Lipopolysaccharide and cecal ligation/puncture differentially affect the subcellular distribution of the pregnane X receptor but consistently cause suppression of its target genes CYP3A

Shock

Volumn 19, Issue 5, 2003, Pages 469-474

  Sachdeva, Karuna ^a   Yan, Bingfang ^a   Chichester, Clinton O ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Cytochrome P450; Dexamethasone; Drug metabolism CYP induction; Sepsis; Translocation

Indexed keywords

CYTOCHROME P450 3A; DEXAMETHASONE; LIPOPOLYSACCHARIDE; PREGNANE X RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MEGADOSE; ENDOTOXEMIA; ENZYME ASSAY; ENZYME INDUCTION; GENE REPRESSION; GENE TARGETING; LIGATION; LOW DRUG DOSE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PUNCTURE; RAT; SEPSIS; SINGLE DRUG DOSE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CECUM; CYTOCHROME P-450 CYP3A; DEXAMETHASONE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; OXIDOREDUCTASES, N-DEMETHYLATING; PUNCTURES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SUBCELLULAR FRACTIONS; SUPPRESSION, GENETIC;

EID: 2942573826     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000048903.46342.ec     Document Type: Article

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