Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

Journal of Experimental Medicine

Volumn 192, Issue 5, 2000, Pages 755-760

  Smyth, Mark J ^a,d   Thia, Kevin Y T ^a   Street, Shayna E A ^a   MacGregor, Duncan ^b   Godfrey, Dale I ^c   Trapani, Joseph A ^a,d  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

^b AUSTIN HEALTH   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Cytotoxic T lymphocyte; Lymphoma; Perforin; Surveillance; Tumor immunity

Indexed keywords

PERFORIN; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CANCER INCIDENCE; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; LYMPHOMA; MOUSE; NATURAL KILLER CELL; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TUMOR REJECTION;

ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; GRAFT REJECTION; HUMANS; LYMPHOMA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; PORE FORMING CYTOTOXIC PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034605122     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.5.755     Document Type: Article

References (32)

1. The concept of immunological surveillance
2. On immunosurveillance in human cancer
3. Cytotoxic T lymphocyte therapy of cancer and tumor escape mechanisms
4. Natural killer cells and tumor therapy
5. + T cells
6. Expression of perforin in murine natural killer cells and cytotoxic T lymphocytes in vivo
7. Perforin: Structure and function
8. CTL granules: Evolution of vesicles essential for combating virus infections
9. Decreased tumor surveillance in perforin-deficient mice
10. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
11. Perforin is a major contributor to NK cell control of tumor metastasis
12. p53, The cellular gatekeeper for growth and division
13. Database of p53 gene somatic mutations in human tumors and cell lines
14. Clinical implications of the p53 tumor-suppressor gene
15. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
16. Tumor spectrum analysis in p53-mutant mice
17. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
18. Immune function in mice lacking the perforin gene
19. p53-Deficient mice are extremely susceptible to radiation-induced tumorigenesis
20. Cooperative tumorigenic effects of germline mutations in Rb and p53
21. Mutations in the p53 and SCID genes cooperate in tumorigenesis
22. Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
23. Cellular responses to interferon-γ
24. Differential tumor surveillance by natural killer (NK) and NKT cells
25. Spontaneous tumors in nude mice: Effect of the viable yellow gene
26. Anti-mu induces lymphoma in germfree congenitally athymic (nude) but not in heterozygous (nu/+) mice
27. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
28. Role of NK cells in tumour growth and metastasis in beige mice
29. Spontaneous and induced primary oncogenesis in natural killer (NK)-cell -deficient beige mutant mice
30. + T cells in persistent infection with lymphocytic choriomeningitis virus
31. A role for perforin in downregulating T-cell responses during chronic viral infection
32. Perforin gene defects in familial hemophagocytic lymphohistiocytosis