Gd(III)-BASED CONTRAST AGENTS FOR MRI

Advances in Inorganic Chemistry

Volumn 57, Issue , 2005, Pages 173-237

  AIME, SILVIO ^a   BOTTA, MAURO ^b   TERRENO, ENZO ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33645674562     PISSN: 08988838     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0898-8838(05)57004-1     Document Type: Review

References (175)

1. Young I.R. Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy (2000), John Wiley & Sons, Chichester
2. Rinck P.A. Magnetic Resonance in Medicine (2003), ABW Wissenschaftsverlag GmbH, Berlin
3. Merbach A.E., and Tóth E. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging (2001), John Wiley & Sons, Chichester
4. Rummeny E.J., and Marchal G. Acta Radiol. 38 (1997) 626-630
5. Wang Y.X.J., Hussain S.M., and Krestin G.P. Eur. Radiol. 11 (2001) 2319-2331
6. Reimer P., and Balzer T. Eur. Radiol. 13 (2003) 1266-1276
7. Caravan P., Ellison J.J., Mc Murry T.J., and Lauffer R.B. Chem Rev. 99 (1999) 2293-2352
8. Brücher E., and Sherry A.D. In: Merbach A.E., and Tóth E. (Eds). The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging (2001), John Wiley & Sons, Chichester 243-279
9. Padhani A.R. JMRI 16 (2002) 407-422
10. Lauffer R.B. Chem. Rev. 87 (1987) 901-927
11. Aime S., Botta M., Fasano M., and Terreno E. Chem. Soc. Rev. 27 (1998) 19-29
12. Tóth E., Helm L., and Merbach A.E. In: Merbach A.E., and Tóth E. (Eds). The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging (2001), John Wiley & Sons, Chichester 45-119
13. Banci L., Bertini I., and Luchinat C. Nuclear and Electron Relaxation (1991), VCH, Weinheim
14. Bertini I., and Luchinat C. NMR of Paramagnetic Molecules in Biological Systems (1986), Benjamin/Cummings, Menlo Park, CA
15. Xu J., Franklin S.J., Whisenhunt D.W., and Raymond K.N. J. Am. Chem. Soc. 1173 (1995) 7245-7246
16. Hajela S., Botta M., Girando S., Xu J., Raymond K.N., and Aime S. J. Am. Chem. Soc. 122 (2000) 11228-11229
17. Cohen S.M., Xu J., Radkov E., Raymond K.N., Botta M., Barge A., and Aime S. Inorg. Chem. 39 (2000) 5747-5756
18. Aime S., Botta M., Fasano M., and Terreno E. Acc. Chem. Res. 32 (1999) 941-949
19. Aime S., Botta M., Fasano M., Paoletti S., Anelli P.L., Uggeri F., and Virtuani M. Inorg. Chem. 33 (1994) 4707-4711
20. Pubanz D., González G., Powell D.H., and Merbach A.E. Inorg. Chem. 34 (1995) 4447-4453
21. Aime S., Barge A., Bruce J.I., Botta M., Howard J.A.K., Moloney J.M., Parker D., de Sousa A.S., and Woods M. J. Am. Chem. Soc. 121 (1999) 5762-5771
22. Powell D.H., Merbach A.E., Gonzalez G., Brücher E., Micskei K., Ottaviani F., Köhler K., von Zelewsky A., Grinberg O.Y., and Lebedev Y.S. Helv. Chim. Acta 76 (1993) 2129-2146
23. Powell D.H., Ni Dhubhghaill O.M., Pubanz D., Helm L., Lebedev Y.S., Schlaepfer W., and Merbach A.E. J. Am. Chem. Soc. 118 (1996) 9333-9346
