Lipopolysaccharide downregulates the expressions of intestinal pregnane X receptor and cytochrome P450 3a11

European Journal of Pharmacology

Volumn 536, Issue 1-2, 2006, Pages 162-170

  Xu, De Xiang ^a,b   Wang, Jian Ping ^a   Sun, Mei Fang ^a   Chen, Yuan Hua ^a   Wei, Wei ^b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b Key Laboratory of Anti inflammatory and Immunopharmacology of Anhui Province   (China)

Author keywords

Cytochrome P450 3A (CYP3A); Erythromycin N demethylase (ERND); Intestine; Lipopolysaccharide (LPS); Pregnane X receptor; Retinoid X receptor

Indexed keywords

ACETYLCYSTEINE; ASCORBIC ACID; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; DEXAMETHASONE; HETERODIMER; LIPOPOLYSACCHARIDE; MESSENGER RNA; N DEMETHYLASE; PREGNANE X RECEPTOR; RETINOID X RECEPTOR ALPHA; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; INTESTINE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; UPREGULATION;

ACETYLCYSTEINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; ASCORBIC ACID; CATALYSIS; CYTOCHROME P-450 CYP3A; DEXAMETHASONE; DOWN-REGULATION; FEMALE; GENE EXPRESSION; INTESTINE, SMALL; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MICE, INBRED ICR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RETINOID X RECEPTOR ALPHA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33645838358     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.02.029     Document Type: Article

References (46)

