Laitinen, T. et al. 2004 Characterization of a common susceptibility locus for asthma-related traits. Science 304, 300-304. (doi:10.1126/science. 1090010)
    • (2004) Science , vol.304 , pp. 300-304
    • Laitinen, T.1
  • 39
    • 0000639579 scopus 로고
    • The location of genetic factors affecting a quantitative characters in wheat
    • Law, C. N. 1966 The location of genetic factors affecting a quantitative characters in wheat. Genetics 53, 487-498.
    • (1966) Genetics , vol.53 , pp. 487-498
    • Law, C.N.1
  • 40
    • 0033975420 scopus 로고    scopus 로고
    • A major effect QTL determined by multiple genes in epileptic EL mice
    • Legare, M. E., Bartlett, F. S. & Frankel, W. N. 2000 A major effect QTL determined by multiple genes in epileptic EL mice. Genome Res. 10, 42-48.
    • (2000) Genome Res. , vol.10 , pp. 42-48
    • Legare, M.E.1    Bartlett, F.S.2    Frankel, W.N.3
  • 41
    • 0030465899 scopus 로고    scopus 로고
    • Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster
    • Long, A. D., Mullaney, S. L., Mackay, T. F. C. & Langley, C. H. 1996 Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster. Genetics 144, 1497-1510.
    • (1996) Genetics , vol.144 , pp. 1497-1510
    • Long, A.D.1    Mullaney, S.L.2    Mackay, T.F.C.3    Langley, C.H.4
  • 43
    • 0032881408 scopus 로고    scopus 로고
    • Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome sustitution strain
    • doi:10.1038/13874
    • Matin, A., Collin, G. B., Asada, Y., Varnum, D. & Nadeau, J. H. 1999 Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome sustitution strain. Nat. Genet. 23, 237-240. (doi:10.1038/13874)
    • (1999) Nat. Genet. , vol.23 , pp. 237-240
    • Matin, A.1    Collin, G.B.2    Asada, Y.3    Varnum, D.4    Nadeau, J.H.5
  • 44
    • 0002640688 scopus 로고
    • The use of isogenic and heterogenic mouse stocks in behavioral research
    • (ed. G. Lindzey & D. Thiessen). New York: Appleton Century Crofts
    • McClearn, G. E., Wilson, J. R. & Meredith, W. 1970 The use of isogenic and heterogenic mouse stocks in behavioral research. In Contributions to behavior-genetic analysis: the mouse as a prototype (ed. G. Lindzey & D. Thiessen), pp. 3-22. New York: Appleton Century Crofts.
    • (1970) Contributions to Behavior-genetic Analysis: The Mouse As a Prototype , pp. 3-22
    • McClearn, G.E.1    Wilson, J.R.2    Meredith, W.3
  • 45
    • 0036177752 scopus 로고    scopus 로고
    • Finescale mapping of disease loci via shattered coalescent modeling of genealogies
    • doi:10.1086/339271
    • Morris, A. P., Whittaker, J. C. & Balding, D. J. 2002 Finescale mapping of disease loci via shattered coalescent modeling of genealogies. Am. J. Hum. Genet. 70, 686-707. (doi:10.1086/339271)
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 686-707
    • Morris, A.P.1    Whittaker, J.C.2    Balding, D.J.3
  • 46
    • 0034619331 scopus 로고    scopus 로고
    • A method for fine mapping quantitative trait loci in outbred animal stocks
    • doi:10.1073/pnas.230304397
    • Mott, R., Talbot, C. J., Turri, M. G., Collins, A. C. & Flint, J. 2000 A method for fine mapping quantitative trait loci in outbred animal stocks. Proc. Natl Acad. Sci. USA 97, 12 649-12 654. (doi:10.1073/pnas.230304397)
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 12649-12654
    • Mott, R.1    Talbot, C.J.2    Turri, M.G.3    Collins, A.C.4    Flint, J.5
  • 47
    • 0034054962 scopus 로고    scopus 로고
    • Analysing complex genetic traits with chromosome substitution strains
    • doi:10.1038/73427
    • Nadeau, J. H., Singer, J. B., Matin, A. & Lander, E. S. 2000 Analysing complex genetic traits with chromosome substitution strains. Nat. Genet. 24, 221-225. (doi:10.1038/73427)
    • (2000) Nat. Genet. , vol.24 , pp. 221-225
    • Nadeau, J.H.1    Singer, J.B.2    Matin, A.3    Lander, E.S.4
  • 48
    • 20044394908 scopus 로고    scopus 로고
    • Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse
    • doi:10.1371/journal.pbio.0020393
    • Pletcher, M. T. et al. 2004 Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol. 2, e393. (doi:10.1371/journal.pbio.0020393)
    • (2004) PLoS Biol. , vol.2
    • Pletcher, M.T.1
  • 49
    • 7144263739 scopus 로고    scopus 로고
    • Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3
    • doi:10.1007/s003359900749
    • Podolin, P. L. et al. 1998 Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3. Mamm. Genome 9, 283-286. (doi:10.1007/s003359900749)
    • (1998) Mamm. Genome , vol.9 , pp. 283-286
    • Podolin, P.L.1
  • 50
    • 0034969437 scopus 로고    scopus 로고
    • Are rare variants responsible for susceptibility to complex diseases?