24. O'Sullivan B., Doble D.M.J., Thompson M.K., Siering C., Xu J., Botta M., Aime S., and Raymond K.N. Inorg. Chem. 42 (2003) 2577-2583
25. Freed J. J. Chem. Phys. 68 (1978) 4034-4037
26. Koenig S.H., and Brown III R.D. Prog. NMR Spectrosc. 22 (1990) 487-567
27. Kim W.D., Kiefer G.E., Maton F., Mc Millan K., Muller R.N., and Sherry A.D. Inorg. Chem. 34 (1995) 2233-2243
28. Chen J.W., Belford R.L., and Clarkson R.B. J. Phys. Chem. 102 (1998) 2117-2130
29. Borel A., Helm L., and Merbach A.E. Chem. Eur. J. 7 (2001) 600-610
30. Aime S., Batsanov A.S., Botta M., Howard J.A.K., Parker D., Senanayake K., and Williams G. Inorg. Chem. 33 (1994) 4696-4706
31. Easteal A.J. In: Wakeham W.A., Nagashima A., and Sengers J.V. (Eds). Measurements of the Transport Properties of Fluids III (1994), Blackwell Scientific Publications, Oxford 265
32. Botta, M.; Ravera, M.; Barge, A.; Bottaro, M.; Osella, D. Dalton Trans. 2003, 1628-1633
33. Botta, M. Eur. J. Inorg. Chem. 2000, 399-407
34. Aime, S.; Botta, M.; Parker, D.; Williams, G. J. A. Dalton Trans. 1996, 17-23
35. Aime S., Botta M., Crich S.G., Giovenzana G., Pagliarin R., Sisti M., and Terreno E. Magn. Reson. Chem. 36 (1998) S200-S208
36. Aime S., Barge A., Botta M., Parker D., and de Sousa A.S. J. Am. Chem. Soc. 119 (1997) 4767-4768
37. Woods M., Zhang S.R., Ebron V., and Sherry A.D. Chem. Eur. J. 9 (2003) 4634-4640
38. Aime S., Botta M., Garino E., Geninatti Crich S., Giovenzana G., Pagliarin R., Palmisano G., and Sisti M. Chem. Eur. J. 6 (2000) 2609-2617
39. Helm, L.; Tóth, E.; Merbach, A.E. "Metal Ions in Biological Systems"; Eds. Sigel, A.; Sigel, H.; Marcel Dekker, Inc.: New York, 2003, Chapter 15, pp. 589-641
40. Tóth E., Helm L., and Merbach A.E. Top. Curr. Chem. 221 (2002) 61-101
41. Bruce J.I., Lowe M.P., and Parker D. In: Merbach A.E., and Tóth E. (Eds). The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging (2001), John Wiley & Sons, Chichester 437-460
42. Horrocks W.deW.J., and Sudnick D.R. Acc. Chem. Res. 14 (1981) 384-395
43. Beeby A., Clarkson I.M., Dickins R.S., Faulkner S., Parker D., Royle L., de Sousa A.S., Williams J.A.G., and Woods M. J. Chem. Soc., Perkin Trans 2 (1999) 493-499
44. Alpoim, M. C.; Urbano, A. M.; Geraldes, C. F. G. C.; Peters, J. A. J. Chem. Soc., Dalton Trans. 1992, 463-468
45. Caravan P., Astashkin A.V., and Raitsimring A.M. Inorg. Chem. 42 (2003) 3972-3974
46. Aime S., Botta M., and Ermondi G. J. Magn. Reson. 92 (1991) 572-580
47. Lammers H., Maton F., Pubanz D., Van Laren M.W., Van Bekkum H., Merbach A.E., Muller R.N., and Peters J.A. Inorg. Chem. 36 (1997) 2527-2532
48. Dunand F.A., Borel A., and Merbach A.E. J. Am. Chem. Soc. 124 (2002) 710-716
49. Micksei K., Helm L., Brücher E., and Merbach A.E. Inorg. Chem. 32 (1993) 3844-3850
