Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage

British Journal of Pharmacology

Volumn 127, Issue 3, 1999, Pages 685-692

  Salvemini, Daniela ^a,b   Riley, Dennis P ^a   Lennon, Patrick J ^a   Wang, Zhi Qiang ^a   Currie, Mark G ^a   Macarthur, Heather ^a   Misko, Thomas P ^a  

^a MONSANTO COMPANY   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Intestinal injury; Peroxynitrite; Superoxide anions

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; COLCHICINE; PEROXYNITRITE; PORPHYRIN DERIVATIVE; SC 55858; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; ENDOTOXEMIA; INFLAMMATION; INTESTINE INJURY; INTRAVENOUS DRUG ADMINISTRATION; LIPID PEROXIDATION; MALE; MICROVASCULATURE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CATALYSIS; COLCHICINE; FERRIC COMPOUNDS; FREE RADICAL SCAVENGERS; INTESTINAL MUCOSA; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; MALE; METALLOPORPHYRINS; NEUTROPHILS; NITRATES; ORGANOMETALLIC COMPOUNDS; OXIDANTS; PORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 0033061712     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702604     Document Type: Article

References (48)

1. BATINIC-HABERLE, L, LIOCHEV, S.I., SPASOJEVIC, I. & FRIDOVICH, I. (1997). A potent Superoxide dismutase mimic: manganese beta-octabromo-meso-tetrakis-(N-methyrpyridinium-4-yl)porphyrin. Arch. Biochem. Biophys., 343, 225-233.
2. BECKMAN, J.S. (1994). Peroxynitrite versus hydroxyl radical: The role of nitric oxide in superoxide-dependent cerebral injury. Ann. NYAcad. Sei., 738, 69-75.
3. BECKMAN, J.S., BECKMAN, T.W., CHEN, J., MARSHALL, P.M. & FREEMAN, B.A. (1990). Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and Superoxide. Proc. Nail. Acad. Sei. U.S.A.. 87, 16201624.
4. BECKMAN, J.S. & CROW, J.P. (1993). Pathological implications of nitric oxide, Superoxide and peroxynitrite formation. Biochem. Soc. Trans., 21, 330-334.
5. BOUGHTON-SMITH, N.K., EVANS, S.M., LASZLO, F., WHITTLE, B.J. & MONCADA, S. (1993). The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat. Br. J. Pharmacol., 110, 1189-1195.
6. BRADLEY, P.P., PRIEBAT, D.A., CHRISTENSEN, R.D. & ROTHSTEIN, G. (1982). Measurement of cutaneous inflammation. Estimation of neutrophil content with an enzyme marker. J. Clin. Invest. Dermatol., 78, 206-209.
7. BRONER, C.W., SHENEP, J.L., STIDHAM, G.L., STOKES, D.C. & HILDNER, B.S. (1988). Effects of scavengers of oxygen-derived free radicals on mortality in endotoxin-challenged mice. Crit. Care Med., 16,848-851.
8. CROW, J.P. & BECKMAN, J.S. (1995). The role of peroxynitrite in nitric oxide mediated toxicity. Current Topics in Microbiology and Immunology., 196, 51-73.
9. DAWSON, V.L. (1995). Nitric oxide: role in neurotoxicity. Clin. Exp. Pharm. Physio!., 22, 305-308.
10. DAY, B.J., SHAWEN, S., LIOCHEV, S.I. & CRAPO, J.D. (1995). A metalloprotin Superoxide dismutase mimic protects against paraquat-induced endothelial cell injury, in vitro. J. Pharmacol. Exp. Thcr., 275, 1227-1232.
11. DEITCH, E.A., BRIDGES, \V., BERG, R., SPECIAN, R.D. & GRANGER, N. (1990). Hemorrhagic shock-induced bacterial translocation: the role of neutrophils and hydroxyl radicals. J. Trauma, 30, 942-951.
12. DROY-LEFAIX, M.T., DROUET, Y., GERAUD, G., HOSFOD, D. & BRAQUET, P. (1991). Superoxide dismutase (SOD) and the PAFantagonist (BN 52021) reduce small intestinal damage induced by ischemia-reperfusion. Free Rad. Res. Commun., 12-13, 725735.
