Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: An application of serum incubation method

Drug Metabolism and Disposition

Volumn 30, Issue 8, 2002, Pages 892-896

  Shibata, Yoshihiro ^a   Takahashi, Hiroyuki ^a   Chiba, Masato ^a   Ishii, Yasuyuki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUSPIRONE; CAFFEINE; DIAZEPAM; DICLOFENAC; IMIPRAMINE; LIDOCAINE; METOPROLOL; NALOXONE; PHENACETIN; PHENAZONE; PROPRANOLOL; QUINIDINE; TIMOLOL; VERAPAMIL;

ANALYTIC METHOD; ARTICLE; CALIBRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYOPRESERVATION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; HUMAN; HUMAN CELL; LIVER CELL; LIVER CLEARANCE; LIVER METABOLISM; MALE; NORMAL HUMAN; PREDICTION; PRIORITY JOURNAL; SERUM;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYOPRESERVATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEPATOCYTES; HUMANS; LIVER; MALE; METABOLIC CLEARANCE RATE; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; SPECIES SPECIFICITY;

EID: 0036320379     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.8.892     Document Type: Article

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