50. Rast S., Fries P.H., and Belorizky E. J. Chem. Phys. 113 (2000) 8724-8735
51. Rast S., Borel A., Helm L., Belorizky E., Fries P.H., and Merbach A.E. J. Am. Chem. Soc. 123 (2001) 2637-2644
52. Messeri, D.; Lowe, M.P.; Parker, D.; Botta, M. Chem. Comm. 2001, 2742-2743
53. Terreno E., Boniforte P., Botta M., Fedeli F., Milone L., Mortillaro A., and Aime S. Eur. J. Inorg. Chem. 19 (2003) 3530-3533
54. Aime S., Botta M., Crich S.G., Giovenzana G.B., Pagliarin R., Piccinini M., Sisti M., and Terreno E. J. Biol. Inorg. Chem. 2 (1997) 470-479
55. Aime S., Botta M., Frullano L., Geninatti Crich S., Giovenzana G., Pagliarin R., Palmisano G., Riccardi Sirtori F., and Sisti M. J. Med. Chem. 43 (2000) 4017-4024
56. Aime S., Botta M., Fedeli F., Gianolio E., Terreno E., and Anelli P.L. Chem. Eur. J. 7 (2001) 5262-5269
57. Okumura M., Mikawa M., Yokawa T., Kanazawa Y., Kato H., and Shinohara H. Acad. Radiol. 9 (2002) S495-S497
58. Bolskar R.D., Benedetto A.F., Husebo L.O., Price R.E., Jackson E.F., Wallace S., Wilson L.J., and Alford J.M. J. Am. Chem. Soc. 125 (2003) 5471-5478
59. Funasaka H., Sakurai K., Oda Y., Yamamoto K., and Takahashi T. Chem. Phys. Lett. 232 (1995) 273-277
60. Aime S., Frullano L., and Geninatti Crich S. Angew. Chemie Int. Ed. 41 (2002) 1017-1019
61. Aime, S.; Botta, M.; Fasano, M.; Terreno, E. "The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging" Eds. Merbach, A.E.; Tóth, E.; John Wiley & Sons: Chichester, 2001, pp. 193-242 and references therein
62. Sieving P.F., Watson A.D., and Rocklage S.M. Bioconjugate Chem. 1 (1990) 65-70
63. Schuhmann-Giampieri G., Schmitt-Willich H., Frenzel T., Press W.R., and Weinmann H.J. Invest. Radiol. 26 (1991) 969-974
64. Desser T., Rubin D., Muller H., Qing F., Khodor S., Zanazzi Y., Ladd D., Wellons J., Kellar K., Toner J., and Snow R.J. Magn. Reson. Imaging 4 (1994) 467-472
65. Vexler V.S., Clement O., Schmitt-Willich H., and Brasch R.C. JMRI 4 (1994) 381-388
66. Aime S., Botta M., Crich S.G., Giovenzana G., Palmisano G., and Sisti M. Bioconjugate Chem. 10 (1999) 192-199
67. Lu Z.R., Wang X.H., Parker D.L., Goodrich K.C., and Buswell H.R. Bioconjugate Chem. 14 (2003) 715-719
68. Heckl S., Pipkorn R., Waldeck W., Spring H., Jenne J., von der Lieth C.W., Corban-Wilhelm H., Debus J., and Braun K. Cancer Res. 63 (2003) 4766-4772
69. Corot, C.; Schaefer, M.; Beaute, S.; Bourrinet, P.; Zehaf, S.; Benize, V.; Sabatou, M.; Meyer, D. Acta Radiol. 1997, 412 (Suppl.), 91-99
70. Casali, C.; Janier, M.; Canet, E.; Obadia, J. F.; Benderbous, S.; Corot, C.; Revel, D. Acad. Radiol. 1998, 5 (Suppl. 1), S214-S218
71. Meyer D., Schaefer M., Bouillot A., Beaute S., and Chambon C. Invest. Radiol. 26 (1991) S50-S52
72. Rebizak R., Schaefer M., and Dellacherie E. Eur. J. Pharm. Sci. 7 (1999) 243-248
