Natural products inhibiting the ubiquitin-proteasome proteolytic pathway, a target for drug development

Current Medicinal Chemistry

Volumn 13, Issue 7, 2006, Pages 745-754

  Tsukamoto, Sachiko ^a   Yokosawa, Hideyoshi ^b  

^a KANAZAWA UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Natural product; Proteasome; Ubiquitin activating enzyme; Ubiquitin conjugating enzyme; Ubiquitin protein ligase; Ubiquitin protesome proteolytic pathway; Ubiquitin; ubiquitination

Indexed keywords

30 HYDROXYMYCALOLIDE A; AGOSTEROL C; BELACTOSIN A; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; CHLOROFUSIN; DNA; DNA 26S; EPOXOMICIN; GLIOTOXIN; LACTACYSTIN; LACTACYSTIN BETA LACTONE; LIGASE INHIBITOR; MYCALOLIDE A; NATURAL PRODUCT; NUTLIN 1; NUTLIN 3; POLYUBIQUITIN; PROTEASOME; PROTEASOME INHIBITOR; SALINOSPORAMIDE A; SECOMYCALOLIDE A; TMC 95A; TP 104; TYROPEPTIN A; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER; CELL CYCLE PROGRESSION; DNA REPAIR; DRUG APPROVAL; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; EUKARYOTE; FOOD AND DRUG ADMINISTRATION; GENETIC TRANSCRIPTION; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; INFLAMMATORY DISEASE; MOLECULAR WEIGHT; MULTIPLE MYELOMA; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SYSTEMATIC REVIEW; UBIQUITINATION;

BIOLOGICAL PRODUCTS; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; HYDROLYSIS; MOLECULAR STRUCTURE; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITIN;

EID: 33645961605     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706776055571     Document Type: Review

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