1. Allen R.G. Oxidative stress and superoxide dismutase in development, aging and gene regulation. Age 21 (1998) 47-76
2. Allen R.G., and Tresini M. Oxidative stress and gene regulation. Free Radic. Biol. Med. .28 (2000) 463-499
3. Ashino T., Oguro T., Shioda S., Horai R., Asano M., Sekikawa K., Iwakura Y., Numazawa S., and Yoshida T. Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver. Drug Metab. Dispos. 32 (2004) 707-714
4. Beigneux A.P., Moser A.H., Shigenaga J.K., Grunfeld C., and Feingold K.R. Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem. Biophys. Res. Commun. 293 (2002) 145-149
5. Bertilsson G., Heidrich J., Svensson K., Asman M., Jendeberg L., Sydow-Backman M., Ohlsson R., Postlind H., Blomquist P., and Berkenstam A. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 12208-12213
6. Chen Y.H., Wang J.P., Wang H., Sun M.F., Wei L.Z., Wei W., and Xu D.X. Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta. Toxicology 211 (2005) 242-252
7. Chun Y.J., Lee S., Yang S.A., Park S., and Kim M.Y. Modulation of CYP3A4 expression by ceramide in human colon carcinoma HT-29 cells. Biochem. Biophys. Res. Commun. 298 (2002) 687-692
8. Fukui H., Brauner B., Bode J.C., and Bode C. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay. J. Hepatol. 12 (1991) 162-169
9. Giguere V. Orphan nuclear receptors: from gene to function. Endocr. Rev. 20 (1999) 689-725
10. Goodwin B., Redinbo M.R., and Kliewer S.A. Regulation of cyp3a gene transcription by the pregnane x receptor. Annu. Rev. Pharmacol. Toxicol. 42 (2002) 1-23
11. Jacob A.L., Goldberg P.K., Bloom N., Degenshein G.A., and Kozinn P.J. Endotoxin and bacteria in portal blood. Gastroenterology 72 (1997) 1268-1270
12. Kalitsky-Szirtes J., Shayeganpour A., Brocks D.R., and Piquette-Miller M. Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats. Drug Metab. Dispos. 32 (2004) 20-27
13. Kliewer S.A., Moore J.T., Wade L., Staudinger J.L., Watson M.A., Jones S.A., McKee D.D., Oliver B.B., Willson T.M., Zetterstrom R.H., Perlmann T., and Lehmann J.M. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92 (1998) 73-82
14. Kliewer S.A., Goodwin B., and Willson T.M. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr. Rev. 23 (2002) 687-702
15. Kolars J.C., Lown K.S., Schmiedlin-Ren P., Ghosh M., Fang C., Wrighton S.A., Merion R.M., and Watkins P.B. CYP3A gene expression in human gut epithelium. Pharmacogenetics 4 (1994) 247-259
16. Lan L.B., Dalton J.T., and Schuetz E.G. Mdr1 limits CYP3A metabolism in vivo. Mol. Pharmacol. 58 (2000) 863-869
17. Lehmann J.M., McKee D.D., Watson M.A., Willson T.M., Moore J.T., and Kliewer S.A. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest. 102 (1998) 1016-1023
18. Li-Masters T., and Morgan E.T. Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice. Drug Metab. Dispos. 29 (2001) 252-257
19. Lin J.H., Chiba M., Chen I.W., Nishime J.A., deLuna F.A., Yamazaki M., and Lin Y.J. Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction. Drug Metab. Dispos. 27 (1999) 1187-1193
20. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
21. Lush C.W., Cepinskas G., and Kvietys P.R. Regulation of intestinal nuclear factor-kappaB activity and E-selectin expression during sepsis: a role for peroxynitrite. Gastroenterology 124 (2003) 118-128
22. Maglich J.M., Stoltz C.M., Goodwin B., Hawkins-Brown D., Moore J.T., and Kliewer S.A. Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol. Pharmacol. 62 (2002) 638-646
23. Mangelsdorf D.J., Thummel C., Beato M., Schutz P.G., Umesono K., Blumberg B., Kastner P., Mark M., and Chambon P. The nuclear receptor superfamily: the second decade. Cell 83 (1995) 835-839
24. Memon R.A., Staprans I., Noor M., Holleran W.M., Uchida Y., Moser A.H., Feingold K.R., and Grunfeld C. Infection and inflammation induce low density lipoprotein oxidation in vivo. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 1536-1542
25. Mercer D.W., Smith G.S., Cross J.M., Russell D.H., Chang L., and Cacioppo J. Effects of lipopolysaccharide on intestinal injury; potential role of nitric oxide and lipid peroxidation. J. Surg. Res. 63 (1996) 185-192
26. Meyer T.A., Wang J., Tiao G.M., Ogle C.K., Fischer J.E., and Hasselgren P.O. Sepsis and endotoxemia stimulate intestinal interleukin-6 production. Surgery 118 (1995) 336-342
27. Miyoshi M., Nadai M., Nitta A., Ueyama J., Shimizu A., Takagi K., Nabeshima T., Takagi K., Saito K., and Hasegawa T. Role of tumor necrosis factor-α in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin Eur. J. Pharmacol. 507 (2005) 229-237
28. Monshouwer M., McLellan R.A., Delaporte E., Witkamp R.F., van Miert A.S., and Renton K.W. Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem. Pharmacol. 52 (1996) 1195-1200
29. Moore L.B., Parks D.J., Jones S.A., Bledsoe R.K., Consler T.G., Stimmel J.B., Goodwin B., Liddle C., Blanchard S.G., Willson T.M., Collins J.L., and Kliewer S.A. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J. Biol. Chem. 275 (2000) 15122-15127
30. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 44 (1979) 276-278
31. Pan J., Xiang Q., Ball S., Scatina J., Kao J., and Hong J.Y. Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice. Drug Metab. Dispos. 31 (2003) 392-397
32. Quattrochi L.C., and Guzelian P.S. CYP3A regulation: from pharmacology to nuclear receptors. Drug Metab. Dispos. 29 (2001) 615-622
33. Sachdeva K., Yan B., and Chichester C.O. Lipopolysaccharide and cecal ligation/puncture differentially affect the subcellular distribution of the pregnane X receptor but consistently cause suppression of its target genes CYP3A. Shock 19 (2003) 469-474
34. Salvemini D., Riley D.P., Lennon P.J., Wang Z.Q., Currie M.G., Macarthur H., and Misko T.P. Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage. Br. J. Pharmacol. 127 (1999) 685-692
35. Sewer M.B., and Morgan E.T. Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1beta and endotoxin in primary rat hepatocytes. Biochem. Pharmacol. 54 (1997) 729-737
36. Sewer M.B., Barclay T.B., and Morgan E.T. Down-regulation of cytochrome P450 mRNAs and proteins in mice lacking a functional NOS2 gene. Mol. Pharmacol. 54 (1998) 273-279
37. Thummel K.E., and Wilkinson G.R. In vitro and in vivo drug interactions involving human CYP3A. Annu. Rev. Pharmacol. Toxicol. 38 (1998) 389-430
38. Ulich T.R., Guo K.Z., Irwin B., Remick D.G., and Davatelis G.N. Endotoxin-induced cytokine gene expression in vivo: II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression. Am. J. Pathol. 137 (1990) 1173-1185
39. Veau C., Faivre L., Tardivel S., Soursac M., Banide H., Lacour B., and Farinotti R. Effect of interleukin-2 on intestinal P-glycoprotein expression and functionality in mice. J. Pharmacol. Exp. Ther. 302 (2002) 742-750
40. Werringloer J. Assay of fomaldehyde generated during microsomal oxidation reactions. Methods Enzymol. 52 (1978) 297-302
41. Xie W., Barwick J.L., Simon C.M., Pierce A.M., Safe S., Blumberg B., Guzelian P.S., and Evans R.M. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev. 14 (2000) 3014-3023
42. Xu D.X., Wei W., Sun M.F., Wu C.Y., Wang J.P., Wei L.Z., and Zhou C.F. Kupffer cells and ROS partially mediate LPS-induced down-regulation of nuclear receptor Pregnane X receptor and its target gene CYP3A in mouse liver. Free Radic. Biol. Med. 37 (2004) 10-22
43. Xu D.X., Wei W., Sun M.F., Wei L.Z., and Wang J.P. Melatonin attenuates lipopolysaccharide-induced down-regulation of pregnane X receptor and its target gene CYP3A in mouse liver. J. Pineal Res. 38 (2005) 27-34
44. Xu D.X., Chen Y.H., Wang J.P., Sun M.F., Wang H., Wei L.Z., and Wei W. Perinatal lipopolysaccharide exposure downregulates pregnane X receptor and Cyp3a11 expression in fetal mouse liver. Toxicol. Sci. 87 (2005) 38-45
45. Yang T., Michele D.E., Park J., Smart A.M., Lin Z., Brosius III F.C., Schnermann J.B., and Briggs J.P. Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney. Am. J. Physiol. .277 6 Pt 2 (1999) F966-F973
46. Zhang H., LeCulyse E., Liu L., Hu M., Matoney L., Zhu W., and Yan B. Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch. Biochem. Biophys. 368 (1999) 14-22