73. Helbich T.H., Gossman A., Mareski P.A., Raduchel B., Roberts T.P.L., Shames D.M., Muhler M., Turetschek K., and Brasch R.C. JMRI 11 (2000) 694-701
74. Sun G., Feng J., Jing F., Pei F., and Liu M. J. Magn. Magn. Mat. 265 (2003) 123-129
75. Aime S., Barbero L., and Botta M. Magn. Reson. Imaging 9 (1991) 843-847
76. Andrè J.P., Toth E., Maecke H.R., and Merbach A.E. Chem. Eur. J. 5 (1999) 2977-2983
77. Nicolle G.M., Toth E., Eisenwiener K.P., Maecke H.R., and Merbach A.E. J. Biol. Inorg. Chem. 7 (2002) 757-769
78. Tournier, H.; Hyacinthe, R.; Schneider, M. Acad. Radiol. 2002, 9 (Suppl. 1), S20-S28
79. Torchilin V.P. Adv. Drug Deliv. Rev. 54 (2002) 235-252
80. Glogard C., Hovland R., Fossheim S.L., Aasen A.J., and Klaveness J. J. Chem. Soc. Perkin Trans. 2 5 (2000) 1047-1052
81. Alhaique F., Bertini I., Fragai M., Carafa M., Luchinat C., and Parigi G. Inorg. Chim. Acta 331 (2002) 151-157
82. Glogard C., Stensrud G., Hovland R., Fossheim S.L., and Klaveness J. Int. J. Pharm. 233 (2002) 131-140
83. Suga K., Mikawa M., Ogasawara N., Okazaki H., and Matsunaga N. Invest. Radiol. 36 (2001) 136-145
84. Weissig V., Babich J., and Torchilin V. Coll. Surf. Biointerfaces 18 (2000) 293-299
85. Fossheim S.L., Fahlvik A.K., Klaveness J., and Muller R.N. Magn. Reson. Imaging 17 (1999) 83-89
86. Bryant L.H., Brechbiel M.W., Wu C.C., Bulte J.W.M., Herynek V., and Frank J.A. JMRI 9 (1999) 348-352
87. Margerum L.D., Campion B.K., Koo M., Shargill N., Lai J.J., Marumoto A., and Sontum P.C. J. Alloys Comp. 249 (1997) 185-190
88. Wiener E.C., Brechbiel M.W., Brothers H., Magin R.L., Gansow O.A., Tomalia D.A., and Lauterbur P.C. Magn. Reson. Med. 31 (1994) 1-8
89. Tacke J., Adam G., Classen H., Muhler A., Prescher A., and Gunther R.W. JMRI 7 (1997) 678-682
90. Roberts H.C., Saeed M., Roberts T.P.L., Muhler A., Shames D.M., Mann J.S., Stiskal M., Demsar F., and Brasch R.C. JMRI 7 (1997) 331-338
91. Dong Q., Hurst D.R., Weinmann H.J., Chenevert T.L., Londy F.J., and Prince M.R. Invest. Radiol. 33 (1998) 699-708
92. Tóth E., Pubanz D., Vauthey S., Helm L., and Merbach A.E. Chem. Eur. J. 2 (1996) 1607-1615
93. Kobayashi H., and Brechbiel M.W. Mol. Imaging 2 (2003) 1-10
94. Tóth E., Helm L., Kellar K.E., and Merbach A.E. Chem. Eur. J. 5 (1999) 1202-1211
95. Toth E., van Uffelen I., Helm L., Merbach A.E., Ladd D., Briley-Saebo K., and Kellar K.E. Magn. Reson. Chem. 36 (1998) S125-S134
96. Duarte M.G., Gil M.H., Peters J.A., Colet J.M., Vander Elst L., Muller R.N., and Geraldes C.F.G.C. Bioconjugate Chem. 12 (2001) 170-177
97. Comblin V., Gilsoul D., Hermann M., Humblet V., Jacques V., Mesbahi M., Sauvage C., and Desreux J.F. Coord. Chem. Rev. 186 (1999) 451-470
98. Aime S., Cabella C., Colombatto S., Crich S.G., Gianolio E., and Maggioni F. JMRI 16 (2002) 394-406
