Application of a convective-dispersion model to predict in vivo hepatic clearance from in vitro measurements utilizing cryopreserved human hepatocytes

Current Drug Metabolism

Volumn 4, Issue 5, 2003, Pages 357-369

  Niro, Ryan ^a   Byers, James P ^b   Fournier, Ronald L ^a   Bachmann, Kenneth ^b  

^a The University of Toledo   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; PHENYTOIN; PROCAINAMIDE; QUINIDINE; THEOPHYLLINE; VALPROIC ACID;

ANALYTIC METHOD; BIOLOGICAL MODEL; BLOOD FLOW; CELL SUSPENSION; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYOPRESERVATION; DISPERSION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG INDUSTRY; DRUG METABOLISM; DRUG RESEARCH; DRUG TISSUE LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; LIVER CELL; LIVER CLEARANCE; MATHEMATICAL MODEL; MEASUREMENT; PHYSIOLOGY; PREDICTION; RATING SCALE; RESOURCE MANAGEMENT; REVIEW; SENSITIVITY ANALYSIS;

ALGORITHMS; CRYOPRESERVATION; HEPATOCYTES; HUMANS; LIVER; MODELS, BIOLOGICAL; PERFUSION; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS;

EID: 0142074692     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200033489334     Document Type: Review

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