Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 360, Issue 3, 1999, Pages 262-269

  Gobbi, Marco ^a   Dalla Valle, Fabio ^a   Ciapparelli, Carlo ^a   Diomede, Luisa ^a   Morazzoni, Paolo ^b   Verotta, Luisella ^c   Caccia, Silvio ^a   Cervo, Luigi ^a   Mennini, Tiziana ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b INDENA S P A   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Antidepressants; Hypericum perforatum L.; Rat brain; Serotonin release; Serotonin transporters; Serotonin uptake; Synaptosomes

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 ETHYL 1,2,3,4,6,7 HEXAHYDRO 2 HYDROXY 3 ISOBUTYL 9,10 DIMETHOXY 11BH BENZO[A]QUINOLIZINE; 4 AMINOBUTYRIC ACID; 5 HYDROXYINDOLEACETIC ACID; ALCOHOL; ANTIDEPRESSANT AGENT; CITALOPRAM; DIMETHYL SULFOXIDE; DOPAMINE; FLUMAZENIL; HYPERICUM PERFORATUM EXTRACT; METHANOL; MUSCIMOL; NORADRENALIN; RESERPINE DERIVATIVE; SEROTONIN; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CATECHOLAMINE DEPLETION; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; MALE; MEMBRANE VESICLE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SEROTONIN BRAIN LEVEL; SEROTONIN RELEASE; SEROTONIN UPTAKE;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CARRIER PROTEINS; CEREBRAL CORTEX; CITALOPRAM; DOPAMINE; HYPERICUM; IMMOBILIZATION; MALE; MEMBRANE FLUIDITY; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; PLANT EXTRACTS; PLANTS, MEDICINAL; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; RECEPTORS, GABA-A; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SYNAPTOSOMES; TIME FACTORS; TRITIUM;

EID: 0032862589     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900073     Document Type: Article

References (40)