99. Bogdanov A., Matuszewski L., Bremer C., Petrovski A., and Weissleder R. Molec. Imag. 1 (2002) 16-23
100. Port M., Meyer D., Bonnemain B., Corot C., Schaefer M., Rousseaux O., Simonot C., Bourrinet P., Benderbous S., Dencausse A., and Devoldere L. MAGMA 8 (1999) 172-176
101. Vander Elst, L.; Port, M.; Raynal, I.; Simonot, C.; Muller, R.N. Eur. J. Inorg. Chem. 2003, 2495-2501
102. Nicolle G.M., Tóth E., Schmitt-Willich H., Radüchel B., and Merbach A.E. Chem. Eur. J. 8 (2002) 1040-1048
103. Aime S., Gianolio E., Terreno E., Giovenzana G.B., Pagliarin R., Sisti M., Palmisano G., Botta M., Lowe M.P., and Parker D. J. Biol. Inorg. Chem. 5 (2000) 488-497
104. Aime S., D'Amelio N., Fragai M., Lee Y.M., Luchinat C., Terreno E., and Valensin G. J. Biol. Inorg. Chem. 7 (2002) 617-622
105. Parker D., Dickins R.S., Puschmann H., Crossland C., and Howard J.A.K. Chem. Rev. 102 (2002) 1977-2010
106. Aime S., Barge A., Bruce J.I., Botta M., Howard J.A.K., Moloney J.M., Parker D., de Sousa A.S., and Woods M. J. Am. Chem. Soc. 121 (1999) 5762-5771
107. Woods M., Aime S., Botta M., Howard J.A.K., Moloney J.M., Navet M., Parker D., Port M., and Rousseaux O. J. Am. Chem. Soc. 122 (2000) 9781-9792
108. Pubanz D., Gonzalez G., Powell D.H., and Merbach A.E. Inorg. Chem. 34 (1995) 4447-4453
109. Parker, D.; Puschmann, H.; Batsanov, A. S.; Senanayake, K. Inorg. Chem. 2003, 42, 8646-8651
110. Aime, S.; Barge, A.; Batsanov, A.S.; Botta, M.; Castelli, D.D.; Fedeli, F.; Mortillaro, A.; Parker, D.; Puschmann, H. Chem. Comm. 2002, 1120-1121
111. Aime S., Barge A., Borel A., Botta M., Chemerisov S., Merbach A.E., Muller U., and Pubanz D. Inorg. Chem. 36 (1997) 5104-5112
112. Barge, A.; Botta, M.; Parker, D.; Puschmann, H. Chem. Comm. 2003, 1386-1387
113. Thompson M.K., Botta M., Nicolle G., Helm L., Aime S., Merbach A.E., and Raymond K.N. J. Am. Chem. Soc. 125 (2003) 14274-14275
114. Toth E., Connac F., Helm L., Adamzli K., and Merbach A.E. J. Biol. Inorg. Chem. 3 (1998) 606-613
115. Aime S., Chiaussa M., Digilio G., Gianolio E., and Terreno E. J. Biol. Inorg. Chem. 4 (1999) 766-774
116. Jacques V., and Desreux J.F. Top. Curr. Chem. 221 (2002) 123-164
117. Meade T.J., Taylor A.K., and Bull S.R. Curr. Opin. Neurobiol. 13 (2003) 597-602
118. Zhang S.R., Merritt M., Woessner D.E., Lenkinski R.E., and Sherry A.D. Acc. Chem. Res. 36 (2003) 783-790
119. Aime S., Barge A., Castelli D.D., Fedeli F., Mortillaro A., Nielsen F.U., and Terreno E. Magn. Reson. Med. 47 (2002) 639-648
120. Aime S., Delli Castelli D., and Terreno E. Angew. Chemie Int. Ed. 41 (2002) 4334-4336
121. Raghunand N., Altbach M.I., Van Sluis R., Bagget B., Taylor C.W., Bhuiwalla Z.M., and Gillies R.J. Biochem. Pharmacol. 57 (1999) 309-312
122. Gerweck L.E., and Seetharaman K. Cancer Res. 56 (1996) 1194-1199