13. ESPLUGUES, J.V. & WHITTLE, B.J. (1989). Gastric damage following local intra-arterial administration of reactive oxygen metabolites in the rat. Br. J. Pharmacol., 97, 1085-1092.
14. FÖRSTERMANN, U. & LEINERT, H. (1995). Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn-Schmiedebcrgs Arch. Pharmacol., 352, 351-364.
15. FUKUYAMA, N., TAKEBAYASHI, Y., HIDA, M., ISHIDA, H., ICHIMORI, K. & NAKAZAWA, H. (1997). Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shock. Free Radical Biol. Med., 22, 771-774.
16. GARDNER, P.R., NGUYEN, D.D.-H. & WHITE, C.W. (1996). Superoxide scavenging by Mn (II/III) tetrakis (l-methyl-4-pyridyl) porphyrin in mammalian cells. Arch. Biochem. Biophys.. 325, 20-28.
17. COW, A.J., THOM, S.R. & ISCHIROPOULUS, II. (1998). Nitric oxide and peroxynitrite mediated pulmonary cell death. Am. J. Physiol, 274, L112-L118.
18. GRAHAM, A., HOGG, N., KALYANARAMAN, B., O'LEARY, V., DARLEY-USMAR, V. & MONCADA, S. (1993). Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. FEES Lett., 330, 181-185.
19. HAGLIND, E., XIA, G. & RYLANDER, R. (1994). Effects of antioxidants and PAF receptor antagonist in intestinal shock in the rat. Circ. Shock, 42, 83-91.
20. HENSON, P.M. & JOHNSTON, R.B. (1987). Tissue injury and inflammation. Oxidants, proteinases and cationic proteins. J. Clin. Invest., 79, 669-674.
21. HIRSCHELMANN, R. & BEKEMEIER, H. (1981). Effects of catalase, peroxidase, Superoxide dismutase and 10 scavengers of oxygen radicals in carrageenan edema and in adjuvant arthritis of rats. Experientia, 37, 1313 -1314.
22. HUIE, R.E. & PADMAJA, S. (1993). The reaction of NO with Superoxide. Free Rad. Res. Commun., 18, 195-199.
23. ISCHIROPOULOS, H., ZHU, L. & BECKMAN, J.S. (1992). Peroxynitrite formation from macrophage-derived nitric oxide. Arch. Biochem. Biophys., 298, 446-451.
24. LAIGHT, D.W., LAD, N., WOODWARD, B. & WATERFALL, J.F. (1994). Assessment of myeloperoxidase activity in renal tissue after ischemia/reperfusion. Eur. J. Pharmacol.., 292, 81-88.
25. LAMARQUE, D. & WHITTLE, B.J.R. (1995a). Involvement of superoxide and xanthine oxidase in neutrophil-independent rat gastric damage induced by NO donors. Br. J. Pharmacol., 116, 18431848.
26. LAMARQUE, D. & WHITTLE, B.J.R. (1995b). Role of oxygen-derived metabolites in the rat gastric mucosal injury induced by nitric oxide donors. Eur. J. Pharmacol., 277, 187-194.
27. LENTZE, M.J., COLONY, P.C. & TRIER, J.S. (1985). Glucocorticoid receptors in isolated intestinal epithelial cells in rats. Am. J. Physiol., 249, G58-G65.
28. MARSHALL, M.J. & WORSFOLD, W. (1978). Superoxide dismutase: a direct, continuous assay using the oxygen electrode. Anal. Biochem., 86, 561-567.
29. MISKO, T.P., HIGHKIN, M.K., VEENHUIZEN, A.W., MANNING, P.T., STERN, M.K., CURRIE, M.G & SALVEMINI, D. (1998). Characterization of the cytoprotective action of peroxynitrite decomposition catalysts. J. Biol. Chem., 273, 15646-15653.
30. OHKAWA, H., OHISHI, H. & YAGI, K. (1979). Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem.. 95, 351-358.
31. PASTERNACK, R.F. & PYSNIK, D. (1983). Catalysis of the Dispropostionation of Superoxide by Metalloporphyrins. In Oxy Radicals and Their Scavenger Systems, eds. Cohen G & Greenwald R. p. 151, The Netherlands: Elsevier.
32. RADI, R., BECKMAN, J.S., BUSH, K.M. & FREEMAN, B.A. (1991a). Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of Superoxide and nitric oxide. Arch. Biochem Biophys.. 288, 481-487.