1. Bhattacharya SK, Chakrabarti A, Chalterjee SS (1998) Activity profiles of two hyperforin-containing Hypericum extracts in behavioural models. Pharmacopsychiatry 31:22-29
2. Biber A, Fischer H, Romer A, Chatterjee SS (1998) Oral bioavailability of hyperforin from Hypericum extracts in rats and human volunteers. Pharmacopsychiatry [Suppl] 31:36-43
3. Bladt S, Wagner H (1994) Inhibition of MAO by fractions and constituents of hypericum extract. J Geriatr Psychiatry Neurol 7 [Suppl 1]:S57-S59
4. Blaschke M, Fischer HD, Rudolph E (1980) Effect of reserpine on monoamine uptake by rat brain synaptosomes. Acta Biol Med Ger 39:1205-1212
5. 3H]5-hydroxytryptamine in the rat CNS. J Neurochem 46:1392-1398
6. Bombardelli E, Morazzoni P (1995) Hypericum perforatum. Fitoterapia 66:43-68
7. Bowery NG, Hill DR, Hudson AL (1983) Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes. Br J Pharmacol 78:191-206
8. Butterweck V, Wall A, Lieflander Wulf U, Winterhoff H, Nahrstedt A (1997) Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry 30:117-124
9. Caccia S, Fracasso C, Garattini S, Guiso G, Sarati S (1992a) Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain. Neuropharmacology 31:343-347
10. Caccia S, Sarati S, Anelli M, Carattini S (1992b) Effect of escalating doses of d-fenfluramine on the content of indoles in brain. Neuropharmacology 31:875-879
11. Cervo L, Samanin R (1991) Effect of chronic treatment with 8-OH-DPAT in the forced swimming test requires the integrity of presynaptic serotonergic mechanisms. Psychopharmacology 103:524-528
12. Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Muller WE (1998) Hyperforin as a possible antidepressant component of Hypericum extracts. Life Sci 63:499-511
13. Cinquanta M, Ratovitski T, Crespi D, Gobbi M, Mennini TS (1997) Carrier-mediated serotonin release induced by d-fenfluramine: studies with human neuroblastoma cells transfected with a rat serotonin transporter. Neuropharmacolopy 36:803-809
14. Colzi A, D'Agostini F, Cesura AM, Da Prada M (1993) Monoamine oxidase-A inhibitors and dopamine metabolism in rat caudatus: evidence that an increased cytosolic level of dopamine displaces reversible monoamine oxidase-A inhibitors in vivo. J Pharmacol Exp Ther 265:103-111
15. Cott JM (1997) In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiatry 30:108-112
16. 3H]imipramine. J Pharrnacol Exp Ther 242:364-371
17. De Smet PAGM, Nolen WA (1996) St. John's wort as an antidepressant: longer term studies are needed before it can be recommended in major depression. BMJ 313:241-242
18. Fuller RW, Snoddy HD, Robertson DW (1988) Mechanisms of effects of d-fenfluramine on brain serotonin metabolism in rats: uptake inhibition versus release. Pharmacol Biochem Behav 30:715-721
19. Gobbi M, Barone D, Mennini T, Garattini S (1987) Diazepam and desmethyldiazepam differ in their affinities and efficacies at 'central' and 'peripheral' benzodiazepine receptors. J Pharm Pharmacol 39:388-391
20. 3H]serotonin. Naunyn-Schmiedeberg's Arch Pharmacol 345:1-6
21. Gobbi M, Regondi MC, Pompeiano M, Palacios JM, Mennini T (1994) Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration on 5-HT(IA) receptors and 5-HT uptake sites in the rat brain. J Chem Neuroanat 7:65-73
22. Gobbi M, Mancini L, Presti ML, Mennini T (1996) Down-regulation of rat brain 5-HT uptake carriers after treatment with high doses of D-fenfluramine. Brain Res 730:165-172
23. Gray EG, Whittaker VP (1962) The isolation of nerve endings from brain: an electron-microcsope study of cell fragments derived by homogenization and centrifugation. J Anat 96:79-87
24. 3H]8-hydroxy-2-(di-n-propylamino)tetralin binding to preand postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. J Neurochem 44:1685-1696
25. Herschel M, Baldessarini RJ (1979) Evidence for two types of binding of 3H-gaba and 3H-muscimol in rat cerebral cortex and cerebellum. Life Sci 24:1849-1854
26. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D (1996) St. John's wort for depression - an overview and meta-analysis of randomised clinical trials. BMJ 313:253-258
27. Mauru G, Gemignani A, Versace P, Martire M, Raiteri M (1982) Carrier-mediated and carrier-independent release of serotonin from isolated central nerve endings. Neurochem Int 4:219-224
28. Mennini T, Gobbi M, Romandini S (1986) Localization of GABAA and GABAB receptor subtypes on serotonergic neurons. Brain Res 371:372-375
29. Meruelo D, Lavie G (1988) Therapeutic agents with dramatic anti-retroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proc Natl Acad Sci USA 85:5230-5234
30. Muller WE, Rolli M, Schafer C, Hafner U (1997) Effects of Hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry 30:102-107
31. Muller WE, Singer A, Wonnemann M, Hafner U, Rolli M, Schafer C (1998) Hyperforin represents the neurotransmitter reuptake inhibiting constituent of Hypericum extract. Pharmacopsychiatry 31:16-21
32. Ozturk Y (1997) Testing the antidepressant effects of Hypericum species on animal models. Pharmacopsychiatry 30:125-128
33. Perovic S, Muller WE (1995) Pharmacological profile of Hypericum extract. Effect on serotonin uptake by postsynaptic receptors. Arzneimittelforschung 45:1145-1148
34. Pulvirenti L, Samanin R (1986) Antagonism by dopamine, but not noradrenaline receptor blockers of the anti-immobility activity of desipramine after different treatment schedules in the rat. Pharmacol Res Commun 18:73-80
35. Raiteri M, Angelini F, Levi G (1974) A simple apparatus for studying the release of neurotransmitters from synaptosomes. Eur J Pharmacol 25:411-414
36. Rampes H (1997) Hypericum, an over the counter antidepressant? J Psychopharmacol 11:191
37. Shinitzky M, Barenholz Y (1978) Fluidity parameters of lipid regions determined by fluorescence polarization. Biochim Biophys Acta 515:367-394
38. Tatsumi M, Groshan K, Blakely RD, Richelson E (1997) Pharmacological profile of antidepressanls and related compounds at human monoamine transporters. Eur J Pharmacol 340:249-258
39. Thiede HM, Walper A (1994) Inhibition of MAO and COMT by Hypericum extracts and hypericin. J Geriatr Psychiatry Neurol 7 [Suppl 1]:S54-S56
40. Volz HP (1997) Controlled clinical trials of Hypericum extracts in depressed patients - an overview. Pharmacopsychiatry 30:72-76