123. Tannock I.F., and Rotin D. Cancer Res. 49 (1989) 4373-4384
124. Naghavi M., John R., Naguib S., Siadaty M.S., Grasu R., Kurian K.C., van Winkle W.B., Soller B., Litovsky S., Madjid M., Willerson J.T., and Casscells W. Atherosclerosis 164 (2002) 27-35
125. Aime, S.; Botta, M.; Milone, L.; Terreno, E. Chem. Comm. 1996, 1265-1266
126. Zhou J.Y., Payen J.F., Wilson D.A., Traystman R.J., and van Zijl P.C.M. Nat. Med. 9 (2003) 1085-1090
127. Pilatus U., Aboagye E., Artemov D., Mori N., Ackerstaff E., and Bhujwalla Z.M. Magn. Reson. Med. 45 (2001) 749-755
128. Sun Y., Sugawara M., Mulkern R.V., Hynynen K., Mochizuki S., Albert M., and Zuo C.S. NMR Biomed. 13 (2000) 460-466
129. Ward K.M., and Balaban R.S. Magn. Reson. Med. 44 (2000) 799-802
130. Lowe M.P., Parker D., Reany O., Aime S., Botta M., Castellano G., Gianolio E., and Pagliarin R. J. Am. Chem. Soc. 123 (2001) 7601-7609
131. Zhang S.R., Wu K.C., and Sherry A.D. Angew. Chemie Int. Ed. 38 (1999) 3192-3194
132. Raghunand N., Howison C., Sherry A.D., Zhang S.R., and Gillies R.J. Magn. Reson. Med. 49 (2003) 249-257
133. Aime, S.; Botta, M.; Crich, S.G.; Giovenzana, G.; Palmisano, G.; Sisti, M. Chem. Comm. 1999, 1577-1578
134. Lokling K.E., Fossheim S.L., Skurtveit R., Bjornerud A., and Klaveness J. Magn. Reson. Imag. 19 (2001) 731-738
135. Lokling K.E., Skurtveit R., Fossheim S.L., Smistad G., Henriksen I., and Klaveness J. Magn. Reson. Imag. 21 (2003) 531-540
136. Quesson B., de Zwart J.A., and Moonen C.T.W. JMRI 12 (2000) 525-533
137. Fossheim S.L., Il'yasov K.A., Hennig J., and Bjornerud A. Acad. Radiol. 7 (2000) 1107-1115
138. Fossheim S.L., Fahlvik A.K., Klaveness J., and Muller R.N. Magn. Reson. Imag. 17 (1999) 83-89
139. Aime S., Ascenzi P., Comoglio E., Fasano M., and Paoletti S. J. Am. Chem. Soc. 117 (1995) 9365-9366
140. Glogard C., Stensrud G., and Aime S. Magn. Reson. Chem. 41 (2003) 585-588
141. Aime S., Botta M., Gianolio E., and Terreno E. Angew. Chemie Int. Ed. 39 (2000) 747-748
142. Seibig S., Toth E., and Merbach A.E. J. Am. Chem. Soc. 122 (2000) 5822-5830
143. Burai L., Toth E., Seibig S., Scopelliti R., and Merbach A.E. Chem. Eur. J. 6 (2000) 3761-3770
144. Burai L., Toth E., Moreau G., Sour A., Scopelliti R., and Merbach A.E. Chem. Eur. J. 9 (2003) 1394-1404
145. Anelli, P.L.; Bertini, I.; Fragai, M.; Lattuada, L.; Luchinat, C.; Parigi, G. Eur. J. Inorg. Chem. 2000, 625-630
146. Lauffer, R.B.; Mc Murry, T.J.; Dunham, S.O.; Scott, D.M.; Parmelee, D.J.; Dumas, S. PCT Int. Appl. WO9736619, 1997
147. Nivorozhkin A.L., Kolodziej A.F., Caravan P., Greenfield M.T., Lauffer R.B., and McMurry T.J. Angew. Chemie Int. Ed. 40 (2001) 2903-2906
148. Moats R.A., Fraser S.E., and Meade T.J. Angew. Chemie Int. Ed. 36 (1997) 726-728
149. Louie A.Y., Huber M.M., Ahrens E.T., Rothbacher U., Moats R., Jacobs R.E., Fraser S.E., and Meade T.J. Nat. Biotechnol. 18 (2000) 321-325
