Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice

Genetics

Volumn 169, Issue 2, 2005, Pages 855-862

  Singer, Jonathan B ^a,d,e   Hill, Annie E ^b   Nadeau, Joseph H ^b,c   Lander, Eric S ^a,d  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CHROMOSOME 1; CHROMOSOME 17; CHROMOSOME 6; CHROMOSOME SUBSTITUTION; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; INBRED STRAIN; LIGHT DARK CYCLE; MALE; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; STRAIN DIFFERENCE; TASK PERFORMANCE;

ANIMALS; ANXIETY; CHROMOSOME MAPPING; CHROMOSOMES; EXPLORATORY BEHAVIOR; MALE; MICE; MICE, INBRED A; MICE, INBRED C57BL; QUANTITATIVE TRAIT LOCI;

EID: 15544382002     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.104.031492     Document Type: Article

References (35)

1. BELKNAP, J. K., 2003 Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping. Mamm. Genome 14: 723-732.
2. COWLEY, A. W., JR., R. J. ROMAN, M. L. KALDUNSKI, P. DUMAS, J. G. DICKHOUT et al., 2001 Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension 37: 456-461.
3. CRABBE, J. C., D. WAHLSTEN and B. C. DUDEK, 1999 Genetics of mouse behavior: interactions with laboratory environment. Science 284: 1670-1672.
4. CRAWLEY, J. N., 2000 What's Wrong With My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice. Wiley-Liss, New York.
5. CRAWLEY, J. N., J. K. BELKNAP, A. COLLINS, J. C. CRABBE, W. FRANKEL et al., 1997 Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology 132: 107-124.
6. FESTING, M. F. W., 1979 Inbred Strains in Biomedical Research. Oxford University Press, Oxford.
7. FILE, S. E., and S. PELLOW, 1987 Behavioral pharmacology of minor tranquilizers. Pharmacol. Ther. 35: 265-290.
8. FLINT, J., 2003a Analysis of quantitative trait loci that influence animal behavior. J. Neurobiol. 54: 46-77.
9. FLINT, J., 2003b Animal models of anxiety and their molecular dissection. Semin. Cell Dev. Biol. 14: 37-42.
10. FLINT, J., R. CORLEY, J. C. DE FRIES, D. W. FULKER, J. A. GRAY et al., 1995 A simple genetic basis for a complex psychological trait in laboratory mice. Science 269: 1432-1435.
11. FRANCIS, D. D., K. SZEGDA, G. CAMPBELL, W. D. MARTIN and T. R. INSEL, 2003 Epigenetic sources of behavioral differences in mice. Nat. Neurosci. 6: 445-446.
12. GERSHENFELD, H. K., and S. M. PAUL, 1997 Mapping quantitative trait loci for fear-like behaviors in mice. Genomics 46: 1-8.
13. GERSHENFELD, H. K., P. E. NEUMANN, C. MATHIS, J. N. CRAWLEY, X. LI et al., 1997 Mapping quantitative trait loci for open-field behavior in mice. Behav. Genet. 27: 201-210.
14. GORHAM, J. D., M. L. GULER, R. G. STEEN, A. J. MACKEY, M. J. DALY et al., 1996 Genetic mapping of amurine locus controlling development of T helper 1/T helper 2 type responses. Proc. Natl. Acad. Sci. USA 93: 12467-12472.
15. KOUMPROGLOU, R., T. M. WILKES, P. TOWNSON, X. Y. WANG, J. BEYNON et al., 2002 STAIRS: a new genetic resource for functional genomic studies of Arabidopsis. Plant J. 31: 355-364.
16. LANDER, E., and L. KRUGLYAK, 1995 Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11: 241-247.
17. LIANG, M., B. YUAN, E. RUTE, A. S. GREENE, A. P. ZOU et al., 2002 Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study. Physiol. Genomics 8: 139-149.
18. MANLY, K. F., and J. M. OLSON, 1999 Overview of QTL mapping software and introduction to map manager QT. Mamm. Genome 10: 327-334.
19. MATHIS, C., S. M. PAUL and J. N. CRAWLEY, 1994 Characterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice. Behav. Genet. 24: 171-180.
20. MATHIS, C., P. E. NEUMANN, H. GERSHENFELD, S. M. PAUL and J. N. CRAWLEY, 1995 Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains. Behav. Genet. 25: 557-568.
21. MATIN, A., G. B. COLLIN, Y. ASADA, D. VARNUM and J. H. NADEAU, 1999 Susceptibility to testicular germ-cell tumours in a 129.MOLF-CHr 19 chromosome substitution strain. Nat. Genet. 23: 237-240.
22. MOTT, R., C. J. TALBOT, M. G. TURRI, A. C. COLLINS and J. FLINT, 2000 A method for fine mapping quantitative trait loci in outbred animal stocks. Proc. Natl. Acad. Sci. USA 97: 12649-12654.
23. MOUSE PHENOME DATABASE, 2001 http://www.jax.org/phenome/.
24. NADEAU, J. H., J. B. SINGER, A. MATIN and E. S. LANDER, 2000 Analysing complex genetic traits with chromosome substitution strains. Nat. Genet. 24: 221-225.
25. PELLOW, S., and S. E. FILE, 1986 Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol. Biochem. Behav. 24: 525-529.
26. PELLOW, S., P. CHOPIN, S. E. FILE and M. BRILEY, 1985 Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 14: 149-167.
27. SINGER, J. B., A. E. HILL, L. C. BURRAGE, K. R. OLSZENS, J. SONG et al., 2004 Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304: 445-448.
28. TALBOT, C. J., A. NICOD, S. S. CHERNY, D. W. FULKER, A. C. COLLINS et al., 1999 High-resolution mapping of quantitative trait loci in outbred mice. Nat. Genet. 21: 305-308.
29. TURRI, M. G., C. J. TALBOT, R. A. RADCLIFFE, J. M. WEHNER and J. FLINT, 1999 High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice. Mamm. Genome 10: 1098-1101.
30. TURRI, M. G., S. R. DATTA, J. DEFRIES, N. D. HENDERSON and J. FLINT, 2001a QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice. Curr. Biol. 11: 725-734.
31. TURRI, M. G., N. D. HENDERSON, J. C. DEFRIES and J. FLINT, 2001b Quantitative trait locus mapping in laboratory mice derived from a replicated selection experiment for open-field activity. Genetics 158: 1217-1226.
32. WADE, C. M., E. J. KULBOKAS, III, A. W. KIRBY, M. C. ZODY, J. C. MULLIKIN et al., 2002 The mosaic structure of variation in the laboratory mouse genome. Nature 420: 574-578.
33. WAHLSTEN, D., P. METTEN, T. J. PHILLIPS, S. L. BOEHM, II, S. BURKHART-KASCH et al., 2003 Different data from different labs: lessons from studies of gene-environment interaction. J. Neurobiol. 54: 283-311.
34. YOUNGREN, K. K., J. H. NADEAU and A. MATIN, 2003 Testicular cancer susceptibility in the 129.MOLF-Chrl9 mouse strain: additive effects, gene interactions and epigenetic modifications. Hum. Mol. Genet. 12: 389-398.
35. ZHANG, S., and H. K. GERSHENFELD, 2003 Genetic contributions to body weight in mice: relationship of exploratory behavior to weight Obes. Res. 11: 828-838.