Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 5, 2005, Pages 1515-1520

  Hardcastle, Ian R ^a   Ahmed, Shafiq U ^b   Atkins, Helen ^b   Calvert, A Hilary ^b   Curtin, Nicola J ^b   Farnie, Gillian ^b   Golding, Bernard T ^a   Griffin, Roger J ^a   Guyenne, Sabrina ^a   Hutton, Claire ^b   Källblad, Per ^c   Kemp, Stuart J ^a   Kitching, Martin S ^a   Newell, David R ^b   Norbedo, Stefano ^a   Northen, Julian S ^a   Reid, Rebecca J ^a   Saravanan, K ^a   Willems, Henriëtte M G ^c   Lunec, John ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c De Novo Pharmaceuticals   (United Kingdom)

Author keywords

Cancer; MDM2; p53; Protein protein interactions

Indexed keywords

3 (4 CHLOROPHENYL) 3 (4 HYDROXY 3,5 DIMETHOXYBENZYLOXY) 2 PROPYL 2,3 DIHYDROISOINDOL 1 ONE; ANTINEOPLASTIC AGENT; ISOINDOLINONE; NU 8231; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IC 50; PROTEIN PROTEIN INTERACTION; SARCOMA CELL;

EID: 13944282529     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.12.061     Document Type: Article

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