    • doi:10.1086/321272
    • Pritchard, J. K. 2001 Are rare variants responsible for susceptibility to complex diseases? Am. J. Hum. Genet. 69, 124-137. (doi:10.1086/321272)
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 124-137
    • Pritchard, J.K.1
  • 51
    • 0031906012 scopus 로고    scopus 로고
    • Identification of two quantitative trait loci involved in antibody production on mouse chromosome 8
    • doi:10.1007/s002510050365
    • Puel, A., Mevel, J. C., Bouthillier, Y., Decreusefond, C., Fridman, W. H., Feingold, N. & Mouton, D. 1998 Identification of two quantitative trait loci involved in antibody production on mouse chromosome 8. Immunogenetics 47, 326-331. (doi:10.1007/s002510050365)
    • (1998) Immunogenetics , vol.47 , pp. 326-331
    • Puel, A.1    Mevel, J.C.2    Bouthillier, Y.3    Decreusefond, C.4    Fridman, W.H.5    Feingold, N.6    Mouton, D.7
  • 52
    • 3943066275 scopus 로고    scopus 로고
    • A gene-driven ENU-based approach to generating an allelic series in any gene
    • doi:10.1007/s00335-004-2379-z
    • Quwailid, M. M. et al. 2004 A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm. Genome 15, 585-591. (doi:10.1007/s00335-004-2379-z)
    • (2004) Mamm. Genome , vol.15 , pp. 585-591
    • Quwailid, M.M.1
  • 53
    • 0034785352 scopus 로고    scopus 로고
    • Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
    • doi:10.1038/ng1001-223
    • Rioux, J. D. et al. 2001 Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat. Genet. 29, 223-228. (doi:10.1038/ng1001-223)
    • (2001) Nat. Genet. , vol.29 , pp. 223-228
    • Rioux, J.D.1
  • 54
    • 0034660559 scopus 로고    scopus 로고
    • Searching for genetic determinants in the new millennium
    • doi:10.1038/35015718
    • Risch, N. J. 2000 Searching for genetic determinants in the new millennium. Nature 405, 847-856. (doi:10.1038/35015718)
    • (2000) Nature , vol.405 , pp. 847-856
    • Risch, N.J.1
  • 55
    • 0038124351 scopus 로고    scopus 로고
    • Consomic rats for the identificaiton of genes and pathways underlying cardiovascular disease
    • New York: Cold Sping Harbor Laboratory Press
    • Roman, R. J., Cowley, A. W., Greene, A., Kwitek, A. E., Tonaellato, P. J. & Jacob, H. J. 2002 Consomic rats for the identificaiton of genes and pathways underlying cardiovascular disease. Cold Spring Harbor Symposia on Quantitative Biology, vol. LXVII, pp. 309-315. New York: Cold Sping Harbor Laboratory Press.
