Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 3, 1999, Pages 1363-1368

  Singer, A ^a   Wonnemann, M ^a   Muller W E ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; ISOPHTHALIC ACID; MONENSIN; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SODIUM; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HYPERICUM PERFORATUM; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; SEROTONINERGIC SYSTEM; SODIUM CELL LEVEL; SYNAPTOSOME;

ANIMALS; ANTIDEPRESSIVE AGENTS; BICYCLO COMPOUNDS; BINDING SITES; BINDING, COMPETITIVE; BRAIN; FEMALE; HUMANS; INTRACELLULAR FLUID; KINETICS; MICE; PAROXETINE; PHLOROGLUCINOL; PLANT EXTRACTS; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SODIUM; SYNAPTOSOMES; TERPENES; THEALES; TRITIUM;

EID: 0032797512     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Adovelande J and Schrével J (1996) Carboxylic ionophores in malaria chemotherapy: The effects of monensin and nigericin on plasmodium falciparum in vitro and plasmodium vinckei petteri in vivo. Life Sci 59:309-315.
2. Bergen WG and Bates DB (1984) Ionophores: Their effect on production efficiency and mode of action. J Anim Sci 58:1465-1483.
3. Bhattacharya SK, Chakrabarti A and Chatterjee, SS (1998) Active profiles of two hyperforin-containing hypericum extracts in behavioral models. Pharmacopsychiatry 31(Suppl 1):22-29.
4. Biber A, Fischer H, Römer A and Chatterjee SS (1998) Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers. Pharmacopsychiatry 31(Suppl 1):36-43.
5. Bogdanski DF, Tissari AH and Brodie BB (1979) Mechanism of transport and storage of biogenic amines. III. Effects of sodium and potassium on kinetics of 5-hydroxytryptamine and norepinephrine transport by rabbit synaptosomes. Biochim Biophys Acta 219:189-199.
6. + concentration in human platelets. J Biol Chem 265:19543-19550.
7. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
8. Butterweck V, Wall A, Liefländer-Wulf U, Winterhoff H and Nahrstedt A (1997) Effects of the total extract and fractions of hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry 30(Suppl 2):117-124.
9. Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A and Müller WE (1998) Hyperforin as a possible antidepressant component of hypericum extracts. Life Sci 63:499-510.
10. Cott JM (1997) In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiatry 30(Suppl 2):108-112.
11. 2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG). Pharmacopsychiatry 31(Suppl 1):30-35.
12. 3H-cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. Neuropsychopharmacology 14:309-323.
13. + in individual fibroblasts and lymphocytes. J Biol Chem 264:19458-19467.
14. 3H-5-HT uptake in rat brain synaptosomes in vitro. Psychopharmacology 60:13-18.
15. 3H]serotonin uptake by cocaine: Comparision between chopped tissue slices and synaptosomes. Life Sci 50:541-547.
16. Kaehler ST, Sinner C, Chatterjee SS and Philippu A (1999) Hyperforin enhances the release of catecholamines, serotonin and glutamate in the rat locus coeruleus. Neurosci Lett 262:199-202.
17. + across liposome membrane. Biochim Biophys Acta 1064:103-110.
18. Laakmann G, Schüle C, Baghai T and Kieser M (1998) St. John's wort in mild to moderate depression: The relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry 31(Suppl 1):54-59.
19. Lester HA, Mager S, Quick MW and Corey JL (1994) Permeation properties of neurotransmitter transporters. Annu Rev Pharmacol Toxicol 34:219-249.
20. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W and Melchart D (1996) St. John's Wort for depression: An overview and meta-analysis of randomised clinical trials. Brit Med J 313:253-258.
21. Marcusson and Ross (1990) Binding of some antidepressants to the 5-HT transporter in brain and platelets. Psychopharmacology 102:145-155.
22. Müller WE, Rolli M, Schäfer C and Hafner U (1997) Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry 30(Suppl 2):102-107
23. Müller WE, Singer A, Wonnemann M, Hafner U, Rolli M and Schäfer C (1998) Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry 31(Suppl 1):16-21.
24. Reith MEA and O'Reilly CA (1990) Inhibition of serotonin uptake into mouse brain synaptosomes by ionophores and ion-channel agents. Brain Res 521:347-351.
25. 39K-NMR. Biochim Biophys Acta 944:279-284.
26. + potentiometry: Relationship with antimicrobial and antimalarial activities. J Med Chem 39:588-595.
27. + by monensin across bimolecular lipid membranes. Biochim Biophys Acta 684:127-132.
28. Schellenberg R, Sauer S and Dimpfel W (1998) Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG. Pharmacopsychiatry 31(Suppl 1):44-53.
29. Sneddon JM (1969) Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets. Br J Pharmacol 37:680-688.
30. Sneddon JM (1973) Blood platelets as a model for monoamine-containing neurones. Prog Neurobiol 1:151-198.
31. Suzuki O, Katsumata Y, Oya M, Bladt S and Wagner H (1984) Inhibition of monoamine oxidase by hypericin. Planta Med 50:272-274.
32. Volz HP (1997) Controlled clinical trials of hypericum extracts in depressed patients: An overview. Pharmacopsychiatry 30(Suppl 2):72-76.
33. Wheatley D (1998) Hypericum extract -Potential in the treatment of depression. CNS Drugs 9:431-440.
34. Wong AHC, Smith M and Boon HS (1998) Herbal remedies in psychiatric practice. Arch Gen Psychiatry 55:1033-1044.