Inhibition of proteasome activity by tyropeptin A in PC12 cells

Bioscience, Biotechnology and Biochemistry

Volumn 66, Issue 10, 2002, Pages 2256-2258

  Momose, Isao ^a   Sekizawa, Ryuichi ^a   Iinuma, Hironobu ^a   Takeuchi, Tomio ^a  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

Neurite outgrowth; Proteasome inhibitor; Tyropeptin A

Indexed keywords

KITASATOSPORA;

ANTINEOPLASTIC ANTIBIOTIC; CYSTEINE PROTEINASE; DIPEPTIDE; MULTIENZYME COMPLEX; PROTEASOME; TYROPEPTIN A;

ANIMAL; ARTICLE; CELL MEMBRANE; CELL STRAIN; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NEURITE; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL MEMBRANE; CYSTEINE ENDOPEPTIDASES; DIPEPTIDES; MULTIENZYME COMPLEXES; NEURITES; PC12 CELLS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS;

EID: 1842869931     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.66.2256     Document Type: Article

References (12)

1. Coux, O., Tanaka, K., and Goldberg, A. L., Structure and function of the 20S and 26S proteasome. Annu. Rev. Biochem., 65, 801-847 (1996).
2. Hershko, A., and Ciechanover, A., The ubiquitin system. Annu. Rev. Biochem., 67, 425-479 (1998).
3. Maki, C. G., and Howley, P. N., Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol. Cell Biol., 17, 355-363 (1997).
4. Pagano, M., Tam, S. W., Theodoras, A. M., Beer-Romero, P., Del Sal, G., Chau, V., Yew, P. R., Draetta, G. F., and Rolfe, M., Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science, 269, 682-685 (1995).
5. Ciechanover, A., DiGiuseppe, J. A., Bercovich, B., Orian, A., Richter, J. D., Schwartz, A. L., and Brodeur, G. M., Degradation of nuclear oncoproteins by the ubiquitin system in vitro. Proc. Natl. Acad. Sci. USA, 88, 139-143 (1991).
6. Palombella, V. J., Rando, O. J., Goldberg, A. L., and Maniatis, T., The ubiquitin-proteasome pathway is required for processing the NF-kB1 precursor protein and the activation of NF-kB. Cell, 78, 773-785 (1994).
7. Obin, M., Mesco, E., Gong, X., Haas, A. L., Joseph, J., and Taylor, A., Neurite outgrowth in PC12 cells: distinguishing the roles of ubiquitylation and ubiquitin-dependent proteolysis. J. Biol. Chem., 274, 11789-11795 (1999).
8. Tsubuki, S., Kawasaki, H., Saito, Y., Miyashita, N., Inomata, M., and Kawashima, S., Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome. Biochem. Biophys. Res. Commun., 196, 1195-1201 (1993).
9. Momose, I., Sekizawa, R., Hashizume, H., Kinoshita, N., Homma, Y., Hamada, M., Iinuma, H., and Takeuchi, T., Tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp. MK993-dF2: I. Taxonomy, isolation, physico-chemical properties and biological activities. J. Antibiot., 54, 997-1003 (2001).
10. Momose, I., Sekizawa, R., Hirosawa, S., Ikeda, D., Naganawa, H., Iinuma, H., and Takeuchi, T., Tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp. MK993-dF2: II. Structure determination and synthesis. J. Antibiot., 54, 1004-1012 (2001).
11. Saito, Y., and Kawashima, S., The neurite-initiating effect of a tripeptide aldehyde protease inhibitor on PC12h cells. J. Biochem., 106, 1035-1040 (1989).
12. Ohtani-Kaneko, R., Takada, K., Iigo, M., Hara, M., Yokosawa, H., Kawashima, S., Ohkawa, K., and Hirata, K., Proteasome inhibitors which induce neurite outgrowth from PC12h cells cause different subcellular accumulation of multi-ubiquitin chains. Neurochem. Res., 23, 1435-1443 (1998).