    • (2002) Cold Spring Harbor Symposia on Quantitative Biology , vol.67 , pp. 309-315
    • Roman, R.J.1    Cowley, A.W.2    Greene, A.3    Kwitek, A.E.4    Tonaellato, P.J.5    Jacob, H.J.6
  • 56
    • 22844446947 scopus 로고    scopus 로고
    • An integrative genomics approach to infer causal associations between gene expression and disease
    • doi:10.1038/ng1589
    • Schadt, E. E. et al. 2005 An integrative genomics approach to infer causal associations between gene expression and disease. Nat. Genet. 37, 710-717. (doi:10.1038/ng1589)
    • (2005) Nat. Genet. , vol.37 , pp. 710-717
    • Schadt, E.E.1
  • 57
    • 3042696861 scopus 로고    scopus 로고
    • Mpdz is a quantitative trait gene for drug withdrawal seizures
    • doi:10.1038/nn1271
    • Shirley, R. L., Walter, N. A., Reilly, M. T., Fehr, C. & Buck, K. J. 2004 Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat. Neurosci. 7, 699-700. (doi:10.1038/nn1271)
    • (2004) Nat. Neurosci. , vol.7 , pp. 699-700
    • Shirley, R.L.1    Walter, N.A.2    Reilly, M.T.3    Fehr, C.4    Buck, K.J.5
  • 58
    • 11144355685 scopus 로고    scopus 로고
    • Genetic dissection of complex traits with chromosome substitution strains of mice
    • doi:10.1126/science.1093139
    • Singer, J. B. et al. 2004 Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304, 445-448. (doi:10.1126/science.1093139)
    • (2004) Science , vol.304 , pp. 445-448
    • Singer, J.B.1
  • 59
    • 15544382002 scopus 로고    scopus 로고
    • Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice
    • Singer, J. B., Hill, A. E., Nadeau, J. H. & Lander, E. S. 2005 Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice. Genetics 169, 855-862.
    • (2005) Genetics , vol.169 , pp. 855-862
    • Singer, J.B.1    Hill, A.E.2    Nadeau, J.H.3    Lander, E.S.4
  • 60
    • 2542440445 scopus 로고    scopus 로고
    • Genetic complexity of an obesity QTL (Fob3) revealed by detailed genetic mapping
    • doi:10.1007/s00335-004-3039-z
    • Stylianou, I. M., Christians, J. K., Keightley, P. D., Bunger, L., Clinton, M., Bulfield, G. & Horvat, S. 2004 Genetic complexity of an obesity QTL (Fob3) revealed by detailed genetic mapping. Mamm. Genome 15, 472-481. (doi:10.1007/s00335-004-3039-z)
    • (2004) Mamm. Genome , vol.15 , pp. 472-481
    • Stylianou, I.M.1    Christians, J.K.2    Keightley, P.D.3    Bunger, L.4    Clinton, M.5    Bulfield, G.6    Horvat, S.7
  • 61
    • 0037173639 scopus 로고    scopus 로고
    • Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    • doi:10.1038/nature00878
    • Van Eerdewegh, P. et al. 2002 Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418, 426-430. (doi:10.1038/ nature00878)
    • (2002) Nature , vol.418 , pp. 426-430
    • Van Eerdewegh, P.1
  • 62
    • 0032832016 scopus 로고    scopus 로고
    • Speed congenics: Accelerated genome recovery using genetic markers
    • doi:10.1017/S0016672399003857
    • Visscher, P. M. 1999 Speed congenics: accelerated genome recovery using genetic markers. Genet. Res. 74, 81-85. (doi:10.1017/S0016672399003857)
    • (1999) Genet. Res. , vol.74 , pp. 81-85
    • Visscher, P.M.1
  • 63
    • 3042840998 scopus 로고    scopus 로고
    • Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice
    • doi:10.1073/pnas.0401189101
    • Yalcin, B. et al. 2004a Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice. Proc. Natl Acad. Sci. USA 101, 9734-9739. (doi:10.1073/pnas.0401189101)
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 9734-9739
    • Yalcin, B.1
  • 64
    • 11844254278 scopus 로고    scopus 로고
    • Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice
    • doi:10.1038/ng1450
    • Yalcin, B. et al. 2004b Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat. Genet. 36, 1197-1202. (doi:10.1038/ng1450)
    • (2004) Nat. Genet. , vol.36 , pp. 1197-1202
    • Yalcin, B.1
  • 65
    • 0037603549 scopus 로고    scopus 로고
    • Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin e levels and asthma
    • doi:10.1038/ng1153
    • Zhang, Y. et al. 2003 Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat. Genet. 34, 181-186. (doi:10.1038/ng1153)
    • (2003) Nat. Genet. , vol.34 , pp. 181-186
    • Zhang, Y.1
  • 66
    • 0742288585 scopus 로고    scopus 로고
    • The complex interplay among factors that influence allelic association
    • doi:10.1038/nrg1270
    • Zondervan, K. T. & Cardon, L. R. 2004 The complex interplay among factors that influence allelic association. Nat. Rev. Genet. 5, 89-100. (doi:10.1038/nrg1270)
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 89-100
    • Zondervan, K.T.1    Cardon, L.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.