33. RADI, R., BECKMAN, J.S., BUSH, K.M. & FREEMAN, B.A. (1991b). Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of Superoxide and nitric oxide. J. Biol. Client., 266, 4244-4250.
34. RILEY, O.P., HENKE, S.L., LENNON, P.J., WEISS, R.H., NEUMANN, W.L., RIVERS, W.J., ASTON, K.W., SAMPLE, K.R., RAHMAN, H.| LING, C.-S., SHIEH, J.-J., BUSCH, D.H. & SZULBINSKI, W. (1996). Synthesis, characterization and stability of manganese (II) Csubstituted 1,4,7,10,13-pentaazacyclopentadecane complexes exhibiting Superoxide dismutase activity. Inorg. Chem., 35, 52135231.
35. RILEY, O.P., LENNON, P.J., NEUMANN, W.L. & WEISS, R.H. (1997). Toward the rational design of Superoxide dismutase mimics: Mechanistic studies for the elucidation of substituent effects on the catalytic activity of macrocyclic manganese(II) complexes. J. Am. Client. Soc.. 119, 6522.
36. SALTER, M., KNOWLES, R.G. & MONCADA, S. (1991). Widespread tissue distribution, species distribution and changes in activity of Ca2 +-dependent and Ca2 +-independent nitric oxide synthases. FEES Lett., 291, 145- 149.
37. SALVEMINI, D., MANNING, P.T., ZWEIFEL, B.S., SEIBERT, K., CONNOR, J., CURRIE, M.G., NEEDLEMAN, P. & MASFERRER, J.L. (1995). Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. J. Clin. Invest., 96, 301-308.
38. SALVEMINI, D., WANG, Z.-Q., STERN, M.K., CURRIE, M.G. & MISKO, T.P. (1998). Peroxynitrite decomposition catalysts: novel therapeutics for peroxynitrite-mediated pathology. Proc. Nail. Acad. Sei. U.S.A., 95, 2659-2663.
39. SALVEMINI, D., WANG, Z.Q., WYATT, P.S., BOURDON, D.M., MARINO, M.H., MANNING, P.Y. & CURRIE, M.G. (1996). Nitric oxide: a key mediator in the early and late phase ofcarrageenaninduced rat paw inflammation. Br. J. Pharmacol., 118, 829-838.
40. SCHLAG, G., REDL, H. & HALLSTRÖM, S. (1991). The cell in shock: the origin of multiple organ failure. Resuscitation, 21, 137-180. !
41. SCRAUFSTATTER, LU., HYSLOP, P.A., JACKSON, J. & COCHRANE, C.C. (1987). Oxidant injury of cells. //;J. J. Tissue. React., 9,317324.
42. SHIGENAGA, M.K., LEE, H.H., BLOUNT, B.C., CHRISTEN, S., SIIIGENO, E.T., YIP, H. & AMES, B.N. (1997). Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection. Proc. Nail. Acad. Sei. U.S.A., 94, 3211-3216.
43. STERN, M.K., JENSEN, M.P. & KRAMER, K. (1996). Peroxynitrite Decomposition Catalysts. J. Am. Client. Soc., 118, 8735-8736.
44. TAYLOR, D.E., GHIO, A.J. & PIANTADOSI, C.A. (1995). Reactive oxygen species produced by liver mitochondria of rats in sepsis. Arch. Biochem. Biophys., 316, 70-76.
45. TEPPERMAN, B.L., BROWN, J.F. & WHITTLE, B.J.R. (1993). Nitric oxide synthase induction and intestinal epithelial cell viability in rats. Am. J. Physiol.. 265, G214-G218.
46. WARREN, J.S., YABROFF, K.R., MANDEL, D.M., JOHNSON, K.J. & WARD, P.A. (1990). Role of O2~ in neutrophil recruitment into sites of dermal and pulmonary vasculitis. Free. Rad. Biol. Med., 8, 163-172.
47. WEISS, R.H., FLICKINGER, A.C., RIVERS, W.J., HARDY, M.D., ASTON, K.W., RYAN, U.S. & RILEY, O.P. (1993). Evaluation of putative Superoxide dismutase mimics. J. Biol. Client., 268, 23049.
48. XIA, Z.F., HOLLYOAK, M., BARROW, R.E., HE, F., MULLER, M.J. & HERNDON, D.N. (1995). Superoxide dismutase and leupeptin prevent delayed reperfusion injury in the rat small intestine during burn shock. J. Burn Care Rehab., 16, 111-117.