B cells alter the phenotype and function of follicular-homing CXCR5+ T cells

European Journal of Immunology

Volumn 34, Issue 12, 2004, Pages 3562-3571

  Ebert, Lisa M ^a   Horn, Michael P ^b   Lang, Alois B ^b   Moser, Bernhard ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Berna Biotech AG   (Switzerland)

Author keywords

B lymphocytes; Chemokines; IL 10; T lymphocytes

Indexed keywords

CD40 LIGAND; CD70 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR5; INTERLEUKIN 10;

ARTICLE; B LYMPHOCYTE; CELLULAR DISTRIBUTION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPH NODE; LYMPHOCYTE FUNCTION; LYMPHOCYTE HOMING; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; PHENOTYPE; PLASMA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIBODY FORMATION; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTES; HUMANS; INTERLEUKIN-10; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; T-LYMPHOCYTES;

EID: 10944228245     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425478     Document Type: Article

References (37)

1. Cyster, J. G., Chemokines and cell migration in secondary lymphoid organs. Science 1999. 286: 2098-2102.
2. Moser, B. and Loetscher, P., Lymphocyte traffic control by chemokines. Nat. Immunol. 2001. 2: 123-128.
3. Müller, G., Höpken, U. E., Stein, H. and Lipp, M., Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors. J. Leukoc. Biol. 2002. 72: 1-8.
4. Moser, B., Wolf, M., Walz, A. and Loetscher, P., Chemokines: multiple levels of leukocyte migration control. Trends Immunol. 2004. 25: 75-84.
5. Gunn, M. D., Ngo, V. N., Ansel, K. M., Ekland, E. H., Cyster, J. G. and Williams, L. T., A B cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 1998. 391: 799-803.
6. Legler, D. F., Loetscher, M., Roos, R. S., Clark-Lewis, I., Baggiolini, M. and Moser, B., B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J. Exp. Med. 1998. 187: 655-660.
7. Förster, R., Emrich, T., Kremmer, E. and Lipp, M., Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood 1994. 84: 830-840.
8. Schaerli, P., Willimann, K., Lang, A. B., Lipp, M., Loetscher, P. and Moser, B., CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 2000. 192: 1553-1562.
9. Breitfeld, D., Ohl, L., Kremmer, E., Ellwart, J., Sallusto, F., Lipp, M. and Forster, R., Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 2000. 192: 1545-1552.
10. Sallusto, F., Lenig, D., Förster, R., Lipp, M. and Lanzavecchia, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
11. Garside, P., Ingulli, E., Merica, R. R., Johnson, J. G., Noelle, R. J. and Jenkins, M. K., Visualization of specific B and T lymphocyte interactions in the lymph node. Science 1998. 281: 96-99.
12. Ansel, K. M., McHeyzer-Williams, L. J., Ngo, V. N., McHeyzer-Williams, M. G. and Cyster, J. G., In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 1999. 190: 1123-1134.
13. Reif, K., Ekland, E. H., Ohl, L., Nakano, H., Lipp, M., Forster, R. and Cyster, J. G., Balanced responsiveness to chemoattractants from adjacent zones determines B cell position. Nature 2002. 416: 94-99.
14. Schaerli, P., Loetscher, P. and Moser, B., Cutting edge: Induction of follicular homing precedes effector Th cell development. J. Immunol. 2001. 167: 6082-6086.
15. Bishop, G. A. and Hostager, B. S., The CD40-CD154 interaction in B cell-T cell liaisons. Cytokine Growth Factor Rev. 2003. 14: 297-309.
16. Rousset, F., Garcia, E., Defrance, T., Peronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W. and Banchereau, J., Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. USA 1992. 89: 1890-1893.
17. Jacquot, S., Kobata, T., Iwata, S., Morimoto, C. and Schlossman, S. F., CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signaling. J. Immunol. 1997. 159: 2652-2657.
18. Agematsu, K., Nagumo, H., Oguchi, Y., Nakazawa, T., Fukushima, K., Yasui, K., Ito, S., Kobata, T., Morimoto, C. and Komiyama, A., Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27/CD70 interaction. Blood 1998. 91: 173-180.
19. Choe, J. and Choi, Y. S., IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells. Eur. J. Immunol. 1998. 28: 508-515.
20. Morimoto, S., Kanno, Y., Tanaka, Y., Tokano, Y., Hashimoto, H., Jacquot, S., Morimoto, C., Schlossman, S. F., Yagita, H., Okumura, K. and Kobata, T., CD134L engagement enhances human B cell Ig production: CD154/CD40, CD70/CD27, and CD134/CD134L interactions coordinately regulate T cell-dependent B cell responses. J. Immunol. 2000. 164: 4097-4104.
21. Tangye, S. G., Avery, D. T. and Hodgkin, P. D., A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells. J. Immunol. 2003. 170: 261-269.
22. Macaulay, A. E., DeKruyff, R. H. and Umetsu, D. T., Antigen-primed T cells from B cell-deficient JHD mice fail to provide B cell help. J. Immunol. 1998. 160: 1694-1700.
23. Stockinger, B., Zal, T., Zal, A. and Gray, D., B cells solicit their own help from T cells. J. Exp. Med. 1996. 183: 891-899.
24. McAdam, A. J., Greenwald, R. J., Levin, M. A., Chernova, T., Malenkovich, N., Ling, V., Freeman, G. J. and Sharpe, A. H., [COS is critical for CD40-mediated antibody class switching. Nature 2001. 409: 102-105.
25. Tafuri, A., Shahinian, A., Bladt, F., Yoshinaga, S. K., Jordana, M., Wakeham, A., Boucher, L. M., Bouchard, D., Chan, V. S., Duncan, G. et al., ICOS is essential for effective T-helper-cell responses. Nature 2001. 409: 105-109.
26. Yellin, M. J., Sippel, K., Inghirami, G., Covey, L. R., Lee, J. J., Sinning, J., Clark, E. A., Chess, L. and Lederman, S., CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function. J. Immunol. 1994. 152: 598-608.
27. + T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Eur. J. Immunol. 2003. 33: 474-482.
28. Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I. and Kroczek, R. A., ICOS is an inducible T cell co-stimulator structurally and functionally related to CD28. Nature 1999. 397: 263-266.
29. Kopf, M., Coyle, A- J., Schmitz, N., Barrier, M., Oxenius, A., Gallimore, A., Gutierrez-Ramos, J. C. and Bachmann, M. F., Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection. J. Exp. Med. 2000. 192: 53-61.
30. + T cells. J. Immunol. 2000. 165: 5035-5040.
31. Witsch, E. J., Peiser, M., Hutloff, A., Buchner, K., Dorner, B. G., Jonuleit, H., Mages, H. W. and Kroczek, R. A., ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells. Eur. J. Immunol. 2002. 32: 2680-2686.
32. Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., Sarmiento, U., Guo, J., Horan, T., Shih, G., Zhang, M., Coccia, M. A., Kohno, T. et al., T cell co-stimulation through B7RP-1 and ICOS. Nature 1999. 402: 827-832.
33. + T cell subset inhibits antigen-specific T cell responses and prevents colitis. Nature 1997. 389: 737-742.
34. Kitani, A., Chua, K., Nakamura, K. and Strober, W., Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells. J. Immunol. 2000. 165: 691-702.
35. Moser, B., Schaerli, P. and Loetscher, P., CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses. Trends Immunol. 2002. 23: 250-254.
36. Moser, B. and Ebert, L., Lymphocyte traffic control by chemokines: follicular B helper T cells. Immunol. Lett. 2003. 85: 105-112.
37. + T cells. J. Exp. Med. 2001. 193: 1373-1381.