150. Aime S., Dastru W., Crich S.G., Gianolio E., and Mainero V. Biopolymers 66 (2002) 419-428
151. Henriksen O., Weislander S., Gierris F., and Jensen K.M. Acta Radiol. 32 (1991) 95-100
152. Castillo M., and Kwock L. In: Castillo M.W.B. (Ed). Proton MR Spectroscopy of Common Brain Tumors in Neuroimaging clinics of North America 8 (1998), Saunders Company, Philadelphia 733-752
153. Grodd W., Krägeloh-Mann I., Klose U., and Santer R. Radiology 181 (1991) 173-180
154. VanderElst L., Vanhaverbeke Y., Goudemant J.F., and Muller R.N. Magn. Reson. Med. 31 (1994) 437-444
155. Bruce J.I., Dickins R.S., Govenlock L.J., Gunnlaugsson T., Lopinski S., Lowe M.P., Parker D., Peacock R.D., Perry J.J.B., Aime S., and Botta M. J. Am. Chem. Soc. 122 (2000) 9674-9684
156. Aime S., Botta M., Mainero V., and Terreno E. Magn. Reson. Med. 47 (2002) 10-13
157. Aime S., Delli Castelli D., Fedeli F., and Terreno E. J. Am. Chem. Soc. 124 (2002) 9364-9365
158. Faulkner, S.; Burton-Pye, B.P.; Khan, T.; Martin, L.R.; Wray, S.D.; Skabara, P. J. Chem. Comm. 2002, 1668-1669
159. Dickins R.S., Love C.S., and Puschmann H. Chem. Comm. 22 (2001) 2308-2309
160. Terreno E., Botta M., Fedeli F., Mondino B., Milone L., and Aime S. Inorg. Chem. 42 (2003) 4891-4897
161. Botta M., Aime S., Barge A., Bobba G., Dickins R.S., Parker D., and Terreno E. Chem. Eur. J. 9 (2003) 2102-2109
162. Li W., Fraser S., and Meade T.J. J. Am. Chem. Soc. 121 (1999) 1413-1414
163. Grynkiewicz G., Poenie M., and Tsien R.Y. J. Biol. Chem. 260 (1985) 3440-3448
164. Hanaoka, K.; Kikuchi, K.; Urano, Y.; Nagano, T. J. Chem. Soc. Perkin Trans. 2 2001, 1840-1843
165. Lawrence Y., Ozil J.P., and Swann K. Biochem. J. 335 (1998) 335-341
166. Weissleder R., and Mahmood U. Radiology 219 (2001) 316-333
167. Sipkins D.A., Cheresh D.A., Kazemi M.R., Nevin L.M., Bednarski M.D., and Li K.C.P. Nat. Med. 4 (1998) 623-626
168. Winter P.M., Caruthers S.D., Kassner A., Harris T.D., Chinen L.K., Allen J.S., Lacy E.K., Zhang H.Y., Robertson J.D., Wickline S.A., and Lanza G.M. Cancer Res. 63 (2003) 5838-5843
169. Artemov D., Mori N., Ravi R., and Bhujwalla Z.M. Cancer Res. 63 (2003) 2723-2727
170. Geninatti Crich, S.; Biancone, L.; Cantaluppi, U.; Duò, D.; Esposito, G.; Russo, S.; Camussi, G.; Aime, S. Magn. Reson. Med., accepted for publication
171. Aime, S.; Cavalli, R.; Cravotto, G.; Gianolio, E. unpublished results
172. Osterloh K., and Aisen P. Biochem. Biophys. Acta 1275 (1996) 161-203
173. Wiener E.C., Konda S., Shadron A., Brechbiel M., and Gansow O. Invest. Radiol. 32 (1997) 748-754
174. Bhorade R., Weissleder R., Nakakoshi T., Moore A., and Tung C.H. Bioconjugate Chem. 11 (2000) 301-305
175. Allen M.J., and Meade T.J. J. Biol. Inorg. Chem. 8 (2003) 746-750