Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA

EMBO Journal

Volumn 23, Issue 17, 2004, Pages 3441-3451

  Kovall, Rhett A ^a   Hendrickson, Wayne A ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Beta trefoil domain; Lag 1; RAM domain; Rel homology region; Transcription factor

Indexed keywords

DNA; NOTCH RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CSL; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CAENORHABDITIS ELEGANS PROTEINS; CRYSTALLOGRAPHY, X-RAY; DNA, RECOMBINANT; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; ELECTROSTATICS; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

LOTUS;

EID: 4644317278     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600349     Document Type: Article

References (47)

1. Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284: 770-776
2. Brunger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T, Warren GL (1998) Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr D 54: 905-921
3. Chen L, Glover JN, Hogan PG, Rao A, Harrison SC (1998) Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature 392: 42-48
4. Christopher JA (1998) SPOCK: The Structural Properties Observation and Calculation Kit (Program Manual), College Station, TX
5. Chung CN, Hamaguchi Y, Honjo T, Kawaichi M (1994) Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-J kappa. Nucleic Acids Res 22: 2938-2944
6. delaFortelle E, Bricogne G (1997) Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods. Methods Enzymol 276: 472-494
7. Doublie S (1997) Preparation of selenomethionyl proteins for phase determination. Methods Enzymol 276: 523-530
8. el Hassan MA, Calladine CR (1996) Propeller-twisting of base-pairs and the conformational mobility of dinucleotide steps in DNA. J Mol Biol 259: 95-103
9. Esnouf RM (1997) An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. J Mol Graph Model 15: 132-134
10. Fenn TD, Ringe D, Petsko GA (2003) POVScript +: a program for model and data visualization using persistence of vision raytracing. J Appl Crystallogr 36: 944-947
11. Fuchs KP, Bommer G, Dumont E, Christoph B, Vidal M, Kremmer E, Kempkes B (2001) Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction. Eur J Biochem 268: 4639-4646
12. Ghosh G, van Duyne G, Ghosh S, Sigler PB (1995) Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature 373: 303-310
13. Gouet P, Courcelle E, Stuart DI, Metoz F (1999) ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics 15: 305-308
14. Graves BJ, Hatada MH, Hendrickson WA, Miller JK, Madison VS, Satow Y (1990) Structure of interleukin 1 alpha at 2.7-Å resolution. Biochemistry 29: 2679-2684
15. Greenwald I (1998) LIN-12/Notch signaling: lessons from worms and flies. Genes Dev 12: 1751-1762
16. Gridley T (2003) Notch signaling and inherited disease syndromes. Hum Mol Genet 12 (Spec no. 1): R9-R13
17. Henkel T, Ling PD, Hayward SD, Peterson MG (1994) Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa. Science 265: 92-95
18. Holm L, Sander C (1993) Protein structure comparison by alignment of distance matrices. J Mol Biol 233: 123-138
19. Hsieh JJ, Hayward SD (1995) Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2. Science 268: 560-563
20. Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (1999) CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci USA 96: 23-28
21. Jones TA, Kjeldgaard M (1997) Electron-density map interpretation. Methods Enzymol 277: 173-208
22. Kabsch W, Sander C (1983) Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers 22: 2577-2637
23. Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T (1998) A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 12: 2269-2277
24. Kraulis PJ (1991) Molscript - a program to produce both detailed and schematic plots of protein structures. J Appl Crystallogr 24: 946-950
25. Laskowski RA, Macarthur MW, Moss DS, Thornton JM (1993) Procheck - a program to check the stereochemical quality of protein structures. J Appl Crystallogr 26: 283-291
26. Ling PD, Hayward SD (1995) Contribution of conserved amino acids in mediating the interaction between EBNA2 and CBF1/RBPJk. J Virol 69: 1944-1950
27. Ling PD, Rawlins DR, Hayward SD (1993) The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein. Proc Natl Acad Sci USA 90: 9237-9241
28. Lu XJ, Olson WK (2003) 3DNA: a software package for the analysis, rebuilding and visualization of three-dimensional nucleic acid structures. Nucleic Acids Res 31: 5108-5121
29. Maillard I, Pear WS (2003) Notch and cancer: best to avoid the ups and downs. Cancer Cell 3: 203-205
30. Muller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC (1995) Structure of the NF-kappa B p50 homodimer bound to DNA. Nature 373: 311-317
31. Mumm JS, Kopan R (2000) Notch signaling: from the outside in. Dev Biol 228: 151-165
32. Murzin AG, Lesk AM, Chothia C (1992) beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. J Mol Biol 223: 531-543
33. Nam Y, Weng AP, Aster JC, Blacklow SC (2003) Structural requirements for assembly of the CSL intracellular Notch1. Mastermind-like 1 transcriptional activation complex. J Biol Chem 278: 21232-21239
34. Nellesen DT, Lai EC, Posakony JW (1999) Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev Biol 213: 33-53
35. Nelson HC, Finch JT, Luisi BF, Klug A (1987) The structure of an oligo(dA).oligo(dT) tract and its biological implications. Nature 330: 221-226
36. Nicholls A, Bharadwaj R, Honig B (1993) Grasp - graphical representation and analysis of surface-properties. Biophys J 64: A166-A166
37. Otwinowski Z, Minor W (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276: 307-326
38. Perrakis A, Morris R, Lamzin VS (1999) Automated protein model building combined with iterative structure refinement. Nat Struct Biol 6: 458-463
39. Roehl H, Bosenberg M, Blelloch R, Kimble J (1996) Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor. EMBO J 15: 7002-7012
40. Sakai T, Taniguchi Y, Tamura K, Minoguchi S, Fukuhara T, Strobl LJ, Zimber-Strobl U, Bornkamm GW, Honjo T (1998) Functional replacement of the intracellular region of the Notchl receptor by Epstein-Barr virus nuclear antigen 2. J Virol 72: 6034-6039
41. Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, Honjo T (1995) Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol 5: 1416-1423
42. Tang Z, Kadesch T (2001) Identification of a novel activation domain in the Notch-responsive transcription factor CSL. Nucleic Acids Res 29: 2284-2291
43. Tani S, Kurooka H, Aoki T, Hashimoto N, Honjo T (2001) The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notchl RAMIC to activate transcription. Nucleic Acids Res 29: 1373-1380
44. Terwilliger TC, Berendzen J (1999) Automated MAD and MIR structure solution. Acta Crystallogr D 55: 849-861
45. Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680
46. Tun T, Hamaguchi Y, Matsunami N, Furukawa T, Honjo T, Kawaichi M (1994) Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. Nucleic Acids Res 22: 965-971
47. Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (2000) SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function. Mol Cell Biol 20: 2400-2410