Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos

Genes and Development

Volumn 17, Issue 10, 2003, Pages 1213-1218

  Raya, Angel ^a   Kawakami, Yasuhiko ^a   Rodríguez Esteban, Concepción ^a   Büscher, Dirk ^a   Koth, Christopher M ^a   Itoh, Tohru ^a   Morita, Masanobu ^a   Raya, R Marina ^a   Dubova, Ilir ^a   Bessa, Joaquín Grego ^b   De la Pompa, José Luis ^b   Izpisúa Belmonte, Juan Carlos ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HOSPITAL DURAN I REYNALS   (Spain)

Author keywords

Left right asymmetry; Nodal; Notch signaling; Pitx2; Sonic hedgehog; Zebrafish

Indexed keywords

DNA; NOTCH RECEPTOR;

ARTICLE; CHICKEN; CONTROLLED STUDY; EMBRYO; GENE; GENE EXPRESSION; GENE SEQUENCE; MESODERM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; ZEBRA FISH;

ANIMALS; BODY PATTERNING; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; HEDGEHOG PROTEINS; MEMBRANE PROTEINS; MICE; ORGANIZERS, EMBRYONIC; PROMOTER REGIONS (GENETICS); RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; SITUS INVERSUS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; ZEBRAFISH;

DANIO RERIO; ERINACEIDAE; GALLUS GALLUS; VERTEBRATA;

EID: 0037598796     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1084403     Document Type: Article

References (33)

1. Adachi, H., Saijoh, Y., Mochida, K., Ohishi, S., Hashiguchi, H., Hirao, A., and Hamada, H. 1999. Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer. Genes & Dev. 13: 1589-1600.
2. Artavanis-Tsakonas, S., Rand, M.D., and Lake, R.J. 1999. Notch signaling: Cell fate control and signal integration in development. Science 284: 770-776.
3. Barrantes, I.B., Ella, A.J., Wunsch, K., De Angelis, M.H., Mak, T.W., Rossant, J., Conlon, R.A., Gossler, A., and de la Pompa, J.L. 1999. Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr. Biol. 9: 470-480.
4. Bettenhausen, B., Hrabe de Angelis, M., Simon, D., Guenet, J.L., and Gossler, A. 1995. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 121: 2407-2418.
5. Brennan, J., Norris, D.P., and Robertson, E.J. 2002. Nodal activity in the node governs left-right asymmetry. Genes & Dev. 16: 2339-2344.
6. Burdine, R.D. and Schier, A.F. 2000. Conserved and divergent mechanisms in left-right axis formation. Genes & Dev. 14: 763-776.
7. Capdevila, J., Vogan, K.J., Tabin, C.J., and Izpisua Belmonte, J.C. 2000. Mechanisms of left-right determination in vertebrates. Cell 101: 9-21.
8. Chiang, C., Litingtung, Y., Lee, E., Young, K.E., Corden, J.L., Westphal, H., and Beachy, P.A. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383: 407-413.
9. Constam, D.B. and Robertson, E.J. 2000. Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping. Development 127: 245-254.
10. de la Pompa, J.L., Wakeham, A., Correia, K.M., Samper, E., Brown, S., Aguilera, R.J., Nakano, T., Honjo, T., Mak, T.W., Rossant, J., et al. 1997. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 124: 1139-1148.
11. Essner, J.J., Vogan, K.J., Wagner, M.K., Tabin, C.J., Yost, H.J., and Brueckner, M. 2002. Conserved function for embryonic nodal cilia. Nature 418: 37-38.
12. Hamada, H., Meno, C., Watanabe, D., and Saijoh, Y. 2002. Establishment of vertebrate left-right asymmetry. Nat. Rev. Genet. 3: 103-113.
13. Hamburger, V. and Hamilton, H.L. 1951. A series of normal stages in the development of the chick embryo. J. Morphol. 88: 49-92.
14. Hrabe de Angelis, M., McIntyre II, J., and Gossler, A. 1997. Maintenance of somite borders in mice requires the Delta homologue DII1. Nature 386: 717-721.
15. Izpisua-Belmonte, J.C., De Robertis, E.M., Storey, K.G., and Stern, C.D. 1993. The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm. Cell 74: 645-659.
16. Krebs, L.T., Iwai, N., Nonaka, S., Welsh, I.C., Lan, Y., Jiang, R., Saijoh, Y., O'Brien, T.P., Hamada, H., and Gridley, T. 2003. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes & Dev. (this issue).
17. Lowe, L.A., Supp, D.M., Sampath, K., Yokoyama, T., Wright, C.V., Potter, S.S., Overbeek, P., and Kuehn, M.R. 1996. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature 381: 158-161.
18. Marszalek, J.R., Ruiz-Lozano, P., Roberts, E., Chien, K.R., and Goldstein, L.S. 1999. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc. Natl. Acad. Sci. 96: 5043-5048.
19. Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H., and Hamada, H. 1998. lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94: 287-297.
20. Mercola, M. and Levin, M. 2001. Left-right asymmetry determination in vertebrates. Annu. Rev. Cell Dev. Biol. 17: 779-805.
21. Morales, A.V., Yasuda, Y., and Ish-Horowicz, D. 2002. Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling. Dev. Cell 3: 63-74.
22. Ng, J.K., Kawakami, Y., Buscher, D., Raya, A., Itoh, T., Koth, C.M., Rodriguez Esteban, C., Rodriguez-Leon, J., Garrity, D.M., Fishman, M.C., et al. 2002. The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Development 129: 5161-5170.
23. Norris, D.P. and Robertson, E.J. 1999. Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements. Genes & Dev. 13: 1575-1588.
24. Oka, C., Nakano, T., Wakeham, A., de la Pompa, J.L., Mori, C., Sakai, T., Okazaki, S., Kawaichi, M., Shiota, K., Mak, T.W., et al. 1995. Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development 121: 3291-3301.
25. Okada, Y., Nonaka, S., Tanaka, Y., Saijoh, Y., Hamada, H., and Hirokawa, N. 1999. Abnormal nodal flow precedes situs inversus in iv and inv mice. Mol. Cell 4: 459-468.
26. Pagan-Westphal, S.M. and Tabin, C.J. 1998. The transfer of left-right positional information during chick embryogenesis. Cell 93: 25-35.
27. Pennekamp, P., Karcher, C., Fischer, A., Schweickert, A., Skryabin, B., Horst, J., Blum, M., and Dworniczak, B. 2002. The ion channel polycystin-2 is required for left-right axis determination in mice. Curr. Biol. 12: 938-943.
28. Przemeck, G.K., Heinzmann, U., Beckers, J., and Hrabe de Angelis, M. 2003. Node and midline defects are associated with left-right development in Delta1 mutant embryos. Development 130: 3-13.
29. Rebagliati, M.R., Toyama, R., Fricke, C., Haffter, P., and Dawid, I.B. 1998. Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Dev. Biol. 199: 261-272.
30. Rodriguez-Esteban, C., Capdevila, J., Economides, A.N., Pascual, J., Ortiz, A., and Izpisua Belmonte, J.C. 1999. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature 401: 243-251.
31. Saijoh, Y., Oki, S., Ohishi, S., and Hamada, H. 2003. Left-right patterning of the mouse lateral plate requires Nodal produced in the node. Dev. Biol. 256: 161-173.
32. Supp, D.M., Witte, D.P., Potter, S.S., and Brueckner, M. 1997. Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice. Nature 389: 963-966.
33. -/- mice analysis. J. Cell Biol. 145: 825-836.